Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

XPC-binding domain/UBA/TS-N domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I4M0_LEIIN

TriTrypDb:

LINF_290022500

Length:

400

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	3
GO:0005730	nucleolus	5	1
GO:0005829	cytosol	2	3
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I4M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4M0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006289	nucleotide-excision repair	6	11
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0010498	proteasomal protein catabolic process	5	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0030163	protein catabolic process	4	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003684	damaged DNA binding	5	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0005515	protein binding	2	3
GO:0031593	polyubiquitin modification-dependent protein binding	4	3
GO:0032182	ubiquitin-like protein binding	3	3
GO:0043130	ubiquitin binding	4	3
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1
GO:0140030	modification-dependent protein binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.720
CLV_C14_Caspase3-7	323	327	PF00656	0.713
CLV_C14_Caspase3-7	65	69	PF00656	0.783
CLV_PCSK_KEX2_1	135	137	PF00082	0.769
CLV_PCSK_KEX2_1	341	343	PF00082	0.582
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.769
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.582
CLV_PCSK_SKI1_1	25	29	PF00082	0.548
CLV_PCSK_SKI1_1	376	380	PF00082	0.317
CLV_PCSK_SKI1_1	89	93	PF00082	0.446
DEG_Nend_UBRbox_1	1	4	PF02207	0.400
DEG_SPOP_SBC_1	71	75	PF00917	0.713
DOC_MAPK_DCC_7	191	199	PF00069	0.403
DOC_MAPK_MEF2A_6	191	199	PF00069	0.406
DOC_MAPK_MEF2A_6	40	47	PF00069	0.374
DOC_PP1_RVXF_1	374	380	PF00149	0.306
DOC_PP1_RVXF_1	48	55	PF00149	0.455
DOC_PP4_FxxP_1	394	397	PF00568	0.473
DOC_USP7_MATH_1	126	130	PF00917	0.791
DOC_USP7_MATH_1	171	175	PF00917	0.668
DOC_USP7_MATH_1	245	249	PF00917	0.575
DOC_USP7_MATH_1	297	301	PF00917	0.673
DOC_USP7_MATH_1	331	335	PF00917	0.753
DOC_USP7_MATH_1	64	68	PF00917	0.719
DOC_USP7_MATH_1	70	74	PF00917	0.701
DOC_WW_Pin1_4	72	77	PF00397	0.727
LIG_14-3-3_CanoR_1	33	37	PF00244	0.529
LIG_14-3-3_CanoR_1	342	350	PF00244	0.530
LIG_14-3-3_CanoR_1	40	44	PF00244	0.481
LIG_Actin_WH2_2	36	52	PF00022	0.449
LIG_BIR_III_4	179	183	PF00653	0.600
LIG_BRCT_BRCA1_1	286	290	PF00533	0.507
LIG_BRCT_BRCA1_1	302	306	PF00533	0.614
LIG_EH1_1	2	10	PF00400	0.483
LIG_FHA_1	132	138	PF00498	0.750
LIG_FHA_1	22	28	PF00498	0.272
LIG_FHA_1	4	10	PF00498	0.480
LIG_FHA_1	40	46	PF00498	0.378
LIG_FHA_2	120	126	PF00498	0.546
LIG_FHA_2	269	275	PF00498	0.763
LIG_FHA_2	63	69	PF00498	0.705
LIG_LIR_Gen_1	185	195	PF02991	0.561
LIG_LIR_Gen_1	221	227	PF02991	0.552
LIG_LIR_Gen_1	231	237	PF02991	0.474
LIG_LIR_Nem_3	185	190	PF02991	0.551
LIG_LIR_Nem_3	221	226	PF02991	0.550
LIG_LIR_Nem_3	231	236	PF02991	0.474
LIG_LIR_Nem_3	287	293	PF02991	0.575
LIG_Pex14_2	54	58	PF04695	0.508
LIG_SH2_CRK	110	114	PF00017	0.629
LIG_SH2_STAT5	293	296	PF00017	0.584
LIG_SH2_STAT5	380	383	PF00017	0.366
LIG_SH3_3	142	148	PF00018	0.723
LIG_SH3_3	26	32	PF00018	0.570
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.400
LIG_SUMO_SIM_anti_2	196	201	PF11976	0.550
LIG_SUMO_SIM_anti_2	231	238	PF11976	0.496
LIG_TRAF2_1	158	161	PF00917	0.705
LIG_TRAF2_1	271	274	PF00917	0.773
LIG_TRAF2_1	354	357	PF00917	0.487
MOD_CK1_1	11	17	PF00069	0.536
MOD_CK1_1	111	117	PF00069	0.681
MOD_CK1_1	124	130	PF00069	0.632
MOD_CK1_1	292	298	PF00069	0.532
MOD_CK1_1	300	306	PF00069	0.450
MOD_CK1_1	74	80	PF00069	0.719
MOD_CK2_1	119	125	PF00069	0.631
MOD_CK2_1	138	144	PF00069	0.551
MOD_CK2_1	150	156	PF00069	0.661
MOD_CK2_1	267	273	PF00069	0.749
MOD_CK2_1	341	347	PF00069	0.664
MOD_GlcNHglycan	113	116	PF01048	0.669
MOD_GlcNHglycan	286	289	PF01048	0.606
MOD_GlcNHglycan	295	298	PF01048	0.606
MOD_GlcNHglycan	299	302	PF01048	0.616
MOD_GlcNHglycan	315	319	PF01048	0.614
MOD_GlcNHglycan	331	334	PF01048	0.752
MOD_GlcNHglycan	68	71	PF01048	0.791
MOD_GlcNHglycan	76	79	PF01048	0.569
MOD_GSK3_1	121	128	PF00069	0.714
MOD_GSK3_1	17	24	PF00069	0.486
MOD_GSK3_1	263	270	PF00069	0.734
MOD_GSK3_1	289	296	PF00069	0.556
MOD_GSK3_1	3	10	PF00069	0.394
MOD_GSK3_1	348	355	PF00069	0.580
MOD_GSK3_1	62	69	PF00069	0.708
MOD_GSK3_1	70	77	PF00069	0.520
MOD_N-GLC_1	108	113	PF02516	0.677
MOD_N-GLC_1	12	17	PF02516	0.500
MOD_N-GLC_1	329	334	PF02516	0.630
MOD_NEK2_1	1	6	PF00069	0.410
MOD_NEK2_1	267	272	PF00069	0.770
MOD_NEK2_1	289	294	PF00069	0.573
MOD_NEK2_1	314	319	PF00069	0.662
MOD_NEK2_1	348	353	PF00069	0.587
MOD_NEK2_1	39	44	PF00069	0.464
MOD_NEK2_1	8	13	PF00069	0.451
MOD_PKA_1	341	347	PF00069	0.548
MOD_PKA_2	32	38	PF00069	0.540
MOD_PKA_2	341	347	PF00069	0.548
MOD_PKA_2	387	393	PF00069	0.433
MOD_PKA_2	39	45	PF00069	0.505
MOD_PKB_1	136	144	PF00069	0.625
MOD_Plk_1	108	114	PF00069	0.637
MOD_Plk_1	12	18	PF00069	0.509
MOD_Plk_1	195	201	PF00069	0.550
MOD_Plk_1	25	31	PF00069	0.439
MOD_Plk_2-3	160	166	PF00069	0.682
MOD_Plk_2-3	263	269	PF00069	0.699
MOD_Plk_2-3	62	68	PF00069	0.574
MOD_Plk_4	101	107	PF00069	0.509
MOD_Plk_4	12	18	PF00069	0.551
MOD_Plk_4	195	201	PF00069	0.550
MOD_Plk_4	218	224	PF00069	0.547
MOD_Plk_4	229	235	PF00069	0.591
MOD_Plk_4	245	251	PF00069	0.526
MOD_Plk_4	289	295	PF00069	0.506
MOD_ProDKin_1	72	78	PF00069	0.725
MOD_SUMO_rev_2	355	362	PF00179	0.305
MOD_SUMO_rev_2	84	92	PF00179	0.489
TRG_DiLeu_BaEn_4	160	166	PF01217	0.750
TRG_ENDOCYTIC_2	110	113	PF00928	0.575
TRG_ER_diArg_1	136	139	PF00400	0.732
TRG_NLS_MonoExtC_3	134	140	PF00514	0.727
TRG_NLS_MonoExtN_4	132	139	PF00514	0.727
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I958	Leptomonas seymouri	61%	100%
A0A1X0NZX2	Trypanosomatidae	30%	100%
A0A3Q8IFF1	Leishmania donovani	100%	100%
A0A422NEC4	Trypanosoma rangeli	29%	100%
A4HHH1	Leishmania braziliensis	77%	100%
C9ZLA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	87%
E9AE18	Leishmania major	93%	98%
E9ALR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B988	Trypanosoma cruzi	27%	100%