C-8 sterol isomerase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-8 sterol isomerase-like protein

Species:

Leishmania infantum

UniProt:

A4I4S3_LEIIN

TriTrypDb:

LINF_290029100

Length:

223

Annotations

LeishMANIAdb annotations

Homologous to fungal ERG2 sterol isomerase and the mammalian sigma receptor 1. A lipid modifying enzyme family. Related to fungal C-8 sterol isomerases, but the catalytic activity of animal orthologs is unclear. Localization: ER (by homology)

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, C-8 sterol isomerase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	10
GO:0016020	membrane	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4I4S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4S3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016853	isomerase activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	60	64	PF00082	0.541
CLV_PCSK_SKI1_1	68	72	PF00082	0.550
DOC_MAPK_MEF2A_6	5	14	PF00069	0.477
DOC_USP7_MATH_1	159	163	PF00917	0.204
DOC_USP7_MATH_1	42	46	PF00917	0.353
DOC_USP7_MATH_1	92	96	PF00917	0.256
DOC_USP7_UBL2_3	56	60	PF12436	0.232
LIG_14-3-3_CanoR_1	216	220	PF00244	0.305
LIG_AP2alpha_1	190	194	PF02296	0.282
LIG_BIR_II_1	1	5	PF00653	0.625
LIG_BRCT_BRCA1_1	183	187	PF00533	0.242
LIG_FHA_1	195	201	PF00498	0.269
LIG_FHA_1	5	11	PF00498	0.483
LIG_FHA_1	64	70	PF00498	0.306
LIG_FHA_2	204	210	PF00498	0.274
LIG_LIR_Gen_1	104	114	PF02991	0.255
LIG_LIR_Gen_1	127	134	PF02991	0.247
LIG_LIR_Gen_1	136	144	PF02991	0.251
LIG_LIR_Gen_1	202	211	PF02991	0.239
LIG_LIR_Nem_3	102	106	PF02991	0.258
LIG_LIR_Nem_3	127	133	PF02991	0.247
LIG_LIR_Nem_3	136	141	PF02991	0.251
LIG_LIR_Nem_3	184	190	PF02991	0.256
LIG_LIR_Nem_3	202	207	PF02991	0.239
LIG_Pex14_1	125	129	PF04695	0.274
LIG_Pex14_1	173	177	PF04695	0.274
LIG_Pex14_2	190	194	PF04695	0.288
LIG_SH2_CRK	204	208	PF00017	0.282
LIG_SH2_CRK	33	37	PF00017	0.317
LIG_SH2_SRC	106	109	PF00017	0.256
LIG_SH2_SRC	33	36	PF00017	0.327
LIG_SH2_STAT3	24	27	PF00017	0.410
LIG_SH2_STAT5	106	109	PF00017	0.255
LIG_SH2_STAT5	123	126	PF00017	0.201
LIG_SH2_STAT5	24	27	PF00017	0.410
LIG_SH2_STAT5	80	83	PF00017	0.327
LIG_SH3_3	146	152	PF00018	0.296
LIG_SH3_3	22	28	PF00018	0.298
LIG_SH3_3	29	35	PF00018	0.237
LIG_SUMO_SIM_anti_2	195	202	PF11976	0.257
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.366
LIG_SUMO_SIM_par_1	195	202	PF11976	0.261
LIG_SUMO_SIM_par_1	7	13	PF11976	0.374
LIG_TYR_ITSM	200	207	PF00017	0.282
LIG_WRC_WIRS_1	1	6	PF05994	0.631
MOD_CK1_1	113	119	PF00069	0.343
MOD_CK1_1	45	51	PF00069	0.274
MOD_CK2_1	203	209	PF00069	0.274
MOD_CK2_1	99	105	PF00069	0.256
MOD_GlcNHglycan	161	164	PF01048	0.513
MOD_GlcNHglycan	209	212	PF01048	0.489
MOD_GSK3_1	109	116	PF00069	0.289
MOD_GSK3_1	199	206	PF00069	0.252
MOD_GSK3_1	74	81	PF00069	0.290
MOD_NEK2_1	10	15	PF00069	0.306
MOD_NEK2_1	110	115	PF00069	0.256
MOD_NEK2_1	193	198	PF00069	0.264
MOD_NEK2_1	4	9	PF00069	0.451
MOD_NEK2_1	99	104	PF00069	0.256
MOD_PKA_2	159	165	PF00069	0.285
MOD_PKA_2	215	221	PF00069	0.260
MOD_PKA_2	78	84	PF00069	0.289
MOD_Plk_1	63	69	PF00069	0.305
MOD_Plk_4	181	187	PF00069	0.239
MOD_Plk_4	199	205	PF00069	0.248
MOD_Plk_4	215	221	PF00069	0.287
MOD_Plk_4	5	11	PF00069	0.463
MOD_Plk_4	94	100	PF00069	0.256
TRG_DiLeu_BaEn_1	65	70	PF01217	0.317
TRG_DiLeu_BaEn_4	170	176	PF01217	0.287
TRG_DiLeu_LyEn_5	65	70	PF01217	0.301
TRG_ENDOCYTIC_2	106	109	PF00928	0.256
TRG_ENDOCYTIC_2	204	207	PF00928	0.282
TRG_ENDOCYTIC_2	33	36	PF00928	0.317
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I584	Leptomonas seymouri	82%	100%
A0A1D8PCB9	Candida albicans (strain SC5314 / ATCC MYA-2876)	47%	100%
A0A1X0P040	Trypanosomatidae	65%	100%
A0A3Q8IDV8	Leishmania donovani	100%	100%
A0A3R7RKQ2	Trypanosoma rangeli	66%	100%
A4HHL4	Leishmania braziliensis	84%	100%
C9ZLG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AE76	Leishmania major	94%	100%
E9ALK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
I1RT23	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	45%	95%
P32352	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
P32360	Ustilago maydis (strain 521 / FGSC 9021)	44%	93%
P33281	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	47%	100%
P87113	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q4WJU9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	45%	93%
Q55BU8	Dictyostelium discoideum	34%	96%
Q92254	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	47%	87%