Amastin, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Amastin, putative

Gene product:

Amastin surface glycoprotein - putative

Species:

Leishmania infantum

UniProt:

A4I4J3_LEIIN

TriTrypDb:

LINF_290019400

Length:

258

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Annotations by Jardim et al.

Plasma membrane, Amastin,

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 183
NetGPI	no	yes: 0, no: 194

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	173
GO:0110165	cellular anatomical entity	1	173

Expansion

Sequence features

A4I4J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4J3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	210	212	PF00675	0.401
CLV_NRD_NRD_1	64	66	PF00675	0.273
CLV_PCSK_FUR_1	138	142	PF00082	0.411
CLV_PCSK_KEX2_1	140	142	PF00082	0.540
CLV_PCSK_KEX2_1	210	212	PF00082	0.402
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.407
CLV_PCSK_SKI1_1	120	124	PF00082	0.524
CLV_PCSK_SKI1_1	66	70	PF00082	0.276
DEG_MDM2_SWIB_1	222	230	PF02201	0.323
DEG_Nend_UBRbox_1	1	4	PF02207	0.594
DOC_CKS1_1	40	45	PF01111	0.549
DOC_CYCLIN_yCln2_LP_2	236	242	PF00134	0.524
DOC_MAPK_gen_1	120	128	PF00069	0.216
DOC_MAPK_gen_1	65	73	PF00069	0.501
DOC_MAPK_MEF2A_6	120	128	PF00069	0.202
DOC_MAPK_MEF2A_6	174	182	PF00069	0.591
DOC_MAPK_MEF2A_6	66	75	PF00069	0.590
DOC_MAPK_MEF2A_6	97	104	PF00069	0.208
DOC_PP2B_LxvP_1	236	239	PF13499	0.541
DOC_SPAK_OSR1_1	141	145	PF12202	0.210
DOC_USP7_UBL2_3	66	70	PF12436	0.473
DOC_WW_Pin1_4	20	25	PF00397	0.645
DOC_WW_Pin1_4	39	44	PF00397	0.686
DOC_WW_Pin1_4	45	50	PF00397	0.550
LIG_14-3-3_CanoR_1	107	113	PF00244	0.318
LIG_14-3-3_CanoR_1	38	43	PF00244	0.555
LIG_14-3-3_CanoR_1	53	58	PF00244	0.505
LIG_14-3-3_CanoR_1	7	13	PF00244	0.582
LIG_BRCT_BRCA1_1	100	104	PF00533	0.206
LIG_BRCT_BRCA1_1	15	19	PF00533	0.582
LIG_BRCT_BRCA1_1	55	59	PF00533	0.496
LIG_Clathr_ClatBox_1	237	241	PF01394	0.336
LIG_eIF4E_1	156	162	PF01652	0.278
LIG_FHA_1	185	191	PF00498	0.439
LIG_FHA_2	199	205	PF00498	0.239
LIG_FHA_2	247	253	PF00498	0.524
LIG_LIR_Gen_1	232	242	PF02991	0.382
LIG_LIR_Nem_3	171	176	PF02991	0.577
LIG_LIR_Nem_3	232	238	PF02991	0.432
LIG_MYND_1	25	29	PF01753	0.575
LIG_Pex14_2	215	219	PF04695	0.363
LIG_Pex14_2	222	226	PF04695	0.412
LIG_Pex14_2	81	85	PF04695	0.260
LIG_SH2_PTP2	76	79	PF00017	0.362
LIG_SH2_STAT3	254	257	PF00017	0.541
LIG_SH2_STAT5	134	137	PF00017	0.382
LIG_SH2_STAT5	213	216	PF00017	0.244
LIG_SH2_STAT5	76	79	PF00017	0.454
LIG_SH3_2	29	34	PF14604	0.572
LIG_SH3_3	26	32	PF00018	0.642
LIG_SH3_3	86	92	PF00018	0.376
LIG_SUMO_SIM_par_1	226	232	PF11976	0.447
LIG_TRFH_1	235	239	PF08558	0.268
LIG_TYR_ITIM	74	79	PF00017	0.446
LIG_UBA3_1	236	243	PF00899	0.282
LIG_WW_3	31	35	PF00397	0.568
MOD_CK1_1	246	252	PF00069	0.551
MOD_CK2_1	198	204	PF00069	0.202
MOD_DYRK1A_RPxSP_1	20	24	PF00069	0.575
MOD_GlcNHglycan	170	173	PF01048	0.323
MOD_GSK3_1	14	21	PF00069	0.587
MOD_LATS_1	51	57	PF00433	0.513
MOD_NEK2_1	18	23	PF00069	0.579
MOD_NEK2_1	52	57	PF00069	0.531
MOD_NEK2_2	149	154	PF00069	0.439
MOD_PIKK_1	2	8	PF00454	0.581
MOD_PKA_2	52	58	PF00069	0.508
MOD_Plk_1	14	20	PF00069	0.585
MOD_Plk_4	108	114	PF00069	0.322
MOD_Plk_4	14	20	PF00069	0.584
MOD_Plk_4	55	61	PF00069	0.498
MOD_ProDKin_1	20	26	PF00069	0.647
MOD_ProDKin_1	39	45	PF00069	0.686
TRG_ENDOCYTIC_2	76	79	PF00928	0.432
TRG_ER_diArg_1	209	211	PF00400	0.196
TRG_NES_CRM1_1	229	241	PF08389	0.443
TRG_NES_CRM1_1	80	94	PF08389	0.196

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P9	Leptomonas seymouri	25%	100%
A0A0N0P993	Leptomonas seymouri	27%	100%
A0A0N1HWY5	Leptomonas seymouri	26%	100%
A0A0N1PAD5	Leptomonas seymouri	25%	100%
A0A0N1PDH0	Leptomonas seymouri	34%	100%
A0A1X0NQ58	Trypanosomatidae	30%	100%
A0A1X0P2R3	Trypanosomatidae	28%	100%
A0A381MTA7	Leishmania infantum	48%	100%
A0A381MTB8	Leishmania infantum	47%	100%
A0A381MTC7	Leishmania infantum	48%	100%
A0A381MTN2	Leishmania infantum	46%	100%
A0A381MVY0	Leishmania infantum	49%	99%
A0A3Q8ID16	Leishmania donovani	30%	100%
A0A3Q8IEC2	Leishmania donovani	45%	100%
A0A3Q8IEI1	Leishmania donovani	50%	100%
A0A3Q8IF65	Leishmania donovani	55%	100%
A0A3Q8IFB9	Leishmania donovani	33%	100%
A0A3Q8IFH7	Leishmania donovani	48%	100%
A0A3Q8IH65	Leishmania donovani	46%	100%
A0A3Q8IHN2	Leishmania donovani	51%	100%
A0A3Q8IHW7	Leishmania donovani	45%	100%
A0A3Q8IHZ6	Leishmania donovani	49%	100%
A0A3Q8IIH1	Leishmania donovani	46%	100%
A0A3Q8IL03	Leishmania donovani	42%	100%
A0A3Q8IUK8	Leishmania donovani	46%	100%
A0A3Q8IUR5	Leishmania donovani	46%	100%
A0A3S5H662	Leishmania donovani	59%	100%
A0A3S5H663	Leishmania donovani	58%	100%
A0A3S5H665	Leishmania donovani	60%	100%
A0A3S5H666	Leishmania donovani	47%	100%
A0A3S5H667	Leishmania donovani	60%	100%
A0A3S5H7L2	Leishmania donovani	61%	100%
A0A3S5H7V9	Leishmania donovani	46%	100%
A0A3S5H7W2	Leishmania donovani	26%	100%
A0A3S5H7W6	Leishmania donovani	48%	100%
A0A3S7WQA0	Leishmania donovani	60%	100%
A0A3S7WQA8	Leishmania donovani	46%	100%
A0A3S7WQC1	Leishmania donovani	45%	100%
A0A3S7X2E6	Leishmania donovani	63%	100%
A0A3S7X357	Leishmania donovani	24%	100%
A0A3S7X453	Leishmania donovani	54%	100%
A0A3S7X472	Leishmania donovani	52%	100%
A0A3S7X7E5	Leishmania donovani	46%	100%
A0A3S7X7M4	Leishmania donovani	49%	100%
A0A3S7X7U1	Leishmania donovani	42%	100%
A0A3S7X7U4	Leishmania donovani	43%	100%
A0A3S7X7W2	Leishmania donovani	41%	100%
A0A3S7X7Y0	Leishmania donovani	44%	100%
A4H595	Leishmania braziliensis	42%	100%
A4H596	Leishmania braziliensis	43%	100%
A4H597	Leishmania braziliensis	43%	100%
A4H5D1	Leishmania braziliensis	46%	100%
A4H5D2	Leishmania braziliensis	36%	100%
A4H5G0	Leishmania braziliensis	49%	100%
A4H5G4	Leishmania braziliensis	39%	100%
A4H5G6	Leishmania braziliensis	42%	100%
A4H5G7	Leishmania braziliensis	42%	100%
A4H5G9	Leishmania braziliensis	47%	99%
A4H5H0	Leishmania braziliensis	47%	100%
A4H5H1	Leishmania braziliensis	48%	100%
A4H5H2	Leishmania braziliensis	49%	100%
A4H5H3	Leishmania braziliensis	40%	100%
A4H6C8	Leishmania braziliensis	49%	100%
A4H7D7	Leishmania braziliensis	46%	99%
A4H9E8	Leishmania braziliensis	51%	100%
A4H9E9	Leishmania braziliensis	46%	100%
A4HAJ4	Leishmania braziliensis	46%	100%
A4HAJ5	Leishmania braziliensis	43%	100%
A4HAJ6	Leishmania braziliensis	43%	100%
A4HAL2	Leishmania braziliensis	29%	100%
A4HAM2	Leishmania braziliensis	47%	99%
A4HAM4	Leishmania braziliensis	47%	99%
A4HAR1	Leishmania braziliensis	44%	100%
A4HAZ8	Leishmania braziliensis	44%	99%
A4HB00	Leishmania braziliensis	43%	100%
A4HB02	Leishmania braziliensis	42%	99%
A4HB47	Leishmania braziliensis	38%	100%
A4HBJ0	Leishmania braziliensis	48%	100%
A4HBJ1	Leishmania braziliensis	47%	99%
A4HBJ2	Leishmania braziliensis	46%	100%
A4HDI3	Leishmania braziliensis	24%	100%
A4HDI4	Leishmania braziliensis	25%	100%
A4HDL3	Leishmania braziliensis	27%	100%
A4HDL4	Leishmania braziliensis	25%	100%
A4HTM3	Leishmania infantum	45%	100%
A4HTM4	Leishmania infantum	47%	100%
A4HTM5	Leishmania infantum	44%	100%
A4I0W5	Leishmania infantum	30%	100%
A4I4J2	Leishmania infantum	57%	100%
A4I5B9	Leishmania infantum	24%	100%
A4I6E5	Leishmania infantum	51%	100%
A4I9R4	Leishmania infantum	26%	100%
A4I9R5	Leishmania infantum	33%	100%
A4I9R7	Leishmania infantum	50%	100%
A4I9W8	Leishmania infantum	43%	100%
A4I9X0	Leishmania infantum	40%	100%
A4IA59	Leishmania infantum	44%	99%
A4IAL7	Leishmania infantum	46%	100%
A4IAM1	Leishmania infantum	50%	100%
A4IAM2	Leishmania infantum	49%	100%
C6K3X9	Leptomonas seymouri	23%	100%
E8NHC3	Leishmania infantum	57%	100%
E8NHD3	Leishmania infantum	61%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	99%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	99%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	99%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	99%
E8NHN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	75%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AG81	Leishmania infantum	58%	100%
E9AG82	Leishmania infantum	58%	100%
E9AG83	Leishmania infantum	43%	100%
E9AG85	Leishmania infantum	58%	100%
E9AHI9	Leishmania infantum	63%	100%
E9AHT2	Leishmania infantum	50%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	97%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	97%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4Q1U9	Leishmania major	46%	97%
Q4Q305	Leishmania major	47%	99%
Q4Q309	Leishmania major	49%	100%
Q4Q313	Leishmania major	47%	99%
Q4Q317	Leishmania major	45%	100%
Q4Q325	Leishmania major	50%	100%
Q4Q327	Leishmania major	47%	99%
Q4Q329	Leishmania major	49%	99%
Q4Q333	Leishmania major	47%	99%
Q4Q335	Leishmania major	48%	99%
Q4Q337	Leishmania major	45%	97%
Q4Q339	Leishmania major	47%	99%
Q4Q341	Leishmania major	55%	100%
Q4Q397	Leishmania major	49%	100%
Q4Q3A7	Leishmania major	28%	100%
Q4Q3A8	Leishmania major	33%	100%
Q4Q3A9	Leishmania major	51%	100%
Q4Q3F7	Leishmania major	52%	100%
Q4Q6L8	Leishmania major	48%	100%
Q4Q7L6	Leishmania major	26%	100%
Q4QAK5	Leishmania major	30%	100%
Q4QAK6	Leishmania major	28%	99%
Q4QAK7	Leishmania major	22%	97%
Q4QI84	Leishmania major	49%	100%
Q4QI85	Leishmania major	48%	100%
Q4QI86	Leishmania major	50%	100%
Q4QI87	Leishmania major	47%	100%
Q4QI88	Leishmania major	48%	100%
Q4QI92	Leishmania major	54%	100%
Q4QI93	Leishmania major	54%	100%
Q4QI95	Leishmania major	54%	100%
Q4QI97	Leishmania major	54%	100%
Q4QIA0	Leishmania major	52%	100%
Q4QIA1	Leishmania major	52%	100%