LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Vesicle coat protein involved in Golgi to plasma membrane transport - putative
Species:
Leishmania infantum
UniProt:
A4I4N9_LEIIN
TriTrypDb:
LINF_290025500
Length:
620

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005765 lysosomal membrane 7 1
GO:0005774 vacuolar membrane 5 1
GO:0005815 microtubule organizing center 2 1
GO:0005819 spindle 5 1
GO:0005829 cytosol 2 1
GO:0005929 cilium 4 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0098852 lytic vacuole membrane 6 1
GO:0110165 cellular anatomical entity 1 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4I4N9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4N9

Function

Biological processes
Term Name Level Count
GO:0009966 regulation of signal transduction 4 1
GO:0009967 positive regulation of signal transduction 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010647 positive regulation of cell communication 5 1
GO:0023051 regulation of signaling 3 1
GO:0023056 positive regulation of signaling 4 1
GO:0032006 regulation of TOR signaling 6 1
GO:0032008 positive regulation of TOR signaling 7 1
GO:0043085 positive regulation of catalytic activity 4 1
GO:0043087 regulation of GTPase activity 5 1
GO:0043547 positive regulation of GTPase activity 6 1
GO:0044093 positive regulation of molecular function 3 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048584 positive regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050790 regulation of catalytic activity 3 1
GO:0050794 regulation of cellular process 3 1
GO:0051336 regulation of hydrolase activity 4 1
GO:0051345 positive regulation of hydrolase activity 5 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902533 positive regulation of intracellular signal transduction 6 1
GO:1903432 regulation of TORC1 signaling 7 1
GO:1904263 positive regulation of TORC1 signaling 8 1
Molecular functions
Term Name Level Count
GO:0005096 GTPase activator activity 4 10
GO:0008047 enzyme activator activity 3 10
GO:0030234 enzyme regulator activity 2 10
GO:0030695 GTPase regulator activity 4 10
GO:0060589 nucleoside-triphosphatase regulator activity 3 10
GO:0098772 molecular function regulator activity 1 10
GO:0140677 molecular function activator activity 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 13 17 PF00656 0.542
CLV_C14_Caspase3-7 188 192 PF00656 0.633
CLV_NRD_NRD_1 114 116 PF00675 0.322
CLV_NRD_NRD_1 144 146 PF00675 0.438
CLV_NRD_NRD_1 172 174 PF00675 0.410
CLV_NRD_NRD_1 423 425 PF00675 0.530
CLV_PCSK_KEX2_1 113 115 PF00082 0.336
CLV_PCSK_KEX2_1 144 146 PF00082 0.382
CLV_PCSK_KEX2_1 172 174 PF00082 0.410
CLV_PCSK_KEX2_1 423 425 PF00082 0.530
CLV_PCSK_PC1ET2_1 113 115 PF00082 0.355
CLV_PCSK_PC7_1 110 116 PF00082 0.335
CLV_PCSK_PC7_1 168 174 PF00082 0.447
CLV_PCSK_SKI1_1 177 181 PF00082 0.447
CLV_PCSK_SKI1_1 273 277 PF00082 0.653
CLV_PCSK_SKI1_1 31 35 PF00082 0.663
CLV_PCSK_SKI1_1 313 317 PF00082 0.473
CLV_PCSK_SKI1_1 363 367 PF00082 0.533
CLV_PCSK_SKI1_1 374 378 PF00082 0.391
CLV_PCSK_SKI1_1 40 44 PF00082 0.491
CLV_PCSK_SKI1_1 448 452 PF00082 0.546
CLV_PCSK_SKI1_1 49 53 PF00082 0.282
DEG_APCC_DBOX_1 114 122 PF00400 0.447
DEG_APCC_DBOX_1 172 180 PF00400 0.480
DEG_APCC_DBOX_1 39 47 PF00400 0.570
DEG_Nend_Nbox_1 1 3 PF02207 0.546
DEG_SCF_FBW7_1 507 513 PF00400 0.662
DOC_AGCK_PIF_2 24 29 PF00069 0.505
DOC_CKS1_1 2 7 PF01111 0.497
DOC_CKS1_1 507 512 PF01111 0.664
DOC_CYCLIN_RxL_1 270 281 PF00134 0.699
DOC_CYCLIN_RxL_1 309 317 PF00134 0.477
DOC_CYCLIN_RxL_1 34 47 PF00134 0.572
DOC_CYCLIN_yCln2_LP_2 2 8 PF00134 0.538
DOC_CYCLIN_yCln2_LP_2 219 225 PF00134 0.609
DOC_CYCLIN_yCln2_LP_2 452 458 PF00134 0.566
DOC_MAPK_gen_1 110 120 PF00069 0.339
DOC_MAPK_gen_1 459 468 PF00069 0.613
DOC_PP1_RVXF_1 271 278 PF00149 0.698
DOC_PP1_RVXF_1 361 368 PF00149 0.404
DOC_PP1_RVXF_1 410 416 PF00149 0.500
DOC_PP2B_LxvP_1 183 186 PF13499 0.344
DOC_PP4_FxxP_1 102 105 PF00568 0.447
DOC_PP4_FxxP_1 120 123 PF00568 0.447
DOC_USP7_MATH_1 359 363 PF00917 0.480
DOC_USP7_MATH_1 433 437 PF00917 0.704
DOC_USP7_MATH_1 510 514 PF00917 0.716
DOC_USP7_MATH_1 557 561 PF00917 0.714
DOC_USP7_MATH_1 578 582 PF00917 0.695
DOC_WW_Pin1_4 1 6 PF00397 0.532
DOC_WW_Pin1_4 377 382 PF00397 0.532
DOC_WW_Pin1_4 386 391 PF00397 0.618
DOC_WW_Pin1_4 503 508 PF00397 0.739
DOC_WW_Pin1_4 519 524 PF00397 0.560
DOC_WW_Pin1_4 526 531 PF00397 0.648
DOC_WW_Pin1_4 586 591 PF00397 0.687
LIG_14-3-3_CanoR_1 177 186 PF00244 0.334
LIG_14-3-3_CanoR_1 363 368 PF00244 0.377
LIG_14-3-3_CanoR_1 412 416 PF00244 0.499
LIG_14-3-3_CanoR_1 448 453 PF00244 0.553
LIG_14-3-3_CanoR_1 525 531 PF00244 0.712
LIG_14-3-3_CanoR_1 535 540 PF00244 0.696
LIG_14-3-3_CanoR_1 544 548 PF00244 0.665
LIG_14-3-3_CanoR_1 574 582 PF00244 0.758
LIG_Actin_WH2_2 409 425 PF00022 0.545
LIG_APCC_ABBAyCdc20_2 273 279 PF00400 0.706
LIG_BRCT_BRCA1_1 98 102 PF00533 0.374
LIG_Clathr_ClatBox_1 275 279 PF01394 0.727
LIG_Clathr_ClatBox_1 395 399 PF01394 0.558
LIG_FHA_1 178 184 PF00498 0.426
LIG_FHA_1 380 386 PF00498 0.621
LIG_FHA_1 473 479 PF00498 0.518
LIG_FHA_2 186 192 PF00498 0.644
LIG_FHA_2 322 328 PF00498 0.547
LIG_FHA_2 441 447 PF00498 0.550
LIG_FHA_2 76 82 PF00498 0.544
LIG_LIR_Apic_2 353 359 PF02991 0.472
LIG_LIR_Apic_2 99 105 PF02991 0.447
LIG_LIR_Gen_1 11 20 PF02991 0.412
LIG_LIR_Gen_1 124 130 PF02991 0.389
LIG_LIR_Gen_1 136 143 PF02991 0.277
LIG_LIR_Gen_1 157 164 PF02991 0.372
LIG_LIR_Gen_1 21 32 PF02991 0.505
LIG_LIR_Gen_1 373 383 PF02991 0.608
LIG_LIR_Nem_3 11 15 PF02991 0.421
LIG_LIR_Nem_3 124 128 PF02991 0.389
LIG_LIR_Nem_3 136 141 PF02991 0.277
LIG_LIR_Nem_3 157 161 PF02991 0.362
LIG_LIR_Nem_3 21 27 PF02991 0.390
LIG_LIR_Nem_3 28 32 PF02991 0.463
LIG_LIR_Nem_3 373 378 PF02991 0.551
LIG_PCNA_yPIPBox_3 31 43 PF02747 0.625
LIG_PCNA_yPIPBox_3 363 376 PF02747 0.463
LIG_Pex14_1 290 294 PF04695 0.381
LIG_Pex14_1 543 547 PF04695 0.666
LIG_Pex14_2 116 120 PF04695 0.447
LIG_Pex14_2 539 543 PF04695 0.762
LIG_Pex14_2 8 12 PF04695 0.489
LIG_Rb_pABgroove_1 390 398 PF01858 0.574
LIG_SH2_CRK 158 162 PF00017 0.441
LIG_SH2_CRK 340 344 PF00017 0.537
LIG_SH2_CRK 356 360 PF00017 0.523
LIG_SH2_CRK 492 496 PF00017 0.525
LIG_SH2_GRB2like 68 71 PF00017 0.518
LIG_SH2_NCK_1 158 162 PF00017 0.441
LIG_SH2_NCK_1 340 344 PF00017 0.570
LIG_SH2_PTP2 375 378 PF00017 0.491
LIG_SH2_SRC 68 71 PF00017 0.505
LIG_SH2_SRC 89 92 PF00017 0.614
LIG_SH2_STAP1 158 162 PF00017 0.480
LIG_SH2_STAP1 22 26 PF00017 0.475
LIG_SH2_STAP1 360 364 PF00017 0.456
LIG_SH2_STAP1 456 460 PF00017 0.552
LIG_SH2_STAT3 592 595 PF00017 0.701
LIG_SH2_STAT5 134 137 PF00017 0.480
LIG_SH2_STAT5 26 29 PF00017 0.522
LIG_SH2_STAT5 340 343 PF00017 0.566
LIG_SH2_STAT5 375 378 PF00017 0.550
LIG_SH2_STAT5 456 459 PF00017 0.557
LIG_SH2_STAT5 485 488 PF00017 0.479
LIG_SH2_STAT5 601 604 PF00017 0.688
LIG_SH2_STAT5 68 71 PF00017 0.518
LIG_SH3_1 172 178 PF00018 0.383
LIG_SH3_3 172 178 PF00018 0.383
LIG_SH3_3 210 216 PF00018 0.519
LIG_SH3_3 280 286 PF00018 0.581
LIG_SH3_3 375 381 PF00018 0.582
LIG_SH3_3 504 510 PF00018 0.741
LIG_TRAF2_1 198 201 PF00917 0.575
LIG_TRAF2_1 497 500 PF00917 0.634
LIG_TRAF2_1 82 85 PF00917 0.518
LIG_TRFH_1 340 344 PF08558 0.570
LIG_WRC_WIRS_1 364 369 PF05994 0.400
LIG_WRC_WIRS_1 536 541 PF05994 0.630
LIG_WRC_WIRS_1 603 608 PF05994 0.633
LIG_WRC_WIRS_1 97 102 PF05994 0.447
MOD_CDC14_SPxK_1 522 525 PF00782 0.725
MOD_CDK_SPxK_1 519 525 PF00069 0.700
MOD_CK1_1 192 198 PF00069 0.630
MOD_CK1_1 379 385 PF00069 0.590
MOD_CK1_1 436 442 PF00069 0.614
MOD_CK1_1 464 470 PF00069 0.653
MOD_CK1_1 529 535 PF00069 0.671
MOD_CK1_1 538 544 PF00069 0.630
MOD_CK1_1 546 552 PF00069 0.609
MOD_CK1_1 555 561 PF00069 0.540
MOD_CK1_1 576 582 PF00069 0.674
MOD_CK1_1 79 85 PF00069 0.512
MOD_CK2_1 121 127 PF00069 0.388
MOD_CK2_1 440 446 PF00069 0.567
MOD_CK2_1 494 500 PF00069 0.657
MOD_CK2_1 75 81 PF00069 0.476
MOD_GlcNHglycan 316 319 PF01048 0.402
MOD_GlcNHglycan 468 471 PF01048 0.625
MOD_GlcNHglycan 512 515 PF01048 0.651
MOD_GlcNHglycan 526 529 PF01048 0.611
MOD_GlcNHglycan 540 543 PF01048 0.704
MOD_GlcNHglycan 549 552 PF01048 0.651
MOD_GlcNHglycan 557 560 PF01048 0.560
MOD_GlcNHglycan 57 60 PF01048 0.439
MOD_GlcNHglycan 91 94 PF01048 0.539
MOD_GSK3_1 144 151 PF00069 0.403
MOD_GSK3_1 177 184 PF00069 0.456
MOD_GSK3_1 185 192 PF00069 0.456
MOD_GSK3_1 338 345 PF00069 0.561
MOD_GSK3_1 359 366 PF00069 0.461
MOD_GSK3_1 436 443 PF00069 0.609
MOD_GSK3_1 444 451 PF00069 0.475
MOD_GSK3_1 462 469 PF00069 0.483
MOD_GSK3_1 502 509 PF00069 0.579
MOD_GSK3_1 534 541 PF00069 0.676
MOD_GSK3_1 542 549 PF00069 0.604
MOD_GSK3_1 573 580 PF00069 0.712
MOD_GSK3_1 582 589 PF00069 0.682
MOD_GSK3_1 75 82 PF00069 0.479
MOD_GSK3_1 96 103 PF00069 0.379
MOD_N-GLC_1 503 508 PF02516 0.685
MOD_N-GLC_1 79 84 PF02516 0.516
MOD_NEK2_1 100 105 PF00069 0.454
MOD_NEK2_1 193 198 PF00069 0.658
MOD_NEK2_1 247 252 PF00069 0.558
MOD_NEK2_1 295 300 PF00069 0.506
MOD_NEK2_1 338 343 PF00069 0.412
MOD_NEK2_1 365 370 PF00069 0.487
MOD_NEK2_1 385 390 PF00069 0.369
MOD_NEK2_1 473 478 PF00069 0.516
MOD_NEK2_1 524 529 PF00069 0.635
MOD_NEK2_1 547 552 PF00069 0.678
MOD_NEK2_2 543 548 PF00069 0.716
MOD_PIKK_1 144 150 PF00454 0.447
MOD_PIKK_1 365 371 PF00454 0.458
MOD_PIKK_1 552 558 PF00454 0.755
MOD_PK_1 34 40 PF00069 0.680
MOD_PKA_1 144 150 PF00069 0.422
MOD_PKA_2 144 150 PF00069 0.422
MOD_PKA_2 411 417 PF00069 0.564
MOD_PKA_2 524 530 PF00069 0.709
MOD_PKA_2 534 540 PF00069 0.721
MOD_PKA_2 543 549 PF00069 0.754
MOD_PKA_2 573 579 PF00069 0.745
MOD_PKB_1 459 467 PF00069 0.594
MOD_Plk_1 156 162 PF00069 0.331
MOD_Plk_1 436 442 PF00069 0.691
MOD_Plk_1 461 467 PF00069 0.675
MOD_Plk_2-3 441 447 PF00069 0.587
MOD_Plk_4 307 313 PF00069 0.458
MOD_Plk_4 34 40 PF00069 0.671
MOD_Plk_4 342 348 PF00069 0.501
MOD_Plk_4 448 454 PF00069 0.533
MOD_Plk_4 96 102 PF00069 0.384
MOD_ProDKin_1 1 7 PF00069 0.521
MOD_ProDKin_1 377 383 PF00069 0.539
MOD_ProDKin_1 386 392 PF00069 0.611
MOD_ProDKin_1 503 509 PF00069 0.742
MOD_ProDKin_1 519 525 PF00069 0.560
MOD_ProDKin_1 526 532 PF00069 0.648
MOD_ProDKin_1 586 592 PF00069 0.685
TRG_DiLeu_BaEn_1 47 52 PF01217 0.512
TRG_DiLeu_BaLyEn_6 360 365 PF01217 0.567
TRG_DiLeu_BaLyEn_6 83 88 PF01217 0.537
TRG_ENDOCYTIC_2 125 128 PF00928 0.447
TRG_ENDOCYTIC_2 158 161 PF00928 0.355
TRG_ENDOCYTIC_2 26 29 PF00928 0.466
TRG_ENDOCYTIC_2 375 378 PF00928 0.580
TRG_ENDOCYTIC_2 492 495 PF00928 0.481
TRG_ER_diArg_1 114 116 PF00400 0.335
TRG_ER_diArg_1 143 145 PF00400 0.430
TRG_ER_diArg_1 422 424 PF00400 0.540
TRG_ER_diArg_1 487 490 PF00400 0.531
TRG_Pf-PMV_PEXEL_1 177 181 PF00026 0.480
TRG_Pf-PMV_PEXEL_1 239 243 PF00026 0.544
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.529

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2V0 Leptomonas seymouri 59% 97%
A0A1X0NZX4 Trypanosomatidae 26% 100%
A0A3Q8IF87 Leishmania donovani 100% 100%
A0A3R7KI94 Trypanosoma rangeli 30% 100%
A4HIY5 Leishmania braziliensis 85% 99%
C9ZLC6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AE42 Leishmania major 94% 99%
E9ALP3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5ATT7 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS