tRNA-uridine aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DTW domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I4S6_LEIIN

TriTrypDb:

LINF_290029400

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4S6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006399	tRNA metabolic process	7	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008033	tRNA processing	8	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0034470	ncRNA processing	7	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034660	ncRNA metabolic process	6	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140101	catalytic activity, acting on a tRNA	4	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.543
CLV_C14_Caspase3-7	456	460	PF00656	0.357
CLV_NRD_NRD_1	168	170	PF00675	0.340
CLV_NRD_NRD_1	303	305	PF00675	0.338
CLV_NRD_NRD_1	331	333	PF00675	0.241
CLV_NRD_NRD_1	374	376	PF00675	0.508
CLV_NRD_NRD_1	418	420	PF00675	0.292
CLV_NRD_NRD_1	491	493	PF00675	0.391
CLV_NRD_NRD_1	497	499	PF00675	0.422
CLV_NRD_NRD_1	502	504	PF00675	0.433
CLV_NRD_NRD_1	518	520	PF00675	0.576
CLV_NRD_NRD_1	567	569	PF00675	0.506
CLV_NRD_NRD_1	578	580	PF00675	0.539
CLV_NRD_NRD_1	84	86	PF00675	0.504
CLV_NRD_NRD_1	91	93	PF00675	0.605
CLV_PCSK_FUR_1	576	580	PF00082	0.586
CLV_PCSK_KEX2_1	168	170	PF00082	0.329
CLV_PCSK_KEX2_1	303	305	PF00082	0.262
CLV_PCSK_KEX2_1	31	33	PF00082	0.401
CLV_PCSK_KEX2_1	331	333	PF00082	0.237
CLV_PCSK_KEX2_1	374	376	PF00082	0.275
CLV_PCSK_KEX2_1	420	422	PF00082	0.351
CLV_PCSK_KEX2_1	462	464	PF00082	0.266
CLV_PCSK_KEX2_1	491	493	PF00082	0.400
CLV_PCSK_KEX2_1	496	498	PF00082	0.466
CLV_PCSK_KEX2_1	502	504	PF00082	0.610
CLV_PCSK_KEX2_1	518	520	PF00082	0.576
CLV_PCSK_KEX2_1	567	569	PF00082	0.506
CLV_PCSK_KEX2_1	578	580	PF00082	0.539
CLV_PCSK_KEX2_1	83	85	PF00082	0.498
CLV_PCSK_KEX2_1	91	93	PF00082	0.606
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.387
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.236
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.351
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.266
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.606
CLV_PCSK_PC7_1	492	498	PF00082	0.428
CLV_PCSK_SKI1_1	150	154	PF00082	0.409
CLV_PCSK_SKI1_1	32	36	PF00082	0.398
CLV_PCSK_SKI1_1	394	398	PF00082	0.395
CLV_PCSK_SKI1_1	468	472	PF00082	0.400
CLV_PCSK_SKI1_1	551	555	PF00082	0.478
CLV_Separin_Metazoa	224	228	PF03568	0.292
CLV_Separin_Metazoa	97	101	PF03568	0.471
DEG_APCC_DBOX_1	31	39	PF00400	0.378
DEG_APCC_DBOX_1	518	526	PF00400	0.536
DEG_SPOP_SBC_1	450	454	PF00917	0.236
DOC_ANK_TNKS_1	311	318	PF00023	0.291
DOC_CKS1_1	46	51	PF01111	0.454
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.351
DOC_MAPK_DCC_7	132	141	PF00069	0.442
DOC_MAPK_gen_1	158	166	PF00069	0.437
DOC_MAPK_gen_1	168	174	PF00069	0.289
DOC_MAPK_gen_1	31	37	PF00069	0.376
DOC_MAPK_gen_1	374	382	PF00069	0.369
DOC_MAPK_gen_1	83	89	PF00069	0.510
DOC_MAPK_MEF2A_6	132	141	PF00069	0.500
DOC_MAPK_MEF2A_6	374	381	PF00069	0.236
DOC_MAPK_MEF2A_6	398	407	PF00069	0.292
DOC_PP2B_LxvP_1	239	242	PF13499	0.351
DOC_PP2B_LxvP_1	520	523	PF13499	0.530
DOC_PP4_FxxP_1	574	577	PF00568	0.549
DOC_USP7_MATH_1	111	115	PF00917	0.615
DOC_USP7_MATH_1	119	123	PF00917	0.550
DOC_USP7_MATH_1	126	130	PF00917	0.500
DOC_USP7_MATH_1	401	405	PF00917	0.357
DOC_USP7_MATH_1	451	455	PF00917	0.355
DOC_USP7_MATH_1	513	517	PF00917	0.469
DOC_USP7_MATH_1	55	59	PF00917	0.476
DOC_WW_Pin1_4	316	321	PF00397	0.357
DOC_WW_Pin1_4	45	50	PF00397	0.451
DOC_WW_Pin1_4	558	563	PF00397	0.453
LIG_14-3-3_CanoR_1	161	167	PF00244	0.371
LIG_14-3-3_CanoR_1	168	173	PF00244	0.306
LIG_14-3-3_CanoR_1	202	206	PF00244	0.302
LIG_14-3-3_CanoR_1	24	30	PF00244	0.494
LIG_14-3-3_CanoR_1	402	406	PF00244	0.357
LIG_14-3-3_CanoR_1	50	54	PF00244	0.647
LIG_14-3-3_CanoR_1	540	546	PF00244	0.476
LIG_14-3-3_CanoR_1	548	558	PF00244	0.437
LIG_14-3-3_CanoR_1	56	64	PF00244	0.437
LIG_14-3-3_CanoR_1	92	102	PF00244	0.515
LIG_Actin_WH2_2	458	474	PF00022	0.351
LIG_APCC_ABBA_1	218	223	PF00400	0.292
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_Clathr_ClatBox_1	379	383	PF01394	0.351
LIG_deltaCOP1_diTrp_1	148	152	PF00928	0.344
LIG_FHA_1	136	142	PF00498	0.466
LIG_FHA_1	215	221	PF00498	0.340
LIG_FHA_1	363	369	PF00498	0.274
LIG_FHA_1	395	401	PF00498	0.357
LIG_FHA_1	540	546	PF00498	0.463
LIG_FHA_2	110	116	PF00498	0.562
LIG_FHA_2	317	323	PF00498	0.313
LIG_FHA_2	454	460	PF00498	0.357
LIG_FHA_2	478	484	PF00498	0.543
LIG_FHA_2	55	61	PF00498	0.501
LIG_FHA_2	550	556	PF00498	0.505
LIG_HP1_1	401	405	PF01393	0.351
LIG_IBAR_NPY_1	28	30	PF08397	0.432
LIG_LIR_Apic_2	573	577	PF02991	0.547
LIG_LIR_Gen_1	138	147	PF02991	0.386
LIG_LIR_Gen_1	409	418	PF02991	0.398
LIG_LIR_Nem_3	138	143	PF02991	0.377
LIG_LIR_Nem_3	146	152	PF02991	0.324
LIG_LIR_Nem_3	409	414	PF02991	0.294
LIG_PTB_Apo_2	472	479	PF02174	0.395
LIG_PTB_Apo_2	524	531	PF02174	0.460
LIG_PTB_Phospho_1	524	530	PF10480	0.469
LIG_SH2_CRK	46	50	PF00017	0.475
LIG_SH2_CRK	528	532	PF00017	0.373
LIG_SH2_GRB2like	473	476	PF00017	0.398
LIG_SH2_NCK_1	473	477	PF00017	0.467
LIG_SH2_SRC	473	476	PF00017	0.436
LIG_SH2_STAP1	411	415	PF00017	0.351
LIG_SH2_STAP1	446	450	PF00017	0.351
LIG_SH2_STAT3	254	257	PF00017	0.357
LIG_SH2_STAT5	140	143	PF00017	0.377
LIG_SH2_STAT5	237	240	PF00017	0.361
LIG_SH2_STAT5	254	257	PF00017	0.474
LIG_SH2_STAT5	528	531	PF00017	0.353
LIG_SH3_3	339	345	PF00018	0.440
LIG_SH3_3	357	363	PF00018	0.269
LIG_SH3_3	566	572	PF00018	0.582
LIG_SH3_3	585	591	PF00018	0.626
LIG_SUMO_SIM_par_1	364	369	PF11976	0.402
LIG_SUMO_SIM_par_1	378	385	PF11976	0.326
LIG_TRAF2_1	142	145	PF00917	0.457
LIG_TRAF2_1	319	322	PF00917	0.312
LIG_TRAF2_1	57	60	PF00917	0.511
LIG_TYR_ITIM	526	531	PF00017	0.396
LIG_UBA3_1	414	420	PF00899	0.309
LIG_WW_3	53	57	PF00397	0.476
MOD_CDK_SPK_2	45	50	PF00069	0.437
MOD_CK1_1	109	115	PF00069	0.573
MOD_CK1_1	122	128	PF00069	0.710
MOD_CK1_1	18	24	PF00069	0.447
MOD_CK1_1	228	234	PF00069	0.399
MOD_CK1_1	549	555	PF00069	0.636
MOD_CK1_1	563	569	PF00069	0.395
MOD_CK1_1	6	12	PF00069	0.662
MOD_CK2_1	139	145	PF00069	0.437
MOD_CK2_1	305	311	PF00069	0.273
MOD_CK2_1	316	322	PF00069	0.274
MOD_CK2_1	425	431	PF00069	0.312
MOD_CK2_1	477	483	PF00069	0.487
MOD_CK2_1	54	60	PF00069	0.506
MOD_CK2_1	549	555	PF00069	0.505
MOD_GlcNHglycan	108	111	PF01048	0.559
MOD_GlcNHglycan	124	127	PF01048	0.553
MOD_GlcNHglycan	129	132	PF01048	0.635
MOD_GlcNHglycan	230	233	PF01048	0.399
MOD_GlcNHglycan	368	371	PF01048	0.438
MOD_GlcNHglycan	480	483	PF01048	0.570
MOD_GlcNHglycan	5	8	PF01048	0.646
MOD_GlcNHglycan	514	518	PF01048	0.593
MOD_GlcNHglycan	562	565	PF01048	0.444
MOD_GlcNHglycan	593	596	PF01048	0.578
MOD_GSK3_1	122	129	PF00069	0.617
MOD_GSK3_1	135	142	PF00069	0.494
MOD_GSK3_1	15	22	PF00069	0.508
MOD_GSK3_1	277	284	PF00069	0.417
MOD_GSK3_1	346	353	PF00069	0.451
MOD_GSK3_1	362	369	PF00069	0.199
MOD_GSK3_1	422	429	PF00069	0.318
MOD_GSK3_1	449	456	PF00069	0.327
MOD_GSK3_1	45	52	PF00069	0.474
MOD_GSK3_1	556	563	PF00069	0.563
MOD_N-GLC_1	122	127	PF02516	0.482
MOD_N-GLC_1	350	355	PF02516	0.280
MOD_N-GLC_2	527	529	PF02516	0.420
MOD_NEK2_1	1	6	PF00069	0.718
MOD_NEK2_1	19	24	PF00069	0.464
MOD_NEK2_1	225	230	PF00069	0.292
MOD_NEK2_1	381	386	PF00069	0.342
MOD_NEK2_1	430	435	PF00069	0.359
MOD_NEK2_1	546	551	PF00069	0.496
MOD_NEK2_2	277	282	PF00069	0.351
MOD_PIKK_1	451	457	PF00454	0.300
MOD_PIKK_1	605	611	PF00454	0.624
MOD_PK_1	168	174	PF00069	0.393
MOD_PK_1	83	89	PF00069	0.390
MOD_PKA_1	168	174	PF00069	0.388
MOD_PKA_1	419	425	PF00069	0.292
MOD_PKA_1	83	89	PF00069	0.390
MOD_PKA_2	168	174	PF00069	0.388
MOD_PKA_2	201	207	PF00069	0.435
MOD_PKA_2	226	232	PF00069	0.292
MOD_PKA_2	23	29	PF00069	0.515
MOD_PKA_2	401	407	PF00069	0.357
MOD_PKA_2	422	428	PF00069	0.272
MOD_PKA_2	49	55	PF00069	0.658
MOD_PKA_2	539	545	PF00069	0.374
MOD_PKA_2	591	597	PF00069	0.609
MOD_PKA_2	83	89	PF00069	0.489
MOD_Plk_1	143	149	PF00069	0.482
MOD_Plk_1	15	21	PF00069	0.584
MOD_Plk_1	214	220	PF00069	0.351
MOD_Plk_1	250	256	PF00069	0.313
MOD_Plk_1	382	388	PF00069	0.351
MOD_Plk_1	430	436	PF00069	0.292
MOD_Plk_4	135	141	PF00069	0.431
MOD_Plk_4	15	21	PF00069	0.475
MOD_Plk_4	162	168	PF00069	0.511
MOD_Plk_4	214	220	PF00069	0.340
MOD_Plk_4	250	256	PF00069	0.384
MOD_Plk_4	277	283	PF00069	0.320
MOD_Plk_4	410	416	PF00069	0.383
MOD_ProDKin_1	316	322	PF00069	0.357
MOD_ProDKin_1	45	51	PF00069	0.447
MOD_ProDKin_1	558	564	PF00069	0.455
MOD_SUMO_for_1	596	599	PF00179	0.520
MOD_SUMO_rev_2	142	152	PF00179	0.422
TRG_DiLeu_BaEn_1	215	220	PF01217	0.351
TRG_DiLeu_BaEn_2	147	153	PF01217	0.405
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.404
TRG_ENDOCYTIC_2	140	143	PF00928	0.423
TRG_ENDOCYTIC_2	411	414	PF00928	0.303
TRG_ENDOCYTIC_2	528	531	PF00928	0.389
TRG_ER_diArg_1	167	169	PF00400	0.390
TRG_ER_diArg_1	418	421	PF00400	0.351
TRG_ER_diArg_1	496	498	PF00400	0.473
TRG_ER_diArg_1	518	521	PF00400	0.539
TRG_ER_diArg_1	567	569	PF00400	0.513
TRG_ER_diArg_1	576	579	PF00400	0.523
TRG_ER_diArg_1	82	85	PF00400	0.478
TRG_NLS_MonoExtC_3	418	423	PF00514	0.351
TRG_NLS_MonoExtN_4	88	95	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6V5	Leptomonas seymouri	56%	100%
A0A0S4JPN0	Bodo saltans	37%	100%
A0A3Q8IHF3	Leishmania donovani	100%	100%
A4HHL7	Leishmania braziliensis	75%	100%
E9AE79	Leishmania major	91%	100%
E9ALK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%