Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cdc2-related kinase 10 - putative

Species:

Leishmania infantum

UniProt:

A4I4S4_LEIIN

TriTrypDb:

LINF_290029200

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4I4S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4S4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	25
GO:0006793	phosphorus metabolic process	3	25
GO:0006796	phosphate-containing compound metabolic process	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0009987	cellular process	1	25
GO:0016310	phosphorylation	5	25
GO:0019538	protein metabolic process	3	25
GO:0036211	protein modification process	4	25
GO:0043170	macromolecule metabolic process	3	25
GO:0043412	macromolecule modification	4	25
GO:0044237	cellular metabolic process	2	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0051301	cell division	2	1
GO:0007165	signal transduction	2	3
GO:0009266	response to temperature stimulus	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0035556	intracellular signal transduction	3	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0050896	response to stimulus	1	1
GO:0065007	biological regulation	1	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	25
GO:0003824	catalytic activity	1	25
GO:0004672	protein kinase activity	3	25
GO:0005488	binding	1	25
GO:0005524	ATP binding	5	25
GO:0016301	kinase activity	4	25
GO:0016740	transferase activity	2	25
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	25
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	25
GO:0017076	purine nucleotide binding	4	25
GO:0030554	adenyl nucleotide binding	5	25
GO:0032553	ribonucleotide binding	3	25
GO:0032555	purine ribonucleotide binding	4	25
GO:0032559	adenyl ribonucleotide binding	5	25
GO:0035639	purine ribonucleoside triphosphate binding	4	25
GO:0036094	small molecule binding	2	25
GO:0043167	ion binding	2	25
GO:0043168	anion binding	3	25
GO:0097159	organic cyclic compound binding	2	25
GO:0097367	carbohydrate derivative binding	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:1901265	nucleoside phosphate binding	3	25
GO:1901363	heterocyclic compound binding	2	25
GO:0004674	protein serine/threonine kinase activity	4	14
GO:0004707	MAP kinase activity	5	11
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.485
CLV_NRD_NRD_1	262	264	PF00675	0.417
CLV_NRD_NRD_1	326	328	PF00675	0.381
CLV_NRD_NRD_1	53	55	PF00675	0.622
CLV_NRD_NRD_1	553	555	PF00675	0.385
CLV_PCSK_KEX2_1	154	156	PF00082	0.508
CLV_PCSK_KEX2_1	195	197	PF00082	0.485
CLV_PCSK_KEX2_1	261	263	PF00082	0.457
CLV_PCSK_KEX2_1	326	328	PF00082	0.381
CLV_PCSK_KEX2_1	358	360	PF00082	0.343
CLV_PCSK_KEX2_1	53	55	PF00082	0.596
CLV_PCSK_KEX2_1	553	555	PF00082	0.386
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.500
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.343
CLV_PCSK_PC7_1	150	156	PF00082	0.413
CLV_PCSK_PC7_1	191	197	PF00082	0.465
CLV_PCSK_SKI1_1	150	154	PF00082	0.551
CLV_PCSK_SKI1_1	191	195	PF00082	0.607
CLV_PCSK_SKI1_1	198	202	PF00082	0.762
CLV_PCSK_SKI1_1	303	307	PF00082	0.424
CLV_PCSK_SKI1_1	347	351	PF00082	0.365
CLV_PCSK_SKI1_1	464	468	PF00082	0.321
CLV_PCSK_SKI1_1	523	527	PF00082	0.343
CLV_PCSK_SKI1_1	529	533	PF00082	0.372
CLV_PCSK_SKI1_1	553	557	PF00082	0.376
CLV_PCSK_SKI1_1	564	568	PF00082	0.384
CLV_PCSK_SKI1_1	96	100	PF00082	0.345
DEG_APCC_DBOX_1	149	157	PF00400	0.423
DEG_APCC_DBOX_1	267	275	PF00400	0.474
DEG_APCC_DBOX_1	281	289	PF00400	0.395
DEG_APCC_DBOX_1	528	536	PF00400	0.268
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DEG_SPOP_SBC_1	241	245	PF00917	0.596
DEG_SPOP_SBC_1	309	313	PF00917	0.222
DEG_SPOP_SBC_1	76	80	PF00917	0.348
DOC_CYCLIN_RxL_1	542	552	PF00134	0.359
DOC_MAPK_gen_1	266	274	PF00069	0.341
DOC_MAPK_gen_1	323	332	PF00069	0.356
DOC_MAPK_gen_1	347	356	PF00069	0.297
DOC_MAPK_gen_1	527	534	PF00069	0.281
DOC_MAPK_HePTP_8	324	336	PF00069	0.343
DOC_MAPK_JIP1_4	350	356	PF00069	0.288
DOC_MAPK_MEF2A_6	326	334	PF00069	0.305
DOC_MIT_MIM_1	541	549	PF04212	0.258
DOC_USP7_MATH_1	181	185	PF00917	0.504
DOC_USP7_MATH_1	206	210	PF00917	0.535
DOC_USP7_MATH_1	241	245	PF00917	0.515
DOC_USP7_MATH_1	369	373	PF00917	0.311
DOC_USP7_MATH_1	473	477	PF00917	0.290
DOC_USP7_MATH_1	64	68	PF00917	0.771
DOC_WW_Pin1_4	100	105	PF00397	0.390
DOC_WW_Pin1_4	121	126	PF00397	0.654
DOC_WW_Pin1_4	35	40	PF00397	0.688
DOC_WW_Pin1_4	418	423	PF00397	0.261
DOC_WW_Pin1_4	471	476	PF00397	0.405
DOC_WW_Pin1_4	59	64	PF00397	0.693
LIG_14-3-3_CanoR_1	25	30	PF00244	0.539
LIG_14-3-3_CanoR_1	310	316	PF00244	0.359
LIG_14-3-3_CanoR_1	326	331	PF00244	0.431
LIG_14-3-3_CanoR_1	553	558	PF00244	0.353
LIG_Actin_WH2_2	158	173	PF00022	0.610
LIG_BIR_III_2	101	105	PF00653	0.359
LIG_BIR_III_2	49	53	PF00653	0.549
LIG_BRCT_BRCA1_1	117	121	PF00533	0.521
LIG_BRCT_BRCA1_1	312	316	PF00533	0.258
LIG_BRCT_BRCA1_1	364	368	PF00533	0.244
LIG_Clathr_ClatBox_1	546	550	PF01394	0.343
LIG_CtBP_PxDLS_1	539	545	PF00389	0.300
LIG_DCNL_PONY_1	1	4	PF03556	0.539
LIG_deltaCOP1_diTrp_1	297	301	PF00928	0.343
LIG_FHA_1	124	130	PF00498	0.556
LIG_FHA_1	28	34	PF00498	0.530
LIG_FHA_1	358	364	PF00498	0.326
LIG_FHA_1	389	395	PF00498	0.351
LIG_FHA_1	80	86	PF00498	0.391
LIG_FHA_2	157	163	PF00498	0.531
LIG_FHA_2	167	173	PF00498	0.393
LIG_FHA_2	504	510	PF00498	0.392
LIG_FHA_2	554	560	PF00498	0.395
LIG_FHA_2	72	78	PF00498	0.385
LIG_FHA_2	82	88	PF00498	0.312
LIG_LIR_Apic_2	416	422	PF02991	0.361
LIG_LIR_Gen_1	297	307	PF02991	0.373
LIG_LIR_Gen_1	488	497	PF02991	0.298
LIG_LIR_Gen_1	567	576	PF02991	0.445
LIG_LIR_Nem_3	313	319	PF02991	0.474
LIG_LIR_Nem_3	488	493	PF02991	0.305
LIG_LIR_Nem_3	567	573	PF02991	0.408
LIG_LIR_Nem_3	93	97	PF02991	0.581
LIG_Pex14_2	217	221	PF04695	0.510
LIG_PTB_Apo_2	425	432	PF02174	0.341
LIG_PTB_Phospho_1	425	431	PF10480	0.341
LIG_RPA_C_Fungi	221	233	PF08784	0.545
LIG_RPA_C_Fungi	257	269	PF08784	0.356
LIG_SH2_CRK	94	98	PF00017	0.540
LIG_SH2_NCK_1	570	574	PF00017	0.417
LIG_SH2_SRC	490	493	PF00017	0.258
LIG_SH2_SRC	497	500	PF00017	0.233
LIG_SH2_SRC	570	573	PF00017	0.417
LIG_SH2_STAP1	390	394	PF00017	0.258
LIG_SH2_STAP1	431	435	PF00017	0.404
LIG_SH2_STAP1	490	494	PF00017	0.302
LIG_SH2_STAP1	570	574	PF00017	0.417
LIG_SH2_STAT5	227	230	PF00017	0.549
LIG_SH2_STAT5	287	290	PF00017	0.413
LIG_SH2_STAT5	292	295	PF00017	0.379
LIG_SH2_STAT5	390	393	PF00017	0.346
LIG_SH2_STAT5	410	413	PF00017	0.455
LIG_SH2_STAT5	431	434	PF00017	0.276
LIG_SH2_STAT5	486	489	PF00017	0.424
LIG_SH2_STAT5	83	86	PF00017	0.525
LIG_SH3_3	106	112	PF00018	0.579
LIG_SH3_3	197	203	PF00018	0.661
LIG_SH3_3	60	66	PF00018	0.548
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.509
LIG_SUMO_SIM_anti_2	329	334	PF11976	0.244
LIG_SUMO_SIM_par_1	545	550	PF11976	0.258
LIG_TRAF2_1	506	509	PF00917	0.272
LIG_WW_2	63	66	PF00397	0.545
LIG_WW_3	50	54	PF00397	0.538
MOD_CK1_1	124	130	PF00069	0.634
MOD_CK1_1	180	186	PF00069	0.573
MOD_CK1_1	308	314	PF00069	0.244
MOD_CK2_1	156	162	PF00069	0.530
MOD_CK2_1	166	172	PF00069	0.392
MOD_CK2_1	35	41	PF00069	0.834
MOD_CK2_1	397	403	PF00069	0.288
MOD_CK2_1	503	509	PF00069	0.384
MOD_CK2_1	553	559	PF00069	0.322
MOD_CK2_1	71	77	PF00069	0.511
MOD_CK2_1	81	87	PF00069	0.356
MOD_DYRK1A_RPxSP_1	59	63	PF00069	0.551
MOD_GlcNHglycan	117	120	PF01048	0.592
MOD_GlcNHglycan	126	129	PF01048	0.545
MOD_GlcNHglycan	177	182	PF01048	0.505
MOD_GlcNHglycan	228	231	PF01048	0.536
MOD_GlcNHglycan	244	247	PF01048	0.465
MOD_GlcNHglycan	256	259	PF01048	0.357
MOD_GlcNHglycan	312	315	PF01048	0.384
MOD_GlcNHglycan	371	374	PF01048	0.244
MOD_GlcNHglycan	433	436	PF01048	0.343
MOD_GlcNHglycan	448	451	PF01048	0.319
MOD_GlcNHglycan	66	69	PF01048	0.603
MOD_GSK3_1	113	120	PF00069	0.636
MOD_GSK3_1	132	139	PF00069	0.538
MOD_GSK3_1	177	184	PF00069	0.495
MOD_GSK3_1	202	209	PF00069	0.534
MOD_GSK3_1	25	32	PF00069	0.601
MOD_GSK3_1	305	312	PF00069	0.244
MOD_GSK3_1	369	376	PF00069	0.292
MOD_GSK3_1	499	506	PF00069	0.422
MOD_GSK3_1	71	78	PF00069	0.689
MOD_LATS_1	224	230	PF00433	0.504
MOD_LATS_1	23	29	PF00433	0.531
MOD_N-GLC_1	157	162	PF02516	0.647
MOD_N-GLC_1	373	378	PF02516	0.231
MOD_N-GLC_1	429	434	PF02516	0.369
MOD_N-GLC_1	503	508	PF02516	0.258
MOD_NEK2_1	113	118	PF00069	0.639
MOD_NEK2_1	156	161	PF00069	0.521
MOD_NEK2_1	242	247	PF00069	0.550
MOD_NEK2_1	305	310	PF00069	0.411
MOD_NEK2_1	338	343	PF00069	0.361
MOD_NEK2_1	364	369	PF00069	0.259
MOD_NEK2_1	397	402	PF00069	0.307
MOD_NEK2_1	426	431	PF00069	0.333
MOD_NEK2_2	81	86	PF00069	0.303
MOD_PIKK_1	113	119	PF00454	0.523
MOD_PK_1	25	31	PF00069	0.540
MOD_PK_1	326	332	PF00069	0.258
MOD_PKA_1	262	268	PF00069	0.342
MOD_PKA_1	326	332	PF00069	0.510
MOD_PKA_1	553	559	PF00069	0.401
MOD_PKA_2	146	152	PF00069	0.453
MOD_PKA_2	262	268	PF00069	0.504
MOD_PKA_2	309	315	PF00069	0.340
MOD_PKA_2	326	332	PF00069	0.490
MOD_PKA_2	516	522	PF00069	0.258
MOD_PKA_2	553	559	PF00069	0.351
MOD_Plk_1	156	162	PF00069	0.534
MOD_Plk_1	429	435	PF00069	0.381
MOD_Plk_1	8	14	PF00069	0.552
MOD_Plk_2-3	157	163	PF00069	0.532
MOD_Plk_4	117	123	PF00069	0.516
MOD_Plk_4	217	223	PF00069	0.629
MOD_Plk_4	413	419	PF00069	0.261
MOD_Plk_4	448	454	PF00069	0.321
MOD_Plk_4	473	479	PF00069	0.322
MOD_Plk_4	553	559	PF00069	0.343
MOD_ProDKin_1	100	106	PF00069	0.403
MOD_ProDKin_1	121	127	PF00069	0.656
MOD_ProDKin_1	35	41	PF00069	0.688
MOD_ProDKin_1	418	424	PF00069	0.261
MOD_ProDKin_1	471	477	PF00069	0.405
MOD_ProDKin_1	59	65	PF00069	0.694
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.261
TRG_ENDOCYTIC_2	287	290	PF00928	0.425
TRG_ENDOCYTIC_2	490	493	PF00928	0.357
TRG_ENDOCYTIC_2	570	573	PF00928	0.444
TRG_ENDOCYTIC_2	94	97	PF00928	0.513
TRG_ER_diArg_1	194	196	PF00400	0.480
TRG_ER_diArg_1	261	263	PF00400	0.461
TRG_ER_diArg_1	279	282	PF00400	0.395
TRG_ER_diArg_1	325	327	PF00400	0.381
TRG_ER_diArg_1	479	482	PF00400	0.258
TRG_ER_diArg_1	52	54	PF00400	0.543
TRG_ER_diArg_1	553	555	PF00400	0.355
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	545	550	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P661	Leptomonas seymouri	51%	92%
A0A3Q8IIY5	Leishmania donovani	100%	100%
A0A3Q8ITZ9	Leishmania donovani	26%	100%
A0A3S7WR45	Leishmania donovani	27%	100%
A0A3S7X2Z6	Leishmania donovani	28%	100%
A4H641	Leishmania braziliensis	28%	100%
A4HHL5	Leishmania braziliensis	84%	100%
A4HHY4	Leishmania braziliensis	27%	100%
A4HIM5	Leishmania braziliensis	27%	100%
A4HLJ9	Leishmania braziliensis	26%	100%
A4HUG1	Leishmania infantum	27%	100%
A4I564	Leishmania infantum	28%	100%
A4I910	Leishmania infantum	26%	100%
C9ZW07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AE77	Leishmania major	95%	100%
E9ALK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AN59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B0G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B3X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q449	Leishmania major	26%	100%
Q4Q7S2	Leishmania major	29%	100%
Q4QHG6	Leishmania major	27%	100%
V5DCN7	Trypanosoma cruzi	31%	97%