HotDog ACOT-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioesterase superfamily - putative

Species:

Leishmania infantum

UniProt:

A4I4M9_LEIIN

TriTrypDb:

LINF_290023600

Length:

353

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, Acyl-coenzyme A thioesterase Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I4M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4M9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006637	acyl-CoA metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035383	thioester metabolic process	3	1
GO:0043436	oxoacid metabolic process	4	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0016790	thiolester hydrolase activity	4	13
GO:0000062	fatty-acyl-CoA binding	4	1
GO:0000166	nucleotide binding	3	4
GO:0005488	binding	1	4
GO:0008289	lipid binding	2	1
GO:0016289	CoA hydrolase activity	5	1
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0033218	amide binding	2	1
GO:0036042	long-chain fatty acyl-CoA binding	5	1
GO:0036094	small molecule binding	2	4
GO:0047617	acyl-CoA hydrolase activity	6	1
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:0120227	acyl-CoA binding	3	1
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4
GO:1901567	fatty acid derivative binding	3	1
GO:1901681	sulfur compound binding	2	1
GO:0005524	ATP binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.538
CLV_NRD_NRD_1	279	281	PF00675	0.611
CLV_NRD_NRD_1	302	304	PF00675	0.539
CLV_NRD_NRD_1	337	339	PF00675	0.544
CLV_PCSK_FUR_1	164	168	PF00082	0.601
CLV_PCSK_KEX2_1	166	168	PF00082	0.591
CLV_PCSK_KEX2_1	337	339	PF00082	0.495
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.591
CLV_PCSK_SKI1_1	125	129	PF00082	0.475
CLV_PCSK_SKI1_1	167	171	PF00082	0.477
CLV_PCSK_SKI1_1	197	201	PF00082	0.476
CLV_PCSK_SKI1_1	228	232	PF00082	0.397
CLV_PCSK_SKI1_1	234	238	PF00082	0.332
CLV_PCSK_SKI1_1	54	58	PF00082	0.483
DEG_MDM2_SWIB_1	251	258	PF02201	0.366
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.522
DOC_MAPK_DCC_7	125	135	PF00069	0.405
DOC_MAPK_gen_1	125	135	PF00069	0.471
DOC_MAPK_gen_1	303	311	PF00069	0.475
DOC_MAPK_HePTP_8	301	313	PF00069	0.515
DOC_MAPK_MEF2A_6	128	135	PF00069	0.387
DOC_MAPK_MEF2A_6	266	274	PF00069	0.307
DOC_MAPK_MEF2A_6	303	311	PF00069	0.515
DOC_MAPK_RevD_3	139	152	PF00069	0.437
DOC_PP1_RVXF_1	195	201	PF00149	0.538
DOC_PP4_FxxP_1	246	249	PF00568	0.293
DOC_PP4_FxxP_1	67	70	PF00568	0.389
DOC_USP7_MATH_1	110	114	PF00917	0.442
DOC_USP7_MATH_1	37	41	PF00917	0.497
DOC_USP7_UBL2_3	277	281	PF12436	0.411
DOC_WW_Pin1_4	105	110	PF00397	0.439
DOC_WW_Pin1_4	118	123	PF00397	0.467
DOC_WW_Pin1_4	15	20	PF00397	0.539
DOC_WW_Pin1_4	66	71	PF00397	0.442
DOC_WW_Pin1_4	98	103	PF00397	0.441
LIG_14-3-3_CanoR_1	164	170	PF00244	0.570
LIG_14-3-3_CanoR_1	228	237	PF00244	0.284
LIG_14-3-3_CanoR_1	266	271	PF00244	0.314
LIG_14-3-3_CanoR_1	27	32	PF00244	0.412
LIG_14-3-3_CanoR_1	290	294	PF00244	0.358
LIG_14-3-3_CanoR_1	330	336	PF00244	0.460
LIG_14-3-3_CanoR_1	38	44	PF00244	0.467
LIG_14-3-3_CanoR_1	54	62	PF00244	0.455
LIG_Actin_WH2_2	110	127	PF00022	0.398
LIG_AP2alpha_2	137	139	PF02296	0.428
LIG_BRCT_BRCA1_1	242	246	PF00533	0.366
LIG_CaM_IQ_9	150	166	PF13499	0.566
LIG_FHA_1	119	125	PF00498	0.472
LIG_FHA_1	169	175	PF00498	0.490
LIG_FHA_1	251	257	PF00498	0.333
LIG_FHA_1	267	273	PF00498	0.268
LIG_FHA_1	281	287	PF00498	0.431
LIG_FHA_1	304	310	PF00498	0.455
LIG_FHA_1	55	61	PF00498	0.424
LIG_FHA_2	102	108	PF00498	0.503
LIG_FHA_2	168	174	PF00498	0.447
LIG_FHA_2	189	195	PF00498	0.490
LIG_FHA_2	266	272	PF00498	0.334
LIG_FHA_2	315	321	PF00498	0.451
LIG_LIR_Apic_2	243	249	PF02991	0.308
LIG_LIR_Apic_2	64	70	PF02991	0.437
LIG_LIR_Gen_1	113	122	PF02991	0.388
LIG_LIR_Gen_1	253	263	PF02991	0.343
LIG_LIR_Gen_1	292	301	PF02991	0.362
LIG_LIR_Gen_1	8	13	PF02991	0.442
LIG_LIR_Nem_3	113	118	PF02991	0.420
LIG_LIR_Nem_3	253	258	PF02991	0.356
LIG_LIR_Nem_3	292	296	PF02991	0.361
LIG_LIR_Nem_3	8	12	PF02991	0.451
LIG_PCNA_yPIPBox_3	318	332	PF02747	0.485
LIG_PDZ_Class_1	348	353	PF00595	0.664
LIG_Pex14_2	251	255	PF04695	0.342
LIG_SH2_PTP2	147	150	PF00017	0.432
LIG_SH2_STAT5	147	150	PF00017	0.442
LIG_SH2_STAT5	264	267	PF00017	0.350
LIG_SH2_STAT5	55	58	PF00017	0.466
LIG_SH2_STAT5	94	97	PF00017	0.433
LIG_SH3_3	241	247	PF00018	0.393
LIG_SUMO_SIM_anti_2	271	276	PF11976	0.400
LIG_SUMO_SIM_par_1	116	121	PF11976	0.413
LIG_TRAF2_1	170	173	PF00917	0.562
LIG_TRAF2_1	316	319	PF00917	0.469
MOD_CDK_SPxxK_3	118	125	PF00069	0.222
MOD_CDK_SPxxK_3	15	22	PF00069	0.563
MOD_CDK_SPxxK_3	98	105	PF00069	0.556
MOD_CK1_1	101	107	PF00069	0.454
MOD_CK1_1	113	119	PF00069	0.328
MOD_CK1_1	15	21	PF00069	0.579
MOD_CK2_1	101	107	PF00069	0.523
MOD_CK2_1	167	173	PF00069	0.511
MOD_CK2_1	188	194	PF00069	0.482
MOD_CK2_1	265	271	PF00069	0.343
MOD_CK2_1	314	320	PF00069	0.452
MOD_Cter_Amidation	301	304	PF01082	0.543
MOD_GSK3_1	101	108	PF00069	0.445
MOD_GSK3_1	250	257	PF00069	0.323
MOD_GSK3_1	281	288	PF00069	0.445
MOD_GSK3_1	341	348	PF00069	0.633
MOD_GSK3_1	56	63	PF00069	0.397
MOD_LATS_1	185	191	PF00433	0.520
MOD_LATS_1	52	58	PF00433	0.503
MOD_N-GLC_1	188	193	PF02516	0.543
MOD_N-GLC_1	206	211	PF02516	0.175
MOD_N-GLC_1	266	271	PF02516	0.353
MOD_N-GLC_2	345	347	PF02516	0.569
MOD_NEK2_1	165	170	PF00069	0.584
MOD_NEK2_1	199	204	PF00069	0.500
MOD_NEK2_1	258	263	PF00069	0.438
MOD_NEK2_1	341	346	PF00069	0.594
MOD_NEK2_1	56	61	PF00069	0.415
MOD_NEK2_2	110	115	PF00069	0.457
MOD_PIKK_1	314	320	PF00454	0.472
MOD_PIKK_1	37	43	PF00454	0.461
MOD_PKA_1	158	164	PF00069	0.576
MOD_PKA_1	280	286	PF00069	0.602
MOD_PKA_1	303	309	PF00069	0.418
MOD_PKA_2	265	271	PF00069	0.314
MOD_PKA_2	289	295	PF00069	0.356
MOD_PKA_2	331	337	PF00069	0.477
MOD_PKA_2	37	43	PF00069	0.480
MOD_Plk_1	206	212	PF00069	0.286
MOD_Plk_1	258	264	PF00069	0.348
MOD_Plk_1	266	272	PF00069	0.299
MOD_Plk_1	281	287	PF00069	0.479
MOD_Plk_2-3	254	260	PF00069	0.366
MOD_Plk_4	110	116	PF00069	0.385
MOD_Plk_4	206	212	PF00069	0.363
MOD_Plk_4	258	264	PF00069	0.383
MOD_Plk_4	27	33	PF00069	0.355
MOD_Plk_4	282	288	PF00069	0.471
MOD_Plk_4	289	295	PF00069	0.328
MOD_Plk_4	62	68	PF00069	0.422
MOD_ProDKin_1	105	111	PF00069	0.432
MOD_ProDKin_1	118	124	PF00069	0.469
MOD_ProDKin_1	15	21	PF00069	0.534
MOD_ProDKin_1	66	72	PF00069	0.442
MOD_ProDKin_1	98	104	PF00069	0.445
MOD_SUMO_for_1	276	279	PF00179	0.411
MOD_SUMO_rev_2	273	283	PF00179	0.404
TRG_DiLeu_BaEn_3	319	325	PF01217	0.474
TRG_ENDOCYTIC_2	147	150	PF00928	0.394
TRG_ENDOCYTIC_2	94	97	PF00928	0.443
TRG_ER_diArg_1	328	331	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.465
TRG_PTS1	350	353	PF00515	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C1	Leptomonas seymouri	34%	78%
A0A0N1PDQ1	Leptomonas seymouri	74%	89%
A0A0S4JR10	Bodo saltans	38%	81%
A0A1X0NZW0	Trypanosomatidae	56%	96%
A0A1X0P0I5	Trypanosomatidae	39%	91%
A0A3S7X2I7	Leishmania donovani	100%	100%
A0A422NEB6	Trypanosoma rangeli	37%	89%
A4HHI1	Leishmania braziliensis	88%	100%
C9ZLB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	96%
E9AE30	Leishmania major	94%	100%
E9ALQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%