Putative histone H2A

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4I4N4_LEIIN

TriTrypDb:

Length:

193

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.568
CLV_NRD_NRD_1	149	151	PF00675	0.729
CLV_NRD_NRD_1	164	166	PF00675	0.636
CLV_NRD_NRD_1	54	56	PF00675	0.617
CLV_NRD_NRD_1	87	89	PF00675	0.737
CLV_PCSK_KEX2_1	104	106	PF00082	0.556
CLV_PCSK_KEX2_1	148	150	PF00082	0.732
CLV_PCSK_KEX2_1	164	166	PF00082	0.624
CLV_PCSK_KEX2_1	54	56	PF00082	0.517
CLV_PCSK_KEX2_1	86	88	PF00082	0.734
CLV_PCSK_PC7_1	100	106	PF00082	0.783
DOC_MAPK_DCC_7	40	50	PF00069	0.469
DOC_MAPK_gen_1	37	47	PF00069	0.441
DOC_MAPK_MEF2A_6	28	35	PF00069	0.442
DOC_MAPK_NFAT4_5	28	36	PF00069	0.440
DOC_WW_Pin1_4	187	192	PF00397	0.646
DOC_WW_Pin1_4	94	99	PF00397	0.687
LIG_14-3-3_CanoR_1	152	161	PF00244	0.717
LIG_BIR_II_1	1	5	PF00653	0.523
LIG_BIR_III_3	1	5	PF00653	0.523
LIG_BRCT_BRCA1_1	25	29	PF00533	0.461
LIG_FHA_1	184	190	PF00498	0.743
LIG_LIR_Gen_1	26	36	PF02991	0.450
LIG_LIR_Gen_1	76	85	PF02991	0.650
LIG_LIR_Nem_3	18	23	PF02991	0.531
LIG_LIR_Nem_3	26	32	PF02991	0.416
LIG_LIR_Nem_3	76	81	PF02991	0.650
LIG_Pex14_2	16	20	PF04695	0.549
LIG_SH2_STAT3	59	62	PF00017	0.791
LIG_SH3_2	49	54	PF14604	0.502
LIG_SH3_2	82	87	PF14604	0.708
LIG_SH3_3	132	138	PF00018	0.804
LIG_SH3_3	186	192	PF00018	0.646
LIG_SH3_3	43	49	PF00018	0.718
LIG_SH3_3	79	85	PF00018	0.785
LIG_SH3_3	92	98	PF00018	0.549
LIG_TRAF2_1	154	157	PF00917	0.820
LIG_WRC_WIRS_1	17	22	PF05994	0.503
MOD_CDC14_SPxK_1	97	100	PF00782	0.684
MOD_CDK_SPxK_1	94	100	PF00069	0.688
MOD_CK1_1	19	25	PF00069	0.494
MOD_GlcNHglycan	23	26	PF01048	0.485
MOD_GSK3_1	15	22	PF00069	0.515
MOD_GSK3_1	183	190	PF00069	0.545
MOD_GSK3_1	53	60	PF00069	0.694
MOD_LATS_1	38	44	PF00433	0.426
MOD_NEK2_1	16	21	PF00069	0.568
MOD_NEK2_1	23	28	PF00069	0.468
MOD_OFUCOSY	3	8	PF10250	0.513
MOD_PIKK_1	159	165	PF00454	0.822
MOD_PIKK_1	58	64	PF00454	0.791
MOD_PKA_2	53	59	PF00069	0.523
MOD_PKB_1	150	158	PF00069	0.714
MOD_Plk_4	40	46	PF00069	0.480
MOD_ProDKin_1	187	193	PF00069	0.650
MOD_ProDKin_1	94	100	PF00069	0.688
TRG_DiLeu_BaEn_1	156	161	PF01217	0.721
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.484
TRG_ER_diArg_1	103	105	PF00400	0.562
TRG_ER_diArg_1	147	150	PF00400	0.812
TRG_ER_diArg_1	85	88	PF00400	0.731
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.719
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I4N2	Leishmania infantum	83%	100%
A4I4N3	Leishmania infantum	98%	100%
E9AV76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%