Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4L6_LEIIN

TriTrypDb:

LINF_290022100

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4L6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.542
CLV_C14_Caspase3-7	699	703	PF00656	0.600
CLV_NRD_NRD_1	123	125	PF00675	0.560
CLV_NRD_NRD_1	141	143	PF00675	0.573
CLV_NRD_NRD_1	245	247	PF00675	0.490
CLV_NRD_NRD_1	329	331	PF00675	0.557
CLV_NRD_NRD_1	401	403	PF00675	0.429
CLV_NRD_NRD_1	55	57	PF00675	0.618
CLV_NRD_NRD_1	555	557	PF00675	0.420
CLV_NRD_NRD_1	72	74	PF00675	0.528
CLV_NRD_NRD_1	740	742	PF00675	0.609
CLV_NRD_NRD_1	751	753	PF00675	0.449
CLV_PCSK_KEX2_1	123	125	PF00082	0.573
CLV_PCSK_KEX2_1	245	247	PF00082	0.410
CLV_PCSK_KEX2_1	329	331	PF00082	0.680
CLV_PCSK_KEX2_1	395	397	PF00082	0.464
CLV_PCSK_KEX2_1	401	403	PF00082	0.417
CLV_PCSK_KEX2_1	55	57	PF00082	0.618
CLV_PCSK_KEX2_1	555	557	PF00082	0.420
CLV_PCSK_KEX2_1	72	74	PF00082	0.528
CLV_PCSK_KEX2_1	740	742	PF00082	0.609
CLV_PCSK_KEX2_1	751	753	PF00082	0.449
CLV_PCSK_KEX2_1	87	89	PF00082	0.536
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.371
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.662
CLV_PCSK_SKI1_1	245	249	PF00082	0.407
CLV_PCSK_SKI1_1	427	431	PF00082	0.435
CLV_PCSK_SKI1_1	476	480	PF00082	0.406
CLV_PCSK_SKI1_1	517	521	PF00082	0.496
CLV_PCSK_SKI1_1	555	559	PF00082	0.421
DEG_APCC_DBOX_1	244	252	PF00400	0.402
DEG_COP1_1	378	387	PF00400	0.412
DEG_Nend_Nbox_1	1	3	PF02207	0.470
DEG_SCF_FBW7_1	254	261	PF00400	0.396
DEG_SCF_FBW7_2	183	189	PF00400	0.499
DOC_CKS1_1	183	188	PF01111	0.501
DOC_CKS1_1	255	260	PF01111	0.402
DOC_CKS1_1	612	617	PF01111	0.484
DOC_CYCLIN_RxL_1	19	28	PF00134	0.469
DOC_CYCLIN_RxL_1	550	560	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	483	489	PF00134	0.460
DOC_MAPK_gen_1	401	408	PF00069	0.385
DOC_PP1_RVXF_1	425	432	PF00149	0.458
DOC_PP4_FxxP_1	612	615	PF00568	0.474
DOC_PP4_FxxP_1	623	626	PF00568	0.528
DOC_USP7_MATH_1	108	112	PF00917	0.599
DOC_USP7_MATH_1	129	133	PF00917	0.572
DOC_USP7_MATH_1	176	180	PF00917	0.558
DOC_USP7_MATH_1	213	217	PF00917	0.490
DOC_USP7_MATH_1	247	251	PF00917	0.399
DOC_USP7_MATH_1	459	463	PF00917	0.580
DOC_USP7_MATH_1	532	536	PF00917	0.480
DOC_USP7_MATH_1	713	717	PF00917	0.591
DOC_USP7_MATH_1	81	85	PF00917	0.629
DOC_USP7_MATH_2	108	114	PF00917	0.526
DOC_WW_Pin1_4	125	130	PF00397	0.579
DOC_WW_Pin1_4	182	187	PF00397	0.491
DOC_WW_Pin1_4	254	259	PF00397	0.399
DOC_WW_Pin1_4	323	328	PF00397	0.519
DOC_WW_Pin1_4	383	388	PF00397	0.355
DOC_WW_Pin1_4	611	616	PF00397	0.479
DOC_WW_Pin1_4	764	769	PF00397	0.751
DOC_WW_Pin1_4	783	788	PF00397	0.451
LIG_14-3-3_CanoR_1	22	27	PF00244	0.473
LIG_14-3-3_CanoR_1	246	252	PF00244	0.485
LIG_14-3-3_CanoR_1	304	312	PF00244	0.484
LIG_14-3-3_CanoR_1	418	424	PF00244	0.440
LIG_14-3-3_CanoR_1	537	545	PF00244	0.466
LIG_14-3-3_CanoR_1	602	607	PF00244	0.492
LIG_14-3-3_CanoR_1	755	763	PF00244	0.480
LIG_14-3-3_CanoR_1	99	108	PF00244	0.523
LIG_BIR_III_4	722	726	PF00653	0.522
LIG_BRCT_BRCA1_1	36	40	PF00533	0.443
LIG_BRCT_BRCA1_1	581	585	PF00533	0.522
LIG_CaM_IQ_9	435	451	PF13499	0.470
LIG_CtBP_PxDLS_1	23	27	PF00389	0.472
LIG_DCNL_PONY_1	1	4	PF03556	0.470
LIG_EH1_1	843	851	PF00400	0.490
LIG_FHA_1	202	208	PF00498	0.520
LIG_FHA_1	323	329	PF00498	0.576
LIG_FHA_1	334	340	PF00498	0.379
LIG_FHA_1	378	384	PF00498	0.522
LIG_FHA_1	537	543	PF00498	0.534
LIG_FHA_1	734	740	PF00498	0.550
LIG_FHA_1	814	820	PF00498	0.596
LIG_FHA_1	821	827	PF00498	0.619
LIG_FHA_1	831	837	PF00498	0.546
LIG_FHA_2	151	157	PF00498	0.597
LIG_FHA_2	160	166	PF00498	0.524
LIG_FHA_2	255	261	PF00498	0.400
LIG_FHA_2	420	426	PF00498	0.451
LIG_FHA_2	518	524	PF00498	0.472
LIG_FHA_2	697	703	PF00498	0.602
LIG_FHA_2	800	806	PF00498	0.571
LIG_LIR_Apic_2	138	144	PF02991	0.563
LIG_LIR_Apic_2	609	615	PF02991	0.654
LIG_LIR_Apic_2	621	626	PF02991	0.523
LIG_LIR_Gen_1	279	288	PF02991	0.393
LIG_LIR_Gen_1	421	431	PF02991	0.430
LIG_LIR_Nem_3	253	259	PF02991	0.400
LIG_LIR_Nem_3	279	284	PF02991	0.401
LIG_LIR_Nem_3	37	43	PF02991	0.447
LIG_LIR_Nem_3	421	426	PF02991	0.428
LIG_LIR_Nem_3	524	530	PF02991	0.505
LIG_MLH1_MIPbox_1	36	40	PF16413	0.443
LIG_NRBOX	250	256	PF00104	0.408
LIG_NRBOX	553	559	PF00104	0.445
LIG_PCNA_APIM_2	739	745	PF02747	0.512
LIG_PCNA_yPIPBox_3	467	479	PF02747	0.525
LIG_Pex14_2	35	39	PF04695	0.442
LIG_Pex14_2	40	44	PF04695	0.446
LIG_SH2_CRK	141	145	PF00017	0.570
LIG_SH2_CRK	281	285	PF00017	0.392
LIG_SH2_CRK	564	568	PF00017	0.435
LIG_SH2_CRK	796	800	PF00017	0.539
LIG_SH2_NCK_1	256	260	PF00017	0.444
LIG_SH2_STAP1	281	285	PF00017	0.392
LIG_SH2_STAP1	607	611	PF00017	0.486
LIG_SH2_STAT3	607	610	PF00017	0.488
LIG_SH2_STAT5	256	259	PF00017	0.448
LIG_SH2_STAT5	399	402	PF00017	0.410
LIG_SH2_STAT5	52	55	PF00017	0.484
LIG_SH2_STAT5	543	546	PF00017	0.532
LIG_SH2_STAT5	742	745	PF00017	0.511
LIG_SH2_STAT5	844	847	PF00017	0.497
LIG_SH3_2	735	740	PF14604	0.547
LIG_SH3_3	17	23	PF00018	0.465
LIG_SH3_3	180	186	PF00018	0.522
LIG_SH3_3	294	300	PF00018	0.417
LIG_SH3_3	381	387	PF00018	0.425
LIG_SH3_3	721	727	PF00018	0.660
LIG_SH3_3	729	735	PF00018	0.569
LIG_Sin3_3	648	655	PF02671	0.440
LIG_SUMO_SIM_anti_2	134	141	PF11976	0.557
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.366
LIG_SUMO_SIM_anti_2	656	663	PF11976	0.472
LIG_SUMO_SIM_par_1	22	28	PF11976	0.472
LIG_SUMO_SIM_par_1	386	392	PF11976	0.576
LIG_SUMO_SIM_par_1	485	491	PF11976	0.470
LIG_SUMO_SIM_par_1	796	805	PF11976	0.532
LIG_TRAF2_1	133	136	PF00917	0.568
LIG_TRAF2_1	503	506	PF00917	0.450
LIG_TRAF2_1	802	805	PF00917	0.570
LIG_TRFH_1	611	615	PF08558	0.469
LIG_TYR_ITIM	254	259	PF00017	0.428
LIG_TYR_ITIM	408	413	PF00017	0.396
LIG_TYR_ITIM	794	799	PF00017	0.525
LIG_WW_3	19	23	PF00397	0.465
MOD_CDK_SPxK_1	323	329	PF00069	0.486
MOD_CDK_SPxxK_3	323	330	PF00069	0.487
MOD_CK1_1	102	108	PF00069	0.522
MOD_CK1_1	306	312	PF00069	0.432
MOD_CK1_1	34	40	PF00069	0.443
MOD_CK1_1	421	427	PF00069	0.437
MOD_CK1_1	579	585	PF00069	0.535
MOD_CK1_1	9	15	PF00069	0.449
MOD_CK2_1	129	135	PF00069	0.572
MOD_CK2_1	151	157	PF00069	0.551
MOD_CK2_1	163	169	PF00069	0.662
MOD_CK2_1	419	425	PF00069	0.458
MOD_CK2_1	459	465	PF00069	0.557
MOD_CK2_1	517	523	PF00069	0.501
MOD_CK2_1	799	805	PF00069	0.565
MOD_CMANNOS	673	676	PF00535	0.541
MOD_Cter_Amidation	70	73	PF01082	0.550
MOD_GlcNHglycan	101	104	PF01048	0.539
MOD_GlcNHglycan	112	115	PF01048	0.516
MOD_GlcNHglycan	131	134	PF01048	0.627
MOD_GlcNHglycan	153	156	PF01048	0.616
MOD_GlcNHglycan	173	177	PF01048	0.542
MOD_GlcNHglycan	178	181	PF01048	0.529
MOD_GlcNHglycan	236	239	PF01048	0.530
MOD_GlcNHglycan	260	264	PF01048	0.441
MOD_GlcNHglycan	308	311	PF01048	0.402
MOD_GlcNHglycan	349	352	PF01048	0.516
MOD_GlcNHglycan	353	356	PF01048	0.537
MOD_GlcNHglycan	460	464	PF01048	0.589
MOD_GlcNHglycan	49	52	PF01048	0.459
MOD_GlcNHglycan	582	585	PF01048	0.521
MOD_GlcNHglycan	714	718	PF01048	0.601
MOD_GlcNHglycan	719	722	PF01048	0.575
MOD_GlcNHglycan	759	762	PF01048	0.535
MOD_GlcNHglycan	8	11	PF01048	0.447
MOD_GlcNHglycan	96	99	PF01048	0.588
MOD_GSK3_1	102	109	PF00069	0.531
MOD_GSK3_1	125	132	PF00069	0.577
MOD_GSK3_1	146	153	PF00069	0.581
MOD_GSK3_1	159	166	PF00069	0.533
MOD_GSK3_1	172	179	PF00069	0.490
MOD_GSK3_1	201	208	PF00069	0.494
MOD_GSK3_1	220	227	PF00069	0.479
MOD_GSK3_1	254	261	PF00069	0.474
MOD_GSK3_1	304	311	PF00069	0.480
MOD_GSK3_1	31	38	PF00069	0.444
MOD_GSK3_1	347	354	PF00069	0.522
MOD_GSK3_1	47	54	PF00069	0.435
MOD_GSK3_1	517	524	PF00069	0.571
MOD_GSK3_1	532	539	PF00069	0.452
MOD_GSK3_1	576	583	PF00069	0.511
MOD_GSK3_1	703	710	PF00069	0.656
MOD_GSK3_1	713	720	PF00069	0.542
MOD_GSK3_1	757	764	PF00069	0.571
MOD_GSK3_1	779	786	PF00069	0.528
MOD_GSK3_1	94	101	PF00069	0.555
MOD_LATS_1	148	154	PF00433	0.595
MOD_N-GLC_1	201	206	PF02516	0.493
MOD_NEK2_1	172	177	PF00069	0.500
MOD_NEK2_1	303	308	PF00069	0.460
MOD_NEK2_1	333	338	PF00069	0.485
MOD_NEK2_1	35	40	PF00069	0.443
MOD_NEK2_1	47	52	PF00069	0.435
MOD_NEK2_1	569	574	PF00069	0.491
MOD_NEK2_1	576	581	PF00069	0.542
MOD_NEK2_1	585	590	PF00069	0.451
MOD_NEK2_1	641	646	PF00069	0.429
MOD_NEK2_2	213	218	PF00069	0.467
MOD_PIKK_1	226	232	PF00454	0.433
MOD_PIKK_1	621	627	PF00454	0.522
MOD_PKA_2	146	152	PF00069	0.572
MOD_PKA_2	303	309	PF00069	0.466
MOD_PKA_2	536	542	PF00069	0.503
MOD_PKA_2	98	104	PF00069	0.561
MOD_PKB_1	203	211	PF00069	0.532
MOD_Plk_1	135	141	PF00069	0.557
MOD_Plk_1	213	219	PF00069	0.510
MOD_Plk_1	517	523	PF00069	0.491
MOD_Plk_2-3	707	713	PF00069	0.572
MOD_Plk_4	135	141	PF00069	0.557
MOD_Plk_4	280	286	PF00069	0.544
MOD_Plk_4	35	41	PF00069	0.445
MOD_Plk_4	488	494	PF00069	0.527
MOD_Plk_4	602	608	PF00069	0.609
MOD_Plk_4	657	663	PF00069	0.472
MOD_ProDKin_1	125	131	PF00069	0.577
MOD_ProDKin_1	182	188	PF00069	0.487
MOD_ProDKin_1	254	260	PF00069	0.399
MOD_ProDKin_1	323	329	PF00069	0.521
MOD_ProDKin_1	383	389	PF00069	0.358
MOD_ProDKin_1	611	617	PF00069	0.479
MOD_ProDKin_1	764	770	PF00069	0.750
MOD_ProDKin_1	783	789	PF00069	0.450
MOD_SUMO_for_1	677	680	PF00179	0.480
MOD_SUMO_for_1	688	691	PF00179	0.647
TRG_DiLeu_BaEn_1	135	140	PF01217	0.554
TRG_DiLeu_BaEn_1	657	662	PF01217	0.471
TRG_DiLeu_BaEn_4	636	642	PF01217	0.441
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.521
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.438
TRG_ENDOCYTIC_2	256	259	PF00928	0.448
TRG_ENDOCYTIC_2	281	284	PF00928	0.395
TRG_ENDOCYTIC_2	410	413	PF00928	0.404
TRG_ENDOCYTIC_2	791	794	PF00928	0.531
TRG_ENDOCYTIC_2	796	799	PF00928	0.523
TRG_ER_diArg_1	144	147	PF00400	0.581
TRG_ER_diArg_1	328	330	PF00400	0.565
TRG_ER_diArg_1	400	402	PF00400	0.432
TRG_ER_diArg_1	554	556	PF00400	0.482
TRG_ER_diArg_1	739	741	PF00400	0.583
TRG_NLS_MonoCore_2	141	146	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	555	560	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM3	Leptomonas seymouri	45%	100%
A0A3Q8IHB4	Leishmania donovani	100%	100%
E9ALR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%