LeishMANIAdb
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Leucine-rich repeat protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat protein
Gene product:
Leucine Rich Repeat/Leucine rich repeat - putative
Species:
Leishmania infantum
UniProt:
A4I4S2_LEIIN
TriTrypDb:
LINF_290029000 *
Length:
476

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 8, no: 0
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005929 cilium 4 9
GO:0042995 cell projection 2 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0110165 cellular anatomical entity 1 9
GO:0120025 plasma membrane bounded cell projection 3 9

Expansion

Sequence features

A4I4S2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4S2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 17 19 PF00675 0.616
CLV_PCSK_KEX2_1 136 138 PF00082 0.576
CLV_PCSK_KEX2_1 17 19 PF00082 0.616
CLV_PCSK_PC1ET2_1 136 138 PF00082 0.576
CLV_PCSK_SKI1_1 100 104 PF00082 0.565
CLV_PCSK_SKI1_1 133 137 PF00082 0.505
CLV_PCSK_SKI1_1 255 259 PF00082 0.514
CLV_Separin_Metazoa 234 238 PF03568 0.548
CLV_Separin_Metazoa 368 372 PF03568 0.446
CLV_Separin_Metazoa 385 389 PF03568 0.583
DEG_APCC_DBOX_1 285 293 PF00400 0.547
DEG_Nend_UBRbox_3 1 3 PF02207 0.605
DEG_SPOP_SBC_1 207 211 PF00917 0.558
DOC_CKS1_1 12 17 PF01111 0.594
DOC_CYCLIN_RxL_1 388 397 PF00134 0.394
DOC_CYCLIN_yCln2_LP_2 145 151 PF00134 0.582
DOC_MAPK_gen_1 144 151 PF00069 0.520
DOC_MAPK_gen_1 60 69 PF00069 0.506
DOC_PP2B_LxvP_1 174 177 PF13499 0.606
DOC_USP7_MATH_1 68 72 PF00917 0.595
DOC_WW_Pin1_4 11 16 PF00397 0.596
DOC_WW_Pin1_4 208 213 PF00397 0.609
DOC_WW_Pin1_4 301 306 PF00397 0.612
LIG_14-3-3_CanoR_1 137 145 PF00244 0.464
LIG_14-3-3_CanoR_1 21 30 PF00244 0.545
LIG_14-3-3_CanoR_1 237 243 PF00244 0.569
LIG_14-3-3_CanoR_1 329 333 PF00244 0.508
LIG_14-3-3_CanoR_1 382 390 PF00244 0.487
LIG_14-3-3_CanoR_1 56 63 PF00244 0.577
LIG_BRCT_BRCA1_1 434 438 PF00533 0.500
LIG_CtBP_PxDLS_1 305 309 PF00389 0.636
LIG_FHA_1 1 7 PF00498 0.724
LIG_FHA_1 108 114 PF00498 0.570
LIG_FHA_1 209 215 PF00498 0.594
LIG_FHA_1 21 27 PF00498 0.530
LIG_FHA_1 331 337 PF00498 0.496
LIG_FHA_1 381 387 PF00498 0.484
LIG_FHA_1 399 405 PF00498 0.400
LIG_FHA_2 162 168 PF00498 0.553
LIG_FHA_2 251 257 PF00498 0.569
LIG_GBD_Chelix_1 30 38 PF00786 0.557
LIG_IRF3_LxIS_1 264 271 PF10401 0.535
LIG_LIR_Apic_2 470 474 PF02991 0.671
LIG_LIR_Gen_1 215 222 PF02991 0.527
LIG_LIR_Gen_1 227 236 PF02991 0.332
LIG_LIR_Gen_1 245 254 PF02991 0.344
LIG_LIR_Gen_1 435 446 PF02991 0.448
LIG_LIR_Gen_1 61 69 PF02991 0.554
LIG_LIR_Nem_3 125 131 PF02991 0.517
LIG_LIR_Nem_3 215 219 PF02991 0.501
LIG_LIR_Nem_3 227 232 PF02991 0.479
LIG_LIR_Nem_3 245 249 PF02991 0.341
LIG_LIR_Nem_3 271 275 PF02991 0.446
LIG_LIR_Nem_3 442 446 PF02991 0.419
LIG_LIR_Nem_3 61 66 PF02991 0.530
LIG_PTB_Apo_2 266 273 PF02174 0.491
LIG_SH2_CRK 246 250 PF00017 0.537
LIG_SH2_GRB2like 415 418 PF00017 0.440
LIG_SH2_SRC 415 418 PF00017 0.479
LIG_SH2_STAP1 246 250 PF00017 0.564
LIG_SH2_STAP1 63 67 PF00017 0.509
LIG_SH2_STAT5 246 249 PF00017 0.533
LIG_SH2_STAT5 326 329 PF00017 0.549
LIG_SH2_STAT5 415 418 PF00017 0.521
LIG_SH2_STAT5 471 474 PF00017 0.664
LIG_SH3_2 12 17 PF14604 0.594
LIG_SH3_3 182 188 PF00018 0.681
LIG_SH3_3 299 305 PF00018 0.662
LIG_SH3_3 450 456 PF00018 0.429
LIG_SH3_3 9 15 PF00018 0.599
LIG_SUMO_SIM_anti_2 365 371 PF11976 0.484
LIG_SUMO_SIM_par_1 147 153 PF11976 0.591
LIG_SUMO_SIM_par_1 218 223 PF11976 0.485
LIG_SUMO_SIM_par_1 304 309 PF11976 0.544
LIG_SUMO_SIM_par_1 64 71 PF11976 0.491
LIG_TRAF2_1 112 115 PF00917 0.586
LIG_TYR_ITIM 244 249 PF00017 0.522
LIG_TYR_ITIM 413 418 PF00017 0.524
MOD_CDK_SPxK_1 11 17 PF00069 0.596
MOD_CDK_SPxxK_3 11 18 PF00069 0.594
MOD_CK1_1 20 26 PF00069 0.706
MOD_CK1_1 304 310 PF00069 0.531
MOD_CK1_1 318 324 PF00069 0.450
MOD_CK2_1 161 167 PF00069 0.542
MOD_CK2_1 250 256 PF00069 0.578
MOD_CK2_1 292 298 PF00069 0.561
MOD_CK2_1 318 324 PF00069 0.477
MOD_CK2_1 40 46 PF00069 0.592
MOD_GlcNHglycan 100 103 PF01048 0.596
MOD_GlcNHglycan 178 181 PF01048 0.732
MOD_GlcNHglycan 222 225 PF01048 0.517
MOD_GlcNHglycan 23 26 PF01048 0.598
MOD_GlcNHglycan 283 286 PF01048 0.540
MOD_GlcNHglycan 293 297 PF01048 0.421
MOD_GlcNHglycan 312 315 PF01048 0.425
MOD_GlcNHglycan 317 320 PF01048 0.454
MOD_GlcNHglycan 405 409 PF01048 0.435
MOD_GlcNHglycan 41 45 PF01048 0.521
MOD_GlcNHglycan 423 426 PF01048 0.459
MOD_GlcNHglycan 57 60 PF01048 0.610
MOD_GlcNHglycan 86 89 PF01048 0.652
MOD_GSK3_1 17 24 PF00069 0.623
MOD_GSK3_1 238 245 PF00069 0.510
MOD_GSK3_1 292 299 PF00069 0.486
MOD_GSK3_1 306 313 PF00069 0.441
MOD_GSK3_1 328 335 PF00069 0.517
MOD_GSK3_1 389 396 PF00069 0.390
MOD_LATS_1 338 344 PF00433 0.436
MOD_N-GLC_1 268 273 PF02516 0.477
MOD_N-GLC_1 340 345 PF02516 0.506
MOD_N-GLC_1 427 432 PF02516 0.495
MOD_N-GLC_1 444 449 PF02516 0.376
MOD_NEK2_1 149 154 PF00069 0.503
MOD_NEK2_1 161 166 PF00069 0.448
MOD_NEK2_1 220 225 PF00069 0.423
MOD_NEK2_1 242 247 PF00069 0.487
MOD_NEK2_1 249 254 PF00069 0.500
MOD_NEK2_1 268 273 PF00069 0.388
MOD_NEK2_1 292 297 PF00069 0.497
MOD_NEK2_1 306 311 PF00069 0.515
MOD_NEK2_1 325 330 PF00069 0.443
MOD_NEK2_1 332 337 PF00069 0.439
MOD_NEK2_1 348 353 PF00069 0.194
MOD_NEK2_1 89 94 PF00069 0.597
MOD_NEK2_1 98 103 PF00069 0.566
MOD_NEK2_2 250 255 PF00069 0.537
MOD_PIKK_1 244 250 PF00454 0.502
MOD_PIKK_1 306 312 PF00454 0.616
MOD_PIKK_1 427 433 PF00454 0.513
MOD_PK_1 62 68 PF00069 0.636
MOD_PKA_1 17 23 PF00069 0.604
MOD_PKA_2 107 113 PF00069 0.588
MOD_PKA_2 138 144 PF00069 0.574
MOD_PKA_2 17 23 PF00069 0.625
MOD_PKA_2 328 334 PF00069 0.507
MOD_PKA_2 381 387 PF00069 0.590
MOD_PKA_2 55 61 PF00069 0.611
MOD_Plk_1 268 274 PF00069 0.428
MOD_Plk_1 40 46 PF00069 0.605
MOD_Plk_1 404 410 PF00069 0.530
MOD_Plk_1 427 433 PF00069 0.489
MOD_Plk_4 169 175 PF00069 0.617
MOD_Plk_4 2 8 PF00069 0.534
MOD_Plk_4 263 269 PF00069 0.510
MOD_Plk_4 62 68 PF00069 0.570
MOD_ProDKin_1 11 17 PF00069 0.596
MOD_ProDKin_1 208 214 PF00069 0.600
MOD_ProDKin_1 301 307 PF00069 0.608
MOD_SUMO_for_1 203 206 PF00179 0.607
TRG_DiLeu_BaEn_1 365 370 PF01217 0.535
TRG_DiLeu_BaEn_2 433 439 PF01217 0.497
TRG_ENDOCYTIC_2 246 249 PF00928 0.533
TRG_ENDOCYTIC_2 415 418 PF00928 0.474
TRG_ENDOCYTIC_2 443 446 PF00928 0.430
TRG_ENDOCYTIC_2 63 66 PF00928 0.634
TRG_ER_diArg_1 137 140 PF00400 0.564
TRG_ER_diArg_1 17 19 PF00400 0.612
TRG_NES_CRM1_1 234 248 PF08389 0.542
TRG_NES_CRM1_1 385 397 PF08389 0.498
TRG_NES_CRM1_1 431 442 PF08389 0.495
TRG_NLS_MonoExtN_4 133 140 PF00514 0.562
TRG_Pf-PMV_PEXEL_1 193 198 PF00026 0.433
TRG_Pf-PMV_PEXEL_1 74 78 PF00026 0.547

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P012 Trypanosomatidae 30% 100%
A0A3R7KGL7 Trypanosoma rangeli 29% 100%
A0A3S5H7L7 Leishmania donovani 98% 100%
A4HHL3 Leishmania braziliensis 69% 100%
E9AE75 Leishmania major 91% 100%
E9ALL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
P17778 Yersinia pestis 26% 100%
V5BBX4 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS