Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein farnesyltransferase alpha subunit - putative

Species:

Leishmania infantum

UniProt:

A4I4Q3_LEIIN

TriTrypDb:

LINF_290027100

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005953	CAAX-protein geranylgeranyltransferase complex	3	1
GO:0005965	protein farnesyltransferase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4I4Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0018342	protein prenylation	4	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0097354	prenylation	3	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0018343	protein farnesylation	5	1
GO:0018344	protein geranylgeranylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004659	prenyltransferase activity	4	11
GO:0008318	protein prenyltransferase activity	3	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0004660	protein farnesyltransferase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	538	542	PF00656	0.457
CLV_C14_Caspase3-7	701	705	PF00656	0.638
CLV_C14_Caspase3-7	710	714	PF00656	0.455
CLV_NRD_NRD_1	146	148	PF00675	0.326
CLV_NRD_NRD_1	246	248	PF00675	0.247
CLV_NRD_NRD_1	300	302	PF00675	0.469
CLV_NRD_NRD_1	349	351	PF00675	0.396
CLV_NRD_NRD_1	669	671	PF00675	0.461
CLV_PCSK_KEX2_1	146	148	PF00082	0.326
CLV_PCSK_KEX2_1	300	302	PF00082	0.469
CLV_PCSK_KEX2_1	669	671	PF00082	0.463
CLV_PCSK_SKI1_1	124	128	PF00082	0.342
CLV_PCSK_SKI1_1	147	151	PF00082	0.440
CLV_PCSK_SKI1_1	161	165	PF00082	0.391
CLV_PCSK_SKI1_1	248	252	PF00082	0.257
CLV_PCSK_SKI1_1	317	321	PF00082	0.479
CLV_PCSK_SKI1_1	350	354	PF00082	0.431
CLV_PCSK_SKI1_1	422	426	PF00082	0.381
CLV_PCSK_SKI1_1	427	431	PF00082	0.342
CLV_PCSK_SKI1_1	520	524	PF00082	0.385
CLV_PCSK_SKI1_1	731	735	PF00082	0.479
DEG_APCC_DBOX_1	160	168	PF00400	0.507
DEG_APCC_DBOX_1	223	231	PF00400	0.305
DEG_APCC_DBOX_1	312	320	PF00400	0.430
DEG_Nend_UBRbox_2	1	3	PF02207	0.521
DEG_SCF_FBW7_2	55	60	PF00400	0.555
DEG_SPOP_SBC_1	442	446	PF00917	0.459
DOC_CDC14_PxL_1	522	530	PF14671	0.451
DOC_CKS1_1	344	349	PF01111	0.473
DOC_CKS1_1	527	532	PF01111	0.393
DOC_CKS1_1	549	554	PF01111	0.442
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.291
DOC_CYCLIN_yCln2_LP_2	527	533	PF00134	0.503
DOC_MAPK_DCC_7	161	169	PF00069	0.513
DOC_MAPK_gen_1	300	307	PF00069	0.446
DOC_MAPK_gen_1	742	751	PF00069	0.354
DOC_MAPK_MEF2A_6	124	131	PF00069	0.426
DOC_MAPK_MEF2A_6	161	169	PF00069	0.513
DOC_MAPK_MEF2A_6	711	719	PF00069	0.381
DOC_MAPK_NFAT4_5	124	132	PF00069	0.426
DOC_PP1_RVXF_1	219	226	PF00149	0.319
DOC_PP1_RVXF_1	560	567	PF00149	0.372
DOC_PP2B_LxvP_1	167	170	PF13499	0.505
DOC_PP2B_LxvP_1	345	348	PF13499	0.466
DOC_USP7_MATH_1	24	28	PF00917	0.663
DOC_USP7_MATH_1	442	446	PF00917	0.473
DOC_USP7_MATH_1	450	454	PF00917	0.460
DOC_USP7_MATH_1	58	62	PF00917	0.651
DOC_USP7_MATH_1	698	702	PF00917	0.618
DOC_WW_Pin1_4	12	17	PF00397	0.662
DOC_WW_Pin1_4	149	154	PF00397	0.448
DOC_WW_Pin1_4	215	220	PF00397	0.477
DOC_WW_Pin1_4	255	260	PF00397	0.414
DOC_WW_Pin1_4	280	285	PF00397	0.543
DOC_WW_Pin1_4	343	348	PF00397	0.405
DOC_WW_Pin1_4	369	374	PF00397	0.493
DOC_WW_Pin1_4	393	398	PF00397	0.523
DOC_WW_Pin1_4	526	531	PF00397	0.390
DOC_WW_Pin1_4	53	58	PF00397	0.553
DOC_WW_Pin1_4	545	550	PF00397	0.532
DOC_WW_Pin1_4	62	67	PF00397	0.606
DOC_WW_Pin1_4	93	98	PF00397	0.473
LIG_14-3-3_CanoR_1	119	127	PF00244	0.440
LIG_14-3-3_CanoR_1	134	143	PF00244	0.317
LIG_14-3-3_CanoR_1	198	206	PF00244	0.450
LIG_14-3-3_CanoR_1	414	423	PF00244	0.526
LIG_14-3-3_CanoR_1	520	528	PF00244	0.493
LIG_14-3-3_CanoR_1	581	587	PF00244	0.507
LIG_14-3-3_CanoR_1	611	618	PF00244	0.692
LIG_14-3-3_CanoR_1	9	19	PF00244	0.673
LIG_Actin_WH2_2	183	200	PF00022	0.495
LIG_Actin_WH2_2	303	319	PF00022	0.436
LIG_Actin_WH2_2	575	592	PF00022	0.448
LIG_APCC_ABBA_1	423	428	PF00400	0.580
LIG_APCC_ABBAyCdc20_2	422	428	PF00400	0.526
LIG_BIR_III_2	162	166	PF00653	0.486
LIG_BRCT_BRCA1_1	281	285	PF00533	0.485
LIG_deltaCOP1_diTrp_1	210	220	PF00928	0.440
LIG_deltaCOP1_diTrp_1	688	695	PF00928	0.540
LIG_FHA_1	397	403	PF00498	0.322
LIG_FHA_1	442	448	PF00498	0.623
LIG_FHA_1	549	555	PF00498	0.533
LIG_FHA_1	596	602	PF00498	0.368
LIG_FHA_1	94	100	PF00498	0.642
LIG_FHA_2	175	181	PF00498	0.603
LIG_FHA_2	292	298	PF00498	0.530
LIG_FHA_2	377	383	PF00498	0.618
LIG_FHA_2	449	455	PF00498	0.512
LIG_FHA_2	457	463	PF00498	0.300
LIG_FHA_2	536	542	PF00498	0.474
LIG_FHA_2	54	60	PF00498	0.505
LIG_FHA_2	590	596	PF00498	0.455
LIG_FHA_2	732	738	PF00498	0.449
LIG_LIR_Apic_2	688	692	PF02991	0.511
LIG_LIR_Gen_1	306	314	PF02991	0.536
LIG_LIR_Gen_1	471	479	PF02991	0.522
LIG_LIR_Gen_1	571	579	PF02991	0.411
LIG_LIR_Gen_1	639	649	PF02991	0.440
LIG_LIR_Nem_3	218	223	PF02991	0.319
LIG_LIR_Nem_3	282	288	PF02991	0.469
LIG_LIR_Nem_3	292	298	PF02991	0.305
LIG_LIR_Nem_3	306	310	PF02991	0.412
LIG_LIR_Nem_3	46	51	PF02991	0.407
LIG_LIR_Nem_3	471	477	PF02991	0.453
LIG_LIR_Nem_3	639	644	PF02991	0.400
LIG_LIR_Nem_3	657	663	PF02991	0.235
LIG_LIR_Nem_3	718	722	PF02991	0.358
LIG_LIR_Nem_3	80	86	PF02991	0.357
LIG_MYND_1	387	391	PF01753	0.547
LIG_MYND_1	526	530	PF01753	0.453
LIG_MYND_1	97	101	PF01753	0.436
LIG_PALB2_WD40_1	121	129	PF16756	0.387
LIG_PCNA_yPIPBox_3	577	587	PF02747	0.388
LIG_Pex14_1	419	423	PF04695	0.446
LIG_PTB_Apo_2	747	754	PF02174	0.456
LIG_PTB_Phospho_1	747	753	PF10480	0.458
LIG_Rb_LxCxE_1	37	60	PF01857	0.510
LIG_SH2_CRK	86	90	PF00017	0.378
LIG_SH2_GRB2like	663	666	PF00017	0.302
LIG_SH2_NCK_1	722	726	PF00017	0.435
LIG_SH2_PTP2	476	479	PF00017	0.463
LIG_SH2_SRC	337	340	PF00017	0.431
LIG_SH2_SRC	476	479	PF00017	0.463
LIG_SH2_SRC	485	488	PF00017	0.448
LIG_SH2_SRC	569	572	PF00017	0.455
LIG_SH2_STAP1	470	474	PF00017	0.335
LIG_SH2_STAP1	722	726	PF00017	0.435
LIG_SH2_STAT3	253	256	PF00017	0.476
LIG_SH2_STAT3	470	473	PF00017	0.348
LIG_SH2_STAT5	140	143	PF00017	0.365
LIG_SH2_STAT5	298	301	PF00017	0.369
LIG_SH2_STAT5	337	340	PF00017	0.409
LIG_SH2_STAT5	476	479	PF00017	0.445
LIG_SH2_STAT5	521	524	PF00017	0.410
LIG_SH2_STAT5	569	572	PF00017	0.459
LIG_SH2_STAT5	649	652	PF00017	0.364
LIG_SH2_STAT5	95	98	PF00017	0.567
LIG_SH3_3	162	168	PF00018	0.483
LIG_SH3_3	281	287	PF00018	0.516
LIG_SH3_3	388	394	PF00018	0.416
LIG_SH3_3	444	450	PF00018	0.591
LIG_SH3_3	546	552	PF00018	0.490
LIG_SH3_3	63	69	PF00018	0.648
LIG_SH3_3	732	738	PF00018	0.463
LIG_SH3_3	94	100	PF00018	0.540
LIG_SUMO_SIM_anti_2	490	495	PF11976	0.401
LIG_TRFH_1	343	347	PF08558	0.455
LIG_WRC_WIRS_1	45	50	PF05994	0.461
LIG_WRC_WIRS_1	570	575	PF05994	0.337
MOD_CDC14_SPxK_1	218	221	PF00782	0.447
MOD_CDK_SPK_2	369	374	PF00069	0.350
MOD_CDK_SPxK_1	215	221	PF00069	0.542
MOD_CDK_SPxxK_3	343	350	PF00069	0.395
MOD_CK1_1	10	16	PF00069	0.616
MOD_CK1_1	138	144	PF00069	0.388
MOD_CK1_1	17	23	PF00069	0.605
MOD_CK1_1	27	33	PF00069	0.521
MOD_CK1_1	291	297	PF00069	0.452
MOD_CK1_1	396	402	PF00069	0.489
MOD_CK1_1	548	554	PF00069	0.445
MOD_CK2_1	174	180	PF00069	0.560
MOD_CK2_1	376	382	PF00069	0.551
MOD_CK2_1	448	454	PF00069	0.593
MOD_CK2_1	589	595	PF00069	0.467
MOD_CMANNOS	502	505	PF00535	0.267
MOD_GlcNHglycan	120	123	PF01048	0.388
MOD_GlcNHglycan	416	419	PF01048	0.231
MOD_GlcNHglycan	700	703	PF01048	0.598
MOD_GSK3_1	134	141	PF00069	0.421
MOD_GSK3_1	172	179	PF00069	0.592
MOD_GSK3_1	20	27	PF00069	0.595
MOD_GSK3_1	339	346	PF00069	0.441
MOD_GSK3_1	389	396	PF00069	0.496
MOD_GSK3_1	437	444	PF00069	0.543
MOD_GSK3_1	508	515	PF00069	0.452
MOD_GSK3_1	543	550	PF00069	0.544
MOD_GSK3_1	58	65	PF00069	0.553
MOD_GSK3_1	607	614	PF00069	0.634
MOD_GSK3_1	7	14	PF00069	0.640
MOD_N-GLC_1	138	143	PF02516	0.427
MOD_N-GLC_1	414	419	PF02516	0.246
MOD_N-GLC_1	468	473	PF02516	0.379
MOD_N-GLC_1	607	612	PF02516	0.549
MOD_N-GLC_1	77	82	PF02516	0.498
MOD_NEK2_1	174	179	PF00069	0.580
MOD_NEK2_1	197	202	PF00069	0.568
MOD_NEK2_1	332	337	PF00069	0.338
MOD_NEK2_1	358	363	PF00069	0.444
MOD_NEK2_1	402	407	PF00069	0.463
MOD_NEK2_1	468	473	PF00069	0.393
MOD_NEK2_1	494	499	PF00069	0.325
MOD_NEK2_1	629	634	PF00069	0.441
MOD_NEK2_1	659	664	PF00069	0.470
MOD_NEK2_1	7	12	PF00069	0.735
MOD_PIKK_1	198	204	PF00454	0.509
MOD_PIKK_1	27	33	PF00454	0.599
MOD_PIKK_1	611	617	PF00454	0.722
MOD_PIKK_1	631	637	PF00454	0.414
MOD_PKA_2	118	124	PF00069	0.370
MOD_PKA_2	197	203	PF00069	0.469
MOD_PKA_2	312	318	PF00069	0.479
MOD_PKA_2	389	395	PF00069	0.520
MOD_PKA_2	589	595	PF00069	0.479
MOD_PKA_2	610	616	PF00069	0.694
MOD_PKA_2	675	681	PF00069	0.481
MOD_PKA_2	8	14	PF00069	0.716
MOD_Plk_1	138	144	PF00069	0.429
MOD_Plk_1	225	231	PF00069	0.439
MOD_Plk_1	291	297	PF00069	0.494
MOD_Plk_1	414	420	PF00069	0.454
MOD_Plk_1	468	474	PF00069	0.405
MOD_Plk_1	58	64	PF00069	0.551
MOD_Plk_1	77	83	PF00069	0.337
MOD_Plk_4	138	144	PF00069	0.376
MOD_Plk_4	332	338	PF00069	0.436
MOD_Plk_4	44	50	PF00069	0.379
MOD_Plk_4	494	500	PF00069	0.362
MOD_Plk_4	582	588	PF00069	0.309
MOD_Plk_4	659	665	PF00069	0.508
MOD_ProDKin_1	12	18	PF00069	0.657
MOD_ProDKin_1	149	155	PF00069	0.445
MOD_ProDKin_1	215	221	PF00069	0.473
MOD_ProDKin_1	255	261	PF00069	0.420
MOD_ProDKin_1	280	286	PF00069	0.530
MOD_ProDKin_1	343	349	PF00069	0.415
MOD_ProDKin_1	369	375	PF00069	0.498
MOD_ProDKin_1	393	399	PF00069	0.517
MOD_ProDKin_1	526	532	PF00069	0.396
MOD_ProDKin_1	53	59	PF00069	0.562
MOD_ProDKin_1	545	551	PF00069	0.527
MOD_ProDKin_1	62	68	PF00069	0.603
MOD_ProDKin_1	93	99	PF00069	0.479
MOD_SUMO_for_1	618	621	PF00179	0.530
MOD_SUMO_rev_2	185	195	PF00179	0.550
MOD_SUMO_rev_2	267	275	PF00179	0.530
MOD_SUMO_rev_2	620	629	PF00179	0.490
MOD_SUMO_rev_2	696	701	PF00179	0.548
TRG_DiLeu_BaEn_1	571	576	PF01217	0.444
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.415
TRG_DiLeu_BaLyEn_6	523	528	PF01217	0.454
TRG_ENDOCYTIC_2	86	89	PF00928	0.326
TRG_ER_diArg_1	299	301	PF00400	0.443
TRG_ER_diArg_1	587	590	PF00400	0.456
TRG_NES_CRM1_1	41	54	PF08389	0.488
TRG_NES_CRM1_1	467	478	PF08389	0.490
TRG_Pf-PMV_PEXEL_1	351	355	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	627	631	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKH9	Leptomonas seymouri	50%	98%
A0A1X0P015	Trypanosomatidae	32%	100%
A0A3S5H7L6	Leishmania donovani	100%	100%
A0A422NNG1	Trypanosoma rangeli	33%	100%
A4HHJ5	Leishmania braziliensis	77%	100%
C9ZLE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AE56	Leishmania major	91%	100%
E9ALM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DCL7	Trypanosoma cruzi	34%	100%