LeishMANIAdb
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Nodulin-like domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nodulin-like domain-containing protein
Gene product:
Nodulin-like - putative
Species:
Leishmania infantum
UniProt:
A4I4L2_LEIIN
TriTrypDb:
LINF_290021400 *
Length:
672

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 78
NetGPI no yes: 0, no: 78
Cellular components
Term Name Level Count
GO:0016020 membrane 2 72
GO:0110165 cellular anatomical entity 1 72
GO:0005737 cytoplasm 2 3

Phosphorylation

Promastigote: 350, 351, 373, 404

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4L2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4L2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 36
GO:0022857 transmembrane transporter activity 2 36

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 341 345 PF00656 0.679
CLV_NRD_NRD_1 223 225 PF00675 0.315
CLV_NRD_NRD_1 239 241 PF00675 0.274
CLV_NRD_NRD_1 509 511 PF00675 0.335
CLV_NRD_NRD_1 648 650 PF00675 0.384
CLV_PCSK_FUR_1 646 650 PF00082 0.235
CLV_PCSK_KEX2_1 239 241 PF00082 0.279
CLV_PCSK_KEX2_1 304 306 PF00082 0.387
CLV_PCSK_KEX2_1 509 511 PF00082 0.314
CLV_PCSK_KEX2_1 648 650 PF00082 0.386
CLV_PCSK_PC1ET2_1 304 306 PF00082 0.417
CLV_PCSK_SKI1_1 224 228 PF00082 0.354
CLV_PCSK_SKI1_1 326 330 PF00082 0.469
CLV_PCSK_SKI1_1 437 441 PF00082 0.347
CLV_PCSK_SKI1_1 510 514 PF00082 0.379
CLV_PCSK_SKI1_1 596 600 PF00082 0.274
CLV_PCSK_SKI1_1 75 79 PF00082 0.222
DEG_Nend_UBRbox_1 1 4 PF02207 0.613
DEG_SPOP_SBC_1 23 27 PF00917 0.291
DOC_CKS1_1 205 210 PF01111 0.562
DOC_CYCLIN_RxL_1 432 443 PF00134 0.554
DOC_CYCLIN_yCln2_LP_2 546 552 PF00134 0.238
DOC_MAPK_gen_1 103 112 PF00069 0.340
DOC_MAPK_gen_1 224 230 PF00069 0.481
DOC_MAPK_gen_1 268 275 PF00069 0.337
DOC_MAPK_MEF2A_6 268 277 PF00069 0.326
DOC_MAPK_MEF2A_6 437 446 PF00069 0.554
DOC_MAPK_MEF2A_6 481 488 PF00069 0.232
DOC_MAPK_MEF2A_6 623 630 PF00069 0.244
DOC_MAPK_RevD_3 255 269 PF00069 0.462
DOC_MAPK_RevD_3 291 305 PF00069 0.512
DOC_MAPK_RevD_3 497 511 PF00069 0.192
DOC_PP1_RVXF_1 73 79 PF00149 0.509
DOC_PP2B_LxvP_1 546 549 PF13499 0.246
DOC_PP4_FxxP_1 121 124 PF00568 0.381
DOC_PP4_FxxP_1 71 74 PF00568 0.457
DOC_USP7_MATH_1 23 27 PF00917 0.251
DOC_USP7_MATH_1 256 260 PF00917 0.359
DOC_USP7_MATH_1 405 409 PF00917 0.766
DOC_WW_Pin1_4 204 209 PF00397 0.532
DOC_WW_Pin1_4 401 406 PF00397 0.720
LIG_14-3-3_CanoR_1 224 229 PF00244 0.519
LIG_14-3-3_CanoR_1 349 353 PF00244 0.713
LIG_14-3-3_CanoR_1 38 44 PF00244 0.337
LIG_14-3-3_CanoR_1 481 485 PF00244 0.305
LIG_14-3-3_CanoR_1 509 519 PF00244 0.542
LIG_APCC_ABBA_1 30 35 PF00400 0.397
LIG_BRCT_BRCA1_1 470 474 PF00533 0.323
LIG_BRCT_BRCA1_1 533 537 PF00533 0.175
LIG_BRCT_BRCA1_1 584 588 PF00533 0.276
LIG_Clathr_ClatBox_1 439 443 PF01394 0.523
LIG_deltaCOP1_diTrp_1 443 452 PF00928 0.327
LIG_eIF4E_1 9 15 PF01652 0.509
LIG_FHA_1 155 161 PF00498 0.305
LIG_FHA_1 225 231 PF00498 0.509
LIG_FHA_1 260 266 PF00498 0.408
LIG_FHA_1 32 38 PF00498 0.282
LIG_FHA_1 439 445 PF00498 0.454
LIG_FHA_1 455 461 PF00498 0.319
LIG_FHA_1 513 519 PF00498 0.612
LIG_FHA_1 589 595 PF00498 0.257
LIG_FHA_2 394 400 PF00498 0.756
LIG_IRF3_LxIS_1 18 25 PF10401 0.164
LIG_IRF3_LxIS_1 252 258 PF10401 0.160
LIG_LIR_Apic_2 70 74 PF02991 0.443
LIG_LIR_Gen_1 141 152 PF02991 0.461
LIG_LIR_Gen_1 180 190 PF02991 0.253
LIG_LIR_Gen_1 27 37 PF02991 0.352
LIG_LIR_Gen_1 270 280 PF02991 0.261
LIG_LIR_Gen_1 327 338 PF02991 0.596
LIG_LIR_Gen_1 483 491 PF02991 0.287
LIG_LIR_Gen_1 534 543 PF02991 0.319
LIG_LIR_Nem_3 141 147 PF02991 0.443
LIG_LIR_Nem_3 151 155 PF02991 0.332
LIG_LIR_Nem_3 176 182 PF02991 0.284
LIG_LIR_Nem_3 27 33 PF02991 0.341
LIG_LIR_Nem_3 270 275 PF02991 0.272
LIG_LIR_Nem_3 327 333 PF02991 0.593
LIG_LIR_Nem_3 434 439 PF02991 0.481
LIG_LIR_Nem_3 471 477 PF02991 0.282
LIG_LIR_Nem_3 483 488 PF02991 0.295
LIG_LIR_Nem_3 520 526 PF02991 0.217
LIG_LIR_Nem_3 534 540 PF02991 0.236
LIG_LYPXL_yS_3 299 302 PF13949 0.557
LIG_PALB2_WD40_1 163 171 PF16756 0.164
LIG_Pex14_1 448 452 PF04695 0.300
LIG_Pex14_2 164 168 PF04695 0.273
LIG_Pex14_2 447 451 PF04695 0.240
LIG_Pex14_2 584 588 PF04695 0.310
LIG_Pex14_2 599 603 PF04695 0.302
LIG_Pex14_2 92 96 PF04695 0.223
LIG_PTB_Apo_2 162 169 PF02174 0.299
LIG_SH2_CRK 144 148 PF00017 0.509
LIG_SH2_GRB2like 163 166 PF00017 0.326
LIG_SH2_GRB2like 572 575 PF00017 0.521
LIG_SH2_PTP2 19 22 PF00017 0.316
LIG_SH2_PTP2 485 488 PF00017 0.215
LIG_SH2_STAP1 182 186 PF00017 0.255
LIG_SH2_STAP1 314 318 PF00017 0.451
LIG_SH2_STAP1 572 576 PF00017 0.456
LIG_SH2_STAT3 231 234 PF00017 0.502
LIG_SH2_STAT5 120 123 PF00017 0.315
LIG_SH2_STAT5 163 166 PF00017 0.269
LIG_SH2_STAT5 184 187 PF00017 0.297
LIG_SH2_STAT5 19 22 PF00017 0.345
LIG_SH2_STAT5 199 202 PF00017 0.286
LIG_SH2_STAT5 206 209 PF00017 0.463
LIG_SH2_STAT5 242 245 PF00017 0.295
LIG_SH2_STAT5 264 267 PF00017 0.348
LIG_SH2_STAT5 272 275 PF00017 0.263
LIG_SH2_STAT5 485 488 PF00017 0.250
LIG_SH2_STAT5 535 538 PF00017 0.264
LIG_SH2_STAT5 60 63 PF00017 0.276
LIG_SH3_1 304 310 PF00018 0.586
LIG_SH3_3 133 139 PF00018 0.491
LIG_SH3_3 202 208 PF00018 0.450
LIG_SH3_3 304 310 PF00018 0.586
LIG_SH3_3 356 362 PF00018 0.682
LIG_SH3_3 73 79 PF00018 0.487
LIG_SUMO_SIM_par_1 281 287 PF11976 0.366
LIG_SUMO_SIM_par_1 438 443 PF11976 0.486
LIG_TRAF2_1 396 399 PF00917 0.792
LIG_UBA3_1 598 605 PF00899 0.402
MOD_CDK_SPK_2 401 406 PF00069 0.590
MOD_CK1_1 177 183 PF00069 0.285
MOD_CK1_1 259 265 PF00069 0.420
MOD_CK1_1 31 37 PF00069 0.236
MOD_CK1_1 350 356 PF00069 0.697
MOD_CK1_1 39 45 PF00069 0.243
MOD_CK1_1 480 486 PF00069 0.289
MOD_CK1_1 554 560 PF00069 0.156
MOD_CK2_1 393 399 PF00069 0.795
MOD_CK2_1 511 517 PF00069 0.560
MOD_CMANNOS 445 448 PF00535 0.326
MOD_GlcNHglycan 152 155 PF01048 0.312
MOD_GlcNHglycan 179 182 PF01048 0.450
MOD_GlcNHglycan 236 239 PF01048 0.261
MOD_GlcNHglycan 269 272 PF01048 0.561
MOD_GlcNHglycan 372 375 PF01048 0.497
MOD_GlcNHglycan 391 394 PF01048 0.495
MOD_GlcNHglycan 492 495 PF01048 0.300
MOD_GlcNHglycan 499 502 PF01048 0.299
MOD_GlcNHglycan 585 588 PF01048 0.362
MOD_GSK3_1 150 157 PF00069 0.281
MOD_GSK3_1 24 31 PF00069 0.342
MOD_GSK3_1 255 262 PF00069 0.311
MOD_GSK3_1 308 315 PF00069 0.628
MOD_GSK3_1 350 357 PF00069 0.682
MOD_GSK3_1 389 396 PF00069 0.728
MOD_GSK3_1 401 408 PF00069 0.722
MOD_GSK3_1 46 53 PF00069 0.257
MOD_GSK3_1 480 487 PF00069 0.284
MOD_GSK3_1 583 590 PF00069 0.296
MOD_GSK3_1 605 612 PF00069 0.340
MOD_GSK3_1 664 671 PF00069 0.574
MOD_N-GLC_1 177 182 PF02516 0.448
MOD_N-GLC_2 56 58 PF02516 0.333
MOD_NEK2_1 155 160 PF00069 0.314
MOD_NEK2_1 22 27 PF00069 0.289
MOD_NEK2_1 255 260 PF00069 0.320
MOD_NEK2_1 273 278 PF00069 0.311
MOD_NEK2_1 447 452 PF00069 0.309
MOD_NEK2_1 454 459 PF00069 0.243
MOD_NEK2_1 484 489 PF00069 0.294
MOD_NEK2_1 497 502 PF00069 0.262
MOD_NEK2_1 519 524 PF00069 0.311
MOD_NEK2_1 531 536 PF00069 0.271
MOD_NEK2_1 551 556 PF00069 0.380
MOD_NEK2_1 582 587 PF00069 0.313
MOD_NEK2_1 588 593 PF00069 0.304
MOD_NEK2_1 8 13 PF00069 0.468
MOD_NEK2_2 28 33 PF00069 0.308
MOD_NEK2_2 564 569 PF00069 0.394
MOD_OFUCOSY 616 621 PF10250 0.514
MOD_PKA_1 224 230 PF00069 0.581
MOD_PKA_1 510 516 PF00069 0.583
MOD_PKA_2 214 220 PF00069 0.548
MOD_PKA_2 348 354 PF00069 0.724
MOD_PKA_2 405 411 PF00069 0.696
MOD_PKA_2 480 486 PF00069 0.318
MOD_Plk_1 46 52 PF00069 0.256
MOD_Plk_1 477 483 PF00069 0.296
MOD_Plk_1 605 611 PF00069 0.221
MOD_Plk_4 127 133 PF00069 0.324
MOD_Plk_4 155 161 PF00069 0.302
MOD_Plk_4 256 262 PF00069 0.298
MOD_Plk_4 431 437 PF00069 0.512
MOD_Plk_4 447 453 PF00069 0.327
MOD_Plk_4 456 462 PF00069 0.299
MOD_Plk_4 480 486 PF00069 0.245
MOD_Plk_4 519 525 PF00069 0.282
MOD_Plk_4 531 537 PF00069 0.264
MOD_ProDKin_1 204 210 PF00069 0.535
MOD_ProDKin_1 401 407 PF00069 0.723
MOD_SUMO_for_1 173 176 PF00179 0.202
MOD_SUMO_rev_2 218 227 PF00179 0.582
MOD_SUMO_rev_2 321 331 PF00179 0.657
TRG_ENDOCYTIC_2 144 147 PF00928 0.440
TRG_ENDOCYTIC_2 182 185 PF00928 0.274
TRG_ENDOCYTIC_2 19 22 PF00928 0.336
TRG_ENDOCYTIC_2 272 275 PF00928 0.260
TRG_ENDOCYTIC_2 299 302 PF00928 0.518
TRG_ENDOCYTIC_2 485 488 PF00928 0.284
TRG_ENDOCYTIC_2 535 538 PF00928 0.275
TRG_ENDOCYTIC_2 580 583 PF00928 0.278
TRG_ENDOCYTIC_2 60 63 PF00928 0.258
TRG_ER_diArg_1 213 216 PF00400 0.550
TRG_ER_diArg_1 239 241 PF00400 0.478
TRG_ER_diArg_1 508 510 PF00400 0.523
TRG_ER_diArg_1 647 649 PF00400 0.596
TRG_ER_diArg_1 9 12 PF00400 0.431
TRG_ER_diLys_1 668 672 PF00400 0.462
TRG_NLS_MonoExtC_3 302 307 PF00514 0.424
TRG_NLS_MonoExtN_4 300 307 PF00514 0.419

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G0 Leptomonas seymouri 28% 100%
A0A0N1HZC2 Leptomonas seymouri 29% 100%
A0A0N1IKC5 Leptomonas seymouri 27% 100%
A0A0N1PB63 Leptomonas seymouri 24% 100%
A0A0N1PD04 Leptomonas seymouri 25% 100%
A0A0N1PFR4 Leptomonas seymouri 66% 100%
A0A1X0NKK0 Trypanosomatidae 27% 100%
A0A1X0NM09 Trypanosomatidae 27% 100%
A0A1X0NRW5 Trypanosomatidae 24% 96%
A0A1X0NVF9 Trypanosomatidae 23% 100%
A0A1X0NWQ1 Trypanosomatidae 26% 100%
A0A1X0NZE6 Trypanosomatidae 26% 100%
A0A1X0NZT1 Trypanosomatidae 24% 81%
A0A1X0NZU2 Trypanosomatidae 32% 100%
A0A1X0NZW1 Trypanosomatidae 49% 100%
A0A1X0P0M7 Trypanosomatidae 24% 100%
A0A381MMW5 Leishmania infantum 31% 97%
A0A3Q8IEC4 Leishmania donovani 31% 100%
A0A3Q8IF95 Leishmania donovani 24% 100%
A0A3Q8IIT5 Leishmania donovani 98% 100%
A0A3Q8ISY9 Leishmania donovani 27% 95%
A0A3R7N3S6 Trypanosoma rangeli 23% 100%
A0A3R7N921 Trypanosoma rangeli 24% 100%
A0A3S7WRJ4 Leishmania donovani 25% 100%
A0A3S7WRJ5 Leishmania donovani 26% 96%
A0A3S7WRS3 Leishmania donovani 25% 100%
A0A3S7WWU1 Leishmania donovani 26% 100%
A0A3S7X2G0 Leishmania donovani 31% 100%
A0A3S7X2K5 Leishmania donovani 31% 100%
A0A3S7XB11 Leishmania donovani 28% 100%
A0A422MU68 Trypanosoma rangeli 24% 100%
A0A422NL17 Trypanosoma rangeli 22% 83%
A4H6J0 Leishmania braziliensis 25% 95%
A4H6J1 Leishmania braziliensis 26% 97%
A4H6Q5 Leishmania braziliensis 23% 98%
A4HC19 Leishmania braziliensis 24% 99%
A4HHG2 Leishmania braziliensis 82% 100%
A4HHG3 Leishmania braziliensis 29% 95%
A4HHG4 Leishmania braziliensis 29% 97%
A4HJW3 Leishmania braziliensis 27% 97%
A4HPE2 Leishmania braziliensis 27% 93%
A4HUX5 Leishmania infantum 25% 97%
A4HUX6 Leishmania infantum 25% 100%
A4HV40 Leishmania infantum 25% 96%
A4HZF5 Leishmania infantum 24% 94%
A4HZJ4 Leishmania infantum 27% 100%
A4I7C5 Leishmania infantum 27% 95%
A4ICI3 Leishmania infantum 28% 100%
D0A7B1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E8NHE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 93%
E9AE01 Leishmania major 30% 98%
E9AE09 Leishmania major 93% 100%
E9AE10 Leishmania major 93% 100%
E9AE11 Leishmania major 30% 95%
E9AHJ0 Leishmania infantum 31% 100%
E9AHJ1 Leishmania infantum 31% 100%
E9ALS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 96%
E9ALS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9ANL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 98%
E9ANL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 98%
E9ANS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 96%
E9APJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 90%
E9AT53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 90%
E9AVF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 91%
E9AVF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B2B8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 94%
Q4Q1E4 Leishmania major 27% 92%
Q4Q5T8 Leishmania major 27% 94%
Q4QC27 Leishmania major 25% 96%
Q4QGU8 Leishmania major 24% 98%
Q4QH14 Leishmania major 25% 97%
Q4QH15 Leishmania major 25% 97%
V5B647 Trypanosoma cruzi 27% 100%
V5BFV8 Trypanosoma cruzi 25% 100%
V5BVP0 Trypanosoma cruzi 27% 100%
V5BWJ7 Trypanosoma cruzi 22% 100%
V5DT25 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS