Putative histone H2A

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4I4N2_LEIIN

TriTrypDb:

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 2
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.555
CLV_NRD_NRD_1	121	123	PF00675	0.560
CLV_NRD_NRD_1	166	168	PF00675	0.551
CLV_NRD_NRD_1	181	183	PF00675	0.528
CLV_NRD_NRD_1	22	24	PF00675	0.492
CLV_PCSK_KEX2_1	103	105	PF00082	0.556
CLV_PCSK_KEX2_1	121	123	PF00082	0.560
CLV_PCSK_KEX2_1	165	167	PF00082	0.559
CLV_PCSK_KEX2_1	181	183	PF00082	0.524
CLV_PCSK_KEX2_1	22	24	PF00082	0.492
CLV_PCSK_PC7_1	117	123	PF00082	0.566
DOC_CDC14_PxL_1	14	22	PF14671	0.427
DOC_PP2B_LxvP_1	15	18	PF13499	0.435
DOC_PP2B_LxvP_1	62	65	PF13499	0.596
DOC_PP4_FxxP_1	43	46	PF00568	0.505
DOC_PP4_FxxP_1	60	63	PF00568	0.432
DOC_USP7_MATH_1	39	43	PF00917	0.528
DOC_USP7_MATH_1	46	50	PF00917	0.448
DOC_WW_Pin1_4	111	116	PF00397	0.693
LIG_14-3-3_CanoR_1	169	178	PF00244	0.542
LIG_14-3-3_CterR_2	236	240	PF00244	0.516
LIG_BRCT_BRCA1_1	4	8	PF00533	0.387
LIG_EVH1_1	15	19	PF00568	0.439
LIG_EVH1_1	62	66	PF00568	0.486
LIG_FHA_1	201	207	PF00498	0.670
LIG_FHA_1	51	57	PF00498	0.437
LIG_GBD_Chelix_1	2	10	PF00786	0.392
LIG_HCF-1_HBM_1	207	210	PF13415	0.552
LIG_LIR_Apic_2	41	46	PF02991	0.513
LIG_LIR_Gen_1	5	16	PF02991	0.391
LIG_LIR_Gen_1	93	102	PF02991	0.533
LIG_LIR_Nem_3	207	213	PF02991	0.549
LIG_LIR_Nem_3	5	11	PF02991	0.381
LIG_LIR_Nem_3	93	98	PF02991	0.534
LIG_LYPXL_yS_3	210	213	PF13949	0.552
LIG_MLH1_MIPbox_1	4	8	PF16413	0.387
LIG_MYND_1	65	69	PF01753	0.544
LIG_NRBOX	51	57	PF00104	0.427
LIG_Pex14_2	7	11	PF04695	0.382
LIG_SH2_STAT3	76	79	PF00017	0.628
LIG_SH3_2	99	104	PF14604	0.540
LIG_SH3_3	109	115	PF00018	0.504
LIG_SH3_3	13	19	PF00018	0.480
LIG_SH3_3	149	155	PF00018	0.595
LIG_SH3_3	60	66	PF00018	0.518
LIG_SH3_3	96	102	PF00018	0.575
LIG_TRAF2_1	171	174	PF00917	0.584
MOD_CDC14_SPxK_1	114	117	PF00782	0.532
MOD_CDK_SPxK_1	111	117	PF00069	0.534
MOD_GlcNHglycan	43	46	PF01048	0.509
MOD_GlcNHglycan	48	51	PF01048	0.434
MOD_GSK3_1	226	233	PF00069	0.484
MOD_GSK3_1	34	41	PF00069	0.564
MOD_GSK3_1	46	53	PF00069	0.451
MOD_GSK3_1	70	77	PF00069	0.582
MOD_N-GLC_1	34	39	PF02516	0.533
MOD_NEK2_1	10	15	PF00069	0.396
MOD_NEK2_1	206	211	PF00069	0.549
MOD_NEK2_1	24	29	PF00069	0.698
MOD_NEK2_1	58	63	PF00069	0.451
MOD_PIKK_1	176	182	PF00454	0.594
MOD_PIKK_1	75	81	PF00454	0.624
MOD_PKA_2	230	236	PF00069	0.493
MOD_PKB_1	167	175	PF00069	0.537
MOD_Plk_1	206	212	PF00069	0.548
MOD_Plk_4	10	16	PF00069	0.537
MOD_Plk_4	2	8	PF00069	0.467
MOD_ProDKin_1	111	117	PF00069	0.695
TRG_DiLeu_BaEn_1	173	178	PF01217	0.547
TRG_ENDOCYTIC_2	210	213	PF00928	0.552
TRG_ER_diArg_1	102	105	PF00400	0.554
TRG_ER_diArg_1	120	122	PF00400	0.571
TRG_ER_diArg_1	164	167	PF00400	0.596
TRG_ER_diArg_1	22	24	PF00400	0.606
TRG_NES_CRM1_1	54	68	PF08389	0.449
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I4N4	Leishmania infantum	83%	100%
E9AV76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%