LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Domain of unknown function (DUF4139) - putative
Species:
Leishmania infantum
UniProt:
A4I4S0_LEIIN
TriTrypDb:
LINF_290028700
Length:
640

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 37 (POMP37) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 12
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4I4S0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4S0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016829 lyase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 120 124 PF00656 0.732
CLV_NRD_NRD_1 140 142 PF00675 0.505
CLV_NRD_NRD_1 335 337 PF00675 0.388
CLV_NRD_NRD_1 40 42 PF00675 0.433
CLV_NRD_NRD_1 597 599 PF00675 0.367
CLV_NRD_NRD_1 613 615 PF00675 0.522
CLV_NRD_NRD_1 99 101 PF00675 0.515
CLV_PCSK_KEX2_1 140 142 PF00082 0.610
CLV_PCSK_KEX2_1 217 219 PF00082 0.516
CLV_PCSK_KEX2_1 335 337 PF00082 0.388
CLV_PCSK_KEX2_1 395 397 PF00082 0.370
CLV_PCSK_KEX2_1 40 42 PF00082 0.433
CLV_PCSK_KEX2_1 508 510 PF00082 0.332
CLV_PCSK_KEX2_1 543 545 PF00082 0.403
CLV_PCSK_KEX2_1 597 599 PF00082 0.375
CLV_PCSK_KEX2_1 613 615 PF00082 0.552
CLV_PCSK_KEX2_1 99 101 PF00082 0.629
CLV_PCSK_PC1ET2_1 217 219 PF00082 0.514
CLV_PCSK_PC1ET2_1 395 397 PF00082 0.301
CLV_PCSK_PC1ET2_1 508 510 PF00082 0.367
CLV_PCSK_PC1ET2_1 543 545 PF00082 0.353
CLV_PCSK_SKI1_1 148 152 PF00082 0.458
CLV_PCSK_SKI1_1 218 222 PF00082 0.536
CLV_PCSK_SKI1_1 224 228 PF00082 0.484
CLV_PCSK_SKI1_1 267 271 PF00082 0.599
CLV_PCSK_SKI1_1 508 512 PF00082 0.352
CLV_PCSK_SKI1_1 543 547 PF00082 0.394
CLV_PCSK_SKI1_1 86 90 PF00082 0.492
CLV_Separin_Metazoa 219 223 PF03568 0.456
DEG_APCC_DBOX_1 427 435 PF00400 0.388
DEG_APCC_DBOX_1 596 604 PF00400 0.247
DEG_Nend_UBRbox_3 1 3 PF02207 0.648
DOC_CKS1_1 356 361 PF01111 0.301
DOC_CKS1_1 47 52 PF01111 0.555
DOC_CYCLIN_RxL_1 213 225 PF00134 0.385
DOC_CYCLIN_yCln2_LP_2 434 440 PF00134 0.435
DOC_CYCLIN_yCln2_LP_2 573 579 PF00134 0.446
DOC_MAPK_gen_1 148 156 PF00069 0.398
DOC_MAPK_gen_1 40 47 PF00069 0.463
DOC_MAPK_gen_1 554 563 PF00069 0.421
DOC_MAPK_gen_1 613 623 PF00069 0.483
DOC_MAPK_gen_1 99 110 PF00069 0.435
DOC_MAPK_MEF2A_6 231 240 PF00069 0.416
DOC_MAPK_MEF2A_6 616 625 PF00069 0.388
DOC_PP2B_LxvP_1 434 437 PF13499 0.425
DOC_PP2B_LxvP_1 465 468 PF13499 0.446
DOC_PP4_FxxP_1 412 415 PF00568 0.353
DOC_PP4_FxxP_1 47 50 PF00568 0.632
DOC_USP7_MATH_1 119 123 PF00917 0.805
DOC_USP7_MATH_1 12 16 PF00917 0.748
DOC_USP7_MATH_1 229 233 PF00917 0.421
DOC_USP7_MATH_1 446 450 PF00917 0.408
DOC_USP7_MATH_1 490 494 PF00917 0.492
DOC_USP7_MATH_1 501 505 PF00917 0.302
DOC_USP7_MATH_1 545 549 PF00917 0.479
DOC_USP7_MATH_1 562 566 PF00917 0.306
DOC_USP7_MATH_1 617 621 PF00917 0.388
DOC_USP7_UBL2_3 527 531 PF12436 0.416
DOC_WW_Pin1_4 243 248 PF00397 0.701
DOC_WW_Pin1_4 352 357 PF00397 0.524
DOC_WW_Pin1_4 361 366 PF00397 0.297
DOC_WW_Pin1_4 46 51 PF00397 0.566
DOC_WW_Pin1_4 572 577 PF00397 0.395
DOC_WW_Pin1_4 6 11 PF00397 0.629
LIG_14-3-3_CanoR_1 100 110 PF00244 0.508
LIG_Actin_WH2_2 255 272 PF00022 0.411
LIG_APCC_ABBA_1 471 476 PF00400 0.446
LIG_APCC_ABBA_1 583 588 PF00400 0.437
LIG_BIR_III_4 125 129 PF00653 0.649
LIG_FHA_1 105 111 PF00498 0.579
LIG_FHA_1 174 180 PF00498 0.506
LIG_FHA_1 18 24 PF00498 0.639
LIG_FHA_1 188 194 PF00498 0.495
LIG_FHA_1 256 262 PF00498 0.527
LIG_FHA_1 263 269 PF00498 0.500
LIG_FHA_1 301 307 PF00498 0.393
LIG_FHA_1 404 410 PF00498 0.346
LIG_FHA_1 424 430 PF00498 0.461
LIG_FHA_1 544 550 PF00498 0.427
LIG_FHA_2 255 261 PF00498 0.613
LIG_LIR_Apic_2 283 287 PF02991 0.331
LIG_LIR_Apic_2 46 50 PF02991 0.627
LIG_LIR_Gen_1 288 299 PF02991 0.282
LIG_LIR_Gen_1 441 450 PF02991 0.338
LIG_LIR_Gen_1 461 472 PF02991 0.396
LIG_LIR_Nem_3 288 294 PF02991 0.359
LIG_LIR_Nem_3 441 445 PF02991 0.338
LIG_LIR_Nem_3 461 467 PF02991 0.415
LIG_PDZ_Class_2 635 640 PF00595 0.485
LIG_Pex14_1 291 295 PF04695 0.347
LIG_Pex14_2 79 83 PF04695 0.425
LIG_SH2_CRK 284 288 PF00017 0.385
LIG_SH2_CRK 442 446 PF00017 0.316
LIG_SH2_GRB2like 309 312 PF00017 0.331
LIG_SH2_GRB2like 33 36 PF00017 0.445
LIG_SH2_STAP1 295 299 PF00017 0.382
LIG_SH2_STAP1 533 537 PF00017 0.353
LIG_SH2_STAT5 170 173 PF00017 0.423
LIG_SH2_STAT5 281 284 PF00017 0.339
LIG_SH2_STAT5 479 482 PF00017 0.446
LIG_SH2_STAT5 498 501 PF00017 0.210
LIG_SH2_STAT5 522 525 PF00017 0.423
LIG_SH2_STAT5 584 587 PF00017 0.399
LIG_SH3_1 270 276 PF00018 0.422
LIG_SH3_3 265 271 PF00018 0.542
LIG_SH3_3 348 354 PF00018 0.429
LIG_SH3_3 53 59 PF00018 0.563
LIG_SH3_3 573 579 PF00018 0.382
LIG_SH3_3 626 632 PF00018 0.355
LIG_SUMO_SIM_anti_2 257 263 PF11976 0.565
LIG_SUMO_SIM_anti_2 619 625 PF11976 0.446
LIG_SUMO_SIM_par_1 104 111 PF11976 0.632
LIG_SUMO_SIM_par_1 260 265 PF11976 0.472
LIG_SUMO_SIM_par_1 606 612 PF11976 0.466
LIG_TRAF2_1 564 567 PF00917 0.374
LIG_TRFH_1 464 468 PF08558 0.446
LIG_TYR_ITIM 440 445 PF00017 0.312
MOD_CDC14_SPxK_1 575 578 PF00782 0.446
MOD_CDK_SPK_2 243 248 PF00069 0.570
MOD_CDK_SPxK_1 572 578 PF00069 0.446
MOD_CK1_1 104 110 PF00069 0.528
MOD_CK1_1 246 252 PF00069 0.710
MOD_CK1_1 355 361 PF00069 0.465
MOD_CK1_1 441 447 PF00069 0.367
MOD_CK1_1 46 52 PF00069 0.549
MOD_CK1_1 633 639 PF00069 0.580
MOD_CK2_1 174 180 PF00069 0.638
MOD_CK2_1 229 235 PF00069 0.518
MOD_CK2_1 441 447 PF00069 0.458
MOD_CK2_1 561 567 PF00069 0.362
MOD_Cter_Amidation 524 527 PF01082 0.525
MOD_GlcNHglycan 119 122 PF01048 0.815
MOD_GlcNHglycan 135 138 PF01048 0.466
MOD_GlcNHglycan 14 17 PF01048 0.588
MOD_GlcNHglycan 176 179 PF01048 0.455
MOD_GlcNHglycan 248 251 PF01048 0.704
MOD_GlcNHglycan 287 290 PF01048 0.450
MOD_GlcNHglycan 330 333 PF01048 0.404
MOD_GlcNHglycan 490 493 PF01048 0.409
MOD_GSK3_1 117 124 PF00069 0.737
MOD_GSK3_1 142 149 PF00069 0.402
MOD_GSK3_1 323 330 PF00069 0.472
MOD_N-GLC_1 207 212 PF02516 0.438
MOD_N-GLC_1 34 39 PF02516 0.646
MOD_N-GLC_1 459 464 PF02516 0.381
MOD_N-GLC_1 633 638 PF02516 0.418
MOD_NEK2_1 187 192 PF00069 0.603
MOD_NEK2_1 327 332 PF00069 0.365
MOD_NEK2_1 45 50 PF00069 0.563
MOD_NEK2_2 535 540 PF00069 0.329
MOD_PIKK_1 142 148 PF00454 0.453
MOD_PKA_1 543 549 PF00069 0.331
MOD_PKA_2 28 34 PF00069 0.421
MOD_PKA_2 535 541 PF00069 0.351
MOD_PKA_2 543 549 PF00069 0.430
MOD_Plk_1 110 116 PF00069 0.759
MOD_Plk_1 168 174 PF00069 0.559
MOD_Plk_1 323 329 PF00069 0.520
MOD_Plk_1 34 40 PF00069 0.472
MOD_Plk_1 446 452 PF00069 0.353
MOD_Plk_1 633 639 PF00069 0.572
MOD_Plk_4 28 34 PF00069 0.464
MOD_Plk_4 280 286 PF00069 0.366
MOD_Plk_4 342 348 PF00069 0.459
MOD_Plk_4 416 422 PF00069 0.492
MOD_Plk_4 518 524 PF00069 0.442
MOD_Plk_4 633 639 PF00069 0.572
MOD_ProDKin_1 243 249 PF00069 0.704
MOD_ProDKin_1 352 358 PF00069 0.536
MOD_ProDKin_1 361 367 PF00069 0.297
MOD_ProDKin_1 46 52 PF00069 0.572
MOD_ProDKin_1 572 578 PF00069 0.395
MOD_ProDKin_1 6 12 PF00069 0.630
MOD_SUMO_for_1 216 219 PF00179 0.471
MOD_SUMO_rev_2 230 238 PF00179 0.510
MOD_SUMO_rev_2 320 325 PF00179 0.543
MOD_SUMO_rev_2 502 510 PF00179 0.365
MOD_SUMO_rev_2 78 88 PF00179 0.552
TRG_DiLeu_BaEn_1 619 624 PF01217 0.301
TRG_DiLeu_BaEn_2 469 475 PF01217 0.331
TRG_DiLeu_BaLyEn_6 598 603 PF01217 0.376
TRG_ENDOCYTIC_2 442 445 PF00928 0.330
TRG_ER_diArg_1 334 336 PF00400 0.426
TRG_ER_diArg_1 481 484 PF00400 0.291
TRG_ER_diArg_1 613 616 PF00400 0.515
TRG_NES_CRM1_1 146 158 PF08389 0.503
TRG_NLS_Bipartite_1 526 546 PF00514 0.247
TRG_NLS_MonoExtN_4 540 546 PF00514 0.437
TRG_NLS_MonoExtN_4 597 602 PF00514 0.301
TRG_Pf-PMV_PEXEL_1 100 105 PF00026 0.441
TRG_Pf-PMV_PEXEL_1 141 146 PF00026 0.589
TRG_Pf-PMV_PEXEL_1 509 514 PF00026 0.388
TRG_Pf-PMV_PEXEL_1 601 606 PF00026 0.392

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3W3 Leptomonas seymouri 61% 100%
A0A0S4JNB4 Bodo saltans 22% 100%
A0A1X0P222 Trypanosomatidae 22% 100%
A0A3Q8IFG9 Leishmania donovani 99% 100%
A0A3Q8IHT6 Leishmania donovani 25% 100%
A0A3R7LIT5 Trypanosoma rangeli 32% 100%
A4HHL0 Leishmania braziliensis 78% 100%
A4I5C4 Leishmania infantum 25% 100%
C9ZQQ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 100%
C9ZUB2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 92%
E9AE72 Leishmania major 94% 100%
E9ALL3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B0M2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
Q4Q7L0 Leishmania major 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS