LeishMANIAdb
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Putative serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine protein kinase
Gene product:
5'-AMP-activated protein kinase catalytic subunit alpha - putative
Species:
Leishmania infantum
UniProt:
A4I4Q9_LEIIN
TriTrypDb:
LINF_290027900
Length:
815

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Protein kinase, serine/threonine kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 462
Promastigote: 502, 679, 682
Promastigote/Amastigote: 192, 193

Expansion

Sequence features

A4I4Q9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4Q9

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 9
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 444 448 PF00656 0.787
CLV_NRD_NRD_1 329 331 PF00675 0.525
CLV_NRD_NRD_1 353 355 PF00675 0.476
CLV_NRD_NRD_1 504 506 PF00675 0.752
CLV_NRD_NRD_1 534 536 PF00675 0.720
CLV_NRD_NRD_1 615 617 PF00675 0.736
CLV_NRD_NRD_1 671 673 PF00675 0.722
CLV_NRD_NRD_1 811 813 PF00675 0.582
CLV_PCSK_FUR_1 351 355 PF00082 0.534
CLV_PCSK_FUR_1 669 673 PF00082 0.707
CLV_PCSK_KEX2_1 320 322 PF00082 0.492
CLV_PCSK_KEX2_1 351 353 PF00082 0.480
CLV_PCSK_KEX2_1 504 506 PF00082 0.727
CLV_PCSK_KEX2_1 615 617 PF00082 0.683
CLV_PCSK_KEX2_1 671 673 PF00082 0.722
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.483
CLV_PCSK_SKI1_1 137 141 PF00082 0.353
CLV_PCSK_SKI1_1 158 162 PF00082 0.323
CLV_PCSK_SKI1_1 577 581 PF00082 0.500
DEG_MDM2_SWIB_1 579 586 PF02201 0.493
DEG_SPOP_SBC_1 480 484 PF00917 0.754
DEG_SPOP_SBC_1 752 756 PF00917 0.777
DOC_ANK_TNKS_1 634 641 PF00023 0.673
DOC_CKS1_1 103 108 PF01111 0.355
DOC_MAPK_gen_1 158 167 PF00069 0.335
DOC_MAPK_gen_1 306 315 PF00069 0.559
DOC_MAPK_gen_1 327 335 PF00069 0.489
DOC_MAPK_gen_1 781 790 PF00069 0.517
DOC_MAPK_gen_1 79 90 PF00069 0.335
DOC_MAPK_HePTP_8 205 217 PF00069 0.355
DOC_MAPK_MEF2A_6 208 217 PF00069 0.355
DOC_MAPK_MEF2A_6 306 315 PF00069 0.559
DOC_MAPK_MEF2A_6 391 399 PF00069 0.542
DOC_PP1_RVXF_1 172 179 PF00149 0.335
DOC_PP1_RVXF_1 206 212 PF00149 0.355
DOC_PP2B_LxvP_1 277 280 PF13499 0.355
DOC_PP4_FxxP_1 91 94 PF00568 0.335
DOC_USP7_MATH_1 252 256 PF00917 0.411
DOC_USP7_MATH_1 454 458 PF00917 0.786
DOC_USP7_MATH_1 459 463 PF00917 0.706
DOC_USP7_MATH_1 676 680 PF00917 0.691
DOC_USP7_MATH_1 712 716 PF00917 0.727
DOC_USP7_MATH_1 728 732 PF00917 0.712
DOC_USP7_MATH_1 751 755 PF00917 0.737
DOC_USP7_UBL2_3 383 387 PF12436 0.667
DOC_USP7_UBL2_3 580 584 PF12436 0.444
DOC_WW_Pin1_4 102 107 PF00397 0.355
DOC_WW_Pin1_4 193 198 PF00397 0.335
DOC_WW_Pin1_4 399 404 PF00397 0.519
DOC_WW_Pin1_4 584 589 PF00397 0.485
DOC_WW_Pin1_4 735 740 PF00397 0.763
DOC_WW_Pin1_4 743 748 PF00397 0.691
DOC_WW_Pin1_4 761 766 PF00397 0.659
LIG_14-3-3_CanoR_1 276 280 PF00244 0.383
LIG_14-3-3_CanoR_1 295 305 PF00244 0.501
LIG_14-3-3_CanoR_1 309 314 PF00244 0.409
LIG_14-3-3_CanoR_1 594 602 PF00244 0.554
LIG_14-3-3_CanoR_1 610 619 PF00244 0.720
LIG_Actin_RPEL_3 147 166 PF02755 0.447
LIG_Actin_WH2_2 59 75 PF00022 0.378
LIG_BIR_II_1 1 5 PF00653 0.722
LIG_BIR_III_3 1 5 PF00653 0.727
LIG_BRCT_BRCA1_1 771 775 PF00533 0.551
LIG_FHA_1 597 603 PF00498 0.566
LIG_FHA_1 619 625 PF00498 0.751
LIG_FHA_1 753 759 PF00498 0.753
LIG_FHA_2 103 109 PF00498 0.335
LIG_FHA_2 387 393 PF00498 0.550
LIG_FHA_2 431 437 PF00498 0.673
LIG_FHA_2 539 545 PF00498 0.530
LIG_GBD_Chelix_1 798 806 PF00786 0.429
LIG_LIR_Apic_2 196 202 PF02991 0.335
LIG_LIR_Gen_1 107 116 PF02991 0.335
LIG_LIR_Gen_1 120 126 PF02991 0.335
LIG_LIR_Gen_1 570 581 PF02991 0.458
LIG_LIR_Gen_1 58 67 PF02991 0.447
LIG_LIR_Gen_1 598 604 PF02991 0.469
LIG_LIR_Nem_3 120 125 PF02991 0.335
LIG_LIR_Nem_3 46 50 PF02991 0.354
LIG_LIR_Nem_3 570 576 PF02991 0.431
LIG_LIR_Nem_3 58 64 PF02991 0.335
LIG_LIR_Nem_3 587 592 PF02991 0.293
LIG_LIR_Nem_3 772 778 PF02991 0.563
LIG_LIR_Nem_3 789 793 PF02991 0.320
LIG_MAD2 154 162 PF02301 0.447
LIG_MLH1_MIPbox_1 771 775 PF16413 0.551
LIG_NRBOX 223 229 PF00104 0.355
LIG_NRBOX 801 807 PF00104 0.553
LIG_OCRL_FandH_1 774 786 PF00620 0.629
LIG_PCNA_yPIPBox_3 767 781 PF02747 0.561
LIG_Pex14_2 579 583 PF04695 0.443
LIG_REV1ctd_RIR_1 773 781 PF16727 0.613
LIG_SH2_CRK 122 126 PF00017 0.408
LIG_SH2_CRK 225 229 PF00017 0.335
LIG_SH2_CRK 251 255 PF00017 0.355
LIG_SH2_CRK 344 348 PF00017 0.358
LIG_SH2_CRK 573 577 PF00017 0.417
LIG_SH2_NCK_1 100 104 PF00017 0.335
LIG_SH2_NCK_1 199 203 PF00017 0.335
LIG_SH2_NCK_1 251 255 PF00017 0.447
LIG_SH2_PTP2 61 64 PF00017 0.447
LIG_SH2_SRC 115 118 PF00017 0.355
LIG_SH2_SRC 122 125 PF00017 0.355
LIG_SH2_SRC 251 254 PF00017 0.376
LIG_SH2_SRC 485 488 PF00017 0.680
LIG_SH2_STAP1 122 126 PF00017 0.355
LIG_SH2_STAP1 298 302 PF00017 0.655
LIG_SH2_STAT3 124 127 PF00017 0.402
LIG_SH2_STAT3 138 141 PF00017 0.249
LIG_SH2_STAT5 110 113 PF00017 0.341
LIG_SH2_STAT5 115 118 PF00017 0.342
LIG_SH2_STAT5 124 127 PF00017 0.355
LIG_SH2_STAT5 138 141 PF00017 0.267
LIG_SH2_STAT5 149 152 PF00017 0.303
LIG_SH2_STAT5 210 213 PF00017 0.335
LIG_SH2_STAT5 36 39 PF00017 0.342
LIG_SH2_STAT5 540 543 PF00017 0.539
LIG_SH2_STAT5 61 64 PF00017 0.447
LIG_SH2_STAT5 700 703 PF00017 0.746
LIG_SH2_STAT5 774 777 PF00017 0.464
LIG_SH2_STAT5 786 789 PF00017 0.409
LIG_SH3_1 23 29 PF00018 0.522
LIG_SH3_3 23 29 PF00018 0.706
LIG_SH3_3 267 273 PF00018 0.335
LIG_SH3_3 582 588 PF00018 0.483
LIG_SH3_3 736 742 PF00018 0.795
LIG_SH3_3 762 768 PF00018 0.670
LIG_SUMO_SIM_anti_2 801 809 PF11976 0.526
LIG_SUMO_SIM_anti_2 84 89 PF11976 0.447
LIG_SUMO_SIM_par_1 267 272 PF11976 0.323
LIG_SUMO_SIM_par_1 404 413 PF11976 0.601
LIG_SUMO_SIM_par_1 767 772 PF11976 0.537
LIG_SUMO_SIM_par_1 801 809 PF11976 0.444
LIG_TRAF2_1 541 544 PF00917 0.551
LIG_TYR_ITIM 223 228 PF00017 0.335
LIG_TYR_ITIM 342 347 PF00017 0.355
LIG_UBA3_1 242 250 PF00899 0.335
LIG_WRC_WIRS_1 460 465 PF05994 0.734
LIG_WRC_WIRS_1 576 581 PF05994 0.472
MOD_CDC14_SPxK_1 587 590 PF00782 0.542
MOD_CDK_SPK_2 735 740 PF00069 0.677
MOD_CDK_SPxK_1 584 590 PF00069 0.535
MOD_CK1_1 104 110 PF00069 0.378
MOD_CK1_1 181 187 PF00069 0.408
MOD_CK1_1 193 199 PF00069 0.258
MOD_CK1_1 301 307 PF00069 0.584
MOD_CK1_1 430 436 PF00069 0.642
MOD_CK1_1 441 447 PF00069 0.622
MOD_CK1_1 479 485 PF00069 0.640
MOD_CK1_1 606 612 PF00069 0.626
MOD_CK1_1 620 626 PF00069 0.569
MOD_CK1_1 641 647 PF00069 0.777
MOD_CK1_1 679 685 PF00069 0.712
MOD_CK1_1 717 723 PF00069 0.724
MOD_CK1_1 733 739 PF00069 0.775
MOD_CK2_1 294 300 PF00069 0.476
MOD_CK2_1 301 307 PF00069 0.535
MOD_CK2_1 363 369 PF00069 0.686
MOD_CK2_1 386 392 PF00069 0.553
MOD_CK2_1 538 544 PF00069 0.535
MOD_CK2_1 592 598 PF00069 0.479
MOD_CK2_1 728 734 PF00069 0.749
MOD_GlcNHglycan 18 21 PF01048 0.761
MOD_GlcNHglycan 205 208 PF01048 0.344
MOD_GlcNHglycan 365 368 PF01048 0.661
MOD_GlcNHglycan 447 451 PF01048 0.775
MOD_GlcNHglycan 470 473 PF01048 0.700
MOD_GlcNHglycan 476 479 PF01048 0.626
MOD_GlcNHglycan 569 572 PF01048 0.521
MOD_GlcNHglycan 625 629 PF01048 0.698
MOD_GlcNHglycan 635 638 PF01048 0.706
MOD_GlcNHglycan 640 643 PF01048 0.649
MOD_GlcNHglycan 681 684 PF01048 0.776
MOD_GlcNHglycan 714 717 PF01048 0.754
MOD_GlcNHglycan 719 722 PF01048 0.673
MOD_GlcNHglycan 724 727 PF01048 0.677
MOD_GlcNHglycan 73 76 PF01048 0.417
MOD_GlcNHglycan 730 733 PF01048 0.732
MOD_GlcNHglycan 749 752 PF01048 0.563
MOD_GlcNHglycan 755 758 PF01048 0.744
MOD_GSK3_1 189 196 PF00069 0.335
MOD_GSK3_1 252 259 PF00069 0.305
MOD_GSK3_1 294 301 PF00069 0.509
MOD_GSK3_1 309 316 PF00069 0.463
MOD_GSK3_1 363 370 PF00069 0.663
MOD_GSK3_1 459 466 PF00069 0.676
MOD_GSK3_1 470 477 PF00069 0.591
MOD_GSK3_1 494 501 PF00069 0.756
MOD_GSK3_1 508 515 PF00069 0.684
MOD_GSK3_1 592 599 PF00069 0.440
MOD_GSK3_1 6 13 PF00069 0.675
MOD_GSK3_1 606 613 PF00069 0.539
MOD_GSK3_1 620 627 PF00069 0.664
MOD_GSK3_1 728 735 PF00069 0.761
MOD_GSK3_1 743 750 PF00069 0.606
MOD_N-GLC_1 181 186 PF02516 0.480
MOD_N-GLC_1 522 527 PF02516 0.680
MOD_N-GLC_1 610 615 PF02516 0.660
MOD_N-GLC_1 688 693 PF02516 0.638
MOD_N-GLC_2 95 97 PF02516 0.335
MOD_NEK2_1 166 171 PF00069 0.415
MOD_NEK2_1 178 183 PF00069 0.292
MOD_NEK2_1 189 194 PF00069 0.301
MOD_NEK2_1 241 246 PF00069 0.403
MOD_NEK2_1 294 299 PF00069 0.491
MOD_NEK2_1 32 37 PF00069 0.475
MOD_NEK2_1 397 402 PF00069 0.524
MOD_NEK2_1 463 468 PF00069 0.627
MOD_NEK2_1 474 479 PF00069 0.576
MOD_NEK2_1 508 513 PF00069 0.673
MOD_NEK2_1 592 597 PF00069 0.435
MOD_NEK2_1 603 608 PF00069 0.507
MOD_NEK2_1 688 693 PF00069 0.704
MOD_NEK2_1 806 811 PF00069 0.386
MOD_NEK2_2 298 303 PF00069 0.543
MOD_NEK2_2 459 464 PF00069 0.736
MOD_PIKK_1 397 403 PF00454 0.528
MOD_PIKK_1 515 521 PF00454 0.738
MOD_PIKK_1 604 610 PF00454 0.666
MOD_PIKK_1 690 696 PF00454 0.771
MOD_PK_1 309 315 PF00069 0.533
MOD_PK_1 529 535 PF00069 0.627
MOD_PKA_1 615 621 PF00069 0.677
MOD_PKA_2 131 137 PF00069 0.447
MOD_PKA_2 275 281 PF00069 0.335
MOD_PKA_2 294 300 PF00069 0.452
MOD_PKA_2 38 44 PF00069 0.447
MOD_PKA_2 463 469 PF00069 0.722
MOD_PKA_2 593 599 PF00069 0.497
MOD_PKA_2 615 621 PF00069 0.699
MOD_Plk_1 235 241 PF00069 0.355
MOD_Plk_1 441 447 PF00069 0.800
MOD_Plk_4 298 304 PF00069 0.517
MOD_Plk_4 309 315 PF00069 0.405
MOD_Plk_4 32 38 PF00069 0.483
MOD_Plk_4 470 476 PF00069 0.735
MOD_Plk_4 806 812 PF00069 0.392
MOD_ProDKin_1 102 108 PF00069 0.355
MOD_ProDKin_1 193 199 PF00069 0.335
MOD_ProDKin_1 399 405 PF00069 0.515
MOD_ProDKin_1 584 590 PF00069 0.482
MOD_ProDKin_1 735 741 PF00069 0.763
MOD_ProDKin_1 743 749 PF00069 0.689
MOD_ProDKin_1 761 767 PF00069 0.649
MOD_SUMO_for_1 160 163 PF00179 0.335
MOD_SUMO_rev_2 74 81 PF00179 0.385
MOD_SUMO_rev_2 783 793 PF00179 0.566
TRG_DiLeu_BaEn_2 542 548 PF01217 0.544
TRG_DiLeu_BaEn_3 543 549 PF01217 0.544
TRG_DiLeu_BaLyEn_6 237 242 PF01217 0.447
TRG_DiLeu_BaLyEn_6 587 592 PF01217 0.469
TRG_ENDOCYTIC_2 100 103 PF00928 0.373
TRG_ENDOCYTIC_2 110 113 PF00928 0.335
TRG_ENDOCYTIC_2 122 125 PF00928 0.355
TRG_ENDOCYTIC_2 225 228 PF00928 0.319
TRG_ENDOCYTIC_2 344 347 PF00928 0.356
TRG_ENDOCYTIC_2 573 576 PF00928 0.389
TRG_ENDOCYTIC_2 61 64 PF00928 0.447
TRG_ER_diArg_1 351 354 PF00400 0.528
TRG_ER_diArg_1 503 505 PF00400 0.738
TRG_ER_diArg_1 669 672 PF00400 0.715
TRG_NES_CRM1_1 355 369 PF08389 0.606
TRG_NLS_MonoExtN_4 245 251 PF00514 0.408
TRG_NLS_MonoExtN_4 49 55 PF00514 0.408
TRG_Pf-PMV_PEXEL_1 137 141 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 158 163 PF00026 0.335
TRG_Pf-PMV_PEXEL_1 262 266 PF00026 0.335

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I379 Leptomonas seymouri 70% 99%
A0A1X0P022 Trypanosomatidae 61% 100%
A0A3R7MPF2 Trypanosoma rangeli 61% 100%
A0A3S7X2Q3 Leishmania donovani 100% 100%
A4HHK1 Leishmania braziliensis 86% 100%
C9ZLF2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AE64 Leishmania major 97% 100%
E9ALM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5BL06 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS