WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I4L9_LEIIN

TriTrypDb:

LINF_290022400

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0019898	extrinsic component of membrane	2	1
GO:0034045	phagophore assembly site membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I4L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4L9

Function

Biological processes
Term	Name	Level	Count
GO:0000422	autophagy of mitochondrion	4	1
GO:0006497	protein lipidation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006914	autophagy	3	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0019538	protein metabolic process	3	1
GO:0022411	cellular component disassembly	4	1
GO:0033036	macromolecule localization	2	1
GO:0034497	protein localization to phagophore assembly site	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044804	autophagy of nucleus	4	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0061726	mitochondrion disassembly	6	1
GO:0061919	process utilizing autophagic mechanism	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903008	organelle disassembly	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0032266	phosphatidylinositol-3-phosphate binding	6	1
GO:0035091	phosphatidylinositol binding	4	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	4	1
GO:1901981	phosphatidylinositol phosphate binding	5	1
GO:1902936	phosphatidylinositol bisphosphate binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.751
CLV_NRD_NRD_1	20	22	PF00675	0.525
CLV_NRD_NRD_1	331	333	PF00675	0.780
CLV_NRD_NRD_1	96	98	PF00675	0.673
CLV_PCSK_KEX2_1	133	135	PF00082	0.728
CLV_PCSK_KEX2_1	20	22	PF00082	0.525
CLV_PCSK_KEX2_1	331	333	PF00082	0.783
CLV_PCSK_SKI1_1	407	411	PF00082	0.779
CLV_PCSK_SKI1_1	85	89	PF00082	0.524
DEG_SPOP_SBC_1	128	132	PF00917	0.600
DEG_SPOP_SBC_1	354	358	PF00917	0.633
DOC_ANK_TNKS_1	196	203	PF00023	0.593
DOC_MAPK_gen_1	231	241	PF00069	0.494
DOC_MAPK_MEF2A_6	234	243	PF00069	0.535
DOC_PP4_FxxP_1	423	426	PF00568	0.746
DOC_USP7_MATH_1	129	133	PF00917	0.608
DOC_USP7_MATH_1	168	172	PF00917	0.696
DOC_USP7_MATH_1	206	210	PF00917	0.482
DOC_USP7_MATH_1	277	281	PF00917	0.680
DOC_USP7_MATH_1	298	302	PF00917	0.710
DOC_USP7_MATH_1	317	321	PF00917	0.481
DOC_USP7_MATH_1	341	345	PF00917	0.772
DOC_USP7_MATH_1	354	358	PF00917	0.679
DOC_USP7_MATH_1	405	409	PF00917	0.686
DOC_USP7_MATH_1	49	53	PF00917	0.547
DOC_USP7_MATH_1	7	11	PF00917	0.624
DOC_USP7_MATH_1	93	97	PF00917	0.649
DOC_WW_Pin1_4	175	180	PF00397	0.597
DOC_WW_Pin1_4	287	292	PF00397	0.696
DOC_WW_Pin1_4	326	331	PF00397	0.782
DOC_WW_Pin1_4	39	44	PF00397	0.502
DOC_WW_Pin1_4	407	412	PF00397	0.768
DOC_WW_Pin1_4	424	429	PF00397	0.493
DOC_WW_Pin1_4	435	440	PF00397	0.616
LIG_14-3-3_CanoR_1	156	160	PF00244	0.682
LIG_14-3-3_CanoR_1	203	211	PF00244	0.469
LIG_14-3-3_CanoR_1	278	284	PF00244	0.637
LIG_14-3-3_CanoR_1	48	54	PF00244	0.461
LIG_14-3-3_CanoR_1	74	79	PF00244	0.513
LIG_Actin_WH2_2	57	73	PF00022	0.483
LIG_AP_GAE_1	375	381	PF02883	0.558
LIG_BRCT_BRCA1_1	170	174	PF00533	0.790
LIG_deltaCOP1_diTrp_1	369	378	PF00928	0.659
LIG_FHA_1	212	218	PF00498	0.426
LIG_FHA_1	220	226	PF00498	0.461
LIG_FHA_1	256	262	PF00498	0.432
LIG_FHA_1	382	388	PF00498	0.542
LIG_FHA_2	205	211	PF00498	0.501
LIG_LIR_Apic_2	421	426	PF02991	0.665
LIG_LIR_Gen_1	60	70	PF02991	0.478
LIG_LIR_Nem_3	60	65	PF02991	0.455
LIG_LIR_Nem_3	77	82	PF02991	0.539
LIG_PDZ_Class_2	447	452	PF00595	0.661
LIG_SH2_CRK	79	83	PF00017	0.521
LIG_SH2_NCK_1	105	109	PF00017	0.490
LIG_SH2_PTP2	22	25	PF00017	0.496
LIG_SH2_PTP2	449	452	PF00017	0.727
LIG_SH2_SRC	353	356	PF00017	0.800
LIG_SH2_STAP1	105	109	PF00017	0.497
LIG_SH2_STAP1	349	353	PF00017	0.593
LIG_SH2_STAT3	72	75	PF00017	0.515
LIG_SH2_STAT5	22	25	PF00017	0.488
LIG_SH2_STAT5	449	452	PF00017	0.735
LIG_SH2_STAT5	72	75	PF00017	0.515
LIG_SH3_3	104	110	PF00018	0.494
LIG_SH3_3	78	84	PF00018	0.500
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.484
LIG_SUMO_SIM_anti_2	51	57	PF11976	0.460
LIG_SUMO_SIM_par_1	63	69	PF11976	0.453
LIG_SUMO_SIM_par_1	86	91	PF11976	0.507
MOD_CDC14_SPxK_1	427	430	PF00782	0.776
MOD_CDK_SPK_2	326	331	PF00069	0.683
MOD_CDK_SPK_2	409	414	PF00069	0.764
MOD_CDK_SPxK_1	326	332	PF00069	0.682
MOD_CDK_SPxK_1	424	430	PF00069	0.769
MOD_CDK_SPxxK_3	407	414	PF00069	0.709
MOD_CDK_SPxxK_3	435	442	PF00069	0.728
MOD_CK1_1	146	152	PF00069	0.786
MOD_CK1_1	158	164	PF00069	0.707
MOD_CK1_1	270	276	PF00069	0.582
MOD_CK1_1	322	328	PF00069	0.725
MOD_CK1_1	433	439	PF00069	0.634
MOD_CK2_1	204	210	PF00069	0.459
MOD_CK2_1	270	276	PF00069	0.405
MOD_CK2_1	349	355	PF00069	0.730
MOD_GlcNHglycan	111	114	PF01048	0.541
MOD_GlcNHglycan	145	148	PF01048	0.728
MOD_GlcNHglycan	170	173	PF01048	0.785
MOD_GlcNHglycan	253	256	PF01048	0.497
MOD_GlcNHglycan	272	275	PF01048	0.337
MOD_GlcNHglycan	29	32	PF01048	0.282
MOD_GlcNHglycan	319	322	PF01048	0.747
MOD_GlcNHglycan	324	327	PF01048	0.762
MOD_GlcNHglycan	334	337	PF01048	0.560
MOD_GlcNHglycan	357	360	PF01048	0.732
MOD_GlcNHglycan	375	378	PF01048	0.525
MOD_GlcNHglycan	407	410	PF01048	0.784
MOD_GlcNHglycan	432	435	PF01048	0.806
MOD_GlcNHglycan	89	93	PF01048	0.444
MOD_GlcNHglycan	9	12	PF01048	0.621
MOD_GSK3_1	154	161	PF00069	0.754
MOD_GSK3_1	206	213	PF00069	0.472
MOD_GSK3_1	251	258	PF00069	0.441
MOD_GSK3_1	322	329	PF00069	0.764
MOD_GSK3_1	349	356	PF00069	0.672
MOD_GSK3_1	399	406	PF00069	0.779
MOD_N-GLC_1	166	171	PF02516	0.681
MOD_N-GLC_1	255	260	PF02516	0.452
MOD_N-GLC_1	347	352	PF02516	0.655
MOD_N-GLC_1	49	54	PF02516	0.499
MOD_N-GLC_1	7	12	PF02516	0.625
MOD_NEK2_1	159	164	PF00069	0.580
MOD_NEK2_1	204	209	PF00069	0.486
MOD_NEK2_1	211	216	PF00069	0.493
MOD_NEK2_1	217	222	PF00069	0.490
MOD_NEK2_1	26	31	PF00069	0.456
MOD_NEK2_1	88	93	PF00069	0.493
MOD_NEK2_2	255	260	PF00069	0.506
MOD_NEK2_2	418	423	PF00069	0.625
MOD_OFUCOSY	416	422	PF10250	0.626
MOD_PKA_2	155	161	PF00069	0.708
MOD_PKA_2	277	283	PF00069	0.618
MOD_Plk_1	118	124	PF00069	0.473
MOD_Plk_1	49	55	PF00069	0.494
MOD_Plk_1	7	13	PF00069	0.623
MOD_Plk_4	118	124	PF00069	0.472
MOD_Plk_4	289	295	PF00069	0.728
MOD_Plk_4	49	55	PF00069	0.470
MOD_Plk_4	74	80	PF00069	0.483
MOD_ProDKin_1	175	181	PF00069	0.585
MOD_ProDKin_1	287	293	PF00069	0.696
MOD_ProDKin_1	326	332	PF00069	0.780
MOD_ProDKin_1	39	45	PF00069	0.503
MOD_ProDKin_1	407	413	PF00069	0.767
MOD_ProDKin_1	424	430	PF00069	0.495
MOD_ProDKin_1	435	441	PF00069	0.610
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.520
TRG_ENDOCYTIC_2	22	25	PF00928	0.496
TRG_ENDOCYTIC_2	449	452	PF00928	0.658
TRG_ENDOCYTIC_2	79	82	PF00928	0.532
TRG_ER_diArg_1	20	22	PF00400	0.529
TRG_ER_diArg_1	330	332	PF00400	0.770
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER0	Leptomonas seymouri	49%	71%
A0A3S7X2H0	Leishmania donovani	100%	100%
A4HHH0	Leishmania braziliensis	79%	100%
C9ZLA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AE17	Leishmania major	94%	100%
E9ALR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%