Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4L0_LEIIN

TriTrypDb:

LINF_290021200

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I4L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4L0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	299	301	PF00675	0.735
CLV_NRD_NRD_1	88	90	PF00675	0.472
CLV_PCSK_KEX2_1	299	301	PF00082	0.735
CLV_PCSK_KEX2_1	90	92	PF00082	0.477
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.477
CLV_PCSK_SKI1_1	24	28	PF00082	0.437
DEG_Nend_UBRbox_4	1	3	PF02207	0.629
DEG_SPOP_SBC_1	59	63	PF00917	0.641
DOC_MAPK_FxFP_2	56	59	PF00069	0.700
DOC_MAPK_gen_1	131	139	PF00069	0.679
DOC_MAPK_gen_1	201	209	PF00069	0.789
DOC_MAPK_gen_1	89	96	PF00069	0.662
DOC_MAPK_MEF2A_6	120	129	PF00069	0.766
DOC_MAPK_MEF2A_6	133	141	PF00069	0.644
DOC_PP2B_LxvP_1	139	142	PF13499	0.766
DOC_PP2B_PxIxI_1	124	130	PF00149	0.764
DOC_PP4_FxxP_1	161	164	PF00568	0.637
DOC_PP4_FxxP_1	258	261	PF00568	0.632
DOC_PP4_FxxP_1	56	59	PF00568	0.701
DOC_USP7_MATH_1	142	146	PF00917	0.756
DOC_USP7_MATH_1	147	151	PF00917	0.766
DOC_USP7_UBL2_3	10	14	PF12436	0.703
DOC_WW_Pin1_4	121	126	PF00397	0.815
DOC_WW_Pin1_4	261	266	PF00397	0.569
LIG_14-3-3_CanoR_1	111	115	PF00244	0.717
LIG_14-3-3_CanoR_1	120	124	PF00244	0.691
LIG_14-3-3_CanoR_1	152	161	PF00244	0.700
LIG_14-3-3_CanoR_1	30	35	PF00244	0.707
LIG_14-3-3_CanoR_1	37	41	PF00244	0.681
LIG_14-3-3_CanoR_1	42	47	PF00244	0.663
LIG_14-3-3_CanoR_1	65	74	PF00244	0.697
LIG_14-3-3_CanoR_1	89	96	PF00244	0.694
LIG_14-3-3_CterR_2	299	301	PF00244	0.501
LIG_BIR_III_2	294	298	PF00653	0.492
LIG_BRCT_BRCA1_1	62	66	PF00533	0.723
LIG_FHA_1	169	175	PF00498	0.749
LIG_FHA_1	269	275	PF00498	0.565
LIG_FHA_2	281	287	PF00498	0.575
LIG_LIR_Nem_3	233	238	PF02991	0.725
LIG_LIR_Nem_3	264	270	PF02991	0.572
LIG_LIR_Nem_3	29	34	PF02991	0.649
LIG_LIR_Nem_3	61	67	PF02991	0.737
LIG_Pex14_1	235	239	PF04695	0.633
LIG_SH2_CRK	64	68	PF00017	0.705
LIG_SH2_STAP1	270	274	PF00017	0.572
LIG_SH2_STAT5	267	270	PF00017	0.575
LIG_SH3_3	71	77	PF00018	0.723
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.764
MOD_CK1_1	154	160	PF00069	0.729
MOD_CK1_1	168	174	PF00069	0.632
MOD_CK1_1	278	284	PF00069	0.609
MOD_CK1_1	68	74	PF00069	0.742
MOD_CK2_1	280	286	PF00069	0.490
MOD_GlcNHglycan	112	115	PF01048	0.514
MOD_GlcNHglycan	144	147	PF01048	0.572
MOD_GlcNHglycan	171	174	PF01048	0.510
MOD_GlcNHglycan	286	289	PF01048	0.698
MOD_GSK3_1	119	126	PF00069	0.813
MOD_GSK3_1	147	154	PF00069	0.756
MOD_GSK3_1	165	172	PF00069	0.622
MOD_GSK3_1	26	33	PF00069	0.608
MOD_GSK3_1	280	287	PF00069	0.618
MOD_GSK3_1	54	61	PF00069	0.713
MOD_GSK3_1	9	16	PF00069	0.754
MOD_GSK3_1	95	102	PF00069	0.819
MOD_LATS_1	97	103	PF00433	0.705
MOD_N-GLC_1	239	244	PF02516	0.410
MOD_N-GLC_1	278	283	PF02516	0.769
MOD_NEK2_1	284	289	PF00069	0.594
MOD_NEK2_1	54	59	PF00069	0.646
MOD_NEK2_1	66	71	PF00069	0.705
MOD_PIKK_1	100	106	PF00454	0.790
MOD_PIKK_1	154	160	PF00454	0.744
MOD_PIKK_1	44	50	PF00454	0.652
MOD_PK_1	30	36	PF00069	0.669
MOD_PK_1	42	48	PF00069	0.697
MOD_PKA_1	89	95	PF00069	0.678
MOD_PKA_2	110	116	PF00069	0.771
MOD_PKA_2	119	125	PF00069	0.700
MOD_PKA_2	132	138	PF00069	0.649
MOD_PKA_2	147	153	PF00069	0.651
MOD_PKA_2	36	42	PF00069	0.650
MOD_Plk_1	239	245	PF00069	0.410
MOD_Plk_4	270	276	PF00069	0.507
MOD_Plk_4	30	36	PF00069	0.735
MOD_ProDKin_1	121	127	PF00069	0.815
MOD_ProDKin_1	261	267	PF00069	0.569
TRG_ENDOCYTIC_2	64	67	PF00928	0.698
TRG_ER_diArg_1	130	133	PF00400	0.680
TRG_ER_diArg_1	88	91	PF00400	0.691
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7L3	Leishmania donovani	95%	100%
A4HHG0	Leishmania braziliensis	60%	81%
E9AE07	Leishmania major	80%	100%
E9ALS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%