DUF4379 domain-containing protein

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379) - putative

Species:

Leishmania infantum

UniProt:

A4I4S7_LEIIN

TriTrypDb:

LINF_290029500

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I4S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.700
CLV_C14_Caspase3-7	127	131	PF00656	0.651
CLV_C14_Caspase3-7	178	182	PF00656	0.716
CLV_C14_Caspase3-7	187	191	PF00656	0.581
CLV_C14_Caspase3-7	206	210	PF00656	0.618
CLV_NRD_NRD_1	115	117	PF00675	0.446
CLV_NRD_NRD_1	196	198	PF00675	0.650
CLV_NRD_NRD_1	199	201	PF00675	0.499
CLV_NRD_NRD_1	33	35	PF00675	0.697
CLV_NRD_NRD_1	443	445	PF00675	0.389
CLV_NRD_NRD_1	446	448	PF00675	0.365
CLV_NRD_NRD_1	99	101	PF00675	0.581
CLV_PCSK_FUR_1	197	201	PF00082	0.671
CLV_PCSK_FUR_1	441	445	PF00082	0.329
CLV_PCSK_KEX2_1	101	103	PF00082	0.543
CLV_PCSK_KEX2_1	115	117	PF00082	0.473
CLV_PCSK_KEX2_1	164	166	PF00082	0.588
CLV_PCSK_KEX2_1	196	198	PF00082	0.641
CLV_PCSK_KEX2_1	199	201	PF00082	0.497
CLV_PCSK_KEX2_1	33	35	PF00082	0.697
CLV_PCSK_KEX2_1	443	445	PF00082	0.383
CLV_PCSK_KEX2_1	446	448	PF00082	0.371
CLV_PCSK_KEX2_1	86	88	PF00082	0.656
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.663
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.544
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.633
CLV_PCSK_PC7_1	111	117	PF00082	0.639
CLV_PCSK_SKI1_1	282	286	PF00082	0.382
CLV_PCSK_SKI1_1	297	301	PF00082	0.244
CLV_PCSK_SKI1_1	456	460	PF00082	0.589
DEG_APCC_DBOX_1	318	326	PF00400	0.279
DEG_APCC_DBOX_1	445	453	PF00400	0.334
DEG_SPOP_SBC_1	217	221	PF00917	0.512
DOC_CYCLIN_RxL_1	240	251	PF00134	0.510
DOC_MAPK_gen_1	317	325	PF00069	0.397
DOC_MAPK_JIP1_4	319	325	PF00069	0.279
DOC_PP1_RVXF_1	417	423	PF00149	0.279
DOC_PP4_FxxP_1	140	143	PF00568	0.704
DOC_PP4_FxxP_1	334	337	PF00568	0.279
DOC_USP7_MATH_1	22	26	PF00917	0.657
DOC_USP7_MATH_1	223	227	PF00917	0.623
DOC_USP7_MATH_1	77	81	PF00917	0.703
DOC_WW_Pin1_4	219	224	PF00397	0.544
DOC_WW_Pin1_4	409	414	PF00397	0.397
DOC_WW_Pin1_4	92	97	PF00397	0.578
LIG_14-3-3_CanoR_1	100	106	PF00244	0.597
LIG_14-3-3_CanoR_1	311	316	PF00244	0.384
LIG_14-3-3_CanoR_1	380	387	PF00244	0.368
LIG_14-3-3_CanoR_1	444	450	PF00244	0.417
LIG_14-3-3_CanoR_1	45	51	PF00244	0.609
LIG_BRCT_BRCA1_1	136	140	PF00533	0.710
LIG_BRCT_BRCA1_1	291	295	PF00533	0.397
LIG_BRCT_BRCA1_1	62	66	PF00533	0.597
LIG_deltaCOP1_diTrp_1	287	295	PF00928	0.334
LIG_EH_1	331	335	PF12763	0.279
LIG_FHA_1	127	133	PF00498	0.647
LIG_FHA_1	203	209	PF00498	0.655
LIG_FHA_1	231	237	PF00498	0.512
LIG_FHA_1	310	316	PF00498	0.509
LIG_FHA_1	457	463	PF00498	0.664
LIG_FHA_2	149	155	PF00498	0.596
LIG_FHA_2	176	182	PF00498	0.717
LIG_LIR_Apic_2	137	143	PF02991	0.705
LIG_LIR_Apic_2	347	353	PF02991	0.279
LIG_LIR_Nem_3	397	401	PF02991	0.279
LIG_MYND_1	333	337	PF01753	0.279
LIG_SH2_NCK_1	256	260	PF00017	0.279
LIG_SH2_STAP1	359	363	PF00017	0.279
LIG_SH2_STAT5	244	247	PF00017	0.466
LIG_SH3_3	368	374	PF00018	0.334
LIG_SH3_3	91	97	PF00018	0.529
LIG_TRAF2_1	152	155	PF00917	0.772
LIG_TRAF2_1	388	391	PF00917	0.536
LIG_TRAF2_1	72	75	PF00917	0.652
MOD_CK1_1	104	110	PF00069	0.557
MOD_CK1_1	219	225	PF00069	0.529
MOD_CK1_1	341	347	PF00069	0.290
MOD_CK1_1	389	395	PF00069	0.442
MOD_CK1_1	445	451	PF00069	0.334
MOD_CK1_1	46	52	PF00069	0.672
MOD_CK2_1	148	154	PF00069	0.606
MOD_CK2_1	171	177	PF00069	0.584
MOD_CK2_1	181	187	PF00069	0.663
MOD_CK2_1	218	224	PF00069	0.625
MOD_CK2_1	69	75	PF00069	0.611
MOD_GlcNHglycan	106	109	PF01048	0.653
MOD_GlcNHglycan	112	115	PF01048	0.486
MOD_GlcNHglycan	166	169	PF01048	0.657
MOD_GlcNHglycan	171	174	PF01048	0.598
MOD_GlcNHglycan	274	277	PF01048	0.279
MOD_GlcNHglycan	291	294	PF01048	0.279
MOD_GlcNHglycan	301	304	PF01048	0.262
MOD_GlcNHglycan	338	343	PF01048	0.253
MOD_GlcNHglycan	382	385	PF01048	0.395
MOD_GlcNHglycan	40	43	PF01048	0.707
MOD_GlcNHglycan	45	48	PF01048	0.695
MOD_GSK3_1	134	141	PF00069	0.707
MOD_GSK3_1	169	176	PF00069	0.685
MOD_GSK3_1	215	222	PF00069	0.583
MOD_GSK3_1	409	416	PF00069	0.429
MOD_GSK3_1	45	52	PF00069	0.706
MOD_GSK3_1	60	67	PF00069	0.706
MOD_LATS_1	454	460	PF00433	0.581
MOD_N-GLC_1	309	314	PF02516	0.528
MOD_N-GLC_2	91	93	PF02516	0.570
MOD_NEK2_1	203	208	PF00069	0.548
MOD_NEK2_1	272	277	PF00069	0.420
MOD_NEK2_1	378	383	PF00069	0.370
MOD_NEK2_1	60	65	PF00069	0.697
MOD_PIKK_1	181	187	PF00454	0.713
MOD_PIKK_1	378	384	PF00454	0.491
MOD_PIKK_1	70	76	PF00454	0.606
MOD_PKA_1	101	107	PF00069	0.593
MOD_PKA_1	164	170	PF00069	0.584
MOD_PKA_2	101	107	PF00069	0.597
MOD_PKA_2	110	116	PF00069	0.616
MOD_PKA_2	164	170	PF00069	0.601
MOD_PKA_2	310	316	PF00069	0.391
MOD_PKA_2	344	350	PF00069	0.243
MOD_PKA_2	355	361	PF00069	0.330
MOD_PKA_2	442	448	PF00069	0.288
MOD_PKA_2	68	74	PF00069	0.658
MOD_Plk_1	389	395	PF00069	0.521
MOD_Plk_1	431	437	PF00069	0.279
MOD_Plk_1	60	66	PF00069	0.599
MOD_Plk_2-3	142	148	PF00069	0.699
MOD_Plk_4	203	209	PF00069	0.490
MOD_Plk_4	344	350	PF00069	0.279
MOD_Plk_4	389	395	PF00069	0.521
MOD_ProDKin_1	219	225	PF00069	0.545
MOD_ProDKin_1	409	415	PF00069	0.397
MOD_ProDKin_1	92	98	PF00069	0.579
MOD_SUMO_for_1	16	19	PF00179	0.541
MOD_SUMO_for_1	163	166	PF00179	0.540
MOD_SUMO_for_1	335	338	PF00179	0.269
MOD_SUMO_rev_2	19	28	PF00179	0.583
MOD_SUMO_rev_2	409	418	PF00179	0.257
MOD_SUMO_rev_2	79	88	PF00179	0.524
TRG_DiLeu_BaEn_4	390	396	PF01217	0.520
TRG_ENDOCYTIC_2	244	247	PF00928	0.492
TRG_ER_diArg_1	115	117	PF00400	0.634
TRG_ER_diArg_1	196	199	PF00400	0.635
TRG_ER_diArg_1	442	444	PF00400	0.391
TRG_NLS_Bipartite_1	86	104	PF00514	0.686
TRG_NLS_MonoExtN_4	97	104	PF00514	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX8	Leptomonas seymouri	52%	98%
A0A3Q8IEK2	Leishmania donovani	99%	100%
A4HHL8	Leishmania braziliensis	73%	100%
E9AE80	Leishmania major	89%	100%
E9ALK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%