Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein - putative

Species:

Leishmania infantum

UniProt:

A4I4J5_LEIIN

TriTrypDb:

LINF_290019800

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4I4J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4J5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.525
CLV_NRD_NRD_1	30	32	PF00675	0.672
CLV_NRD_NRD_1	300	302	PF00675	0.562
CLV_NRD_NRD_1	312	314	PF00675	0.333
CLV_NRD_NRD_1	407	409	PF00675	0.656
CLV_NRD_NRD_1	674	676	PF00675	0.734
CLV_NRD_NRD_1	808	810	PF00675	0.645
CLV_NRD_NRD_1	854	856	PF00675	0.656
CLV_PCSK_KEX2_1	29	31	PF00082	0.680
CLV_PCSK_KEX2_1	406	408	PF00082	0.652
CLV_PCSK_KEX2_1	808	810	PF00082	0.645
CLV_PCSK_KEX2_1	819	821	PF00082	0.531
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.656
CLV_PCSK_SKI1_1	315	319	PF00082	0.510
CLV_PCSK_SKI1_1	344	348	PF00082	0.363
CLV_PCSK_SKI1_1	407	411	PF00082	0.643
DEG_COP1_1	203	210	PF00400	0.634
DEG_Nend_UBRbox_3	1	3	PF02207	0.536
DEG_SCF_FBW7_1	178	184	PF00400	0.732
DEG_SCF_FBW7_1	36	42	PF00400	0.720
DEG_SCF_FBW7_1	435	441	PF00400	0.619
DEG_SCF_FBW7_1	527	532	PF00400	0.672
DEG_SCF_FBW7_1	698	705	PF00400	0.583
DEG_SCF_FBW7_1	870	877	PF00400	0.718
DEG_SPOP_SBC_1	54	58	PF00917	0.667
DEG_SPOP_SBC_1	559	563	PF00917	0.669
DEG_SPOP_SBC_1	869	873	PF00917	0.556
DOC_CDC14_PxL_1	195	203	PF14671	0.581
DOC_CKS1_1	167	172	PF01111	0.743
DOC_CKS1_1	175	180	PF01111	0.734
DOC_CKS1_1	207	212	PF01111	0.707
DOC_CKS1_1	36	41	PF01111	0.720
DOC_CKS1_1	435	440	PF01111	0.687
DOC_CKS1_1	508	513	PF01111	0.636
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.658
DOC_CYCLIN_yCln2_LP_2	422	428	PF00134	0.545
DOC_MAPK_gen_1	313	321	PF00069	0.511
DOC_MAPK_gen_1	45	54	PF00069	0.692
DOC_MAPK_gen_1	855	862	PF00069	0.646
DOC_MAPK_MEF2A_6	135	142	PF00069	0.750
DOC_MAPK_MEF2A_6	313	321	PF00069	0.549
DOC_MAPK_NFAT4_5	314	322	PF00069	0.505
DOC_PP1_RVXF_1	360	367	PF00149	0.563
DOC_PP2B_LxvP_1	592	595	PF13499	0.650
DOC_PP4_FxxP_1	167	170	PF00568	0.672
DOC_USP7_MATH_1	339	343	PF00917	0.476
DOC_USP7_MATH_1	387	391	PF00917	0.541
DOC_USP7_MATH_1	401	405	PF00917	0.425
DOC_USP7_MATH_1	418	422	PF00917	0.489
DOC_USP7_MATH_1	438	442	PF00917	0.569
DOC_USP7_MATH_1	448	452	PF00917	0.577
DOC_USP7_MATH_1	463	467	PF00917	0.576
DOC_USP7_MATH_1	478	482	PF00917	0.609
DOC_USP7_MATH_1	529	533	PF00917	0.675
DOC_USP7_MATH_1	55	59	PF00917	0.665
DOC_USP7_MATH_1	559	563	PF00917	0.669
DOC_USP7_MATH_1	569	573	PF00917	0.558
DOC_USP7_MATH_1	617	621	PF00917	0.633
DOC_USP7_MATH_1	661	665	PF00917	0.585
DOC_USP7_MATH_1	686	690	PF00917	0.700
DOC_USP7_MATH_1	713	717	PF00917	0.692
DOC_USP7_MATH_1	761	765	PF00917	0.638
DOC_USP7_MATH_1	790	794	PF00917	0.655
DOC_USP7_MATH_1	803	807	PF00917	0.606
DOC_USP7_MATH_1	835	839	PF00917	0.650
DOC_USP7_MATH_1	910	914	PF00917	0.655
DOC_USP7_MATH_2	213	219	PF00917	0.613
DOC_USP7_UBL2_3	314	318	PF12436	0.530
DOC_WW_Pin1_4	10	15	PF00397	0.693
DOC_WW_Pin1_4	118	123	PF00397	0.631
DOC_WW_Pin1_4	166	171	PF00397	0.739
DOC_WW_Pin1_4	174	179	PF00397	0.731
DOC_WW_Pin1_4	184	189	PF00397	0.589
DOC_WW_Pin1_4	202	207	PF00397	0.501
DOC_WW_Pin1_4	209	214	PF00397	0.635
DOC_WW_Pin1_4	304	309	PF00397	0.453
DOC_WW_Pin1_4	32	37	PF00397	0.756
DOC_WW_Pin1_4	350	355	PF00397	0.563
DOC_WW_Pin1_4	431	436	PF00397	0.717
DOC_WW_Pin1_4	440	445	PF00397	0.621
DOC_WW_Pin1_4	46	51	PF00397	0.586
DOC_WW_Pin1_4	476	481	PF00397	0.660
DOC_WW_Pin1_4	507	512	PF00397	0.672
DOC_WW_Pin1_4	520	525	PF00397	0.638
DOC_WW_Pin1_4	535	540	PF00397	0.545
DOC_WW_Pin1_4	555	560	PF00397	0.506
DOC_WW_Pin1_4	57	62	PF00397	0.603
DOC_WW_Pin1_4	624	629	PF00397	0.670
DOC_WW_Pin1_4	641	646	PF00397	0.555
DOC_WW_Pin1_4	680	685	PF00397	0.741
DOC_WW_Pin1_4	698	703	PF00397	0.690
DOC_WW_Pin1_4	709	714	PF00397	0.613
DOC_WW_Pin1_4	720	725	PF00397	0.653
DOC_WW_Pin1_4	782	787	PF00397	0.679
DOC_WW_Pin1_4	793	798	PF00397	0.655
DOC_WW_Pin1_4	827	832	PF00397	0.672
DOC_WW_Pin1_4	846	851	PF00397	0.526
DOC_WW_Pin1_4	870	875	PF00397	0.712
DOC_WW_Pin1_4	895	900	PF00397	0.725
LIG_14-3-3_CanoR_1	105	112	PF00244	0.711
LIG_14-3-3_CanoR_1	29	39	PF00244	0.729
LIG_14-3-3_CanoR_1	344	349	PF00244	0.563
LIG_14-3-3_CanoR_1	513	519	PF00244	0.672
LIG_14-3-3_CanoR_1	574	580	PF00244	0.652
LIG_AP2alpha_2	240	242	PF02296	0.563
LIG_APCC_ABBA_1	239	244	PF00400	0.515
LIG_APCC_ABBA_1	346	351	PF00400	0.563
LIG_APCC_ABBA_1	366	371	PF00400	0.400
LIG_BRCT_BRCA1_1	441	445	PF00533	0.672
LIG_BRCT_BRCA1_1	577	581	PF00533	0.636
LIG_BRCT_BRCA1_1	617	621	PF00533	0.687
LIG_BRCT_BRCA1_1	702	706	PF00533	0.747
LIG_BRCT_BRCA1_1	776	780	PF00533	0.744
LIG_EH1_1	3	11	PF00400	0.569
LIG_FHA_1	112	118	PF00498	0.664
LIG_FHA_1	137	143	PF00498	0.633
LIG_FHA_1	202	208	PF00498	0.654
LIG_FHA_1	217	223	PF00498	0.416
LIG_FHA_1	260	266	PF00498	0.563
LIG_FHA_1	282	288	PF00498	0.631
LIG_FHA_1	350	356	PF00498	0.563
LIG_FHA_1	414	420	PF00498	0.616
LIG_FHA_1	782	788	PF00498	0.727
LIG_FHA_1	874	880	PF00498	0.736
LIG_FHA_2	210	216	PF00498	0.686
LIG_FHA_2	235	241	PF00498	0.525
LIG_FHA_2	654	660	PF00498	0.693
LIG_GSK3_LRP6_1	874	880	PF00069	0.682
LIG_HP1_1	418	422	PF01393	0.535
LIG_IBAR_NPY_1	909	911	PF08397	0.693
LIG_LIR_Apic_2	481	486	PF02991	0.661
LIG_LIR_Apic_2	491	497	PF02991	0.632
LIG_LIR_Gen_1	618	628	PF02991	0.643
LIG_LIR_LC3C_4	292	297	PF02991	0.539
LIG_LIR_Nem_3	196	201	PF02991	0.634
LIG_LIR_Nem_3	237	242	PF02991	0.557
LIG_LIR_Nem_3	262	267	PF02991	0.563
LIG_LIR_Nem_3	334	340	PF02991	0.563
LIG_LIR_Nem_3	618	624	PF02991	0.646
LIG_LYPXL_yS_3	198	201	PF13949	0.634
LIG_MYND_1	148	152	PF01753	0.619
LIG_PDZ_Class_2	915	920	PF00595	0.686
LIG_PTB_Apo_2	905	912	PF02174	0.708
LIG_PTB_Phospho_1	905	911	PF10480	0.713
LIG_Rb_LxCxE_1	858	877	PF01857	0.660
LIG_Rb_pABgroove_1	233	241	PF01858	0.563
LIG_SH2_CRK	340	344	PF00017	0.543
LIG_SH2_CRK	483	487	PF00017	0.611
LIG_SH2_CRK	907	911	PF00017	0.706
LIG_SH2_GRB2like	906	909	PF00017	0.719
LIG_SH2_NCK_1	494	498	PF00017	0.723
LIG_SH2_NCK_1	907	911	PF00017	0.706
LIG_SH2_SRC	494	497	PF00017	0.693
LIG_SH2_STAP1	267	271	PF00017	0.563
LIG_SH2_STAP1	474	478	PF00017	0.565
LIG_SH2_STAT3	107	110	PF00017	0.746
LIG_SH2_STAT5	107	110	PF00017	0.746
LIG_SH2_STAT5	369	372	PF00017	0.563
LIG_SH2_STAT5	549	552	PF00017	0.584
LIG_SH2_STAT5	623	626	PF00017	0.648
LIG_SH2_STAT5	84	87	PF00017	0.651
LIG_SH3_1	432	438	PF00018	0.716
LIG_SH3_2	692	697	PF14604	0.667
LIG_SH3_3	146	152	PF00018	0.692
LIG_SH3_3	175	181	PF00018	0.807
LIG_SH3_3	204	210	PF00018	0.704
LIG_SH3_3	33	39	PF00018	0.733
LIG_SH3_3	432	438	PF00018	0.672
LIG_SH3_3	493	499	PF00018	0.695
LIG_SH3_3	561	567	PF00018	0.613
LIG_SH3_3	61	67	PF00018	0.614
LIG_SH3_3	642	648	PF00018	0.655
LIG_SH3_3	689	695	PF00018	0.621
LIG_SH3_3	829	835	PF00018	0.648
LIG_SH3_3	840	846	PF00018	0.648
LIG_SH3_3	872	878	PF00018	0.675
LIG_SUMO_SIM_par_1	138	143	PF11976	0.633
LIG_SUMO_SIM_par_1	15	20	PF11976	0.681
LIG_SUMO_SIM_par_1	858	863	PF11976	0.708
MOD_CDC14_SPxK_1	538	541	PF00782	0.716
MOD_CDK_SPxK_1	507	513	PF00069	0.585
MOD_CDK_SPxK_1	535	541	PF00069	0.718
MOD_CDK_SPxxK_3	793	800	PF00069	0.747
MOD_CK1_1	183	189	PF00069	0.814
MOD_CK1_1	281	287	PF00069	0.541
MOD_CK1_1	32	38	PF00069	0.756
MOD_CK1_1	434	440	PF00069	0.680
MOD_CK1_1	479	485	PF00069	0.688
MOD_CK1_1	503	509	PF00069	0.691
MOD_CK1_1	558	564	PF00069	0.669
MOD_CK1_1	57	63	PF00069	0.695
MOD_CK1_1	593	599	PF00069	0.699
MOD_CK1_1	626	632	PF00069	0.577
MOD_CK1_1	700	706	PF00069	0.746
MOD_CK1_1	723	729	PF00069	0.744
MOD_CK1_1	764	770	PF00069	0.718
MOD_CK1_1	782	788	PF00069	0.619
MOD_CK1_1	793	799	PF00069	0.597
MOD_CK1_1	8	14	PF00069	0.639
MOD_CK1_1	830	836	PF00069	0.711
MOD_CK1_1	849	855	PF00069	0.487
MOD_CK1_1	858	864	PF00069	0.578
MOD_CK1_1	868	874	PF00069	0.520
MOD_CK1_1	877	883	PF00069	0.574
MOD_CK1_1	895	901	PF00069	0.518
MOD_CK1_1	912	918	PF00069	0.537
MOD_CK2_1	191	197	PF00069	0.712
MOD_CK2_1	209	215	PF00069	0.495
MOD_CK2_1	860	866	PF00069	0.711
MOD_GlcNHglycan	171	174	PF01048	0.667
MOD_GlcNHglycan	183	186	PF01048	0.608
MOD_GlcNHglycan	41	44	PF01048	0.722
MOD_GlcNHglycan	518	521	PF01048	0.736
MOD_GlcNHglycan	592	595	PF01048	0.670
MOD_GlcNHglycan	598	601	PF01048	0.644
MOD_GlcNHglycan	617	620	PF01048	0.515
MOD_GlcNHglycan	649	652	PF01048	0.731
MOD_GlcNHglycan	688	691	PF01048	0.724
MOD_GlcNHglycan	707	710	PF01048	0.574
MOD_GlcNHglycan	755	758	PF01048	0.660
MOD_GlcNHglycan	764	767	PF01048	0.679
MOD_GlcNHglycan	781	784	PF01048	0.535
MOD_GlcNHglycan	787	790	PF01048	0.673
MOD_GlcNHglycan	827	830	PF01048	0.725
MOD_GlcNHglycan	837	840	PF01048	0.595
MOD_GlcNHglycan	86	89	PF01048	0.623
MOD_GlcNHglycan	866	870	PF01048	0.640
MOD_GlcNHglycan	884	887	PF01048	0.585
MOD_GlcNHglycan	900	903	PF01048	0.540
MOD_GSK3_1	176	183	PF00069	0.806
MOD_GSK3_1	184	191	PF00069	0.738
MOD_GSK3_1	202	209	PF00069	0.577
MOD_GSK3_1	211	218	PF00069	0.541
MOD_GSK3_1	31	38	PF00069	0.734
MOD_GSK3_1	430	437	PF00069	0.687
MOD_GSK3_1	472	479	PF00069	0.589
MOD_GSK3_1	503	510	PF00069	0.707
MOD_GSK3_1	516	523	PF00069	0.616
MOD_GSK3_1	525	532	PF00069	0.621
MOD_GSK3_1	53	60	PF00069	0.681
MOD_GSK3_1	555	562	PF00069	0.735
MOD_GSK3_1	622	629	PF00069	0.645
MOD_GSK3_1	637	644	PF00069	0.589
MOD_GSK3_1	663	670	PF00069	0.728
MOD_GSK3_1	698	705	PF00069	0.691
MOD_GSK3_1	709	716	PF00069	0.642
MOD_GSK3_1	719	726	PF00069	0.576
MOD_GSK3_1	761	768	PF00069	0.706
MOD_GSK3_1	770	777	PF00069	0.598
MOD_GSK3_1	781	788	PF00069	0.521
MOD_GSK3_1	791	798	PF00069	0.665
MOD_GSK3_1	833	840	PF00069	0.657
MOD_GSK3_1	865	872	PF00069	0.632
MOD_GSK3_1	873	880	PF00069	0.619
MOD_GSK3_1	888	895	PF00069	0.545
MOD_GSK3_1	909	916	PF00069	0.558
MOD_LATS_1	27	33	PF00433	0.732
MOD_N-GLC_1	191	196	PF02516	0.803
MOD_N-GLC_1	661	666	PF02516	0.731
MOD_N-GLC_1	771	776	PF02516	0.686
MOD_N-GLC_1	825	830	PF02516	0.718
MOD_N-GLC_1	880	885	PF02516	0.712
MOD_NEK2_1	131	136	PF00069	0.639
MOD_NEK2_1	201	206	PF00069	0.678
MOD_NEK2_1	400	405	PF00069	0.572
MOD_NEK2_1	41	46	PF00069	0.737
MOD_NEK2_1	470	475	PF00069	0.657
MOD_NEK2_1	488	493	PF00069	0.553
MOD_NEK2_1	514	519	PF00069	0.725
MOD_NEK2_1	622	627	PF00069	0.701
MOD_NEK2_1	667	672	PF00069	0.755
MOD_NEK2_1	678	683	PF00069	0.626
MOD_NEK2_1	704	709	PF00069	0.729
MOD_NEK2_1	719	724	PF00069	0.605
MOD_NEK2_1	771	776	PF00069	0.671
MOD_NEK2_1	825	830	PF00069	0.664
MOD_NEK2_1	837	842	PF00069	0.553
MOD_NEK2_1	860	865	PF00069	0.708
MOD_NEK2_1	893	898	PF00069	0.583
MOD_NEK2_2	234	239	PF00069	0.532
MOD_NEK2_2	339	344	PF00069	0.476
MOD_PIKK_1	105	111	PF00454	0.692
MOD_PIKK_1	401	407	PF00454	0.603
MOD_PIKK_1	448	454	PF00454	0.595
MOD_PIKK_1	463	469	PF00454	0.614
MOD_PIKK_1	55	61	PF00454	0.663
MOD_PIKK_1	668	674	PF00454	0.692
MOD_PKA_1	29	35	PF00069	0.678
MOD_PKA_1	855	861	PF00069	0.645
MOD_PKA_2	265	271	PF00069	0.563
MOD_PKA_2	29	35	PF00069	0.726
MOD_PKB_1	118	126	PF00069	0.678
MOD_PKB_1	29	37	PF00069	0.610
MOD_Plk_1	191	197	PF00069	0.803
MOD_Plk_1	326	332	PF00069	0.543
MOD_Plk_1	771	777	PF00069	0.706
MOD_Plk_1	880	886	PF00069	0.711
MOD_Plk_2-3	472	478	PF00069	0.569
MOD_Plk_4	234	240	PF00069	0.525
MOD_Plk_4	5	11	PF00069	0.663
MOD_Plk_4	545	551	PF00069	0.586
MOD_Plk_4	617	623	PF00069	0.640
MOD_Plk_4	663	669	PF00069	0.669
MOD_Plk_4	839	845	PF00069	0.581
MOD_Plk_4	855	861	PF00069	0.594
MOD_Plk_4	91	97	PF00069	0.673
MOD_ProDKin_1	10	16	PF00069	0.693
MOD_ProDKin_1	118	124	PF00069	0.629
MOD_ProDKin_1	166	172	PF00069	0.741
MOD_ProDKin_1	174	180	PF00069	0.733
MOD_ProDKin_1	184	190	PF00069	0.588
MOD_ProDKin_1	202	208	PF00069	0.501
MOD_ProDKin_1	209	215	PF00069	0.626
MOD_ProDKin_1	304	310	PF00069	0.453
MOD_ProDKin_1	32	38	PF00069	0.756
MOD_ProDKin_1	350	356	PF00069	0.563
MOD_ProDKin_1	431	437	PF00069	0.715
MOD_ProDKin_1	440	446	PF00069	0.622
MOD_ProDKin_1	46	52	PF00069	0.586
MOD_ProDKin_1	476	482	PF00069	0.658
MOD_ProDKin_1	507	513	PF00069	0.672
MOD_ProDKin_1	520	526	PF00069	0.637
MOD_ProDKin_1	535	541	PF00069	0.546
MOD_ProDKin_1	555	561	PF00069	0.507
MOD_ProDKin_1	57	63	PF00069	0.606
MOD_ProDKin_1	624	630	PF00069	0.673
MOD_ProDKin_1	641	647	PF00069	0.554
MOD_ProDKin_1	680	686	PF00069	0.741
MOD_ProDKin_1	698	704	PF00069	0.690
MOD_ProDKin_1	709	715	PF00069	0.613
MOD_ProDKin_1	720	726	PF00069	0.652
MOD_ProDKin_1	782	788	PF00069	0.682
MOD_ProDKin_1	793	799	PF00069	0.651
MOD_ProDKin_1	827	833	PF00069	0.672
MOD_ProDKin_1	846	852	PF00069	0.528
MOD_ProDKin_1	870	876	PF00069	0.716
MOD_ProDKin_1	895	901	PF00069	0.723
MOD_SUMO_rev_2	625	634	PF00179	0.649
TRG_DiLeu_BaEn_1	197	202	PF01217	0.647
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.563
TRG_ENDOCYTIC_2	198	201	PF00928	0.634
TRG_ENDOCYTIC_2	340	343	PF00928	0.621
TRG_ER_diArg_1	117	120	PF00400	0.684
TRG_ER_diArg_1	28	31	PF00400	0.679
TRG_ER_diArg_1	406	408	PF00400	0.652
TRG_ER_diArg_1	807	809	PF00400	0.653
TRG_ER_diArg_1	903	906	PF00400	0.734
TRG_NES_CRM1_1	358	372	PF08389	0.563
TRG_NLS_Bipartite_1	301	317	PF00514	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2K7	Leishmania donovani	99%	100%
A4HHU3	Leishmania braziliensis	70%	100%
E9ADZ4	Leishmania major	92%	100%
E9ALT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%