LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I4K3_LEIIN
TriTrypDb:
LINF_290020700
Length:
539

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0020023 kinetoplast 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I4K3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4K3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 221 223 PF00675 0.372
CLV_NRD_NRD_1 469 471 PF00675 0.595
CLV_NRD_NRD_1 512 514 PF00675 0.537
CLV_NRD_NRD_1 520 522 PF00675 0.541
CLV_NRD_NRD_1 53 55 PF00675 0.644
CLV_PCSK_KEX2_1 138 140 PF00082 0.383
CLV_PCSK_KEX2_1 176 178 PF00082 0.517
CLV_PCSK_KEX2_1 221 223 PF00082 0.417
CLV_PCSK_KEX2_1 520 522 PF00082 0.589
CLV_PCSK_KEX2_1 53 55 PF00082 0.648
CLV_PCSK_PC1ET2_1 138 140 PF00082 0.377
CLV_PCSK_PC1ET2_1 176 178 PF00082 0.535
CLV_PCSK_PC7_1 516 522 PF00082 0.536
CLV_PCSK_SKI1_1 191 195 PF00082 0.505
CLV_PCSK_SKI1_1 375 379 PF00082 0.355
CLV_PCSK_SKI1_1 382 386 PF00082 0.414
CLV_PCSK_SKI1_1 521 525 PF00082 0.625
CLV_PCSK_SKI1_1 54 58 PF00082 0.511
CLV_PCSK_SKI1_1 6 10 PF00082 0.522
DEG_APCC_DBOX_1 221 229 PF00400 0.468
DEG_APCC_DBOX_1 374 382 PF00400 0.453
DEG_ODPH_VHL_1 385 397 PF01847 0.427
DEG_SCF_FBW7_1 474 479 PF00400 0.550
DOC_ANK_TNKS_1 265 272 PF00023 0.417
DOC_CKS1_1 182 187 PF01111 0.585
DOC_CKS1_1 78 83 PF01111 0.578
DOC_CYCLIN_yCln2_LP_2 78 84 PF00134 0.558
DOC_MAPK_gen_1 138 144 PF00069 0.439
DOC_MAPK_gen_1 191 199 PF00069 0.536
DOC_MAPK_gen_1 221 229 PF00069 0.459
DOC_MAPK_MEF2A_6 138 146 PF00069 0.361
DOC_MAPK_MEF2A_6 221 229 PF00069 0.412
DOC_MAPK_NFAT4_5 139 147 PF00069 0.355
DOC_MAPK_NFAT4_5 222 230 PF00069 0.411
DOC_PP1_RVXF_1 532 539 PF00149 0.548
DOC_PP2B_LxvP_1 197 200 PF13499 0.476
DOC_PP2B_LxvP_1 524 527 PF13499 0.502
DOC_USP7_MATH_1 128 132 PF00917 0.439
DOC_USP7_MATH_1 15 19 PF00917 0.492
DOC_USP7_MATH_1 365 369 PF00917 0.614
DOC_USP7_MATH_1 98 102 PF00917 0.614
DOC_WW_Pin1_4 11 16 PF00397 0.499
DOC_WW_Pin1_4 181 186 PF00397 0.552
DOC_WW_Pin1_4 238 243 PF00397 0.393
DOC_WW_Pin1_4 310 315 PF00397 0.441
DOC_WW_Pin1_4 388 393 PF00397 0.513
DOC_WW_Pin1_4 472 477 PF00397 0.532
DOC_WW_Pin1_4 527 532 PF00397 0.621
DOC_WW_Pin1_4 77 82 PF00397 0.760
DOC_WW_Pin1_4 84 89 PF00397 0.685
LIG_14-3-3_CanoR_1 16 20 PF00244 0.689
LIG_14-3-3_CanoR_1 274 283 PF00244 0.365
LIG_14-3-3_CanoR_1 367 374 PF00244 0.552
LIG_14-3-3_CanoR_1 415 423 PF00244 0.371
LIG_14-3-3_CanoR_1 425 433 PF00244 0.307
LIG_14-3-3_CanoR_1 462 469 PF00244 0.509
LIG_14-3-3_CanoR_1 53 59 PF00244 0.599
LIG_14-3-3_CanoR_1 66 73 PF00244 0.577
LIG_14-3-3_CanoR_1 99 103 PF00244 0.799
LIG_Actin_WH2_2 366 384 PF00022 0.415
LIG_AP2alpha_1 209 213 PF02296 0.442
LIG_APCC_ABBA_1 206 211 PF00400 0.503
LIG_APCC_ABBA_1 254 259 PF00400 0.380
LIG_APCC_ABBA_1 506 511 PF00400 0.467
LIG_BIR_II_1 1 5 PF00653 0.624
LIG_BIR_III_4 334 338 PF00653 0.612
LIG_deltaCOP1_diTrp_1 112 121 PF00928 0.508
LIG_deltaCOP1_diTrp_1 161 170 PF00928 0.552
LIG_EVH1_2 246 250 PF00568 0.358
LIG_EVH1_2 393 397 PF00568 0.478
LIG_EVH1_2 43 47 PF00568 0.566
LIG_FHA_1 102 108 PF00498 0.623
LIG_FHA_1 239 245 PF00498 0.389
LIG_FHA_1 284 290 PF00498 0.320
LIG_FHA_1 473 479 PF00498 0.622
LIG_FHA_1 53 59 PF00498 0.748
LIG_FHA_2 337 343 PF00498 0.603
LIG_Integrin_RGD_1 215 217 PF01839 0.463
LIG_LIR_Gen_1 112 119 PF02991 0.506
LIG_LIR_Gen_1 161 170 PF02991 0.603
LIG_LIR_Gen_1 420 431 PF02991 0.457
LIG_LIR_Nem_3 112 118 PF02991 0.516
LIG_LIR_Nem_3 161 167 PF02991 0.599
LIG_LIR_Nem_3 324 329 PF02991 0.543
LIG_LIR_Nem_3 420 426 PF02991 0.515
LIG_NRBOX 224 230 PF00104 0.410
LIG_NRP_CendR_1 537 539 PF00754 0.581
LIG_Pex14_2 209 213 PF04695 0.500
LIG_PTB_Apo_2 444 451 PF02174 0.379
LIG_PTB_Phospho_1 444 450 PF10480 0.375
LIG_SH2_GRB2like 445 448 PF00017 0.374
LIG_SH2_GRB2like 486 489 PF00017 0.515
LIG_SH2_SRC 198 201 PF00017 0.530
LIG_SH2_SRC 445 448 PF00017 0.412
LIG_SH2_STAT5 174 177 PF00017 0.595
LIG_SH2_STAT5 198 201 PF00017 0.463
LIG_SH2_STAT5 231 234 PF00017 0.555
LIG_SH2_STAT5 405 408 PF00017 0.408
LIG_SH2_STAT5 429 432 PF00017 0.376
LIG_SH2_STAT5 435 438 PF00017 0.389
LIG_SH2_STAT5 445 448 PF00017 0.421
LIG_SH2_STAT5 486 489 PF00017 0.604
LIG_SH3_1 525 531 PF00018 0.521
LIG_SH3_3 179 185 PF00018 0.646
LIG_SH3_3 196 202 PF00018 0.398
LIG_SH3_3 241 247 PF00018 0.330
LIG_SH3_3 37 43 PF00018 0.526
LIG_SH3_3 525 531 PF00018 0.547
LIG_SH3_3 78 84 PF00018 0.641
LIG_SH3_3 92 98 PF00018 0.655
LIG_SH3_CIN85_PxpxPR_1 94 99 PF14604 0.588
LIG_SUMO_SIM_anti_2 315 322 PF11976 0.391
LIG_SUMO_SIM_par_1 315 322 PF11976 0.391
LIG_TRAF2_1 322 325 PF00917 0.604
LIG_UBA3_1 227 233 PF00899 0.403
MOD_CDK_SPK_2 11 16 PF00069 0.499
MOD_CDK_SPK_2 86 91 PF00069 0.632
MOD_CDK_SPxxK_3 527 534 PF00069 0.547
MOD_CDK_SPxxK_3 84 91 PF00069 0.633
MOD_CK1_1 101 107 PF00069 0.639
MOD_CK1_1 11 17 PF00069 0.499
MOD_CK1_1 172 178 PF00069 0.553
MOD_CK1_1 277 283 PF00069 0.310
MOD_CK1_1 318 324 PF00069 0.615
MOD_CK1_1 83 89 PF00069 0.723
MOD_CK2_1 110 116 PF00069 0.593
MOD_CK2_1 318 324 PF00069 0.522
MOD_CK2_1 336 342 PF00069 0.662
MOD_Cter_Amidation 136 139 PF01082 0.425
MOD_GlcNHglycan 10 13 PF01048 0.509
MOD_GlcNHglycan 276 279 PF01048 0.338
MOD_GlcNHglycan 369 372 PF01048 0.489
MOD_GlcNHglycan 459 462 PF01048 0.597
MOD_GlcNHglycan 74 77 PF01048 0.549
MOD_GSK3_1 101 108 PF00069 0.627
MOD_GSK3_1 11 18 PF00069 0.497
MOD_GSK3_1 110 117 PF00069 0.561
MOD_GSK3_1 147 154 PF00069 0.450
MOD_GSK3_1 277 284 PF00069 0.415
MOD_GSK3_1 315 322 PF00069 0.451
MOD_GSK3_1 329 336 PF00069 0.658
MOD_GSK3_1 356 363 PF00069 0.453
MOD_GSK3_1 472 479 PF00069 0.532
MOD_GSK3_1 480 487 PF00069 0.730
MOD_GSK3_1 72 79 PF00069 0.625
MOD_GSK3_1 80 87 PF00069 0.676
MOD_N-GLC_1 496 501 PF02516 0.596
MOD_NEK2_1 169 174 PF00069 0.547
MOD_NEK2_1 496 501 PF00069 0.558
MOD_PIKK_1 277 283 PF00454 0.336
MOD_PIKK_1 462 468 PF00454 0.585
MOD_PKA_2 15 21 PF00069 0.494
MOD_PKA_2 424 430 PF00069 0.335
MOD_PKA_2 52 58 PF00069 0.572
MOD_PKA_2 98 104 PF00069 0.624
MOD_Plk_1 341 347 PF00069 0.597
MOD_Plk_4 110 116 PF00069 0.640
MOD_Plk_4 147 153 PF00069 0.469
MOD_Plk_4 15 21 PF00069 0.490
MOD_Plk_4 302 308 PF00069 0.499
MOD_ProDKin_1 11 17 PF00069 0.499
MOD_ProDKin_1 181 187 PF00069 0.550
MOD_ProDKin_1 238 244 PF00069 0.396
MOD_ProDKin_1 310 316 PF00069 0.441
MOD_ProDKin_1 388 394 PF00069 0.521
MOD_ProDKin_1 472 478 PF00069 0.524
MOD_ProDKin_1 527 533 PF00069 0.618
MOD_ProDKin_1 77 83 PF00069 0.762
MOD_ProDKin_1 84 90 PF00069 0.685
TRG_DiLeu_BaEn_1 223 228 PF01217 0.421
TRG_DiLeu_BaLyEn_6 188 193 PF01217 0.532
TRG_DiLeu_BaLyEn_6 412 417 PF01217 0.400
TRG_ENDOCYTIC_2 210 213 PF00928 0.503
TRG_Pf-PMV_PEXEL_1 155 159 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 191 195 PF00026 0.487
TRG_Pf-PMV_PEXEL_1 310 315 PF00026 0.391
TRG_Pf-PMV_PEXEL_1 415 420 PF00026 0.309
TRG_Pf-PMV_PEXEL_1 467 472 PF00026 0.556

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P950 Leptomonas seymouri 39% 96%
A0A3Q8IAB6 Leishmania donovani 25% 99%
A0A3R7KFA4 Trypanosoma rangeli 31% 100%
A0A3S7X2J5 Leishmania donovani 100% 100%
A4H889 Leishmania braziliensis 26% 100%
A4HHF5 Leishmania braziliensis 81% 100%
A4HWL2 Leishmania infantum 25% 100%
C9ZL87 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AE02 Leishmania major 94% 100%
E9ALT0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AQB9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
Q4QF55 Leishmania major 25% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS