LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I4P2_LEIIN
TriTrypDb:
LINF_290026000
Length:
332

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 8
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4P2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4P2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 202 206 PF00656 0.624
CLV_C14_Caspase3-7 220 224 PF00656 0.342
CLV_C14_Caspase3-7 3 7 PF00656 0.662
CLV_NRD_NRD_1 102 104 PF00675 0.533
CLV_NRD_NRD_1 320 322 PF00675 0.733
CLV_PCSK_FUR_1 111 115 PF00082 0.479
CLV_PCSK_KEX2_1 102 104 PF00082 0.529
CLV_PCSK_KEX2_1 113 115 PF00082 0.445
CLV_PCSK_KEX2_1 212 214 PF00082 0.555
CLV_PCSK_KEX2_1 319 321 PF00082 0.735
CLV_PCSK_KEX2_1 329 331 PF00082 0.758
CLV_PCSK_PC1ET2_1 113 115 PF00082 0.480
CLV_PCSK_PC1ET2_1 212 214 PF00082 0.555
CLV_PCSK_PC1ET2_1 319 321 PF00082 0.758
CLV_PCSK_PC7_1 109 115 PF00082 0.533
CLV_PCSK_SKI1_1 237 241 PF00082 0.627
CLV_PCSK_SKI1_1 255 259 PF00082 0.375
CLV_PCSK_SKI1_1 295 299 PF00082 0.683
CLV_PCSK_SKI1_1 85 89 PF00082 0.462
DEG_APCC_DBOX_1 225 233 PF00400 0.611
DEG_APCC_DBOX_1 62 70 PF00400 0.593
DEG_SCF_FBW7_2 297 302 PF00400 0.744
DOC_MAPK_gen_1 212 218 PF00069 0.495
DOC_MAPK_gen_1 255 261 PF00069 0.503
DOC_USP7_MATH_1 19 23 PF00917 0.724
DOC_USP7_MATH_1 270 274 PF00917 0.613
DOC_USP7_MATH_1 40 44 PF00917 0.631
DOC_USP7_MATH_1 7 11 PF00917 0.731
DOC_WW_Pin1_4 295 300 PF00397 0.700
LIG_Actin_WH2_2 225 242 PF00022 0.590
LIG_Clathr_ClatBox_1 189 193 PF01394 0.604
LIG_eIF4E_1 254 260 PF01652 0.545
LIG_FHA_1 117 123 PF00498 0.493
LIG_FHA_1 270 276 PF00498 0.510
LIG_FHA_1 40 46 PF00498 0.650
LIG_FHA_1 68 74 PF00498 0.586
LIG_FHA_1 82 88 PF00498 0.467
LIG_GBD_Chelix_1 141 149 PF00786 0.551
LIG_LIR_Gen_1 157 167 PF02991 0.483
LIG_LIR_Gen_1 305 315 PF02991 0.699
LIG_LIR_Nem_3 157 163 PF02991 0.485
LIG_LIR_Nem_3 251 257 PF02991 0.493
LIG_LIR_Nem_3 305 311 PF02991 0.672
LIG_NRP_CendR_1 329 332 PF00754 0.729
LIG_SH2_CRK 254 258 PF00017 0.499
LIG_SH2_CRK 308 312 PF00017 0.699
LIG_SH2_NCK_1 4 8 PF00017 0.636
LIG_SH2_SRC 4 7 PF00017 0.659
LIG_SH2_STAP1 4 8 PF00017 0.636
LIG_SH2_STAT3 32 35 PF00017 0.763
LIG_SH2_STAT5 32 35 PF00017 0.744
LIG_SH2_STAT5 8 11 PF00017 0.652
LIG_TRAF2_1 58 61 PF00917 0.644
LIG_TRAF2_1 92 95 PF00917 0.571
LIG_TYR_ITIM 252 257 PF00017 0.540
LIG_UBA3_1 258 266 PF00899 0.508
MOD_CK1_1 178 184 PF00069 0.605
MOD_CK2_1 270 276 PF00069 0.582
MOD_CK2_1 89 95 PF00069 0.565
MOD_Cter_Amidation 317 320 PF01082 0.716
MOD_GlcNHglycan 149 152 PF01048 0.539
MOD_GlcNHglycan 244 247 PF01048 0.522
MOD_GlcNHglycan 42 45 PF01048 0.681
MOD_GlcNHglycan 9 12 PF01048 0.702
MOD_GSK3_1 19 26 PF00069 0.763
MOD_GSK3_1 200 207 PF00069 0.533
MOD_GSK3_1 238 245 PF00069 0.506
MOD_GSK3_1 291 298 PF00069 0.613
MOD_GSK3_1 69 76 PF00069 0.622
MOD_N-GLC_1 81 86 PF02516 0.466
MOD_NEK2_1 239 244 PF00069 0.542
MOD_NEK2_1 69 74 PF00069 0.597
MOD_NEK2_1 81 86 PF00069 0.566
MOD_NEK2_1 89 94 PF00069 0.565
MOD_PIKK_1 197 203 PF00454 0.594
MOD_PIKK_1 87 93 PF00454 0.521
MOD_PKA_2 175 181 PF00069 0.606
MOD_Plk_1 81 87 PF00069 0.565
MOD_Plk_4 270 276 PF00069 0.564
MOD_ProDKin_1 295 301 PF00069 0.701
MOD_SUMO_rev_2 247 257 PF00179 0.468
MOD_SUMO_rev_2 302 307 PF00179 0.740
MOD_SUMO_rev_2 72 81 PF00179 0.535
MOD_SUMO_rev_2 90 99 PF00179 0.282
TRG_DiLeu_BaEn_1 48 53 PF01217 0.641
TRG_ENDOCYTIC_2 254 257 PF00928 0.501
TRG_ENDOCYTIC_2 308 311 PF00928 0.651
TRG_ER_diArg_1 101 103 PF00400 0.560
TRG_ER_diArg_1 108 111 PF00400 0.526
TRG_ER_diArg_1 329 332 PF00400 0.777
TRG_NLS_MonoExtC_3 318 324 PF00514 0.635

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC73 Leptomonas seymouri 70% 100%
A0A0S4J6B5 Bodo saltans 32% 70%
A0A1X0P000 Trypanosomatidae 32% 91%
A0A3S7X2L2 Leishmania donovani 100% 100%
A4HIY8 Leishmania braziliensis 88% 100%
C9ZLD3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 86%
E9AE45 Leishmania major 97% 100%
E9ALP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS