Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4Q0_LEIIN

TriTrypDb:

LINF_290026800

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.530
CLV_NRD_NRD_1	158	160	PF00675	0.677
CLV_NRD_NRD_1	248	250	PF00675	0.562
CLV_PCSK_FUR_1	246	250	PF00082	0.697
CLV_PCSK_KEX2_1	158	160	PF00082	0.705
CLV_PCSK_KEX2_1	246	248	PF00082	0.623
CLV_PCSK_KEX2_1	270	272	PF00082	0.583
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.583
CLV_PCSK_PC7_1	242	248	PF00082	0.500
CLV_PCSK_SKI1_1	175	179	PF00082	0.618
CLV_PCSK_SKI1_1	249	253	PF00082	0.653
DEG_SPOP_SBC_1	99	103	PF00917	0.727
DOC_CKS1_1	59	64	PF01111	0.709
DOC_CKS1_1	69	74	PF01111	0.611
DOC_CYCLIN_RxL_1	172	180	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	252	255	PF00134	0.678
DOC_MAPK_DCC_7	107	117	PF00069	0.468
DOC_MAPK_gen_1	129	138	PF00069	0.649
DOC_MAPK_gen_1	172	181	PF00069	0.656
DOC_MAPK_gen_1	246	253	PF00069	0.582
DOC_MAPK_MEF2A_6	172	181	PF00069	0.668
DOC_MAPK_MEF2A_6	260	269	PF00069	0.622
DOC_PP1_RVXF_1	173	179	PF00149	0.564
DOC_PP2B_LxvP_1	252	255	PF13499	0.678
DOC_PP4_FxxP_1	113	116	PF00568	0.567
DOC_SPAK_OSR1_1	35	39	PF12202	0.539
DOC_USP7_MATH_1	120	124	PF00917	0.547
DOC_USP7_MATH_1	188	192	PF00917	0.623
DOC_USP7_MATH_1	211	215	PF00917	0.670
DOC_USP7_MATH_1	235	239	PF00917	0.683
DOC_USP7_MATH_1	99	103	PF00917	0.721
DOC_USP7_UBL2_3	224	228	PF12436	0.755
DOC_WW_Pin1_4	182	187	PF00397	0.574
DOC_WW_Pin1_4	58	63	PF00397	0.725
DOC_WW_Pin1_4	68	73	PF00397	0.616
DOC_WW_Pin1_4	7	12	PF00397	0.655
DOC_WW_Pin1_4	88	93	PF00397	0.457
LIG_14-3-3_CanoR_1	121	125	PF00244	0.683
LIG_14-3-3_CanoR_1	189	193	PF00244	0.622
LIG_14-3-3_CanoR_1	209	218	PF00244	0.427
LIG_14-3-3_CanoR_1	35	39	PF00244	0.539
LIG_Actin_WH2_2	177	195	PF00022	0.653
LIG_BIR_II_1	1	5	PF00653	0.737
LIG_FHA_1	13	19	PF00498	0.648
LIG_FHA_1	172	178	PF00498	0.580
LIG_FHA_1	195	201	PF00498	0.563
LIG_FHA_1	259	265	PF00498	0.544
LIG_FHA_1	52	58	PF00498	0.691
LIG_FHA_1	78	84	PF00498	0.581
LIG_FHA_2	193	199	PF00498	0.546
LIG_FHA_2	59	65	PF00498	0.586
LIG_LIR_Apic_2	123	127	PF02991	0.684
LIG_LIR_Gen_1	261	269	PF02991	0.563
LIG_LIR_Nem_3	261	265	PF02991	0.548
LIG_SH2_CRK	124	128	PF00017	0.709
LIG_SH2_STAP1	118	122	PF00017	0.562
LIG_SH2_STAT5	154	157	PF00017	0.587
LIG_SH2_STAT5	207	210	PF00017	0.610
LIG_SH3_3	136	142	PF00018	0.677
LIG_SH3_3	25	31	PF00018	0.719
LIG_SH3_3	86	92	PF00018	0.732
LIG_TRAF2_1	196	199	PF00917	0.460
LIG_TRAF2_1	61	64	PF00917	0.595
MOD_CDK_SPxxK_3	182	189	PF00069	0.575
MOD_CK1_1	201	207	PF00069	0.647
MOD_CK1_1	212	218	PF00069	0.665
MOD_CK1_1	220	226	PF00069	0.586
MOD_CK1_1	98	104	PF00069	0.800
MOD_CK2_1	192	198	PF00069	0.611
MOD_CK2_1	58	64	PF00069	0.702
MOD_DYRK1A_RPxSP_1	88	92	PF00069	0.572
MOD_GlcNHglycan	167	171	PF01048	0.723
MOD_GlcNHglycan	211	214	PF01048	0.647
MOD_GlcNHglycan	219	222	PF01048	0.669
MOD_GlcNHglycan	237	240	PF01048	0.685
MOD_GlcNHglycan	96	100	PF01048	0.773
MOD_GSK3_1	188	195	PF00069	0.654
MOD_GSK3_1	209	216	PF00069	0.655
MOD_GSK3_1	47	54	PF00069	0.655
MOD_GSK3_1	94	101	PF00069	0.765
MOD_NEK2_1	1	6	PF00069	0.813
MOD_NEK2_1	192	197	PF00069	0.660
MOD_NEK2_2	188	193	PF00069	0.655
MOD_PIKK_1	240	246	PF00454	0.782
MOD_PKA_1	158	164	PF00069	0.710
MOD_PKA_2	120	126	PF00069	0.685
MOD_PKA_2	158	164	PF00069	0.786
MOD_PKA_2	188	194	PF00069	0.622
MOD_PKA_2	34	40	PF00069	0.545
MOD_Plk_1	198	204	PF00069	0.576
MOD_Plk_1	47	53	PF00069	0.776
MOD_ProDKin_1	182	188	PF00069	0.575
MOD_ProDKin_1	58	64	PF00069	0.721
MOD_ProDKin_1	68	74	PF00069	0.612
MOD_ProDKin_1	7	13	PF00069	0.654
MOD_ProDKin_1	88	94	PF00069	0.457
TRG_ER_diArg_1	246	249	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ42	Leptomonas seymouri	37%	100%
A0A3Q8IBJ9	Leishmania donovani	99%	100%
A4HHJ2	Leishmania braziliensis	68%	100%
E9AE53	Leishmania major	91%	100%
E9ALN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%