Putative RNA binding protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LYAR-type C2HC zinc finger containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I4K0_LEIIN

TriTrypDb:

LINF_290020400

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	7
GO:0005634	nucleus	5	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I4K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4K0

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.561
CLV_NRD_NRD_1	127	129	PF00675	0.536
CLV_NRD_NRD_1	208	210	PF00675	0.663
CLV_PCSK_KEX2_1	129	131	PF00082	0.449
CLV_PCSK_KEX2_1	208	210	PF00082	0.663
CLV_PCSK_KEX2_1	286	288	PF00082	0.435
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.430
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.454
CLV_PCSK_SKI1_1	159	163	PF00082	0.575
CLV_PCSK_SKI1_1	211	215	PF00082	0.670
CLV_PCSK_SKI1_1	283	287	PF00082	0.554
CLV_PCSK_SKI1_1	70	74	PF00082	0.520
DEG_COP1_1	239	247	PF00400	0.464
DEG_SIAH_1	149	157	PF03145	0.472
DOC_MAPK_gen_1	128	137	PF00069	0.570
DOC_MAPK_gen_1	226	233	PF00069	0.509
DOC_MAPK_HePTP_8	125	137	PF00069	0.446
DOC_MAPK_MEF2A_6	128	137	PF00069	0.633
DOC_PP2B_LxvP_1	231	234	PF13499	0.543
DOC_USP7_MATH_1	113	117	PF00917	0.607
DOC_USP7_MATH_1	201	205	PF00917	0.611
DOC_USP7_UBL2_3	191	195	PF12436	0.584
DOC_USP7_UBL2_3	274	278	PF12436	0.566
DOC_USP7_UBL2_3	286	290	PF12436	0.290
DOC_USP7_UBL2_3	56	60	PF12436	0.442
DOC_WW_Pin1_4	167	172	PF00397	0.587
DOC_WW_Pin1_4	183	188	PF00397	0.631
DOC_WW_Pin1_4	197	202	PF00397	0.580
DOC_WW_Pin1_4	226	231	PF00397	0.597
LIG_14-3-3_CanoR_1	235	239	PF00244	0.567
LIG_14-3-3_CanoR_1	287	293	PF00244	0.465
LIG_Actin_WH2_2	251	266	PF00022	0.412
LIG_FHA_1	149	155	PF00498	0.578
LIG_FHA_1	227	233	PF00498	0.581
LIG_FHA_1	244	250	PF00498	0.437
LIG_FHA_1	271	277	PF00498	0.560
LIG_FHA_1	46	52	PF00498	0.229
LIG_FHA_2	249	255	PF00498	0.549
LIG_FHA_2	29	35	PF00498	0.354
LIG_FHA_2	296	302	PF00498	0.412
LIG_FHA_2	50	56	PF00498	0.260
LIG_LIR_Gen_1	28	38	PF02991	0.254
LIG_LIR_Nem_3	28	33	PF02991	0.254
LIG_MYND_1	230	234	PF01753	0.576
LIG_PDZ_Class_1	311	316	PF00595	0.401
LIG_PTAP_UEV_1	149	154	PF05743	0.480
LIG_SH2_STAP1	284	288	PF00017	0.385
LIG_SH2_STAT5	8	11	PF00017	0.454
LIG_SH3_1	147	153	PF00018	0.487
LIG_SH3_3	10	16	PF00018	0.338
LIG_SH3_3	147	153	PF00018	0.648
LIG_SH3_3	218	224	PF00018	0.713
LIG_SH3_3	83	89	PF00018	0.595
LIG_SH3_4	15	22	PF00018	0.384
LIG_SH3_4	191	198	PF00018	0.587
LIG_TRAF2_1	251	254	PF00917	0.511
LIG_TRAF2_1	52	55	PF00917	0.383
LIG_UBA3_1	38	45	PF00899	0.223
LIG_WRC_WIRS_1	1	6	PF05994	0.302
LIG_WRC_WIRS_1	244	249	PF05994	0.427
MOD_CK1_1	166	172	PF00069	0.452
MOD_CK1_1	236	242	PF00069	0.468
MOD_CK1_1	266	272	PF00069	0.484
MOD_CK1_1	49	55	PF00069	0.270
MOD_CK1_1	96	102	PF00069	0.570
MOD_CK2_1	137	143	PF00069	0.559
MOD_CK2_1	248	254	PF00069	0.448
MOD_CK2_1	295	301	PF00069	0.407
MOD_CK2_1	49	55	PF00069	0.320
MOD_Cter_Amidation	224	227	PF01082	0.570
MOD_GlcNHglycan	108	111	PF01048	0.587
MOD_GlcNHglycan	122	125	PF01048	0.610
MOD_GlcNHglycan	165	168	PF01048	0.593
MOD_GlcNHglycan	172	175	PF01048	0.513
MOD_GlcNHglycan	265	268	PF01048	0.536
MOD_GSK3_1	163	170	PF00069	0.539
MOD_GSK3_1	197	204	PF00069	0.622
MOD_GSK3_1	263	270	PF00069	0.478
MOD_GSK3_1	45	52	PF00069	0.271
MOD_GSK3_1	92	99	PF00069	0.595
MOD_LATS_1	158	164	PF00433	0.467
MOD_N-GLC_1	311	316	PF02516	0.432
MOD_N-GLC_1	66	71	PF02516	0.455
MOD_N-GLC_2	7	9	PF02516	0.363
MOD_NEK2_1	135	140	PF00069	0.507
MOD_NEK2_1	263	268	PF00069	0.490
MOD_NEK2_2	267	272	PF00069	0.432
MOD_OFUCOSY	25	32	PF10250	0.404
MOD_PIKK_1	103	109	PF00454	0.543
MOD_PKA_1	195	201	PF00069	0.677
MOD_PKA_2	234	240	PF00069	0.570
MOD_PKA_2	263	269	PF00069	0.438
MOD_Plk_2-3	97	103	PF00069	0.645
MOD_Plk_4	243	249	PF00069	0.434
MOD_ProDKin_1	167	173	PF00069	0.587
MOD_ProDKin_1	183	189	PF00069	0.632
MOD_ProDKin_1	197	203	PF00069	0.580
MOD_ProDKin_1	226	232	PF00069	0.596
MOD_SUMO_for_1	213	216	PF00179	0.589
MOD_SUMO_rev_2	212	222	PF00179	0.591
TRG_DiLeu_BaEn_3	253	259	PF01217	0.493
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.545
TRG_ER_diArg_1	127	130	PF00400	0.467
TRG_ER_diArg_1	208	210	PF00400	0.656
TRG_NLS_MonoCore_2	13	18	PF00514	0.325
TRG_NLS_MonoExtN_4	156	163	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGN4	Leptomonas seymouri	53%	100%
A0A3Q8IRD2	Leishmania donovani	99%	100%
A4HHF0	Leishmania braziliensis	71%	99%
A4HHF1	Leishmania braziliensis	67%	99%
C9ZL83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ADZ9	Leishmania major	90%	100%
E9ALT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%