Protein KRI1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4J8_LEIIN

TriTrypDb:

LINF_290020200

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0030684	preribosome	3	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4I4J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4J8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	8
GO:0022613	ribonucleoprotein complex biogenesis	4	8
GO:0042274	ribosomal small subunit biogenesis	5	8
GO:0044085	cellular component biogenesis	3	8
GO:0071840	cellular component organization or biogenesis	2	8
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000056	ribosomal small subunit export from nucleus	4	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.647
CLV_C14_Caspase3-7	20	24	PF00656	0.610
CLV_C14_Caspase3-7	208	212	PF00656	0.526
CLV_C14_Caspase3-7	428	432	PF00656	0.633
CLV_NRD_NRD_1	251	253	PF00675	0.574
CLV_NRD_NRD_1	258	260	PF00675	0.621
CLV_NRD_NRD_1	401	403	PF00675	0.537
CLV_NRD_NRD_1	41	43	PF00675	0.574
CLV_NRD_NRD_1	476	478	PF00675	0.598
CLV_NRD_NRD_1	482	484	PF00675	0.597
CLV_NRD_NRD_1	491	493	PF00675	0.587
CLV_NRD_NRD_1	56	58	PF00675	0.639
CLV_NRD_NRD_1	586	588	PF00675	0.641
CLV_NRD_NRD_1	598	600	PF00675	0.484
CLV_NRD_NRD_1	609	611	PF00675	0.471
CLV_NRD_NRD_1	629	631	PF00675	0.341
CLV_NRD_NRD_1	638	640	PF00675	0.504
CLV_NRD_NRD_1	74	76	PF00675	0.501
CLV_NRD_NRD_1	77	79	PF00675	0.516
CLV_PCSK_FUR_1	256	260	PF00082	0.675
CLV_PCSK_FUR_1	607	611	PF00082	0.557
CLV_PCSK_FUR_1	75	79	PF00082	0.511
CLV_PCSK_KEX2_1	250	252	PF00082	0.569
CLV_PCSK_KEX2_1	256	258	PF00082	0.615
CLV_PCSK_KEX2_1	401	403	PF00082	0.546
CLV_PCSK_KEX2_1	41	43	PF00082	0.571
CLV_PCSK_KEX2_1	476	478	PF00082	0.583
CLV_PCSK_KEX2_1	482	484	PF00082	0.561
CLV_PCSK_KEX2_1	491	493	PF00082	0.549
CLV_PCSK_KEX2_1	56	58	PF00082	0.635
CLV_PCSK_KEX2_1	586	588	PF00082	0.601
CLV_PCSK_KEX2_1	598	600	PF00082	0.484
CLV_PCSK_KEX2_1	609	611	PF00082	0.471
CLV_PCSK_KEX2_1	629	631	PF00082	0.341
CLV_PCSK_KEX2_1	638	640	PF00082	0.496
CLV_PCSK_KEX2_1	74	76	PF00082	0.499
CLV_PCSK_KEX2_1	77	79	PF00082	0.518
CLV_PCSK_PC7_1	252	258	PF00082	0.592
CLV_PCSK_SKI1_1	10	14	PF00082	0.476
CLV_PCSK_SKI1_1	139	143	PF00082	0.709
CLV_PCSK_SKI1_1	236	240	PF00082	0.546
CLV_PCSK_SKI1_1	294	298	PF00082	0.488
CLV_PCSK_SKI1_1	327	331	PF00082	0.567
CLV_PCSK_SKI1_1	482	486	PF00082	0.715
CLV_PCSK_SKI1_1	550	554	PF00082	0.556
CLV_PCSK_SKI1_1	610	614	PF00082	0.494
CLV_PCSK_SKI1_1	630	634	PF00082	0.467
CLV_Separin_Metazoa	298	302	PF03568	0.502
DEG_SPOP_SBC_1	530	534	PF00917	0.688
DOC_CYCLIN_RxL_1	199	208	PF00134	0.565
DOC_MAPK_gen_1	401	408	PF00069	0.525
DOC_MAPK_gen_1	549	557	PF00069	0.643
DOC_MAPK_gen_1	574	583	PF00069	0.606
DOC_MAPK_MEF2A_6	127	135	PF00069	0.549
DOC_MAPK_MEF2A_6	574	583	PF00069	0.597
DOC_PP1_RVXF_1	200	207	PF00149	0.484
DOC_PP1_RVXF_1	637	644	PF00149	0.576
DOC_USP7_MATH_1	151	155	PF00917	0.673
DOC_USP7_MATH_1	368	372	PF00917	0.568
DOC_USP7_MATH_1	425	429	PF00917	0.685
DOC_USP7_MATH_1	475	479	PF00917	0.627
DOC_USP7_MATH_1	530	534	PF00917	0.700
DOC_USP7_UBL2_3	243	247	PF12436	0.496
DOC_USP7_UBL2_3	549	553	PF12436	0.620
DOC_USP7_UBL2_3	588	592	PF12436	0.549
DOC_USP7_UBL2_3	6	10	PF12436	0.546
DOC_USP7_UBL2_3	613	617	PF12436	0.485
DOC_WW_Pin1_4	423	428	PF00397	0.610
LIG_14-3-3_CanoR_1	250	260	PF00244	0.475
LIG_14-3-3_CanoR_1	294	303	PF00244	0.473
LIG_14-3-3_CanoR_1	476	484	PF00244	0.712
LIG_14-3-3_CanoR_1	610	620	PF00244	0.557
LIG_14-3-3_CanoR_1	638	642	PF00244	0.572
LIG_BIR_III_4	23	27	PF00653	0.689
LIG_BIR_III_4	372	376	PF00653	0.644
LIG_BIR_III_4	85	89	PF00653	0.647
LIG_Clathr_ClatBox_1	441	445	PF01394	0.719
LIG_deltaCOP1_diTrp_1	112	122	PF00928	0.676
LIG_FHA_1	11	17	PF00498	0.459
LIG_FHA_1	377	383	PF00498	0.529
LIG_FHA_1	395	401	PF00498	0.580
LIG_FHA_1	515	521	PF00498	0.664
LIG_FHA_1	539	545	PF00498	0.724
LIG_FHA_1	552	558	PF00498	0.540
LIG_FHA_1	567	573	PF00498	0.638
LIG_FHA_2	237	243	PF00498	0.541
LIG_FHA_2	328	334	PF00498	0.555
LIG_FHA_2	431	437	PF00498	0.655
LIG_FHA_2	497	503	PF00498	0.714
LIG_FHA_2	589	595	PF00498	0.485
LIG_FHA_2	617	623	PF00498	0.595
LIG_Integrin_RGD_1	521	523	PF01839	0.608
LIG_LIR_Apic_2	463	469	PF02991	0.530
LIG_LIR_Gen_1	293	303	PF02991	0.494
LIG_LIR_Nem_3	13	17	PF02991	0.452
LIG_LIR_Nem_3	222	227	PF02991	0.650
LIG_LIR_Nem_3	232	238	PF02991	0.552
LIG_LIR_Nem_3	619	623	PF02991	0.539
LIG_Pex14_2	389	393	PF04695	0.483
LIG_RPA_C_Fungi	245	257	PF08784	0.603
LIG_SH2_CRK	14	18	PF00017	0.518
LIG_SH2_CRK	466	470	PF00017	0.618
LIG_SH2_GRB2like	465	468	PF00017	0.538
LIG_SH2_NCK_1	466	470	PF00017	0.615
LIG_SH2_NCK_1	62	66	PF00017	0.536
LIG_SH2_SRC	107	110	PF00017	0.531
LIG_SH2_SRC	90	93	PF00017	0.672
LIG_SH2_STAP1	62	66	PF00017	0.536
LIG_SH2_STAT3	465	468	PF00017	0.538
LIG_SH2_STAT5	313	316	PF00017	0.531
LIG_SH2_STAT5	328	331	PF00017	0.621
LIG_SH2_STAT5	361	364	PF00017	0.536
LIG_SH3_3	125	131	PF00018	0.736
LIG_SH3_3	554	560	PF00018	0.641
LIG_SH3_4	6	13	PF00018	0.545
LIG_SUMO_SIM_anti_2	436	445	PF11976	0.710
LIG_TRAF2_1	101	104	PF00917	0.706
LIG_TRAF2_1	178	181	PF00917	0.701
LIG_TRAF2_1	331	334	PF00917	0.433
LIG_TRAF2_1	434	437	PF00917	0.671
LIG_TRAF2_1	591	594	PF00917	0.493
LIG_TRFH_1	14	18	PF08558	0.518
LIG_TYR_ITIM	12	17	PF00017	0.514
LIG_UBA3_1	355	360	PF00899	0.543
LIG_UBA3_1	441	449	PF00899	0.641
MOD_CK1_1	460	466	PF00069	0.507
MOD_CK1_1	503	509	PF00069	0.660
MOD_CK1_1	515	521	PF00069	0.755
MOD_CK1_1	533	539	PF00069	0.626
MOD_CK1_1	542	548	PF00069	0.630
MOD_CK1_1	566	572	PF00069	0.691
MOD_CK1_1	631	637	PF00069	0.548
MOD_CK2_1	236	242	PF00069	0.544
MOD_CK2_1	32	38	PF00069	0.518
MOD_CK2_1	327	333	PF00069	0.558
MOD_CK2_1	423	429	PF00069	0.726
MOD_CK2_1	430	436	PF00069	0.795
MOD_CK2_1	496	502	PF00069	0.688
MOD_CK2_1	561	567	PF00069	0.703
MOD_CK2_1	588	594	PF00069	0.489
MOD_CK2_1	616	622	PF00069	0.597
MOD_CK2_1	98	104	PF00069	0.640
MOD_Cter_Amidation	75	78	PF01082	0.469
MOD_GlcNHglycan	145	148	PF01048	0.677
MOD_GlcNHglycan	207	210	PF01048	0.612
MOD_GlcNHglycan	44	47	PF01048	0.709
MOD_GlcNHglycan	459	462	PF01048	0.510
MOD_GlcNHglycan	477	480	PF01048	0.633
MOD_GlcNHglycan	513	517	PF01048	0.702
MOD_GlcNHglycan	525	528	PF01048	0.645
MOD_GlcNHglycan	533	536	PF01048	0.689
MOD_GlcNHglycan	546	549	PF01048	0.586
MOD_GlcNHglycan	613	616	PF01048	0.550
MOD_GlcNHglycan	630	633	PF01048	0.535
MOD_GSK3_1	169	176	PF00069	0.641
MOD_GSK3_1	246	253	PF00069	0.495
MOD_GSK3_1	277	284	PF00069	0.591
MOD_GSK3_1	457	464	PF00069	0.497
MOD_GSK3_1	496	503	PF00069	0.732
MOD_GSK3_1	511	518	PF00069	0.638
MOD_GSK3_1	529	536	PF00069	0.613
MOD_GSK3_1	538	545	PF00069	0.651
MOD_N-GLC_1	503	508	PF02516	0.622
MOD_NEK2_1	152	157	PF00069	0.664
MOD_NEK2_1	271	276	PF00069	0.668
MOD_NEK2_1	335	340	PF00069	0.579
MOD_NEK2_1	531	536	PF00069	0.604
MOD_NEK2_1	616	621	PF00069	0.602
MOD_NEK2_1	628	633	PF00069	0.450
MOD_NEK2_2	637	642	PF00069	0.501
MOD_PIKK_1	285	291	PF00454	0.571
MOD_PIKK_1	631	637	PF00454	0.533
MOD_PKA_1	250	256	PF00069	0.579
MOD_PKA_2	250	256	PF00069	0.595
MOD_PKA_2	475	481	PF00069	0.648
MOD_PKA_2	542	548	PF00069	0.689
MOD_PKA_2	628	634	PF00069	0.584
MOD_PKA_2	637	643	PF00069	0.515
MOD_Plk_2-3	173	179	PF00069	0.611
MOD_Plk_2-3	311	317	PF00069	0.522
MOD_Plk_2-3	622	628	PF00069	0.594
MOD_Plk_4	377	383	PF00069	0.535
MOD_Plk_4	461	467	PF00069	0.518
MOD_Plk_4	515	521	PF00069	0.731
MOD_ProDKin_1	423	429	PF00069	0.617
MOD_SUMO_rev_2	119	128	PF00179	0.717
MOD_SUMO_rev_2	179	188	PF00179	0.596
MOD_SUMO_rev_2	240	245	PF00179	0.504
MOD_SUMO_rev_2	439	448	PF00179	0.650
MOD_SUMO_rev_2	589	597	PF00179	0.493
TRG_DiLeu_BaEn_1	233	238	PF01217	0.553
TRG_DiLeu_BaEn_1	437	442	PF01217	0.720
TRG_DiLeu_BaEn_3	437	443	PF01217	0.650
TRG_DiLeu_LyEn_5	233	238	PF01217	0.553
TRG_ENDOCYTIC_2	14	17	PF00928	0.507
TRG_ENDOCYTIC_2	620	623	PF00928	0.475
TRG_ER_diArg_1	250	252	PF00400	0.569
TRG_ER_diArg_1	256	259	PF00400	0.618
TRG_ER_diArg_1	40	42	PF00400	0.552
TRG_ER_diArg_1	400	402	PF00400	0.554
TRG_ER_diArg_1	405	408	PF00400	0.516
TRG_ER_diArg_1	475	477	PF00400	0.646
TRG_ER_diArg_1	482	484	PF00400	0.617
TRG_ER_diArg_1	585	587	PF00400	0.646
TRG_ER_diArg_1	597	599	PF00400	0.516
TRG_ER_diArg_1	628	630	PF00400	0.609
TRG_ER_diArg_1	74	77	PF00400	0.501
TRG_NLS_MonoCore_2	4	9	PF00514	0.548
TRG_NLS_MonoExtN_4	2	9	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D0	Leptomonas seymouri	51%	91%
A0A3Q8IHA2	Leishmania donovani	99%	100%
A4HHE8	Leishmania braziliensis	67%	96%
E9ADZ7	Leishmania major	87%	100%
E9ALT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BH77	Trypanosoma cruzi	38%	100%