Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein - putative

Species:

Leishmania infantum

UniProt:

A4I4J9_LEIIN

TriTrypDb:

LINF_290020300

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4I4J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4J9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.512
CLV_C14_Caspase3-7	149	153	PF00656	0.494
CLV_NRD_NRD_1	197	199	PF00675	0.484
CLV_NRD_NRD_1	246	248	PF00675	0.664
CLV_NRD_NRD_1	324	326	PF00675	0.642
CLV_NRD_NRD_1	446	448	PF00675	0.824
CLV_NRD_NRD_1	585	587	PF00675	0.654
CLV_NRD_NRD_1	662	664	PF00675	0.682
CLV_PCSK_FUR_1	244	248	PF00082	0.659
CLV_PCSK_KEX2_1	246	248	PF00082	0.664
CLV_PCSK_KEX2_1	324	326	PF00082	0.642
CLV_PCSK_KEX2_1	446	448	PF00082	0.824
CLV_PCSK_KEX2_1	585	587	PF00082	0.654
CLV_PCSK_KEX2_1	662	664	PF00082	0.682
CLV_PCSK_SKI1_1	129	133	PF00082	0.363
CLV_PCSK_SKI1_1	151	155	PF00082	0.424
CLV_PCSK_SKI1_1	157	161	PF00082	0.481
CLV_PCSK_SKI1_1	198	202	PF00082	0.426
CLV_PCSK_SKI1_1	246	250	PF00082	0.662
CLV_PCSK_SKI1_1	99	103	PF00082	0.405
DEG_SCF_FBW7_1	425	431	PF00400	0.591
DEG_SPOP_SBC_1	517	521	PF00917	0.660
DEG_SPOP_SBC_1	623	627	PF00917	0.641
DOC_CKS1_1	168	173	PF01111	0.532
DOC_CKS1_1	425	430	PF01111	0.652
DOC_CKS1_1	467	472	PF01111	0.700
DOC_CKS1_1	547	552	PF01111	0.653
DOC_CKS1_1	573	578	PF01111	0.666
DOC_MAPK_DCC_7	494	504	PF00069	0.699
DOC_MAPK_gen_1	155	164	PF00069	0.599
DOC_PP4_FxxP_1	440	443	PF00568	0.658
DOC_PP4_FxxP_1	692	695	PF00568	0.515
DOC_USP7_MATH_1	124	128	PF00917	0.512
DOC_USP7_MATH_1	24	28	PF00917	0.785
DOC_USP7_MATH_1	262	266	PF00917	0.734
DOC_USP7_MATH_1	301	305	PF00917	0.567
DOC_USP7_MATH_1	355	359	PF00917	0.694
DOC_USP7_MATH_1	506	510	PF00917	0.704
DOC_USP7_MATH_1	522	526	PF00917	0.542
DOC_USP7_MATH_1	538	542	PF00917	0.537
DOC_USP7_MATH_1	623	627	PF00917	0.672
DOC_USP7_MATH_1	697	701	PF00917	0.577
DOC_USP7_MATH_1	774	778	PF00917	0.576
DOC_USP7_MATH_1	94	98	PF00917	0.536
DOC_WW_Pin1_4	164	169	PF00397	0.556
DOC_WW_Pin1_4	20	25	PF00397	0.694
DOC_WW_Pin1_4	238	243	PF00397	0.750
DOC_WW_Pin1_4	249	254	PF00397	0.651
DOC_WW_Pin1_4	297	302	PF00397	0.527
DOC_WW_Pin1_4	359	364	PF00397	0.692
DOC_WW_Pin1_4	415	420	PF00397	0.641
DOC_WW_Pin1_4	424	429	PF00397	0.640
DOC_WW_Pin1_4	454	459	PF00397	0.678
DOC_WW_Pin1_4	466	471	PF00397	0.604
DOC_WW_Pin1_4	478	483	PF00397	0.588
DOC_WW_Pin1_4	518	523	PF00397	0.683
DOC_WW_Pin1_4	534	539	PF00397	0.547
DOC_WW_Pin1_4	542	547	PF00397	0.645
DOC_WW_Pin1_4	552	557	PF00397	0.558
DOC_WW_Pin1_4	572	577	PF00397	0.523
DOC_WW_Pin1_4	684	689	PF00397	0.582
DOC_WW_Pin1_4	727	732	PF00397	0.615
DOC_WW_Pin1_4	746	751	PF00397	0.551
DOC_WW_Pin1_4	775	780	PF00397	0.651
LIG_14-3-3_CanoR_1	163	168	PF00244	0.570
LIG_14-3-3_CanoR_1	208	216	PF00244	0.444
LIG_14-3-3_CanoR_1	372	376	PF00244	0.633
LIG_14-3-3_CanoR_1	446	450	PF00244	0.770
LIG_14-3-3_CanoR_1	768	774	PF00244	0.620
LIG_APCC_ABBA_1	227	232	PF00400	0.516
LIG_BIR_III_2	235	239	PF00653	0.623
LIG_CaM_IQ_9	207	222	PF13499	0.421
LIG_FHA_1	140	146	PF00498	0.546
LIG_FHA_1	3	9	PF00498	0.666
LIG_FHA_1	33	39	PF00498	0.675
LIG_FHA_1	363	369	PF00498	0.634
LIG_FHA_1	491	497	PF00498	0.665
LIG_FHA_1	573	579	PF00498	0.629
LIG_FHA_1	770	776	PF00498	0.614
LIG_FHA_2	107	113	PF00498	0.546
LIG_FHA_2	208	214	PF00498	0.494
LIG_FHA_2	255	261	PF00498	0.793
LIG_FHA_2	267	273	PF00498	0.597
LIG_FHA_2	280	286	PF00498	0.473
LIG_FHA_2	298	304	PF00498	0.588
LIG_IBAR_NPY_1	763	765	PF08397	0.594
LIG_LIR_Apic_2	607	613	PF02991	0.628
LIG_LIR_Gen_1	117	126	PF02991	0.611
LIG_LIR_Gen_1	141	150	PF02991	0.546
LIG_LIR_Gen_1	567	578	PF02991	0.586
LIG_LIR_Gen_1	72	80	PF02991	0.509
LIG_LIR_Nem_3	117	122	PF02991	0.522
LIG_LIR_Nem_3	141	147	PF02991	0.546
LIG_LIR_Nem_3	219	224	PF02991	0.491
LIG_LIR_Nem_3	567	573	PF02991	0.628
LIG_LIR_Nem_3	603	608	PF02991	0.685
LIG_LIR_Nem_3	72	76	PF02991	0.625
LIG_LYPXL_SIV_4	697	705	PF13949	0.609
LIG_MYND_1	684	688	PF01753	0.619
LIG_PCNA_PIPBox_1	378	387	PF02747	0.547
LIG_Pex14_2	217	221	PF04695	0.484
LIG_PTAP_UEV_1	481	486	PF05743	0.643
LIG_PTB_Apo_2	759	766	PF02174	0.640
LIG_PTB_Phospho_1	759	765	PF10480	0.646
LIG_REV1ctd_RIR_1	157	167	PF16727	0.514
LIG_SH2_CRK	370	374	PF00017	0.613
LIG_SH2_CRK	392	396	PF00017	0.599
LIG_SH2_CRK	570	574	PF00017	0.621
LIG_SH2_GRB2like	412	415	PF00017	0.622
LIG_SH2_NCK_1	234	238	PF00017	0.601
LIG_SH2_NCK_1	352	356	PF00017	0.666
LIG_SH2_NCK_1	392	396	PF00017	0.659
LIG_SH2_NCK_1	698	702	PF00017	0.607
LIG_SH2_STAP1	352	356	PF00017	0.666
LIG_SH2_STAP1	673	677	PF00017	0.584
LIG_SH2_STAP1	765	769	PF00017	0.634
LIG_SH2_STAT3	421	424	PF00017	0.666
LIG_SH2_STAT3	430	433	PF00017	0.637
LIG_SH2_STAT5	412	415	PF00017	0.629
LIG_SH2_STAT5	570	573	PF00017	0.657
LIG_SH2_STAT5	577	580	PF00017	0.605
LIG_SH2_STAT5	732	735	PF00017	0.583
LIG_SH3_1	422	428	PF00018	0.649
LIG_SH3_1	494	500	PF00018	0.645
LIG_SH3_1	610	616	PF00018	0.561
LIG_SH3_3	165	171	PF00018	0.565
LIG_SH3_3	370	376	PF00018	0.575
LIG_SH3_3	396	402	PF00018	0.645
LIG_SH3_3	422	428	PF00018	0.687
LIG_SH3_3	464	470	PF00018	0.697
LIG_SH3_3	479	485	PF00018	0.558
LIG_SH3_3	493	499	PF00018	0.605
LIG_SH3_3	511	517	PF00018	0.523
LIG_SH3_3	521	527	PF00018	0.581
LIG_SH3_3	544	550	PF00018	0.704
LIG_SH3_3	570	576	PF00018	0.632
LIG_SH3_3	610	616	PF00018	0.585
LIG_SH3_3	674	680	PF00018	0.569
LIG_SH3_3	725	731	PF00018	0.668
LIG_SUMO_SIM_par_1	771	778	PF11976	0.608
LIG_TRFH_1	732	736	PF08558	0.583
LIG_TYR_ITIM	368	373	PF00017	0.639
LIG_WRC_WIRS_1	280	285	PF05994	0.468
LIG_WRC_WIRS_1	539	544	PF05994	0.596
MOD_CDC14_SPxK_1	241	244	PF00782	0.583
MOD_CDK_SPK_2	424	429	PF00069	0.567
MOD_CDK_SPK_2	546	551	PF00069	0.672
MOD_CDK_SPxK_1	238	244	PF00069	0.582
MOD_CDK_SPxK_1	534	540	PF00069	0.643
MOD_CDK_SPxxK_3	415	422	PF00069	0.613
MOD_CDK_SPxxK_3	546	553	PF00069	0.672
MOD_CK1_1	139	145	PF00069	0.546
MOD_CK1_1	166	172	PF00069	0.568
MOD_CK1_1	225	231	PF00069	0.464
MOD_CK1_1	254	260	PF00069	0.715
MOD_CK1_1	27	33	PF00069	0.670
MOD_CK1_1	350	356	PF00069	0.766
MOD_CK1_1	374	380	PF00069	0.640
MOD_CK1_1	393	399	PF00069	0.511
MOD_CK1_1	423	429	PF00069	0.799
MOD_CK1_1	431	437	PF00069	0.714
MOD_CK1_1	457	463	PF00069	0.651
MOD_CK1_1	46	52	PF00069	0.719
MOD_CK1_1	466	472	PF00069	0.600
MOD_CK1_1	474	480	PF00069	0.568
MOD_CK1_1	490	496	PF00069	0.555
MOD_CK1_1	509	515	PF00069	0.540
MOD_CK1_1	54	60	PF00069	0.652
MOD_CK1_1	555	561	PF00069	0.675
MOD_CK1_1	626	632	PF00069	0.689
MOD_CK1_1	642	648	PF00069	0.510
MOD_CK1_1	726	732	PF00069	0.601
MOD_CK1_1	745	751	PF00069	0.608
MOD_CK1_1	752	758	PF00069	0.648
MOD_CK2_1	207	213	PF00069	0.369
MOD_CK2_1	249	255	PF00069	0.759
MOD_CK2_1	264	270	PF00069	0.601
MOD_CK2_1	279	285	PF00069	0.353
MOD_CK2_1	44	50	PF00069	0.650
MOD_CK2_1	538	544	PF00069	0.592
MOD_CK2_1	78	84	PF00069	0.585
MOD_Cter_Amidation	244	247	PF01082	0.659
MOD_GlcNHglycan	126	129	PF01048	0.346
MOD_GlcNHglycan	266	269	PF01048	0.580
MOD_GlcNHglycan	29	32	PF01048	0.682
MOD_GlcNHglycan	353	356	PF01048	0.660
MOD_GlcNHglycan	392	395	PF01048	0.692
MOD_GlcNHglycan	408	411	PF01048	0.692
MOD_GlcNHglycan	433	436	PF01048	0.739
MOD_GlcNHglycan	452	455	PF01048	0.519
MOD_GlcNHglycan	459	462	PF01048	0.605
MOD_GlcNHglycan	508	511	PF01048	0.636
MOD_GlcNHglycan	55	59	PF01048	0.771
MOD_GlcNHglycan	557	560	PF01048	0.717
MOD_GlcNHglycan	626	629	PF01048	0.630
MOD_GlcNHglycan	643	647	PF01048	0.522
MOD_GlcNHglycan	66	69	PF01048	0.492
MOD_GlcNHglycan	673	676	PF01048	0.654
MOD_GlcNHglycan	699	702	PF01048	0.582
MOD_GlcNHglycan	725	728	PF01048	0.676
MOD_GlcNHglycan	742	745	PF01048	0.511
MOD_GlcNHglycan	751	754	PF01048	0.611
MOD_GSK3_1	163	170	PF00069	0.562
MOD_GSK3_1	20	27	PF00069	0.664
MOD_GSK3_1	262	269	PF00069	0.637
MOD_GSK3_1	297	304	PF00069	0.578
MOD_GSK3_1	327	334	PF00069	0.538
MOD_GSK3_1	346	353	PF00069	0.654
MOD_GSK3_1	355	362	PF00069	0.586
MOD_GSK3_1	37	44	PF00069	0.650
MOD_GSK3_1	408	415	PF00069	0.668
MOD_GSK3_1	420	427	PF00069	0.543
MOD_GSK3_1	450	457	PF00069	0.639
MOD_GSK3_1	471	478	PF00069	0.706
MOD_GSK3_1	500	507	PF00069	0.704
MOD_GSK3_1	518	525	PF00069	0.524
MOD_GSK3_1	534	541	PF00069	0.553
MOD_GSK3_1	542	549	PF00069	0.653
MOD_GSK3_1	564	571	PF00069	0.652
MOD_GSK3_1	622	629	PF00069	0.691
MOD_GSK3_1	667	674	PF00069	0.617
MOD_GSK3_1	723	730	PF00069	0.586
MOD_GSK3_1	740	747	PF00069	0.600
MOD_GSK3_1	748	755	PF00069	0.626
MOD_N-GLC_1	222	227	PF02516	0.443
MOD_N-GLC_1	297	302	PF02516	0.530
MOD_N-GLC_1	317	322	PF02516	0.469
MOD_N-GLC_1	44	49	PF02516	0.649
MOD_N-GLC_2	652	654	PF02516	0.547
MOD_N-GLC_2	7	9	PF02516	0.643
MOD_NEK2_1	408	413	PF00069	0.789
MOD_NEK2_1	43	48	PF00069	0.670
MOD_NEK2_1	476	481	PF00069	0.663
MOD_NEK2_1	53	58	PF00069	0.615
MOD_NEK2_1	557	562	PF00069	0.593
MOD_NEK2_1	566	571	PF00069	0.534
MOD_NEK2_1	769	774	PF00069	0.618
MOD_NEK2_2	538	543	PF00069	0.590
MOD_PIKK_1	175	181	PF00454	0.527
MOD_PIKK_1	207	213	PF00454	0.502
MOD_PIKK_1	216	222	PF00454	0.395
MOD_PIKK_1	374	380	PF00454	0.688
MOD_PIKK_1	420	426	PF00454	0.768
MOD_PIKK_1	429	435	PF00454	0.723
MOD_PIKK_1	557	563	PF00454	0.660
MOD_PIKK_1	718	724	PF00454	0.580
MOD_PIKK_1	742	748	PF00454	0.629
MOD_PKA_2	207	213	PF00069	0.440
MOD_PKA_2	371	377	PF00069	0.634
MOD_PKA_2	445	451	PF00069	0.771
MOD_PKB_1	161	169	PF00069	0.550
MOD_Plk_1	225	231	PF00069	0.499
MOD_Plk_1	44	50	PF00069	0.650
MOD_Plk_1	606	612	PF00069	0.650
MOD_Plk_1	642	648	PF00069	0.635
MOD_Plk_4	273	279	PF00069	0.520
MOD_Plk_4	408	414	PF00069	0.649
MOD_Plk_4	463	469	PF00069	0.674
MOD_Plk_4	471	477	PF00069	0.649
MOD_ProDKin_1	164	170	PF00069	0.556
MOD_ProDKin_1	20	26	PF00069	0.692
MOD_ProDKin_1	238	244	PF00069	0.752
MOD_ProDKin_1	249	255	PF00069	0.652
MOD_ProDKin_1	297	303	PF00069	0.534
MOD_ProDKin_1	359	365	PF00069	0.696
MOD_ProDKin_1	415	421	PF00069	0.640
MOD_ProDKin_1	424	430	PF00069	0.642
MOD_ProDKin_1	454	460	PF00069	0.676
MOD_ProDKin_1	466	472	PF00069	0.606
MOD_ProDKin_1	478	484	PF00069	0.588
MOD_ProDKin_1	518	524	PF00069	0.681
MOD_ProDKin_1	534	540	PF00069	0.550
MOD_ProDKin_1	542	548	PF00069	0.647
MOD_ProDKin_1	552	558	PF00069	0.558
MOD_ProDKin_1	572	578	PF00069	0.522
MOD_ProDKin_1	684	690	PF00069	0.583
MOD_ProDKin_1	727	733	PF00069	0.615
MOD_ProDKin_1	746	752	PF00069	0.551
MOD_ProDKin_1	775	781	PF00069	0.652
TRG_DiLeu_BaEn_2	212	218	PF01217	0.359
TRG_DiLeu_BaEn_3	272	278	PF01217	0.552
TRG_ENDOCYTIC_2	370	373	PF00928	0.617
TRG_ENDOCYTIC_2	392	395	PF00928	0.599
TRG_ENDOCYTIC_2	570	573	PF00928	0.617
TRG_ER_diArg_1	154	157	PF00400	0.546
TRG_ER_diArg_1	160	163	PF00400	0.442
TRG_ER_diArg_1	244	247	PF00400	0.659
TRG_ER_diArg_1	445	447	PF00400	0.699
TRG_ER_diArg_1	491	494	PF00400	0.660
TRG_ER_diArg_1	550	553	PF00400	0.681
TRG_ER_diArg_1	585	587	PF00400	0.654
TRG_ER_diArg_1	662	664	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEF2	Leishmania donovani	99%	100%
A4HHE9	Leishmania braziliensis	64%	99%
E9ADZ8	Leishmania major	90%	99%
E9ALT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%