Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4R5_LEIIN

TriTrypDb:

LINF_290028100

Length:

1287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4R5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1015	1019	PF00656	0.796
CLV_C14_Caspase3-7	1099	1103	PF00656	0.773
CLV_C14_Caspase3-7	1151	1155	PF00656	0.753
CLV_C14_Caspase3-7	604	608	PF00656	0.713
CLV_NRD_NRD_1	1158	1160	PF00675	0.770
CLV_NRD_NRD_1	1199	1201	PF00675	0.775
CLV_NRD_NRD_1	242	244	PF00675	0.584
CLV_NRD_NRD_1	363	365	PF00675	0.639
CLV_NRD_NRD_1	389	391	PF00675	0.655
CLV_NRD_NRD_1	426	428	PF00675	0.586
CLV_NRD_NRD_1	433	435	PF00675	0.499
CLV_NRD_NRD_1	516	518	PF00675	0.597
CLV_NRD_NRD_1	557	559	PF00675	0.634
CLV_NRD_NRD_1	685	687	PF00675	0.629
CLV_NRD_NRD_1	71	73	PF00675	0.713
CLV_NRD_NRD_1	919	921	PF00675	0.525
CLV_NRD_NRD_1	972	974	PF00675	0.479
CLV_PCSK_FUR_1	387	391	PF00082	0.558
CLV_PCSK_FUR_1	754	758	PF00082	0.676
CLV_PCSK_KEX2_1	1051	1053	PF00082	0.842
CLV_PCSK_KEX2_1	1111	1113	PF00082	0.736
CLV_PCSK_KEX2_1	1201	1203	PF00082	0.758
CLV_PCSK_KEX2_1	242	244	PF00082	0.584
CLV_PCSK_KEX2_1	363	365	PF00082	0.639
CLV_PCSK_KEX2_1	389	391	PF00082	0.655
CLV_PCSK_KEX2_1	432	434	PF00082	0.542
CLV_PCSK_KEX2_1	516	518	PF00082	0.597
CLV_PCSK_KEX2_1	557	559	PF00082	0.671
CLV_PCSK_KEX2_1	685	687	PF00082	0.629
CLV_PCSK_KEX2_1	71	73	PF00082	0.713
CLV_PCSK_KEX2_1	756	758	PF00082	0.553
CLV_PCSK_PC1ET2_1	1051	1053	PF00082	0.842
CLV_PCSK_PC1ET2_1	1111	1113	PF00082	0.736
CLV_PCSK_PC1ET2_1	1201	1203	PF00082	0.758
CLV_PCSK_PC1ET2_1	756	758	PF00082	0.553
CLV_PCSK_SKI1_1	128	132	PF00082	0.558
CLV_PCSK_SKI1_1	160	164	PF00082	0.619
CLV_PCSK_SKI1_1	201	205	PF00082	0.780
CLV_PCSK_SKI1_1	305	309	PF00082	0.646
CLV_PCSK_SKI1_1	427	431	PF00082	0.507
CLV_PCSK_SKI1_1	451	455	PF00082	0.650
CLV_PCSK_SKI1_1	458	462	PF00082	0.616
CLV_PCSK_SKI1_1	506	510	PF00082	0.579
CLV_PCSK_SKI1_1	516	520	PF00082	0.671
CLV_PCSK_SKI1_1	920	924	PF00082	0.558
CLV_PCSK_SKI1_1	931	935	PF00082	0.466
CLV_PCSK_SKI1_1	981	985	PF00082	0.745
CLV_Separin_Metazoa	1186	1190	PF03568	0.612
DEG_APCC_DBOX_1	127	135	PF00400	0.557
DEG_Nend_UBRbox_2	1	3	PF02207	0.746
DEG_SCF_FBW7_1	19	24	PF00400	0.689
DEG_SCF_SKP2-CKS1_1	479	486	PF00560	0.674
DEG_SPOP_SBC_1	788	792	PF00917	0.617
DOC_CDC14_PxL_1	878	886	PF14671	0.591
DOC_CYCLIN_RxL_1	761	771	PF00134	0.549
DOC_CYCLIN_RxL_1	917	927	PF00134	0.570
DOC_CYCLIN_RxL_1	978	987	PF00134	0.742
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.702
DOC_MAPK_gen_1	503	511	PF00069	0.576
DOC_MAPK_gen_1	754	763	PF00069	0.570
DOC_MAPK_gen_1	818	827	PF00069	0.619
DOC_MAPK_MEF2A_6	754	763	PF00069	0.570
DOC_MAPK_MEF2A_6	826	834	PF00069	0.681
DOC_MIT_MIM_1	758	768	PF04212	0.544
DOC_PP1_RVXF_1	126	133	PF00149	0.563
DOC_PP1_RVXF_1	564	571	PF00149	0.639
DOC_PP2B_LxvP_1	93	96	PF13499	0.720
DOC_PP4_FxxP_1	342	345	PF00568	0.534
DOC_PP4_FxxP_1	475	478	PF00568	0.705
DOC_USP7_MATH_1	1042	1046	PF00917	0.665
DOC_USP7_MATH_1	1093	1097	PF00917	0.863
DOC_USP7_MATH_1	189	193	PF00917	0.767
DOC_USP7_MATH_1	21	25	PF00917	0.673
DOC_USP7_MATH_1	210	214	PF00917	0.601
DOC_USP7_MATH_1	460	464	PF00917	0.736
DOC_USP7_MATH_1	469	473	PF00917	0.552
DOC_USP7_MATH_1	522	526	PF00917	0.634
DOC_USP7_MATH_1	531	535	PF00917	0.557
DOC_USP7_MATH_1	620	624	PF00917	0.578
DOC_USP7_MATH_1	669	673	PF00917	0.665
DOC_USP7_MATH_1	695	699	PF00917	0.745
DOC_USP7_MATH_1	772	776	PF00917	0.629
DOC_USP7_MATH_1	788	792	PF00917	0.622
DOC_USP7_MATH_1	81	85	PF00917	0.808
DOC_USP7_MATH_1	904	908	PF00917	0.649
DOC_USP7_MATH_1	979	983	PF00917	0.557
DOC_USP7_UBL2_3	1194	1198	PF12436	0.755
DOC_USP7_UBL2_3	1201	1205	PF12436	0.671
DOC_USP7_UBL2_3	887	891	PF12436	0.457
DOC_WW_Pin1_4	1016	1021	PF00397	0.752
DOC_WW_Pin1_4	17	22	PF00397	0.762
DOC_WW_Pin1_4	307	312	PF00397	0.712
DOC_WW_Pin1_4	411	416	PF00397	0.609
DOC_WW_Pin1_4	474	479	PF00397	0.681
DOC_WW_Pin1_4	480	485	PF00397	0.657
DOC_WW_Pin1_4	571	576	PF00397	0.673
DOC_WW_Pin1_4	790	795	PF00397	0.652
LIG_14-3-3_CanoR_1	1163	1169	PF00244	0.841
LIG_14-3-3_CanoR_1	242	251	PF00244	0.637
LIG_14-3-3_CanoR_1	267	275	PF00244	0.595
LIG_14-3-3_CanoR_1	305	312	PF00244	0.795
LIG_14-3-3_CanoR_1	33	39	PF00244	0.633
LIG_14-3-3_CanoR_1	458	467	PF00244	0.575
LIG_14-3-3_CanoR_1	557	562	PF00244	0.548
LIG_14-3-3_CanoR_1	614	620	PF00244	0.727
LIG_14-3-3_CanoR_1	640	645	PF00244	0.584
LIG_14-3-3_CanoR_1	820	828	PF00244	0.609
LIG_14-3-3_CanoR_1	860	870	PF00244	0.562
LIG_14-3-3_CanoR_1	905	912	PF00244	0.678
LIG_Actin_WH2_2	414	429	PF00022	0.596
LIG_Actin_WH2_2	544	559	PF00022	0.625
LIG_BIR_III_4	814	818	PF00653	0.689
LIG_BRCT_BRCA1_1	1250	1254	PF00533	0.672
LIG_BRCT_BRCA1_1	128	132	PF00533	0.558
LIG_BRCT_BRCA1_1	471	475	PF00533	0.757
LIG_deltaCOP1_diTrp_1	395	399	PF00928	0.653
LIG_DLG_GKlike_1	557	564	PF00625	0.699
LIG_DLG_GKlike_1	640	647	PF00625	0.588
LIG_EH_1	1275	1279	PF12763	0.681
LIG_EVH1_2	1259	1263	PF00568	0.735
LIG_FHA_1	1179	1185	PF00498	0.755
LIG_FHA_1	216	222	PF00498	0.519
LIG_FHA_1	270	276	PF00498	0.670
LIG_FHA_1	302	308	PF00498	0.756
LIG_FHA_1	323	329	PF00498	0.581
LIG_FHA_1	40	46	PF00498	0.741
LIG_FHA_1	440	446	PF00498	0.665
LIG_FHA_1	656	662	PF00498	0.659
LIG_FHA_1	677	683	PF00498	0.599
LIG_FHA_1	710	716	PF00498	0.682
LIG_FHA_1	791	797	PF00498	0.630
LIG_FHA_1	854	860	PF00498	0.575
LIG_FHA_1	962	968	PF00498	0.567
LIG_FHA_2	1060	1066	PF00498	0.771
LIG_FHA_2	1162	1168	PF00498	0.753
LIG_FHA_2	18	24	PF00498	0.807
LIG_FHA_2	380	386	PF00498	0.567
LIG_FHA_2	415	421	PF00498	0.588
LIG_FHA_2	698	704	PF00498	0.754
LIG_FHA_2	730	736	PF00498	0.527
LIG_FHA_2	790	796	PF00498	0.583
LIG_FHA_2	802	808	PF00498	0.747
LIG_FHA_2	92	98	PF00498	0.754
LIG_FHA_2	925	931	PF00498	0.655
LIG_GBD_Chelix_1	733	741	PF00786	0.559
LIG_Integrin_RGD_1	586	588	PF01839	0.708
LIG_Integrin_RGD_1	779	781	PF01839	0.624
LIG_LIR_Apic_2	1255	1260	PF02991	0.731
LIG_LIR_Apic_2	2	8	PF02991	0.640
LIG_LIR_Apic_2	340	345	PF02991	0.593
LIG_LIR_Apic_2	472	478	PF02991	0.664
LIG_LIR_Gen_1	395	403	PF02991	0.641
LIG_LIR_Nem_3	1251	1257	PF02991	0.671
LIG_LIR_Nem_3	126	130	PF02991	0.567
LIG_LIR_Nem_3	395	399	PF02991	0.558
LIG_LIR_Nem_3	411	416	PF02991	0.650
LIG_LIR_Nem_3	560	564	PF02991	0.569
LIG_LIR_Nem_3	871	876	PF02991	0.554
LIG_LIR_Nem_3	977	983	PF02991	0.573
LIG_NRBOX	504	510	PF00104	0.589
LIG_NRBOX	643	649	PF00104	0.591
LIG_NRBOX	761	767	PF00104	0.544
LIG_Pex14_2	1278	1282	PF04695	0.678
LIG_PTB_Apo_2	1273	1280	PF02174	0.682
LIG_PTB_Phospho_1	1273	1279	PF10480	0.684
LIG_RPA_C_Fungi	937	949	PF08784	0.646
LIG_RPA_C_Insects	1148	1163	PF08784	0.596
LIG_SH2_CRK	127	131	PF00017	0.558
LIG_SH2_CRK	413	417	PF00017	0.665
LIG_SH2_CRK	5	9	PF00017	0.635
LIG_SH2_CRK	561	565	PF00017	0.594
LIG_SH2_NCK_1	413	417	PF00017	0.665
LIG_SH2_NCK_1	876	880	PF00017	0.617
LIG_SH2_NCK_1	932	936	PF00017	0.443
LIG_SH2_STAP1	123	127	PF00017	0.691
LIG_SH2_STAP1	932	936	PF00017	0.618
LIG_SH2_STAT5	1232	1235	PF00017	0.607
LIG_SH2_STAT5	172	175	PF00017	0.624
LIG_SH2_STAT5	510	513	PF00017	0.580
LIG_SH3_2	828	833	PF14604	0.756
LIG_SH3_3	1261	1267	PF00018	0.794
LIG_SH3_3	24	30	PF00018	0.776
LIG_SH3_3	465	471	PF00018	0.691
LIG_SH3_3	572	578	PF00018	0.662
LIG_SH3_3	822	828	PF00018	0.691
LIG_SUMO_SIM_anti_2	442	447	PF11976	0.649
LIG_SUMO_SIM_anti_2	643	650	PF11976	0.695
LIG_SUMO_SIM_anti_2	758	763	PF11976	0.551
LIG_SUMO_SIM_par_1	414	420	PF11976	0.578
LIG_SUMO_SIM_par_1	712	719	PF11976	0.728
LIG_TRAF2_1	1062	1065	PF00917	0.767
LIG_TRAF2_1	1088	1091	PF00917	0.776
LIG_TRAF2_1	1113	1116	PF00917	0.733
LIG_TRAF2_1	1144	1147	PF00917	0.797
LIG_TRAF2_1	894	897	PF00917	0.585
LIG_TRAF2_2	1124	1129	PF00917	0.780
LIG_UBA3_1	504	513	PF00899	0.575
LIG_Vh1_VBS_1	619	637	PF01044	0.513
MOD_CDK_SPK_2	571	576	PF00069	0.673
MOD_CDK_SPxK_1	480	486	PF00069	0.668
MOD_CK1_1	196	202	PF00069	0.785
MOD_CK1_1	414	420	PF00069	0.587
MOD_CK1_1	615	621	PF00069	0.700
MOD_CK1_1	623	629	PF00069	0.649
MOD_CK1_1	643	649	PF00069	0.529
MOD_CK1_1	697	703	PF00069	0.742
MOD_CK1_1	729	735	PF00069	0.536
MOD_CK1_1	842	848	PF00069	0.679
MOD_CK1_1	908	914	PF00069	0.637
MOD_CK2_1	1016	1022	PF00069	0.762
MOD_CK2_1	1059	1065	PF00069	0.769
MOD_CK2_1	1093	1099	PF00069	0.738
MOD_CK2_1	414	420	PF00069	0.587
MOD_CK2_1	522	528	PF00069	0.668
MOD_CK2_1	629	635	PF00069	0.601
MOD_CK2_1	729	735	PF00069	0.478
MOD_CK2_1	789	795	PF00069	0.601
MOD_CK2_1	801	807	PF00069	0.742
MOD_CK2_1	874	880	PF00069	0.717
MOD_CK2_1	91	97	PF00069	0.665
MOD_CK2_1	924	930	PF00069	0.571
MOD_CK2_1	959	965	PF00069	0.574
MOD_Cter_Amidation	1194	1197	PF01082	0.751
MOD_Cter_Amidation	361	364	PF01082	0.628
MOD_GlcNHglycan	1048	1051	PF01048	0.751
MOD_GlcNHglycan	114	117	PF01048	0.743
MOD_GlcNHglycan	1279	1282	PF01048	0.653
MOD_GlcNHglycan	185	188	PF01048	0.727
MOD_GlcNHglycan	195	198	PF01048	0.594
MOD_GlcNHglycan	206	209	PF01048	0.620
MOD_GlcNHglycan	212	215	PF01048	0.461
MOD_GlcNHglycan	23	26	PF01048	0.711
MOD_GlcNHglycan	289	292	PF01048	0.646
MOD_GlcNHglycan	464	467	PF01048	0.659
MOD_GlcNHglycan	783	786	PF01048	0.695
MOD_GlcNHglycan	797	800	PF01048	0.541
MOD_GlcNHglycan	83	86	PF01048	0.728
MOD_GlcNHglycan	841	844	PF01048	0.679
MOD_GlcNHglycan	907	910	PF01048	0.599
MOD_GSK3_1	1042	1049	PF00069	0.665
MOD_GSK3_1	1174	1181	PF00069	0.825
MOD_GSK3_1	1248	1255	PF00069	0.695
MOD_GSK3_1	1258	1265	PF00069	0.651
MOD_GSK3_1	156	163	PF00069	0.613
MOD_GSK3_1	17	24	PF00069	0.673
MOD_GSK3_1	183	190	PF00069	0.687
MOD_GSK3_1	301	308	PF00069	0.759
MOD_GSK3_1	322	329	PF00069	0.562
MOD_GSK3_1	349	356	PF00069	0.651
MOD_GSK3_1	40	47	PF00069	0.720
MOD_GSK3_1	458	465	PF00069	0.662
MOD_GSK3_1	469	476	PF00069	0.738
MOD_GSK3_1	527	534	PF00069	0.563
MOD_GSK3_1	538	545	PF00069	0.588
MOD_GSK3_1	636	643	PF00069	0.683
MOD_GSK3_1	695	702	PF00069	0.787
MOD_GSK3_1	722	729	PF00069	0.577
MOD_GSK3_1	900	907	PF00069	0.597
MOD_GSK3_1	921	928	PF00069	0.620
MOD_GSK3_1	959	966	PF00069	0.677
MOD_N-GLC_1	193	198	PF02516	0.835
MOD_N-GLC_1	349	354	PF02516	0.562
MOD_N-GLC_1	905	910	PF02516	0.505
MOD_NEK2_1	1106	1111	PF00069	0.639
MOD_NEK2_1	183	188	PF00069	0.742
MOD_NEK2_1	203	208	PF00069	0.557
MOD_NEK2_1	250	255	PF00069	0.576
MOD_NEK2_1	331	336	PF00069	0.478
MOD_NEK2_1	394	399	PF00069	0.588
MOD_NEK2_1	570	575	PF00069	0.682
MOD_NEK2_1	722	727	PF00069	0.616
MOD_NEK2_1	80	85	PF00069	0.732
MOD_NEK2_1	863	868	PF00069	0.574
MOD_NEK2_1	923	928	PF00069	0.573
MOD_PIKK_1	1162	1168	PF00454	0.770
MOD_PIKK_1	172	178	PF00454	0.713
MOD_PIKK_1	522	528	PF00454	0.668
MOD_PIKK_1	655	661	PF00454	0.613
MOD_PIKK_1	726	732	PF00454	0.632
MOD_PIKK_1	820	826	PF00454	0.720
MOD_PIKK_1	863	869	PF00454	0.546
MOD_PK_1	974	980	PF00069	0.483
MOD_PKA_1	1196	1202	PF00069	0.766
MOD_PKA_1	242	248	PF00069	0.573
MOD_PKA_1	557	563	PF00069	0.623
MOD_PKA_2	1162	1168	PF00069	0.740
MOD_PKA_2	1173	1179	PF00069	0.700
MOD_PKA_2	1201	1207	PF00069	0.763
MOD_PKA_2	156	162	PF00069	0.632
MOD_PKA_2	242	248	PF00069	0.644
MOD_PKA_2	266	272	PF00069	0.595
MOD_PKA_2	322	328	PF00069	0.547
MOD_PKA_2	557	563	PF00069	0.708
MOD_PKA_2	810	816	PF00069	0.718
MOD_PKA_2	904	910	PF00069	0.579
MOD_Plk_1	1006	1012	PF00069	0.662
MOD_Plk_1	349	355	PF00069	0.552
MOD_Plk_1	394	400	PF00069	0.528
MOD_Plk_1	527	533	PF00069	0.533
MOD_Plk_2-3	1006	1012	PF00069	0.750
MOD_Plk_2-3	699	705	PF00069	0.794
MOD_Plk_2-3	880	886	PF00069	0.685
MOD_Plk_4	1224	1230	PF00069	0.729
MOD_Plk_4	1258	1264	PF00069	0.635
MOD_Plk_4	337	343	PF00069	0.583
MOD_Plk_4	349	355	PF00069	0.548
MOD_Plk_4	629	635	PF00069	0.645
MOD_Plk_4	640	646	PF00069	0.559
MOD_Plk_4	729	735	PF00069	0.522
MOD_Plk_4	848	854	PF00069	0.489
MOD_Plk_4	880	886	PF00069	0.685
MOD_Plk_4	979	985	PF00069	0.627
MOD_ProDKin_1	1016	1022	PF00069	0.756
MOD_ProDKin_1	17	23	PF00069	0.764
MOD_ProDKin_1	307	313	PF00069	0.709
MOD_ProDKin_1	411	417	PF00069	0.604
MOD_ProDKin_1	474	480	PF00069	0.676
MOD_ProDKin_1	571	577	PF00069	0.675
MOD_ProDKin_1	790	796	PF00069	0.641
MOD_SUMO_for_1	1004	1007	PF00179	0.726
MOD_SUMO_for_1	1012	1015	PF00179	0.793
MOD_SUMO_for_1	1027	1030	PF00179	0.610
MOD_SUMO_for_1	1043	1046	PF00179	0.802
MOD_SUMO_rev_2	1022	1029	PF00179	0.721
MOD_SUMO_rev_2	594	602	PF00179	0.831
MOD_SUMO_rev_2	842	851	PF00179	0.497
TRG_DiLeu_BaEn_1	126	131	PF01217	0.563
TRG_DiLeu_BaEn_1	246	251	PF01217	0.649
TRG_DiLeu_BaEn_1	271	276	PF01217	0.678
TRG_DiLeu_BaEn_1	880	885	PF01217	0.685
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.599
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.621
TRG_DiLeu_BaLyEn_6	711	716	PF01217	0.755
TRG_DiLeu_BaLyEn_6	761	766	PF01217	0.608
TRG_DiLeu_BaLyEn_6	817	822	PF01217	0.626
TRG_ENDOCYTIC_2	127	130	PF00928	0.562
TRG_ENDOCYTIC_2	1279	1282	PF00928	0.679
TRG_ENDOCYTIC_2	413	416	PF00928	0.712
TRG_ENDOCYTIC_2	561	564	PF00928	0.596
TRG_ER_diArg_1	1200	1203	PF00400	0.665
TRG_ER_diArg_1	241	243	PF00400	0.584
TRG_ER_diArg_1	386	389	PF00400	0.651
TRG_ER_diArg_1	431	434	PF00400	0.542
TRG_ER_diArg_1	516	518	PF00400	0.639
TRG_ER_diArg_1	556	558	PF00400	0.660
TRG_ER_diArg_1	684	686	PF00400	0.618
TRG_ER_diArg_1	70	72	PF00400	0.708
TRG_NLS_MonoExtC_3	1195	1200	PF00514	0.762
TRG_NLS_MonoExtN_4	1194	1201	PF00514	0.759
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	820	824	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	893	897	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	920	925	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE03	Leptomonas seymouri	36%	100%
A0A3Q8IHE1	Leishmania donovani	99%	100%
A4HHK3	Leishmania braziliensis	63%	97%
E9AE66	Leishmania major	86%	99%
E9ALL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%