ATP-binding cassette protein subfamily H, member 2

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily H - member 2 - putative

Species:

Leishmania infantum

UniProt:

A4I4M8_LEIIN

TriTrypDb:

LINF_290023300

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 49

Expansion

Sequence features

A4I4M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4M8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0005215	transporter activity	1	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.610
CLV_NRD_NRD_1	126	128	PF00675	0.363
CLV_NRD_NRD_1	288	290	PF00675	0.467
CLV_PCSK_KEX2_1	126	128	PF00082	0.363
CLV_PCSK_KEX2_1	288	290	PF00082	0.467
CLV_PCSK_SKI1_1	222	226	PF00082	0.326
CLV_PCSK_SKI1_1	320	324	PF00082	0.504
CLV_PCSK_SKI1_1	344	348	PF00082	0.558
CLV_PCSK_SKI1_1	41	45	PF00082	0.506
CLV_PCSK_SKI1_1	88	92	PF00082	0.460
DEG_APCC_DBOX_1	221	229	PF00400	0.303
DOC_CYCLIN_RxL_1	178	189	PF00134	0.276
DOC_CYCLIN_RxL_1	218	226	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.586
DOC_MAPK_gen_1	126	133	PF00069	0.363
DOC_MAPK_gen_1	218	227	PF00069	0.305
DOC_MAPK_gen_1	288	297	PF00069	0.377
DOC_PP1_RVXF_1	179	186	PF00149	0.303
DOC_PP2B_LxvP_1	118	121	PF13499	0.557
DOC_PP2B_LxvP_1	413	416	PF13499	0.676
DOC_PP4_FxxP_1	23	26	PF00568	0.536
DOC_USP7_MATH_1	381	385	PF00917	0.629
DOC_USP7_MATH_1	402	406	PF00917	0.531
DOC_USP7_MATH_1	445	449	PF00917	0.674
DOC_USP7_MATH_1	95	99	PF00917	0.669
DOC_USP7_UBL2_3	211	215	PF12436	0.298
DOC_WW_Pin1_4	14	19	PF00397	0.647
DOC_WW_Pin1_4	27	32	PF00397	0.474
DOC_WW_Pin1_4	6	11	PF00397	0.781
LIG_14-3-3_CanoR_1	222	228	PF00244	0.363
LIG_14-3-3_CanoR_1	288	297	PF00244	0.377
LIG_14-3-3_CanoR_1	55	59	PF00244	0.462
LIG_14-3-3_CanoR_1	8	14	PF00244	0.629
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BRCT_BRCA1_1	19	23	PF00533	0.587
LIG_FHA_1	108	114	PF00498	0.675
LIG_FHA_1	140	146	PF00498	0.307
LIG_FHA_1	156	162	PF00498	0.406
LIG_FHA_1	187	193	PF00498	0.303
LIG_FHA_1	266	272	PF00498	0.395
LIG_FHA_1	274	280	PF00498	0.391
LIG_FHA_1	290	296	PF00498	0.475
LIG_FHA_1	334	340	PF00498	0.529
LIG_FHA_2	101	107	PF00498	0.666
LIG_FHA_2	195	201	PF00498	0.303
LIG_FHA_2	31	37	PF00498	0.631
LIG_FHA_2	89	95	PF00498	0.473
LIG_Integrin_isoDGR_2	162	164	PF01839	0.358
LIG_LIR_Apic_2	20	26	PF02991	0.548
LIG_LIR_Gen_1	129	136	PF02991	0.356
LIG_LIR_Gen_1	189	198	PF02991	0.303
LIG_LIR_Gen_1	321	330	PF02991	0.435
LIG_LIR_Gen_1	347	355	PF02991	0.514
LIG_LIR_Nem_3	129	133	PF02991	0.356
LIG_LIR_Nem_3	189	193	PF02991	0.313
LIG_LIR_Nem_3	321	326	PF02991	0.467
LIG_LIR_Nem_3	333	338	PF02991	0.509
LIG_LIR_Nem_3	347	352	PF02991	0.605
LIG_LIR_Nem_3	74	78	PF02991	0.353
LIG_LYPXL_yS_3	75	78	PF13949	0.364
LIG_PTB_Apo_2	179	186	PF02174	0.333
LIG_SH2_STAP1	306	310	PF00017	0.336
LIG_SH2_STAP1	335	339	PF00017	0.451
LIG_SH2_STAT5	312	315	PF00017	0.406
LIG_SH2_STAT5	335	338	PF00017	0.415
LIG_SH3_2	121	126	PF14604	0.442
LIG_SH3_3	118	124	PF00018	0.507
LIG_SH3_3	199	205	PF00018	0.303
LIG_SH3_3	437	443	PF00018	0.536
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.303
LIG_SUMO_SIM_anti_2	276	281	PF11976	0.366
LIG_SUMO_SIM_par_1	260	266	PF11976	0.303
LIG_SUMO_SIM_par_1	275	281	PF11976	0.367
LIG_SUMO_SIM_par_1	80	89	PF11976	0.482
LIG_TRAF2_1	103	106	PF00917	0.556
LIG_TRAF2_1	33	36	PF00917	0.617
LIG_UBA3_1	208	215	PF00899	0.363
LIG_UBA3_1	282	291	PF00899	0.437
LIG_WRC_WIRS_1	187	192	PF05994	0.303
MOD_CK1_1	150	156	PF00069	0.364
MOD_CK1_1	17	23	PF00069	0.453
MOD_CK1_1	2	8	PF00069	0.659
MOD_CK1_1	239	245	PF00069	0.303
MOD_CK1_1	30	36	PF00069	0.533
MOD_CK1_1	395	401	PF00069	0.721
MOD_CK1_1	425	431	PF00069	0.577
MOD_CK1_1	51	57	PF00069	0.618
MOD_CK2_1	100	106	PF00069	0.686
MOD_CK2_1	150	156	PF00069	0.363
MOD_CK2_1	194	200	PF00069	0.303
MOD_CK2_1	239	245	PF00069	0.311
MOD_CK2_1	30	36	PF00069	0.635
MOD_CK2_1	386	392	PF00069	0.575
MOD_CK2_1	46	52	PF00069	0.439
MOD_CK2_1	88	94	PF00069	0.455
MOD_GlcNHglycan	136	139	PF01048	0.335
MOD_GlcNHglycan	19	22	PF01048	0.617
MOD_GlcNHglycan	212	215	PF01048	0.298
MOD_GlcNHglycan	240	244	PF01048	0.321
MOD_GlcNHglycan	394	397	PF01048	0.785
MOD_GlcNHglycan	406	409	PF01048	0.495
MOD_GlcNHglycan	424	427	PF01048	0.495
MOD_GlcNHglycan	448	451	PF01048	0.567
MOD_GlcNHglycan	98	101	PF01048	0.692
MOD_GSK3_1	17	24	PF00069	0.511
MOD_GSK3_1	2	9	PF00069	0.577
MOD_GSK3_1	247	254	PF00069	0.319
MOD_GSK3_1	388	395	PF00069	0.630
MOD_GSK3_1	427	434	PF00069	0.746
MOD_GSK3_1	54	61	PF00069	0.562
MOD_GSK3_1	96	103	PF00069	0.619
MOD_N-GLC_1	27	32	PF02516	0.604
MOD_N-GLC_1	333	338	PF02516	0.416
MOD_N-GLC_1	381	386	PF02516	0.613
MOD_NEK2_1	192	197	PF00069	0.303
MOD_NEK2_1	446	451	PF00069	0.603
MOD_PIKK_1	101	107	PF00454	0.615
MOD_PIKK_1	425	431	PF00454	0.642
MOD_PKA_2	247	253	PF00069	0.325
MOD_PKA_2	287	293	PF00069	0.384
MOD_PKA_2	361	367	PF00069	0.606
MOD_PKA_2	54	60	PF00069	0.433
MOD_Plk_1	381	387	PF00069	0.550
MOD_Plk_1	46	52	PF00069	0.664
MOD_Plk_1	88	94	PF00069	0.451
MOD_Plk_4	140	146	PF00069	0.309
MOD_Plk_4	170	176	PF00069	0.333
MOD_Plk_4	204	210	PF00069	0.398
MOD_Plk_4	223	229	PF00069	0.363
MOD_Plk_4	257	263	PF00069	0.303
MOD_Plk_4	395	401	PF00069	0.546
MOD_Plk_4	54	60	PF00069	0.385
MOD_ProDKin_1	14	20	PF00069	0.645
MOD_ProDKin_1	27	33	PF00069	0.474
MOD_ProDKin_1	6	12	PF00069	0.782
MOD_SUMO_rev_2	167	173	PF00179	0.348
TRG_DiLeu_BaEn_1	278	283	PF01217	0.421
TRG_ENDOCYTIC_2	75	78	PF00928	0.364
TRG_ER_diArg_1	125	127	PF00400	0.363
TRG_ER_diArg_1	217	220	PF00400	0.303
TRG_ER_diArg_1	230	233	PF00400	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICD4	Leptomonas seymouri	76%	99%
A0A0S4J9X9	Bodo saltans	58%	100%
A0A3S7X2I8	Leishmania donovani	99%	100%
A4HHH8	Leishmania braziliensis	68%	96%
E9AE26	Leishmania major	89%	100%
E9ALQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%