LeishMANIAdb
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Transmembrane 9 superfamily member

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane 9 superfamily member
Gene product:
Endomembrane protein 70 - putative
Species:
Leishmania infantum
UniProt:
A4I4M3_LEIIN
TriTrypDb:
LINF_290022800
Length:
680

Annotations

Annotations by Jardim et al.

Transporters, endomembrane 70, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 14, no: 1
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4M3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4M3

Function

Biological processes
Term Name Level Count
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0033036 macromolecule localization 2 1
GO:0051179 localization 1 1
GO:0051641 cellular localization 2 1
GO:0051668 localization within membrane 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0072657 protein localization to membrane 4 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 137 139 PF00675 0.497
CLV_NRD_NRD_1 233 235 PF00675 0.438
CLV_NRD_NRD_1 413 415 PF00675 0.425
CLV_NRD_NRD_1 671 673 PF00675 0.256
CLV_PCSK_KEX2_1 137 139 PF00082 0.473
CLV_PCSK_KEX2_1 233 235 PF00082 0.342
CLV_PCSK_KEX2_1 413 415 PF00082 0.425
CLV_PCSK_KEX2_1 671 673 PF00082 0.334
CLV_PCSK_SKI1_1 142 146 PF00082 0.453
CLV_PCSK_SKI1_1 182 186 PF00082 0.475
CLV_PCSK_SKI1_1 204 208 PF00082 0.412
CLV_PCSK_SKI1_1 270 274 PF00082 0.517
CLV_PCSK_SKI1_1 275 279 PF00082 0.498
CLV_PCSK_SKI1_1 299 303 PF00082 0.493
CLV_PCSK_SKI1_1 414 418 PF00082 0.439
CLV_PCSK_SKI1_1 449 453 PF00082 0.208
DEG_APCC_DBOX_1 18 26 PF00400 0.397
DEG_APCC_KENBOX_2 292 296 PF00400 0.197
DOC_MAPK_gen_1 150 158 PF00069 0.248
DOC_MAPK_gen_1 178 186 PF00069 0.267
DOC_MAPK_gen_1 233 240 PF00069 0.302
DOC_MAPK_gen_1 53 63 PF00069 0.354
DOC_MAPK_gen_1 671 679 PF00069 0.464
DOC_MAPK_MEF2A_6 19 28 PF00069 0.466
DOC_MAPK_MEF2A_6 233 242 PF00069 0.257
DOC_PP1_RVXF_1 243 250 PF00149 0.284
DOC_PP1_RVXF_1 58 64 PF00149 0.306
DOC_PP2B_LxvP_1 194 197 PF13499 0.255
DOC_PP4_FxxP_1 374 377 PF00568 0.383
DOC_PP4_FxxP_1 408 411 PF00568 0.189
DOC_PP4_FxxP_1 45 48 PF00568 0.340
DOC_PP4_FxxP_1 456 459 PF00568 0.376
DOC_PP4_FxxP_1 84 87 PF00568 0.204
DOC_USP7_MATH_1 529 533 PF00917 0.443
DOC_USP7_UBL2_3 116 120 PF12436 0.316
DOC_USP7_UBL2_3 142 146 PF12436 0.256
DOC_USP7_UBL2_3 178 182 PF12436 0.260
DOC_USP7_UBL2_3 53 57 PF12436 0.350
DOC_WW_Pin1_4 37 42 PF00397 0.488
DOC_WW_Pin1_4 407 412 PF00397 0.189
LIG_14-3-3_CanoR_1 105 111 PF00244 0.251
LIG_14-3-3_CanoR_1 351 360 PF00244 0.476
LIG_14-3-3_CanoR_1 69 77 PF00244 0.301
LIG_APCC_ABBA_1 236 241 PF00400 0.243
LIG_BIR_II_1 1 5 PF00653 0.698
LIG_BRCT_BRCA1_1 506 510 PF00533 0.252
LIG_BRCT_BRCA1_1 570 574 PF00533 0.302
LIG_BRCT_BRCA1_1 623 627 PF00533 0.310
LIG_BRCT_BRCA1_1 665 669 PF00533 0.291
LIG_BRCT_BRCA1_1 71 75 PF00533 0.371
LIG_CaM_NSCaTE_8 304 311 PF13499 0.302
LIG_EH1_1 321 329 PF00400 0.374
LIG_eIF4E_1 434 440 PF01652 0.281
LIG_FHA_1 131 137 PF00498 0.258
LIG_FHA_1 143 149 PF00498 0.196
LIG_FHA_1 25 31 PF00498 0.421
LIG_FHA_1 285 291 PF00498 0.205
LIG_FHA_1 394 400 PF00498 0.259
LIG_FHA_1 417 423 PF00498 0.286
LIG_FHA_1 426 432 PF00498 0.231
LIG_FHA_1 477 483 PF00498 0.236
LIG_FHA_1 490 496 PF00498 0.255
LIG_FHA_1 576 582 PF00498 0.294
LIG_FHA_2 164 170 PF00498 0.243
LIG_FHA_2 225 231 PF00498 0.243
LIG_FHA_2 300 306 PF00498 0.190
LIG_FHA_2 484 490 PF00498 0.243
LIG_GBD_Chelix_1 552 560 PF00786 0.268
LIG_LIR_Apic_2 372 377 PF02991 0.383
LIG_LIR_Apic_2 43 48 PF02991 0.428
LIG_LIR_Apic_2 453 459 PF02991 0.248
LIG_LIR_Gen_1 232 242 PF02991 0.225
LIG_LIR_Gen_1 424 435 PF02991 0.352
LIG_LIR_Gen_1 492 501 PF02991 0.307
LIG_LIR_Gen_1 571 581 PF02991 0.263
LIG_LIR_Gen_1 78 87 PF02991 0.302
LIG_LIR_LC3C_4 27 31 PF02991 0.306
LIG_LIR_LC3C_4 326 329 PF02991 0.240
LIG_LIR_LC3C_4 546 551 PF02991 0.255
LIG_LIR_Nem_3 232 238 PF02991 0.205
LIG_LIR_Nem_3 283 288 PF02991 0.272
LIG_LIR_Nem_3 302 307 PF02991 0.167
LIG_LIR_Nem_3 348 352 PF02991 0.409
LIG_LIR_Nem_3 363 369 PF02991 0.383
LIG_LIR_Nem_3 424 430 PF02991 0.331
LIG_LIR_Nem_3 492 497 PF02991 0.307
LIG_LIR_Nem_3 571 577 PF02991 0.261
LIG_LIR_Nem_3 592 598 PF02991 0.269
LIG_NRBOX 24 30 PF00104 0.376
LIG_Pex14_1 151 155 PF04695 0.243
LIG_Pex14_1 382 386 PF04695 0.502
LIG_Pex14_1 448 452 PF04695 0.383
LIG_Pex14_1 606 610 PF04695 0.383
LIG_Pex14_2 452 456 PF04695 0.343
LIG_Pex14_2 539 543 PF04695 0.300
LIG_PTB_Apo_2 105 112 PF02174 0.239
LIG_PTB_Apo_2 146 153 PF02174 0.276
LIG_PTB_Phospho_1 105 111 PF10480 0.239
LIG_PTB_Phospho_1 146 152 PF10480 0.276
LIG_SH2_CRK 674 678 PF00017 0.441
LIG_SH2_GRB2like 155 158 PF00017 0.302
LIG_SH2_GRB2like 379 382 PF00017 0.493
LIG_SH2_GRB2like 442 445 PF00017 0.439
LIG_SH2_GRB2like 600 603 PF00017 0.439
LIG_SH2_PTP2 235 238 PF00017 0.267
LIG_SH2_PTP2 466 469 PF00017 0.376
LIG_SH2_SRC 46 49 PF00017 0.336
LIG_SH2_SRC 600 603 PF00017 0.439
LIG_SH2_STAP1 111 115 PF00017 0.225
LIG_SH2_STAP1 288 292 PF00017 0.206
LIG_SH2_STAP1 379 383 PF00017 0.463
LIG_SH2_STAT3 558 561 PF00017 0.388
LIG_SH2_STAT5 111 114 PF00017 0.202
LIG_SH2_STAT5 235 238 PF00017 0.254
LIG_SH2_STAT5 307 310 PF00017 0.204
LIG_SH2_STAT5 434 437 PF00017 0.229
LIG_SH2_STAT5 442 445 PF00017 0.383
LIG_SH2_STAT5 46 49 PF00017 0.318
LIG_SH2_STAT5 466 469 PF00017 0.252
LIG_SH2_STAT5 558 561 PF00017 0.278
LIG_SH2_STAT5 596 599 PF00017 0.397
LIG_SH2_STAT5 610 613 PF00017 0.240
LIG_SH3_3 262 268 PF00018 0.312
LIG_SH3_3 370 376 PF00018 0.447
LIG_SH3_3 494 500 PF00018 0.300
LIG_SH3_3 539 545 PF00018 0.295
LIG_SUMO_SIM_anti_2 27 33 PF11976 0.429
LIG_SUMO_SIM_anti_2 326 332 PF11976 0.225
LIG_SUMO_SIM_par_1 21 27 PF11976 0.463
LIG_SUMO_SIM_par_1 549 555 PF11976 0.279
LIG_SUMO_SIM_par_1 587 592 PF11976 0.338
LIG_SxIP_EBH_1 474 488 PF03271 0.243
LIG_TRAF2_1 228 231 PF00917 0.296
LIG_TRAF2_1 88 91 PF00917 0.206
LIG_TYR_ITIM 464 469 PF00017 0.352
LIG_UBA3_1 341 347 PF00899 0.253
LIG_UBA3_1 467 474 PF00899 0.304
LIG_UBA3_1 74 81 PF00899 0.243
LIG_WRC_WIRS_1 569 574 PF05994 0.261
LIG_WRC_WIRS_1 634 639 PF05994 0.222
LIG_WW_1 376 379 PF00397 0.493
MOD_CDC14_SPxK_1 410 413 PF00782 0.225
MOD_CDK_SPxK_1 407 413 PF00069 0.225
MOD_CDK_SPxxK_3 407 414 PF00069 0.189
MOD_CK1_1 10 16 PF00069 0.661
MOD_CK1_1 109 115 PF00069 0.200
MOD_CK1_1 2 8 PF00069 0.703
MOD_CK1_1 222 228 PF00069 0.303
MOD_CK1_1 429 435 PF00069 0.310
MOD_CK1_1 630 636 PF00069 0.242
MOD_CK1_1 67 73 PF00069 0.225
MOD_CK2_1 163 169 PF00069 0.258
MOD_CK2_1 224 230 PF00069 0.243
MOD_CK2_1 483 489 PF00069 0.243
MOD_CK2_1 67 73 PF00069 0.315
MOD_CK2_1 93 99 PF00069 0.223
MOD_GlcNHglycan 334 337 PF01048 0.332
MOD_GlcNHglycan 42 45 PF01048 0.592
MOD_GlcNHglycan 431 434 PF01048 0.331
MOD_GlcNHglycan 638 641 PF01048 0.510
MOD_GSK3_1 138 145 PF00069 0.227
MOD_GSK3_1 163 170 PF00069 0.303
MOD_GSK3_1 219 226 PF00069 0.293
MOD_GSK3_1 243 250 PF00069 0.264
MOD_GSK3_1 280 287 PF00069 0.193
MOD_GSK3_1 417 424 PF00069 0.388
MOD_GSK3_1 425 432 PF00069 0.363
MOD_GSK3_1 450 457 PF00069 0.486
MOD_GSK3_1 495 502 PF00069 0.323
MOD_GSK3_1 632 639 PF00069 0.215
MOD_GSK3_1 64 71 PF00069 0.339
MOD_GSK3_1 7 14 PF00069 0.637
MOD_N-GLC_1 142 147 PF02516 0.392
MOD_N-GLC_1 275 280 PF02516 0.408
MOD_NEK2_1 1 6 PF00069 0.651
MOD_NEK2_1 106 111 PF00069 0.257
MOD_NEK2_1 212 217 PF00069 0.237
MOD_NEK2_1 24 29 PF00069 0.449
MOD_NEK2_1 306 311 PF00069 0.210
MOD_NEK2_1 332 337 PF00069 0.247
MOD_NEK2_1 417 422 PF00069 0.301
MOD_NEK2_1 452 457 PF00069 0.360
MOD_NEK2_1 504 509 PF00069 0.259
MOD_NEK2_1 575 580 PF00069 0.358
MOD_NEK2_1 621 626 PF00069 0.269
MOD_NEK2_1 627 632 PF00069 0.253
MOD_NEK2_1 64 69 PF00069 0.300
MOD_NEK2_1 642 647 PF00069 0.177
MOD_NEK2_2 286 291 PF00069 0.283
MOD_OFUCOSY 586 593 PF10250 0.388
MOD_PIKK_1 168 174 PF00454 0.326
MOD_PIKK_1 2 8 PF00454 0.576
MOD_PIKK_1 219 225 PF00454 0.174
MOD_PIKK_1 254 260 PF00454 0.142
MOD_PIKK_1 275 281 PF00454 0.291
MOD_PIKK_1 527 533 PF00454 0.388
MOD_PK_1 243 249 PF00069 0.243
MOD_PK_1 93 99 PF00069 0.276
MOD_PKA_1 138 144 PF00069 0.216
MOD_PKA_2 68 74 PF00069 0.360
MOD_Plk_1 168 174 PF00069 0.303
MOD_Plk_1 212 218 PF00069 0.278
MOD_Plk_1 93 99 PF00069 0.297
MOD_Plk_4 106 112 PF00069 0.214
MOD_Plk_4 24 30 PF00069 0.504
MOD_Plk_4 280 286 PF00069 0.249
MOD_Plk_4 323 329 PF00069 0.261
MOD_Plk_4 417 423 PF00069 0.324
MOD_Plk_4 426 432 PF00069 0.228
MOD_Plk_4 483 489 PF00069 0.221
MOD_Plk_4 499 505 PF00069 0.152
MOD_Plk_4 529 535 PF00069 0.440
MOD_Plk_4 621 627 PF00069 0.255
MOD_Plk_4 648 654 PF00069 0.274
MOD_Plk_4 663 669 PF00069 0.332
MOD_ProDKin_1 37 43 PF00069 0.494
MOD_ProDKin_1 407 413 PF00069 0.189
MOD_SUMO_for_1 92 95 PF00179 0.302
MOD_SUMO_rev_2 117 122 PF00179 0.330
MOD_SUMO_rev_2 134 144 PF00179 0.230
TRG_DiLeu_BaEn_2 58 64 PF01217 0.322
TRG_DiLeu_BaEn_3 231 237 PF01217 0.289
TRG_DiLeu_BaLyEn_6 18 23 PF01217 0.466
TRG_ENDOCYTIC_2 155 158 PF00928 0.233
TRG_ENDOCYTIC_2 235 238 PF00928 0.255
TRG_ENDOCYTIC_2 466 469 PF00928 0.323
TRG_ENDOCYTIC_2 557 560 PF00928 0.306
TRG_ENDOCYTIC_2 569 572 PF00928 0.139
TRG_ENDOCYTIC_2 595 598 PF00928 0.383
TRG_ENDOCYTIC_2 646 649 PF00928 0.215
TRG_ENDOCYTIC_2 674 677 PF00928 0.430
TRG_ENDOCYTIC_2 79 82 PF00928 0.214
TRG_ER_diArg_1 136 138 PF00400 0.300
TRG_ER_diArg_1 233 235 PF00400 0.142
TRG_ER_diArg_1 670 672 PF00400 0.532
TRG_NES_CRM1_1 104 118 PF08389 0.258
TRG_Pf-PMV_PEXEL_1 343 348 PF00026 0.189

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P948 Leptomonas seymouri 63% 100%
A0A0N1I2B1 Leptomonas seymouri 29% 100%
A0A0N1I6Y7 Leptomonas seymouri 30% 100%
A0A0N1IME8 Leptomonas seymouri 20% 100%
A0A0S4IV41 Bodo saltans 32% 100%
A0A0S4J9X2 Bodo saltans 40% 100%
A0A0S4JBB1 Bodo saltans 34% 100%
A0A0S4JCH7 Bodo saltans 33% 99%
A0A0S4JEU5 Bodo saltans 27% 100%
A0A0S4JIF4 Bodo saltans 37% 100%
A0A0S4JWZ9 Bodo saltans 21% 100%
A0A0S4JZ31 Bodo saltans 26% 100%
A0A1X0NJN3 Trypanosomatidae 24% 100%
A0A1X0NK64 Trypanosomatidae 29% 100%
A0A1X0NZX5 Trypanosomatidae 48% 100%
A0A1X0P2G3 Trypanosomatidae 31% 100%
A0A1X0P6M4 Trypanosomatidae 29% 89%
A0A1X0PA12 Trypanosomatidae 34% 100%
A0A3Q8IBT4 Leishmania donovani 26% 100%
A0A3Q8IFM1 Leishmania donovani 30% 100%
A0A3Q8IHT3 Leishmania donovani 29% 100%
A0A3R7MBZ3 Trypanosoma rangeli 31% 100%
A0A3S7X2L7 Leishmania donovani 99% 100%
A0A422NED2 Trypanosoma rangeli 49% 100%
A0A422NMS9 Trypanosoma rangeli 31% 100%
A4H7C1 Leishmania braziliensis 25% 100%
A4HB85 Leishmania braziliensis 28% 98%
A4HHH4 Leishmania braziliensis 81% 100%
A4HHY3 Leishmania braziliensis 29% 100%
A4HVR6 Leishmania infantum 26% 100%
A4I563 Leishmania infantum 30% 100%
A4IAD3 Leishmania infantum 29% 100%
A4IFE9 Bos taurus 27% 100%
A5D7E2 Bos taurus 32% 100%
C9ZLB0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 93%
C9ZLW2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZUX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AE21 Leishmania major 94% 100%
E9ALR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9APG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B0G0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B5F7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
F4HW17 Arabidopsis thaliana 25% 100%
F4JRE0 Arabidopsis thaliana 29% 100%
F4KIB2 Arabidopsis thaliana 32% 100%
O15321 Homo sapiens 27% 100%
P32802 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P40071 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 96%
P58021 Mus musculus 31% 100%
Q04562 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
Q4KLL4 Rattus norvegicus 33% 100%
Q4Q2H8 Leishmania major 30% 100%
Q4Q7S3 Leishmania major 29% 97%
Q4QG16 Leishmania major 21% 91%
Q54ZW0 Dictyostelium discoideum 26% 100%
Q55FP0 Dictyostelium discoideum 31% 100%
Q5R8F1 Pongo abelii 27% 100%
Q5R8Y6 Pongo abelii 30% 100%
Q5RDY2 Pongo abelii 33% 100%
Q66HF2 Rattus norvegicus 27% 100%
Q66HG5 Rattus norvegicus 30% 100%
Q7YTA6 Dictyostelium discoideum 22% 100%
Q8BH24 Mus musculus 33% 100%
Q8RWW1 Arabidopsis thaliana 32% 100%
Q92544 Homo sapiens 33% 100%
Q940G0 Arabidopsis thaliana 26% 100%
Q940S0 Arabidopsis thaliana 27% 100%
Q99805 Homo sapiens 30% 100%
Q9C5N2 Arabidopsis thaliana 33% 100%
Q9C720 Arabidopsis thaliana 33% 100%
Q9DBU0 Mus musculus 27% 100%
Q9FHT4 Arabidopsis thaliana 28% 100%
Q9FYQ8 Arabidopsis thaliana 29% 100%
Q9LIC2 Arabidopsis thaliana 32% 100%
Q9Y819 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
Q9ZPS7 Arabidopsis thaliana 27% 100%
V5BCD5 Trypanosoma cruzi 32% 100%
V5BHS7 Trypanosoma cruzi 28% 100%
V5D9U0 Trypanosoma cruzi 49% 100%
V5DII3 Trypanosoma cruzi 22% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS