LeishMANIAdb
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Short-chain dehydrogenase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Short-chain dehydrogenase
Gene product:
short chain dehydrogenase - putative
Species:
Leishmania infantum
UniProt:
A4I4R8_LEIIN
TriTrypDb:
LINF_290028500
Length:
451

Annotations

LeishMANIAdb annotations

The closest related human enzyme is a retinol dehydrogenase. Anchored to the membrane from the inner side.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4I4R8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4R8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 441 445 PF00656 0.591
CLV_MEL_PAP_1 7 13 PF00089 0.557
CLV_NRD_NRD_1 372 374 PF00675 0.416
CLV_NRD_NRD_1 88 90 PF00675 0.386
CLV_PCSK_KEX2_1 372 374 PF00082 0.328
CLV_PCSK_KEX2_1 46 48 PF00082 0.357
CLV_PCSK_KEX2_1 88 90 PF00082 0.386
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.396
CLV_PCSK_SKI1_1 142 146 PF00082 0.390
CLV_PCSK_SKI1_1 151 155 PF00082 0.427
CLV_PCSK_SKI1_1 23 27 PF00082 0.396
CLV_PCSK_SKI1_1 75 79 PF00082 0.426
DEG_Nend_Nbox_1 1 3 PF02207 0.455
DOC_CYCLIN_RxL_1 136 147 PF00134 0.623
DOC_CYCLIN_yCln2_LP_2 248 254 PF00134 0.560
DOC_MAPK_MEF2A_6 240 248 PF00069 0.614
DOC_PP1_RVXF_1 8 14 PF00149 0.438
DOC_PP2B_LxvP_1 248 251 PF13499 0.583
DOC_USP7_MATH_1 138 142 PF00917 0.473
DOC_USP7_MATH_1 295 299 PF00917 0.573
DOC_USP7_MATH_1 329 333 PF00917 0.555
DOC_USP7_MATH_1 417 421 PF00917 0.570
DOC_USP7_MATH_1 67 71 PF00917 0.580
DOC_USP7_MATH_1 99 103 PF00917 0.549
DOC_WW_Pin1_4 201 206 PF00397 0.516
DOC_WW_Pin1_4 354 359 PF00397 0.495
DOC_WW_Pin1_4 63 68 PF00397 0.561
LIG_14-3-3_CanoR_1 10 16 PF00244 0.350
LIG_14-3-3_CanoR_1 207 213 PF00244 0.602
LIG_14-3-3_CanoR_1 235 244 PF00244 0.647
LIG_14-3-3_CanoR_1 446 451 PF00244 0.591
LIG_14-3-3_CanoR_1 49 54 PF00244 0.542
LIG_14-3-3_CanoR_1 68 77 PF00244 0.554
LIG_Actin_WH2_2 179 195 PF00022 0.546
LIG_Actin_WH2_2 339 357 PF00022 0.613
LIG_APCC_ABBA_1 153 158 PF00400 0.612
LIG_BRCT_BRCA1_1 407 411 PF00533 0.553
LIG_DLG_GKlike_1 240 248 PF00625 0.544
LIG_eIF4E_1 116 122 PF01652 0.478
LIG_FHA_1 174 180 PF00498 0.494
LIG_FHA_1 217 223 PF00498 0.504
LIG_FHA_1 317 323 PF00498 0.495
LIG_FHA_1 355 361 PF00498 0.547
LIG_FHA_1 37 43 PF00498 0.628
LIG_FHA_1 429 435 PF00498 0.578
LIG_FHA_1 437 443 PF00498 0.595
LIG_FHA_1 74 80 PF00498 0.664
LIG_FHA_2 270 276 PF00498 0.545
LIG_FHA_2 69 75 PF00498 0.642
LIG_Integrin_isoDGR_2 134 136 PF01839 0.393
LIG_Integrin_isoDGR_2 160 162 PF01839 0.402
LIG_Integrin_RGD_1 55 57 PF01839 0.423
LIG_LIR_Gen_1 12 22 PF02991 0.306
LIG_LIR_Gen_1 283 292 PF02991 0.598
LIG_LIR_Gen_1 76 86 PF02991 0.647
LIG_LIR_Nem_3 109 113 PF02991 0.524
LIG_LIR_Nem_3 12 18 PF02991 0.306
LIG_LIR_Nem_3 283 289 PF02991 0.550
LIG_LIR_Nem_3 31 36 PF02991 0.232
LIG_LIR_Nem_3 408 414 PF02991 0.595
LIG_LIR_Nem_3 76 81 PF02991 0.647
LIG_NRBOX 118 124 PF00104 0.553
LIG_OCRL_FandH_1 308 320 PF00620 0.552
LIG_PCNA_yPIPBox_3 157 167 PF02747 0.602
LIG_PCNA_yPIPBox_3 288 301 PF02747 0.551
LIG_Pex14_1 13 17 PF04695 0.335
LIG_REV1ctd_RIR_1 379 387 PF16727 0.528
LIG_SH2_CRK 110 114 PF00017 0.498
LIG_SH2_CRK 116 120 PF00017 0.479
LIG_SH2_STAT5 116 119 PF00017 0.479
LIG_SH2_STAT5 143 146 PF00017 0.619
LIG_SH2_STAT5 33 36 PF00017 0.439
LIG_SH2_STAT5 364 367 PF00017 0.487
LIG_SH2_STAT5 436 439 PF00017 0.500
LIG_SH3_3 243 249 PF00018 0.634
LIG_SH3_3 321 327 PF00018 0.469
LIG_SH3_3 409 415 PF00018 0.560
LIG_SUMO_SIM_par_1 253 259 PF11976 0.552
LIG_TRAF2_1 277 280 PF00917 0.573
LIG_TYR_ITIM 108 113 PF00017 0.502
LIG_WW_3 204 208 PF00397 0.567
MOD_CDC14_SPxK_1 204 207 PF00782 0.583
MOD_CDK_SPK_2 63 68 PF00069 0.617
MOD_CDK_SPxK_1 201 207 PF00069 0.561
MOD_CK1_1 238 244 PF00069 0.620
MOD_CK2_1 269 275 PF00069 0.614
MOD_CK2_1 68 74 PF00069 0.619
MOD_Cter_Amidation 44 47 PF01082 0.386
MOD_GlcNHglycan 101 104 PF01048 0.323
MOD_GlcNHglycan 123 126 PF01048 0.364
MOD_GlcNHglycan 146 149 PF01048 0.401
MOD_GlcNHglycan 258 261 PF01048 0.368
MOD_GlcNHglycan 402 405 PF01048 0.412
MOD_GSK3_1 236 243 PF00069 0.614
MOD_GSK3_1 261 268 PF00069 0.551
MOD_GSK3_1 63 70 PF00069 0.561
MOD_GSK3_1 99 106 PF00069 0.483
MOD_N-GLC_1 180 185 PF02516 0.368
MOD_N-GLC_1 406 411 PF02516 0.449
MOD_N-GLC_1 81 86 PF02516 0.361
MOD_NEK2_1 121 126 PF00069 0.553
MOD_NEK2_1 144 149 PF00069 0.552
MOD_NEK2_1 173 178 PF00069 0.469
MOD_NEK2_1 236 241 PF00069 0.619
MOD_NEK2_1 302 307 PF00069 0.573
MOD_NEK2_1 316 321 PF00069 0.467
MOD_NEK2_1 368 373 PF00069 0.552
MOD_NEK2_1 405 410 PF00069 0.616
MOD_NEK2_1 62 67 PF00069 0.613
MOD_NEK2_1 81 86 PF00069 0.437
MOD_NEK2_2 269 274 PF00069 0.644
MOD_PIKK_1 206 212 PF00454 0.592
MOD_PIKK_1 238 244 PF00454 0.624
MOD_PIKK_1 275 281 PF00454 0.601
MOD_PIKK_1 335 341 PF00454 0.624
MOD_PKA_2 206 212 PF00069 0.610
MOD_PKA_2 67 73 PF00069 0.578
MOD_PKA_2 9 15 PF00069 0.425
MOD_PKB_1 47 55 PF00069 0.586
MOD_Plk_1 138 144 PF00069 0.547
MOD_Plk_1 386 392 PF00069 0.557
MOD_Plk_1 406 412 PF00069 0.625
MOD_Plk_1 73 79 PF00069 0.610
MOD_Plk_1 81 87 PF00069 0.522
MOD_Plk_4 222 228 PF00069 0.491
MOD_Plk_4 359 365 PF00069 0.560
MOD_Plk_4 386 392 PF00069 0.557
MOD_Plk_4 406 412 PF00069 0.601
MOD_Plk_4 49 55 PF00069 0.631
MOD_Plk_4 73 79 PF00069 0.610
MOD_ProDKin_1 201 207 PF00069 0.521
MOD_ProDKin_1 354 360 PF00069 0.493
MOD_ProDKin_1 63 69 PF00069 0.559
TRG_DiLeu_BaEn_1 349 354 PF01217 0.623
TRG_DiLeu_BaEn_2 15 21 PF01217 0.411
TRG_DiLeu_BaEn_2 73 79 PF01217 0.635
TRG_DiLeu_BaLyEn_6 227 232 PF01217 0.478
TRG_ENDOCYTIC_2 110 113 PF00928 0.504
TRG_ENDOCYTIC_2 116 119 PF00928 0.479
TRG_ENDOCYTIC_2 392 395 PF00928 0.628
TRG_ER_diArg_1 140 143 PF00400 0.635
TRG_ER_diArg_1 312 315 PF00400 0.582
TRG_ER_diArg_1 330 333 PF00400 0.461
TRG_ER_diArg_1 88 90 PF00400 0.586

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKI4 Leptomonas seymouri 72% 100%
A0A1X0P177 Trypanosomatidae 49% 100%
A0A3Q8IBK9 Leishmania donovani 100% 100%
A0A3R7NQF7 Trypanosoma rangeli 50% 100%
A4HHK7 Leishmania braziliensis 84% 100%
E9AE70 Leishmania major 95% 100%
E9ALL5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q9ERI6 Mus musculus 26% 100%
Q9HBH5 Homo sapiens 27% 100%
V5BBW8 Trypanosoma cruzi 49% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS