Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4K6_LEIIN

TriTrypDb:

LINF_290023500

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I4K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4K6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.532
CLV_C14_Caspase3-7	225	229	PF00656	0.378
CLV_NRD_NRD_1	186	188	PF00675	0.374
CLV_NRD_NRD_1	33	35	PF00675	0.533
CLV_PCSK_KEX2_1	186	188	PF00082	0.372
CLV_PCSK_KEX2_1	33	35	PF00082	0.587
CLV_PCSK_SKI1_1	187	191	PF00082	0.336
DEG_APCC_DBOX_1	186	194	PF00400	0.332
DOC_MAPK_gen_1	186	193	PF00069	0.351
DOC_MAPK_gen_1	46	56	PF00069	0.501
DOC_MAPK_MEF2A_6	186	195	PF00069	0.330
DOC_MAPK_MEF2A_6	49	56	PF00069	0.497
DOC_MAPK_NFAT4_5	49	57	PF00069	0.442
DOC_USP7_MATH_1	172	176	PF00917	0.467
LIG_APCC_ABBA_1	109	114	PF00400	0.556
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_deltaCOP1_diTrp_1	252	260	PF00928	0.391
LIG_EVH1_2	146	150	PF00568	0.581
LIG_FHA_1	23	29	PF00498	0.467
LIG_FHA_2	1	7	PF00498	0.512
LIG_FHA_2	124	130	PF00498	0.462
LIG_FHA_2	244	250	PF00498	0.433
LIG_FHA_2	45	51	PF00498	0.503
LIG_LIR_Gen_1	115	124	PF02991	0.405
LIG_LIR_Gen_1	204	212	PF02991	0.427
LIG_LIR_Gen_1	232	242	PF02991	0.380
LIG_LIR_Gen_1	80	90	PF02991	0.476
LIG_LIR_Nem_3	115	121	PF02991	0.398
LIG_LIR_Nem_3	204	209	PF02991	0.472
LIG_LIR_Nem_3	232	237	PF02991	0.372
LIG_LIR_Nem_3	252	256	PF02991	0.380
LIG_LIR_Nem_3	55	61	PF02991	0.465
LIG_LIR_Nem_3	80	85	PF02991	0.482
LIG_NRBOX	189	195	PF00104	0.410
LIG_Pex14_1	234	238	PF04695	0.442
LIG_Pex14_4	78	83	PF04695	0.407
LIG_SH2_NCK_1	265	269	PF00017	0.463
LIG_SH2_NCK_1	72	76	PF00017	0.491
LIG_SH2_STAT5	206	209	PF00017	0.467
LIG_SH2_STAT5	265	268	PF00017	0.507
LIG_SH2_STAT5	95	98	PF00017	0.594
LIG_SH3_3	165	171	PF00018	0.664
LIG_SUMO_SIM_par_1	192	197	PF11976	0.319
LIG_TRAF2_1	246	249	PF00917	0.528
LIG_TRAF2_1	67	70	PF00917	0.354
MOD_CK1_1	153	159	PF00069	0.670
MOD_CK1_1	161	167	PF00069	0.680
MOD_CK1_1	213	219	PF00069	0.608
MOD_CK2_1	119	125	PF00069	0.419
MOD_CK2_1	2	8	PF00069	0.595
MOD_CK2_1	218	224	PF00069	0.535
MOD_CK2_1	243	249	PF00069	0.435
MOD_CK2_1	44	50	PF00069	0.502
MOD_CK2_1	85	91	PF00069	0.482
MOD_GlcNHglycan	11	14	PF01048	0.579
MOD_GlcNHglycan	120	124	PF01048	0.495
MOD_GlcNHglycan	174	177	PF01048	0.534
MOD_GSK3_1	119	126	PF00069	0.466
MOD_GSK3_1	146	153	PF00069	0.690
MOD_GSK3_1	154	161	PF00069	0.743
MOD_NEK2_1	150	155	PF00069	0.631
MOD_NEK2_1	158	163	PF00069	0.560
MOD_NEK2_1	194	199	PF00069	0.333
MOD_NEK2_1	261	266	PF00069	0.487
MOD_NEK2_1	52	57	PF00069	0.462
MOD_NEK2_1	85	90	PF00069	0.390
MOD_PIKK_1	22	28	PF00454	0.521
MOD_PIKK_1	44	50	PF00454	0.549
MOD_PK_1	208	214	PF00069	0.429
MOD_PKA_2	150	156	PF00069	0.655
MOD_PKA_2	85	91	PF00069	0.456
MOD_Plk_4	123	129	PF00069	0.481
MOD_Plk_4	229	235	PF00069	0.390
MOD_Plk_4	256	262	PF00069	0.310
MOD_Plk_4	85	91	PF00069	0.535
MOD_SUMO_rev_2	161	168	PF00179	0.535
MOD_SUMO_rev_2	248	256	PF00179	0.419
TRG_ENDOCYTIC_2	118	121	PF00928	0.409
TRG_ENDOCYTIC_2	206	209	PF00928	0.467
TRG_ER_diArg_1	33	35	PF00400	0.535
TRG_NES_CRM1_1	188	204	PF08389	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM1	Leptomonas seymouri	57%	100%
A0A0S4ING2	Bodo saltans	25%	100%
A0A1X0NZY4	Trypanosomatidae	33%	100%
A0A3Q8IIV0	Leishmania donovani	99%	100%
A0A3R7KCM5	Trypanosoma rangeli	36%	100%
A4HHI0	Leishmania braziliensis	72%	100%
C9ZLB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AE28	Leishmania major	94%	100%
E9ALQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B997	Trypanosoma cruzi	35%	100%