LeishMANIAdb
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Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin domain-containing protein
Gene product:
Thioredoxin - putative
Species:
Leishmania infantum
UniProt:
A4I4K5_LEIIN
TriTrypDb:
LINF_290023400 *
Length:
112

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I4K5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4K5

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_USP7_MATH_1 19 23 PF00917 0.287
DOC_USP7_MATH_1 80 84 PF00917 0.684
DOC_WW_Pin1_4 84 89 PF00397 0.749
DOC_WW_Pin1_4 91 96 PF00397 0.673
LIG_14-3-3_CanoR_1 86 95 PF00244 0.584
LIG_Clathr_ClatBox_1 29 33 PF01394 0.287
LIG_LIR_Nem_3 51 55 PF02991 0.322
LIG_NRBOX 74 80 PF00104 0.438
LIG_SUMO_SIM_anti_2 26 31 PF11976 0.322
LIG_SUMO_SIM_par_1 26 31 PF11976 0.322
LIG_TRAF2_1 99 102 PF00917 0.547
LIG_WRC_WIRS_1 49 54 PF05994 0.322
MOD_CK1_1 48 54 PF00069 0.322
MOD_CK1_1 87 93 PF00069 0.761
MOD_GlcNHglycan 109 112 PF01048 0.616
MOD_GSK3_1 103 110 PF00069 0.609
MOD_GSK3_1 19 26 PF00069 0.395
MOD_GSK3_1 80 87 PF00069 0.684
MOD_N-GLC_1 81 86 PF02516 0.555
MOD_N-GLC_1 91 96 PF02516 0.592
MOD_N-GLC_2 57 59 PF02516 0.322
MOD_NEK2_1 23 28 PF00069 0.458
MOD_NEK2_2 103 108 PF00069 0.508
MOD_PIKK_1 64 70 PF00454 0.287
MOD_Plk_1 38 44 PF00069 0.322
MOD_Plk_4 23 29 PF00069 0.322
MOD_Plk_4 48 54 PF00069 0.322
MOD_ProDKin_1 84 90 PF00069 0.752
MOD_ProDKin_1 91 97 PF00069 0.672
MOD_SUMO_rev_2 4 8 PF00179 0.413
TRG_DiLeu_BaEn_1 71 76 PF01217 0.322
TRG_Pf-PMV_PEXEL_1 14 18 PF00026 0.424

Homologs

Protein Taxonomy Sequence identity Coverage
E9AE27 Leishmania major 90% 100%
E9ALQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS