Integral membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Integral membrane protein S linking to the trans Golgi network - putative

Species:

Leishmania infantum

UniProt:

A4I4M5_LEIIN

TriTrypDb:

LINF_290023000

Length:

376

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein, involved in protein trafficking.. Localization: Golgi (by homology)

Annotations by Jardim et al.

Intracellular protein trafficking, Integral membrane S linking to the trans Golgi network

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	7
GO:0005802	trans-Golgi network	4	1
GO:0005829	cytosol	2	1
GO:0031984	organelle subcompartment	2	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

A4I4M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4M5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006893	Golgi to plasma membrane transport	5	1
GO:0006895	Golgi to endosome transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034067	protein localization to Golgi apparatus	6	1
GO:0043001	Golgi to plasma membrane protein transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061951	establishment of protein localization to plasma membrane	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0072659	protein localization to plasma membrane	5	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1
GO:1990778	protein localization to cell periphery	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.744
CLV_NRD_NRD_1	193	195	PF00675	0.345
CLV_NRD_NRD_1	216	218	PF00675	0.346
CLV_NRD_NRD_1	269	271	PF00675	0.418
CLV_PCSK_KEX2_1	193	195	PF00082	0.345
CLV_PCSK_KEX2_1	216	218	PF00082	0.346
CLV_PCSK_KEX2_1	269	271	PF00082	0.345
CLV_PCSK_SKI1_1	218	222	PF00082	0.346
CLV_PCSK_SKI1_1	34	38	PF00082	0.404
DEG_APCC_DBOX_1	193	201	PF00400	0.546
DEG_APCC_DBOX_1	269	277	PF00400	0.618
DEG_ODPH_VHL_1	114	125	PF01847	0.726
DEG_SPOP_SBC_1	291	295	PF00917	0.767
DOC_CKS1_1	76	81	PF01111	0.749
DOC_CYCLIN_RxL_1	214	222	PF00134	0.618
DOC_CYCLIN_RxL_1	31	41	PF00134	0.598
DOC_MAPK_gen_1	216	223	PF00069	0.546
DOC_MAPK_gen_1	269	278	PF00069	0.545
DOC_MAPK_MEF2A_6	216	223	PF00069	0.618
DOC_MAPK_NFAT4_5	216	224	PF00069	0.618
DOC_PP4_FxxP_1	133	136	PF00568	0.673
DOC_USP7_MATH_1	119	123	PF00917	0.768
DOC_USP7_MATH_1	136	140	PF00917	0.602
DOC_USP7_MATH_1	330	334	PF00917	0.786
DOC_USP7_MATH_1	340	344	PF00917	0.675
DOC_USP7_MATH_1	349	353	PF00917	0.754
DOC_WW_Pin1_4	50	55	PF00397	0.738
DOC_WW_Pin1_4	75	80	PF00397	0.749
DOC_WW_Pin1_4	8	13	PF00397	0.382
LIG_14-3-3_CanoR_1	148	154	PF00244	0.715
LIG_14-3-3_CanoR_1	7	12	PF00244	0.455
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BIR_III_4	329	333	PF00653	0.791
LIG_BIR_III_4	338	342	PF00653	0.647
LIG_BRCT_BRCA1_1	10	14	PF00533	0.368
LIG_BRCT_BRCA1_1	121	125	PF00533	0.704
LIG_BRCT_BRCA1_1	129	133	PF00533	0.640
LIG_BRCT_BRCA1_1	23	27	PF00533	0.385
LIG_eIF4E_1	208	214	PF01652	0.546
LIG_eIF4E_1	228	234	PF01652	0.183
LIG_FHA_1	109	115	PF00498	0.762
LIG_FHA_1	142	148	PF00498	0.679
LIG_FHA_1	224	230	PF00498	0.411
LIG_FHA_1	262	268	PF00498	0.411
LIG_FHA_1	293	299	PF00498	0.757
LIG_FHA_1	31	37	PF00498	0.594
LIG_FHA_1	44	50	PF00498	0.645
LIG_FHA_2	45	51	PF00498	0.714
LIG_LIR_Apic_2	130	136	PF02991	0.667
LIG_LIR_Gen_1	11	20	PF02991	0.308
LIG_LIR_Gen_1	124	133	PF02991	0.647
LIG_LIR_Gen_1	24	35	PF02991	0.348
LIG_LIR_Nem_3	11	17	PF02991	0.308
LIG_LIR_Nem_3	124	129	PF02991	0.647
LIG_LIR_Nem_3	226	231	PF02991	0.352
LIG_LIR_Nem_3	24	30	PF02991	0.385
LIG_MLH1_MIPbox_1	23	27	PF16413	0.387
LIG_NRBOX	200	206	PF00104	0.456
LIG_NRBOX	238	244	PF00104	0.430
LIG_PCNA_yPIPBox_3	193	205	PF02747	0.456
LIG_REV1ctd_RIR_1	123	132	PF16727	0.675
LIG_SH2_CRK	71	75	PF00017	0.727
LIG_SH2_SRC	93	96	PF00017	0.689
LIG_SH2_STAT5	131	134	PF00017	0.672
LIG_SH2_STAT5	196	199	PF00017	0.546
LIG_SH2_STAT5	228	231	PF00017	0.411
LIG_SH2_STAT5	265	268	PF00017	0.428
LIG_SH3_3	113	119	PF00018	0.802
LIG_SH3_3	160	166	PF00018	0.648
LIG_SH3_3	73	79	PF00018	0.705
LIG_SUMO_SIM_anti_2	97	106	PF11976	0.606
LIG_SUMO_SIM_par_1	356	361	PF11976	0.698
LIG_TRAF2_1	365	368	PF00917	0.770
LIG_TYR_ITIM	229	234	PF00017	0.411
LIG_Vh1_VBS_1	92	110	PF01044	0.638
MOD_CDK_SPK_2	75	80	PF00069	0.675
MOD_CK1_1	108	114	PF00069	0.819
MOD_CK1_1	316	322	PF00069	0.685
MOD_CK1_1	348	354	PF00069	0.763
MOD_CK1_1	43	49	PF00069	0.752
MOD_CK2_1	121	127	PF00069	0.724
MOD_CK2_1	44	50	PF00069	0.705
MOD_GlcNHglycan	176	179	PF01048	0.469
MOD_GlcNHglycan	278	281	PF01048	0.516
MOD_GlcNHglycan	322	325	PF01048	0.581
MOD_GlcNHglycan	347	350	PF01048	0.511
MOD_GSK3_1	103	110	PF00069	0.754
MOD_GSK3_1	136	143	PF00069	0.697
MOD_GSK3_1	276	283	PF00069	0.697
MOD_GSK3_1	316	323	PF00069	0.632
MOD_GSK3_1	345	352	PF00069	0.747
MOD_GSK3_1	40	47	PF00069	0.688
MOD_NEK2_1	107	112	PF00069	0.746
MOD_NEK2_1	140	145	PF00069	0.708
MOD_NEK2_1	204	209	PF00069	0.620
MOD_NEK2_1	223	228	PF00069	0.198
MOD_NEK2_1	255	260	PF00069	0.499
MOD_NEK2_1	30	35	PF00069	0.455
MOD_NEK2_1	42	47	PF00069	0.584
MOD_NEK2_1	5	10	PF00069	0.411
MOD_NEK2_1	60	65	PF00069	0.678
MOD_NEK2_2	121	126	PF00069	0.724
MOD_NEK2_2	136	141	PF00069	0.625
MOD_PIKK_1	316	322	PF00454	0.779
MOD_PKA_2	174	180	PF00069	0.716
MOD_PKA_2	276	282	PF00069	0.782
MOD_PKA_2	316	322	PF00069	0.779
MOD_Plk_1	103	109	PF00069	0.816
MOD_Plk_1	40	46	PF00069	0.716
MOD_Plk_4	121	127	PF00069	0.707
MOD_Plk_4	136	142	PF00069	0.535
MOD_Plk_4	209	215	PF00069	0.572
MOD_Plk_4	21	27	PF00069	0.404
MOD_Plk_4	223	229	PF00069	0.260
MOD_Plk_4	255	261	PF00069	0.392
MOD_Plk_4	292	298	PF00069	0.721
MOD_Plk_4	94	100	PF00069	0.658
MOD_ProDKin_1	50	56	PF00069	0.740
MOD_ProDKin_1	75	81	PF00069	0.747
MOD_ProDKin_1	8	14	PF00069	0.376
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.430
TRG_ENDOCYTIC_2	231	234	PF00928	0.411
TRG_ER_diArg_1	193	195	PF00400	0.545
TRG_ER_diArg_1	342	345	PF00400	0.762
TRG_ER_diLys_1	372	376	PF00400	0.775
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAN0	Leptomonas seymouri	45%	100%
A0A3Q8IDS8	Leishmania donovani	100%	100%
A4HHH5	Leishmania braziliensis	69%	100%
E9AE23	Leishmania major	86%	94%
E9ALR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%