LeishMANIAdb
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Putative GTPase activator protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative GTPase activator protein
Gene product:
GTPase activator protein - putative
Species:
Leishmania infantum
UniProt:
A4I4L7_LEIIN
TriTrypDb:
LINF_290022200
Length:
529

Annotations

LeishMANIAdb annotations

Related to animal TBC proteins. Likely cytosolic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4L7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4L7

Function

Biological processes
Term Name Level Count
GO:0043085 positive regulation of catalytic activity 4 1
GO:0043087 regulation of GTPase activity 5 1
GO:0043547 positive regulation of GTPase activity 6 1
GO:0044093 positive regulation of molecular function 3 1
GO:0050790 regulation of catalytic activity 3 1
GO:0051336 regulation of hydrolase activity 4 1
GO:0051345 positive regulation of hydrolase activity 5 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:0090630 activation of GTPase activity 7 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0003924 GTPase activity 7 5
GO:0003925 G protein activity 2 5
GO:0016462 pyrophosphatase activity 5 5
GO:0016787 hydrolase activity 2 5
GO:0016817 hydrolase activity, acting on acid anhydrides 3 5
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 5
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 5
GO:0098772 molecular function regulator activity 1 5
GO:0005096 GTPase activator activity 4 1
GO:0008047 enzyme activator activity 3 1
GO:0030234 enzyme regulator activity 2 1
GO:0030695 GTPase regulator activity 4 1
GO:0060589 nucleoside-triphosphatase regulator activity 3 1
GO:0140677 molecular function activator activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 7 11 PF00656 0.677
CLV_NRD_NRD_1 188 190 PF00675 0.415
CLV_NRD_NRD_1 35 37 PF00675 0.532
CLV_NRD_NRD_1 455 457 PF00675 0.401
CLV_NRD_NRD_1 485 487 PF00675 0.338
CLV_NRD_NRD_1 509 511 PF00675 0.394
CLV_NRD_NRD_1 92 94 PF00675 0.479
CLV_PCSK_KEX2_1 190 192 PF00082 0.381
CLV_PCSK_KEX2_1 35 37 PF00082 0.535
CLV_PCSK_KEX2_1 455 457 PF00082 0.348
CLV_PCSK_KEX2_1 485 487 PF00082 0.337
CLV_PCSK_KEX2_1 509 511 PF00082 0.396
CLV_PCSK_KEX2_1 92 94 PF00082 0.479
CLV_PCSK_PC1ET2_1 190 192 PF00082 0.365
DEG_SCF_FBW7_2 73 79 PF00400 0.670
DOC_CKS1_1 142 147 PF01111 0.682
DOC_CKS1_1 165 170 PF01111 0.542
DOC_CKS1_1 70 75 PF01111 0.731
DOC_CYCLIN_yClb3_PxF_3 278 286 PF00134 0.450
DOC_MAPK_gen_1 375 383 PF00069 0.354
DOC_MAPK_gen_1 485 493 PF00069 0.566
DOC_MAPK_MEF2A_6 230 237 PF00069 0.448
DOC_MAPK_MEF2A_6 329 337 PF00069 0.314
DOC_MAPK_MEF2A_6 421 430 PF00069 0.514
DOC_MAPK_NFAT4_5 230 238 PF00069 0.448
DOC_PP1_RVXF_1 160 166 PF00149 0.548
DOC_PP1_RVXF_1 228 235 PF00149 0.477
DOC_PP4_FxxP_1 132 135 PF00568 0.601
DOC_PP4_FxxP_1 165 168 PF00568 0.599
DOC_USP7_MATH_1 116 120 PF00917 0.660
DOC_USP7_MATH_1 126 130 PF00917 0.728
DOC_USP7_MATH_1 147 151 PF00917 0.630
DOC_USP7_MATH_1 166 170 PF00917 0.435
DOC_USP7_MATH_1 55 59 PF00917 0.733
DOC_USP7_MATH_1 61 65 PF00917 0.704
DOC_USP7_MATH_1 81 85 PF00917 0.753
DOC_USP7_MATH_1 98 102 PF00917 0.723
DOC_USP7_UBL2_3 190 194 PF12436 0.573
DOC_WW_Pin1_4 130 135 PF00397 0.740
DOC_WW_Pin1_4 141 146 PF00397 0.605
DOC_WW_Pin1_4 164 169 PF00397 0.563
DOC_WW_Pin1_4 206 211 PF00397 0.570
DOC_WW_Pin1_4 412 417 PF00397 0.534
DOC_WW_Pin1_4 419 424 PF00397 0.489
DOC_WW_Pin1_4 474 479 PF00397 0.511
DOC_WW_Pin1_4 69 74 PF00397 0.738
LIG_14-3-3_CanoR_1 200 205 PF00244 0.527
LIG_14-3-3_CanoR_1 455 462 PF00244 0.534
LIG_14-3-3_CanoR_1 469 475 PF00244 0.457
LIG_14-3-3_CanoR_1 56 60 PF00244 0.612
LIG_Actin_WH2_2 215 232 PF00022 0.491
LIG_APCC_ABBA_1 335 340 PF00400 0.242
LIG_BRCT_BRCA1_1 128 132 PF00533 0.604
LIG_BRCT_BRCA1_1 311 315 PF00533 0.384
LIG_Clathr_ClatBox_1 321 325 PF01394 0.292
LIG_DCNL_PONY_1 1 4 PF03556 0.589
LIG_eIF4E_1 249 255 PF01652 0.514
LIG_eIF4E_1 462 468 PF01652 0.519
LIG_FHA_1 292 298 PF00498 0.494
LIG_FHA_1 328 334 PF00498 0.236
LIG_FHA_1 456 462 PF00498 0.518
LIG_FHA_2 165 171 PF00498 0.545
LIG_FHA_2 181 187 PF00498 0.469
LIG_FHA_2 5 11 PF00498 0.661
LIG_GBD_Chelix_1 316 324 PF00786 0.414
LIG_LIR_Apic_2 129 135 PF02991 0.602
LIG_LIR_Gen_1 156 165 PF02991 0.653
LIG_LIR_Gen_1 312 321 PF02991 0.292
LIG_LIR_Gen_1 330 338 PF02991 0.248
LIG_LIR_Gen_1 393 402 PF02991 0.369
LIG_LIR_Nem_3 156 160 PF02991 0.573
LIG_LIR_Nem_3 192 198 PF02991 0.505
LIG_LIR_Nem_3 312 316 PF02991 0.301
LIG_LIR_Nem_3 328 334 PF02991 0.327
LIG_LIR_Nem_3 393 398 PF02991 0.369
LIG_PCNA_yPIPBox_3 358 371 PF02747 0.261
LIG_Pex14_1 408 412 PF04695 0.535
LIG_Pex14_2 315 319 PF04695 0.384
LIG_Pex14_2 395 399 PF04695 0.351
LIG_PTB_Apo_2 27 34 PF02174 0.579
LIG_PTB_Apo_2 341 348 PF02174 0.272
LIG_PTB_Phospho_1 341 347 PF10480 0.272
LIG_SH2_NCK_1 462 466 PF00017 0.523
LIG_SH2_STAP1 462 466 PF00017 0.523
LIG_SH2_STAT5 249 252 PF00017 0.534
LIG_SH2_STAT5 260 263 PF00017 0.539
LIG_SH2_STAT5 282 285 PF00017 0.448
LIG_SH2_STAT5 309 312 PF00017 0.332
LIG_SH2_STAT5 410 413 PF00017 0.514
LIG_SH2_STAT5 435 438 PF00017 0.514
LIG_SH3_1 275 281 PF00018 0.473
LIG_SH3_3 165 171 PF00018 0.587
LIG_SH3_3 258 264 PF00018 0.493
LIG_SH3_3 275 281 PF00018 0.442
LIG_SH3_3 70 76 PF00018 0.752
LIG_Sin3_3 464 471 PF02671 0.536
LIG_SUMO_SIM_par_1 319 328 PF11976 0.292
LIG_SUMO_SIM_par_1 489 494 PF11976 0.643
LIG_TRAF2_1 38 41 PF00917 0.645
LIG_UBA3_1 1 9 PF00899 0.596
MOD_CDC14_SPxK_1 133 136 PF00782 0.602
MOD_CDK_SPK_2 474 479 PF00069 0.512
MOD_CDK_SPxK_1 130 136 PF00069 0.604
MOD_CK1_1 150 156 PF00069 0.592
MOD_CK1_1 180 186 PF00069 0.540
MOD_CK1_1 82 88 PF00069 0.761
MOD_CK2_1 164 170 PF00069 0.566
MOD_CK2_1 180 186 PF00069 0.638
MOD_GlcNHglycan 106 109 PF01048 0.467
MOD_GlcNHglycan 120 123 PF01048 0.460
MOD_GlcNHglycan 17 21 PF01048 0.520
MOD_GlcNHglycan 206 209 PF01048 0.320
MOD_GlcNHglycan 49 52 PF01048 0.529
MOD_GlcNHglycan 523 526 PF01048 0.415
MOD_GlcNHglycan 63 66 PF01048 0.487
MOD_GlcNHglycan 89 92 PF01048 0.588
MOD_GlcNHglycan 94 97 PF01048 0.470
MOD_GSK3_1 126 133 PF00069 0.670
MOD_GSK3_1 146 153 PF00069 0.545
MOD_GSK3_1 200 207 PF00069 0.577
MOD_GSK3_1 233 240 PF00069 0.491
MOD_GSK3_1 305 312 PF00069 0.364
MOD_GSK3_1 470 477 PF00069 0.493
MOD_GSK3_1 5 12 PF00069 0.740
MOD_GSK3_1 71 78 PF00069 0.721
MOD_NEK2_1 16 21 PF00069 0.607
MOD_NEK2_1 204 209 PF00069 0.501
MOD_NEK2_1 233 238 PF00069 0.469
MOD_NEK2_1 4 9 PF00069 0.631
MOD_NEK2_1 426 431 PF00069 0.501
MOD_NEK2_1 450 455 PF00069 0.568
MOD_NEK2_1 470 475 PF00069 0.378
MOD_NEK2_1 54 59 PF00069 0.660
MOD_NEK2_2 390 395 PF00069 0.414
MOD_NEK2_2 98 103 PF00069 0.667
MOD_PIKK_1 177 183 PF00454 0.594
MOD_PIKK_1 82 88 PF00454 0.707
MOD_PKA_1 455 461 PF00069 0.500
MOD_PKA_1 92 98 PF00069 0.672
MOD_PKA_2 455 461 PF00069 0.524
MOD_PKA_2 55 61 PF00069 0.619
MOD_PKA_2 92 98 PF00069 0.672
MOD_Plk_1 155 161 PF00069 0.594
MOD_Plk_1 327 333 PF00069 0.293
MOD_Plk_1 426 432 PF00069 0.470
MOD_Plk_4 127 133 PF00069 0.647
MOD_Plk_4 200 206 PF00069 0.537
MOD_Plk_4 347 353 PF00069 0.287
MOD_Plk_4 382 388 PF00069 0.260
MOD_Plk_4 390 396 PF00069 0.299
MOD_ProDKin_1 130 136 PF00069 0.743
MOD_ProDKin_1 141 147 PF00069 0.604
MOD_ProDKin_1 164 170 PF00069 0.564
MOD_ProDKin_1 206 212 PF00069 0.568
MOD_ProDKin_1 412 418 PF00069 0.534
MOD_ProDKin_1 419 425 PF00069 0.489
MOD_ProDKin_1 474 480 PF00069 0.510
MOD_ProDKin_1 69 75 PF00069 0.739
MOD_SUMO_for_1 135 138 PF00179 0.606
MOD_SUMO_rev_2 362 370 PF00179 0.250
MOD_SUMO_rev_2 39 45 PF00179 0.665
TRG_DiLeu_BaEn_4 40 46 PF01217 0.598
TRG_DiLeu_BaLyEn_6 302 307 PF01217 0.448
TRG_ER_diArg_1 34 36 PF00400 0.579
TRG_ER_diArg_1 454 456 PF00400 0.565
TRG_ER_diArg_1 484 486 PF00400 0.504
TRG_ER_diArg_1 509 511 PF00400 0.598

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2C6 Leptomonas seymouri 76% 70%
A0A1X0P1D7 Trypanosomatidae 44% 94%
A0A3Q8IEG1 Leishmania donovani 99% 100%
A4HHG8 Leishmania braziliensis 75% 100%
A4HQC7 Leishmania braziliensis 27% 100%
E9AE15 Leishmania major 92% 100%
E9ALR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AU42 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
P87234 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 83%
V5BDT8 Trypanosoma cruzi 46% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS