Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4Q7_LEIIN

TriTrypDb:

LINF_290027500

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	418	422	PF00656	0.573
CLV_NRD_NRD_1	121	123	PF00675	0.695
CLV_NRD_NRD_1	370	372	PF00675	0.580
CLV_NRD_NRD_1	42	44	PF00675	0.620
CLV_NRD_NRD_1	97	99	PF00675	0.591
CLV_PCSK_FUR_1	40	44	PF00082	0.615
CLV_PCSK_KEX2_1	121	123	PF00082	0.687
CLV_PCSK_KEX2_1	343	345	PF00082	0.687
CLV_PCSK_KEX2_1	370	372	PF00082	0.580
CLV_PCSK_KEX2_1	42	44	PF00082	0.620
CLV_PCSK_KEX2_1	97	99	PF00082	0.591
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.615
DEG_SPOP_SBC_1	348	352	PF00917	0.639
DOC_ANK_TNKS_1	451	458	PF00023	0.588
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.512
DOC_PP2B_LxvP_1	189	192	PF13499	0.557
DOC_PP2B_LxvP_1	273	276	PF13499	0.446
DOC_PP4_FxxP_1	150	153	PF00568	0.688
DOC_SPAK_OSR1_1	238	242	PF12202	0.596
DOC_USP7_MATH_1	161	165	PF00917	0.724
DOC_USP7_MATH_1	198	202	PF00917	0.596
DOC_USP7_MATH_1	223	227	PF00917	0.563
DOC_USP7_MATH_1	348	352	PF00917	0.723
DOC_USP7_MATH_1	405	409	PF00917	0.668
DOC_USP7_MATH_1	438	442	PF00917	0.754
DOC_USP7_MATH_1	66	70	PF00917	0.758
DOC_WW_Pin1_4	127	132	PF00397	0.676
DOC_WW_Pin1_4	165	170	PF00397	0.650
DOC_WW_Pin1_4	172	177	PF00397	0.609
DOC_WW_Pin1_4	255	260	PF00397	0.517
DOC_WW_Pin1_4	41	46	PF00397	0.643
DOC_WW_Pin1_4	434	439	PF00397	0.709
DOC_WW_Pin1_4	6	11	PF00397	0.772
LIG_14-3-3_CanoR_1	238	242	PF00244	0.498
LIG_14-3-3_CanoR_1	370	377	PF00244	0.572
LIG_14-3-3_CanoR_1	394	402	PF00244	0.528
LIG_14-3-3_CanoR_1	439	447	PF00244	0.636
LIG_14-3-3_CanoR_1	64	74	PF00244	0.735
LIG_14-3-3_CanoR_1	97	107	PF00244	0.609
LIG_APCC_ABBA_1	241	246	PF00400	0.439
LIG_APCC_ABBA_1	90	95	PF00400	0.614
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_BIR_III_4	421	425	PF00653	0.629
LIG_BIR_III_4	429	433	PF00653	0.576
LIG_BIR_III_4	480	484	PF00653	0.639
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.552
LIG_deltaCOP1_diTrp_1	373	380	PF00928	0.495
LIG_FHA_1	166	172	PF00498	0.646
LIG_FHA_1	34	40	PF00498	0.633
LIG_FHA_1	370	376	PF00498	0.588
LIG_FHA_1	386	392	PF00498	0.424
LIG_FHA_1	397	403	PF00498	0.555
LIG_FHA_1	42	48	PF00498	0.629
LIG_FHA_1	448	454	PF00498	0.637
LIG_FHA_2	410	416	PF00498	0.681
LIG_LIR_Gen_1	132	142	PF02991	0.573
LIG_LIR_Gen_1	521	530	PF02991	0.521
LIG_LIR_Nem_3	13	18	PF02991	0.638
LIG_LIR_Nem_3	132	137	PF02991	0.630
LIG_LIR_Nem_3	140	145	PF02991	0.588
LIG_LIR_Nem_3	374	380	PF02991	0.535
LIG_LIR_Nem_3	521	526	PF02991	0.591
LIG_LIR_Nem_3	91	96	PF02991	0.581
LIG_PCNA_PIPBox_1	498	507	PF02747	0.573
LIG_SH2_CRK	134	138	PF00017	0.627
LIG_SH2_PTP2	270	273	PF00017	0.427
LIG_SH2_STAP1	134	138	PF00017	0.627
LIG_SH2_STAT3	282	285	PF00017	0.528
LIG_SH2_STAT3	324	327	PF00017	0.497
LIG_SH2_STAT5	181	184	PF00017	0.494
LIG_SH2_STAT5	270	273	PF00017	0.448
LIG_SH2_STAT5	33	36	PF00017	0.631
LIG_SH3_3	101	107	PF00018	0.620
LIG_SH3_3	146	152	PF00018	0.699
LIG_SH3_3	166	172	PF00018	0.521
LIG_SH3_3	295	301	PF00018	0.622
LIG_SH3_3	441	447	PF00018	0.681
LIG_SH3_3	514	520	PF00018	0.704
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.563
LIG_TRAF2_1	416	419	PF00917	0.575
LIG_UBA3_1	379	387	PF00899	0.517
MOD_CDK_SPK_2	41	46	PF00069	0.643
MOD_CDK_SPK_2	434	439	PF00069	0.576
MOD_CK1_1	126	132	PF00069	0.639
MOD_CK1_1	365	371	PF00069	0.644
MOD_CK1_1	413	419	PF00069	0.730
MOD_CK1_1	437	443	PF00069	0.602
MOD_CK1_1	53	59	PF00069	0.685
MOD_CK1_1	68	74	PF00069	0.530
MOD_CK2_1	334	340	PF00069	0.601
MOD_CK2_1	349	355	PF00069	0.571
MOD_CK2_1	409	415	PF00069	0.752
MOD_Cter_Amidation	119	122	PF01082	0.613
MOD_GlcNHglycan	202	205	PF01048	0.627
MOD_GlcNHglycan	218	222	PF01048	0.538
MOD_GlcNHglycan	252	255	PF01048	0.613
MOD_GlcNHglycan	29	32	PF01048	0.569
MOD_GlcNHglycan	328	331	PF01048	0.512
MOD_GlcNHglycan	351	354	PF01048	0.754
MOD_GlcNHglycan	412	415	PF01048	0.760
MOD_GlcNHglycan	52	55	PF01048	0.782
MOD_GlcNHglycan	70	73	PF01048	0.543
MOD_GlcNHglycan	86	90	PF01048	0.443
MOD_GSK3_1	122	129	PF00069	0.797
MOD_GSK3_1	161	168	PF00069	0.629
MOD_GSK3_1	223	230	PF00069	0.531
MOD_GSK3_1	334	341	PF00069	0.637
MOD_GSK3_1	343	350	PF00069	0.564
MOD_GSK3_1	365	372	PF00069	0.769
MOD_GSK3_1	405	412	PF00069	0.655
MOD_GSK3_1	41	48	PF00069	0.714
MOD_GSK3_1	434	441	PF00069	0.718
MOD_GSK3_1	50	57	PF00069	0.722
MOD_GSK3_1	6	13	PF00069	0.754
MOD_N-GLC_1	405	410	PF02516	0.651
MOD_N-GLC_1	66	71	PF02516	0.640
MOD_NEK2_1	113	118	PF00069	0.678
MOD_NEK2_1	137	142	PF00069	0.583
MOD_NEK2_1	217	222	PF00069	0.630
MOD_NEK2_1	326	331	PF00069	0.564
MOD_NEK2_1	349	354	PF00069	0.587
MOD_NEK2_1	380	385	PF00069	0.662
MOD_NEK2_2	59	64	PF00069	0.606
MOD_PIKK_1	114	120	PF00454	0.652
MOD_PIKK_1	33	39	PF00454	0.593
MOD_PIKK_1	405	411	PF00454	0.681
MOD_PK_1	280	286	PF00069	0.596
MOD_PKA_1	343	349	PF00069	0.674
MOD_PKA_2	237	243	PF00069	0.579
MOD_PKA_2	333	339	PF00069	0.646
MOD_PKA_2	343	349	PF00069	0.618
MOD_PKA_2	369	375	PF00069	0.608
MOD_PKA_2	438	444	PF00069	0.591
MOD_PKA_2	45	51	PF00069	0.749
MOD_Plk_1	280	286	PF00069	0.596
MOD_Plk_1	334	340	PF00069	0.659
MOD_Plk_1	85	91	PF00069	0.597
MOD_Plk_2-3	369	375	PF00069	0.560
MOD_Plk_4	380	386	PF00069	0.560
MOD_Plk_4	387	393	PF00069	0.480
MOD_Plk_4	440	446	PF00069	0.658
MOD_ProDKin_1	127	133	PF00069	0.674
MOD_ProDKin_1	165	171	PF00069	0.647
MOD_ProDKin_1	172	178	PF00069	0.600
MOD_ProDKin_1	255	261	PF00069	0.515
MOD_ProDKin_1	41	47	PF00069	0.644
MOD_ProDKin_1	434	440	PF00069	0.709
MOD_ProDKin_1	6	12	PF00069	0.771
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.702
TRG_ENDOCYTIC_2	134	137	PF00928	0.616
TRG_ENDOCYTIC_2	270	273	PF00928	0.448
TRG_ENDOCYTIC_2	523	526	PF00928	0.536
TRG_ENDOCYTIC_2	93	96	PF00928	0.558
TRG_ER_diArg_1	121	123	PF00400	0.640
TRG_ER_diArg_1	41	43	PF00400	0.616
TRG_ER_diArg_1	96	98	PF00400	0.582
TRG_NES_CRM1_1	456	469	PF08389	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXW3	Leptomonas seymouri	26%	92%
A0A3Q8IDU7	Leishmania donovani	99%	100%
A4HHJ8	Leishmania braziliensis	68%	100%
E9AE60	Leishmania major	88%	100%
E9ALM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%