PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4R6_LEIIN

TriTrypDb:

LINF_290028200

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4R6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.597
CLV_C14_Caspase3-7	70	74	PF00656	0.586
CLV_NRD_NRD_1	240	242	PF00675	0.681
CLV_NRD_NRD_1	389	391	PF00675	0.590
CLV_NRD_NRD_1	489	491	PF00675	0.629
CLV_NRD_NRD_1	584	586	PF00675	0.703
CLV_NRD_NRD_1	661	663	PF00675	0.652
CLV_NRD_NRD_1	696	698	PF00675	0.613
CLV_NRD_NRD_1	709	711	PF00675	0.747
CLV_NRD_NRD_1	719	721	PF00675	0.689
CLV_PCSK_KEX2_1	488	490	PF00082	0.636
CLV_PCSK_KEX2_1	584	586	PF00082	0.640
CLV_PCSK_KEX2_1	661	663	PF00082	0.646
CLV_PCSK_KEX2_1	696	698	PF00082	0.584
CLV_PCSK_KEX2_1	709	711	PF00082	0.629
CLV_PCSK_KEX2_1	725	727	PF00082	0.630
CLV_PCSK_PC1ET2_1	725	727	PF00082	0.638
CLV_PCSK_PC7_1	484	490	PF00082	0.664
CLV_PCSK_SKI1_1	484	488	PF00082	0.661
CLV_PCSK_SKI1_1	662	666	PF00082	0.699
CLV_PCSK_SKI1_1	725	729	PF00082	0.534
CLV_PCSK_SKI1_1	732	736	PF00082	0.548
CLV_PCSK_SKI1_1	94	98	PF00082	0.740
DEG_SCF_FBW7_1	218	223	PF00400	0.576
DEG_SIAH_1	44	52	PF03145	0.584
DEG_SPOP_SBC_1	269	273	PF00917	0.670
DEG_SPOP_SBC_1	303	307	PF00917	0.490
DEG_SPOP_SBC_1	428	432	PF00917	0.692
DEG_SPOP_SBC_1	607	611	PF00917	0.753
DEG_SPOP_SBC_1	98	102	PF00917	0.597
DOC_ANK_TNKS_1	696	703	PF00023	0.699
DOC_CKS1_1	549	554	PF01111	0.649
DOC_CYCLIN_RxL_1	481	491	PF00134	0.690
DOC_CYCLIN_RxL_1	656	668	PF00134	0.689
DOC_CYCLIN_RxL_1	90	101	PF00134	0.672
DOC_CYCLIN_yClb1_LxF_4	730	735	PF00134	0.566
DOC_MAPK_DCC_7	111	121	PF00069	0.611
DOC_MAPK_DCC_7	510	520	PF00069	0.653
DOC_PP1_RVXF_1	494	500	PF00149	0.675
DOC_PP1_RVXF_1	730	736	PF00149	0.563
DOC_PP2B_LxvP_1	162	165	PF13499	0.753
DOC_PP4_FxxP_1	92	95	PF00568	0.680
DOC_USP7_MATH_1	10	14	PF00917	0.640
DOC_USP7_MATH_1	155	159	PF00917	0.715
DOC_USP7_MATH_1	202	206	PF00917	0.560
DOC_USP7_MATH_1	248	252	PF00917	0.705
DOC_USP7_MATH_1	264	268	PF00917	0.577
DOC_USP7_MATH_1	269	273	PF00917	0.577
DOC_USP7_MATH_1	303	307	PF00917	0.486
DOC_USP7_MATH_1	365	369	PF00917	0.654
DOC_USP7_MATH_1	428	432	PF00917	0.692
DOC_USP7_MATH_1	445	449	PF00917	0.698
DOC_USP7_MATH_1	473	477	PF00917	0.640
DOC_USP7_MATH_1	575	579	PF00917	0.646
DOC_USP7_MATH_1	607	611	PF00917	0.637
DOC_USP7_MATH_1	98	102	PF00917	0.563
DOC_USP7_UBL2_3	721	725	PF12436	0.617
DOC_WW_Pin1_4	171	176	PF00397	0.735
DOC_WW_Pin1_4	216	221	PF00397	0.684
DOC_WW_Pin1_4	252	257	PF00397	0.678
DOC_WW_Pin1_4	451	456	PF00397	0.713
DOC_WW_Pin1_4	513	518	PF00397	0.697
DOC_WW_Pin1_4	548	553	PF00397	0.607
DOC_WW_Pin1_4	570	575	PF00397	0.650
DOC_WW_Pin1_4	577	582	PF00397	0.641
LIG_14-3-3_CanoR_1	482	487	PF00244	0.621
LIG_14-3-3_CanoR_1	492	500	PF00244	0.642
LIG_14-3-3_CanoR_1	584	590	PF00244	0.693
LIG_14-3-3_CanoR_1	740	745	PF00244	0.661
LIG_APCC_ABBAyCdc20_2	390	396	PF00400	0.580
LIG_BRCT_BRCA1_1	294	298	PF00533	0.478
LIG_BRCT_BRCA1_1	619	623	PF00533	0.653
LIG_BRCT_BRCA1_1	626	630	PF00533	0.628
LIG_EVH1_1	162	166	PF00568	0.752
LIG_FHA_1	209	215	PF00498	0.614
LIG_FHA_1	347	353	PF00498	0.649
LIG_FHA_1	367	373	PF00498	0.565
LIG_FHA_1	565	571	PF00498	0.675
LIG_FHA_1	584	590	PF00498	0.562
LIG_FHA_1	675	681	PF00498	0.745
LIG_FHA_2	221	227	PF00498	0.654
LIG_FHA_2	30	36	PF00498	0.750
LIG_FHA_2	303	309	PF00498	0.518
LIG_FHA_2	543	549	PF00498	0.679
LIG_FHA_2	666	672	PF00498	0.697
LIG_LIR_Apic_2	233	237	PF02991	0.639
LIG_LIR_Nem_3	148	153	PF02991	0.723
LIG_LIR_Nem_3	627	633	PF02991	0.585
LIG_MYND_1	663	667	PF01753	0.665
LIG_Pex14_2	734	738	PF04695	0.584
LIG_RPA_C_Fungi	485	497	PF08784	0.636
LIG_SH2_STAT5	234	237	PF00017	0.669
LIG_SH2_STAT5	480	483	PF00017	0.656
LIG_SH3_1	16	22	PF00018	0.595
LIG_SH3_1	160	166	PF00018	0.554
LIG_SH3_2	657	662	PF14604	0.622
LIG_SH3_3	16	22	PF00018	0.755
LIG_SH3_3	160	166	PF00018	0.632
LIG_SH3_3	215	221	PF00018	0.612
LIG_SH3_3	42	48	PF00018	0.641
LIG_SH3_3	546	552	PF00018	0.599
LIG_SH3_3	571	577	PF00018	0.697
LIG_SH3_3	654	660	PF00018	0.670
LIG_SH3_3	667	673	PF00018	0.692
LIG_SH3_3	692	698	PF00018	0.798
LIG_SH3_3	92	98	PF00018	0.600
LIG_SUMO_SIM_anti_2	545	551	PF11976	0.710
LIG_SUMO_SIM_par_1	285	292	PF11976	0.591
LIG_SUMO_SIM_par_1	566	573	PF11976	0.680
LIG_TRAF2_1	384	387	PF00917	0.627
LIG_UBA3_1	733	742	PF00899	0.504
LIG_WW_2	574	577	PF00397	0.685
MOD_CDK_SPxxK_3	577	584	PF00069	0.698
MOD_CK1_1	132	138	PF00069	0.616
MOD_CK1_1	142	148	PF00069	0.613
MOD_CK1_1	151	157	PF00069	0.735
MOD_CK1_1	193	199	PF00069	0.590
MOD_CK1_1	201	207	PF00069	0.574
MOD_CK1_1	230	236	PF00069	0.606
MOD_CK1_1	244	250	PF00069	0.623
MOD_CK1_1	272	278	PF00069	0.713
MOD_CK1_1	292	298	PF00069	0.503
MOD_CK1_1	338	344	PF00069	0.604
MOD_CK1_1	345	351	PF00069	0.645
MOD_CK1_1	354	360	PF00069	0.703
MOD_CK1_1	368	374	PF00069	0.655
MOD_CK1_1	378	384	PF00069	0.534
MOD_CK1_1	431	437	PF00069	0.680
MOD_CK1_1	448	454	PF00069	0.648
MOD_CK1_1	564	570	PF00069	0.707
MOD_CK1_1	611	617	PF00069	0.657
MOD_CK1_1	619	625	PF00069	0.746
MOD_CK1_1	67	73	PF00069	0.654
MOD_CK1_1	80	86	PF00069	0.657
MOD_CK1_1	99	105	PF00069	0.553
MOD_CK2_1	132	138	PF00069	0.695
MOD_CK2_1	155	161	PF00069	0.668
MOD_CK2_1	302	308	PF00069	0.525
MOD_CK2_1	379	385	PF00069	0.616
MOD_CK2_1	444	450	PF00069	0.614
MOD_CK2_1	700	706	PF00069	0.770
MOD_Cter_Amidation	707	710	PF01082	0.757
MOD_GlcNHglycan	147	150	PF01048	0.703
MOD_GlcNHglycan	153	156	PF01048	0.698
MOD_GlcNHglycan	200	203	PF01048	0.597
MOD_GlcNHglycan	204	207	PF01048	0.669
MOD_GlcNHglycan	229	232	PF01048	0.654
MOD_GlcNHglycan	243	246	PF01048	0.585
MOD_GlcNHglycan	285	288	PF01048	0.586
MOD_GlcNHglycan	331	335	PF01048	0.627
MOD_GlcNHglycan	340	343	PF01048	0.765
MOD_GlcNHglycan	344	347	PF01048	0.648
MOD_GlcNHglycan	40	43	PF01048	0.792
MOD_GlcNHglycan	434	437	PF01048	0.670
MOD_GlcNHglycan	464	467	PF01048	0.725
MOD_GlcNHglycan	476	479	PF01048	0.615
MOD_GlcNHglycan	563	566	PF01048	0.792
MOD_GlcNHglycan	610	613	PF01048	0.646
MOD_GlcNHglycan	686	689	PF01048	0.625
MOD_GlcNHglycan	701	705	PF01048	0.774
MOD_GlcNHglycan	86	89	PF01048	0.689
MOD_GSK3_1	107	114	PF00069	0.607
MOD_GSK3_1	139	146	PF00069	0.784
MOD_GSK3_1	151	158	PF00069	0.630
MOD_GSK3_1	198	205	PF00069	0.608
MOD_GSK3_1	216	223	PF00069	0.607
MOD_GSK3_1	244	251	PF00069	0.842
MOD_GSK3_1	264	271	PF00069	0.666
MOD_GSK3_1	30	37	PF00069	0.690
MOD_GSK3_1	330	337	PF00069	0.645
MOD_GSK3_1	338	345	PF00069	0.772
MOD_GSK3_1	354	361	PF00069	0.548
MOD_GSK3_1	371	378	PF00069	0.775
MOD_GSK3_1	427	434	PF00069	0.758
MOD_GSK3_1	444	451	PF00069	0.823
MOD_GSK3_1	504	511	PF00069	0.596
MOD_GSK3_1	560	567	PF00069	0.795
MOD_GSK3_1	607	614	PF00069	0.642
MOD_GSK3_1	615	622	PF00069	0.733
MOD_GSK3_1	64	71	PF00069	0.756
MOD_GSK3_1	651	658	PF00069	0.760
MOD_GSK3_1	696	703	PF00069	0.749
MOD_GSK3_1	73	80	PF00069	0.696
MOD_GSK3_1	736	743	PF00069	0.690
MOD_GSK3_1	96	103	PF00069	0.703
MOD_N-GLC_1	143	148	PF02516	0.572
MOD_N-GLC_1	193	198	PF02516	0.618
MOD_N-GLC_1	428	433	PF02516	0.696
MOD_N-GLC_1	601	606	PF02516	0.609
MOD_N-GLC_2	467	469	PF02516	0.698
MOD_NEK2_1	139	144	PF00069	0.645
MOD_NEK2_1	190	195	PF00069	0.734
MOD_NEK2_1	208	213	PF00069	0.614
MOD_NEK2_1	268	273	PF00069	0.738
MOD_NEK2_1	335	340	PF00069	0.688
MOD_NEK2_1	601	606	PF00069	0.729
MOD_NEK2_1	608	613	PF00069	0.640
MOD_NEK2_2	155	160	PF00069	0.555
MOD_NEK2_2	651	656	PF00069	0.597
MOD_NMyristoyl	1	7	PF02799	0.708
MOD_PIKK_1	346	352	PF00454	0.758
MOD_PIKK_1	551	557	PF00454	0.644
MOD_PIKK_1	665	671	PF00454	0.698
MOD_PK_1	638	644	PF00069	0.620
MOD_PK_1	64	70	PF00069	0.683
MOD_PKA_1	241	247	PF00069	0.702
MOD_PKA_1	584	590	PF00069	0.693
MOD_PKA_1	696	702	PF00069	0.618
MOD_PKA_2	338	344	PF00069	0.769
MOD_PKA_2	491	497	PF00069	0.791
MOD_PKA_2	504	510	PF00069	0.554
MOD_PKA_2	583	589	PF00069	0.697
MOD_PKA_2	655	661	PF00069	0.695
MOD_PKA_2	696	702	PF00069	0.728
MOD_PKA_2	708	714	PF00069	0.554
MOD_PKB_1	490	498	PF00069	0.725
MOD_Plk_1	139	145	PF00069	0.725
MOD_Plk_1	155	161	PF00069	0.516
MOD_Plk_1	193	199	PF00069	0.557
MOD_Plk_1	225	231	PF00069	0.617
MOD_Plk_1	289	295	PF00069	0.577
MOD_Plk_1	330	336	PF00069	0.558
MOD_Plk_1	34	40	PF00069	0.675
MOD_Plk_1	379	385	PF00069	0.615
MOD_Plk_1	651	657	PF00069	0.598
MOD_Plk_4	204	210	PF00069	0.629
MOD_Plk_4	416	422	PF00069	0.581
MOD_Plk_4	638	644	PF00069	0.620
MOD_Plk_4	64	70	PF00069	0.571
MOD_ProDKin_1	171	177	PF00069	0.735
MOD_ProDKin_1	216	222	PF00069	0.684
MOD_ProDKin_1	252	258	PF00069	0.677
MOD_ProDKin_1	451	457	PF00069	0.712
MOD_ProDKin_1	513	519	PF00069	0.698
MOD_ProDKin_1	548	554	PF00069	0.606
MOD_ProDKin_1	570	576	PF00069	0.652
MOD_ProDKin_1	577	583	PF00069	0.641
MOD_SUMO_rev_2	597	607	PF00179	0.680
MOD_SUMO_rev_2	729	734	PF00179	0.559
TRG_DiLeu_BaEn_1	331	336	PF01217	0.574
TRG_DiLeu_BaEn_2	395	401	PF01217	0.513
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.687
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.451
TRG_DiLeu_BaLyEn_6	660	665	PF01217	0.673
TRG_ER_diArg_1	481	484	PF00400	0.642
TRG_ER_diArg_1	487	490	PF00400	0.615
TRG_ER_diArg_1	660	662	PF00400	0.649
TRG_ER_diArg_1	695	697	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.699
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW90	Leptomonas seymouri	29%	88%
A0A3S7X2M1	Leishmania donovani	99%	100%
A4HHK4	Leishmania braziliensis	51%	99%
E9AE67	Leishmania major	86%	100%
E9ALL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%