LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Nodulin-like domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nodulin-like domain-containing protein
Gene product:
Nodulin-like - putative
Species:
Leishmania infantum
UniProt:
A4I4L2_LEIIN
TriTrypDb:
LINF_290021400 *
Length:
672

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 78
NetGPI no yes: 0, no: 78
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 3
GO:0016020 membrane 2 72
GO:0110165 cellular anatomical entity 1 72
Previous1Next

Phosphorylation

Promastigote: 350, 351, 373, 404

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4L2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4L2

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0005215 transporter activity 1 36
GO:0022857 transmembrane transporter activity 2 36
Previous1Next

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 341 345 PF00656 0.679
CLV_NRD_NRD_1 223 225 PF00675 0.315
CLV_NRD_NRD_1 239 241 PF00675 0.274
CLV_NRD_NRD_1 509 511 PF00675 0.335
CLV_NRD_NRD_1 648 650 PF00675 0.384
CLV_PCSK_FUR_1 646 650 PF00082 0.235
CLV_PCSK_KEX2_1 239 241 PF00082 0.279
CLV_PCSK_KEX2_1 304 306 PF00082 0.387
CLV_PCSK_KEX2_1 509 511 PF00082 0.314
CLV_PCSK_KEX2_1 648 650 PF00082 0.386
Previous12345…22Next

Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P6G0 Leptomonas seymouri 28% 100%
A0A0N1HZC2 Leptomonas seymouri 29% 100%
A0A0N1IKC5 Leptomonas seymouri 27% 100%
A0A0N1PB63 Leptomonas seymouri 24% 100%
A0A0N1PD04 Leptomonas seymouri 25% 100%
A0A0N1PFR4 Leptomonas seymouri 66% 100%
A0A1X0NKK0 Trypanosomatidae 27% 100%
A0A1X0NM09 Trypanosomatidae 27% 100%
A0A1X0NRW5 Trypanosomatidae 24% 96%
A0A1X0NVF9 Trypanosomatidae 23% 100%
Previous12345…8Next

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS