LeishMANIAdb
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Putative carnitine/choline acetyltransferase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative carnitine/choline acetyltransferase
Gene product:
carnitine/choline acetyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4I4I8_LEIIN
TriTrypDb:
LINF_290019000
Length:
627

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, carnitine/choline acetyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4I8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4I8

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006631 fatty acid metabolic process 4 1
GO:0006635 fatty acid beta-oxidation 6 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009062 fatty acid catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0016042 lipid catabolic process 4 1
GO:0016054 organic acid catabolic process 4 1
GO:0019395 fatty acid oxidation 5 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0030258 lipid modification 4 1
GO:0032787 monocarboxylic acid metabolic process 6 1
GO:0034440 lipid oxidation 5 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044242 cellular lipid catabolic process 4 1
GO:0044248 cellular catabolic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044282 small molecule catabolic process 3 1
GO:0046395 carboxylic acid catabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0072329 monocarboxylic acid catabolic process 6 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016740 transferase activity 2 12
GO:0016746 acyltransferase activity 3 12
GO:0004095 carnitine O-palmitoyltransferase activity 7 3
GO:0008374 O-acyltransferase activity 5 3
GO:0016406 carnitine O-acyltransferase activity 6 3
GO:0016409 palmitoyltransferase activity 5 3
GO:0016416 O-palmitoyltransferase activity 6 3
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 350 354 PF00656 0.443
CLV_NRD_NRD_1 209 211 PF00675 0.407
CLV_PCSK_KEX2_1 2 4 PF00082 0.407
CLV_PCSK_KEX2_1 209 211 PF00082 0.395
CLV_PCSK_PC1ET2_1 2 4 PF00082 0.426
CLV_PCSK_PC7_1 205 211 PF00082 0.356
CLV_PCSK_SKI1_1 482 486 PF00082 0.330
CLV_PCSK_SKI1_1 526 530 PF00082 0.360
CLV_PCSK_SKI1_1 542 546 PF00082 0.220
CLV_PCSK_SKI1_1 598 602 PF00082 0.396
CLV_Separin_Metazoa 258 262 PF03568 0.361
DEG_APCC_DBOX_1 31 39 PF00400 0.434
DEG_APCC_DBOX_1 400 408 PF00400 0.378
DEG_Nend_UBRbox_1 1 4 PF02207 0.444
DEG_SPOP_SBC_1 450 454 PF00917 0.424
DEG_SPOP_SBC_1 544 548 PF00917 0.407
DOC_CKS1_1 251 256 PF01111 0.322
DOC_CYCLIN_yCln2_LP_2 143 149 PF00134 0.356
DOC_MAPK_gen_1 377 386 PF00069 0.322
DOC_MAPK_MEF2A_6 214 222 PF00069 0.434
DOC_PP1_RVXF_1 323 329 PF00149 0.392
DOC_PP2B_LxvP_1 14 17 PF13499 0.386
DOC_PP2B_LxvP_1 143 146 PF13499 0.395
DOC_PP2B_LxvP_1 19 22 PF13499 0.282
DOC_PP4_FxxP_1 550 553 PF00568 0.408
DOC_USP7_MATH_1 20 24 PF00917 0.340
DOC_USP7_MATH_1 284 288 PF00917 0.407
DOC_USP7_MATH_1 501 505 PF00917 0.434
DOC_USP7_MATH_1 562 566 PF00917 0.434
DOC_USP7_MATH_1 73 77 PF00917 0.405
DOC_USP7_MATH_1 92 96 PF00917 0.187
DOC_USP7_MATH_2 179 185 PF00917 0.356
DOC_USP7_UBL2_3 425 429 PF12436 0.322
DOC_WW_Pin1_4 153 158 PF00397 0.303
DOC_WW_Pin1_4 175 180 PF00397 0.292
DOC_WW_Pin1_4 220 225 PF00397 0.303
DOC_WW_Pin1_4 227 232 PF00397 0.303
DOC_WW_Pin1_4 250 255 PF00397 0.322
DOC_WW_Pin1_4 37 42 PF00397 0.434
DOC_WW_Pin1_4 586 591 PF00397 0.287
DOC_WW_Pin1_4 94 99 PF00397 0.400
LIG_14-3-3_CanoR_1 3 13 PF00244 0.506
LIG_14-3-3_CanoR_1 32 36 PF00244 0.411
LIG_14-3-3_CanoR_1 362 367 PF00244 0.331
LIG_14-3-3_CanoR_1 401 411 PF00244 0.395
LIG_14-3-3_CanoR_1 490 499 PF00244 0.341
LIG_14-3-3_CanoR_1 542 550 PF00244 0.352
LIG_14-3-3_CanoR_1 556 561 PF00244 0.305
LIG_14-3-3_CanoR_1 580 590 PF00244 0.287
LIG_APCC_ABBA_1 197 202 PF00400 0.303
LIG_APCC_ABBA_1 260 265 PF00400 0.407
LIG_APCC_Cbox_2 494 500 PF00515 0.434
LIG_CSL_BTD_1 38 41 PF09270 0.434
LIG_eIF4E_1 153 159 PF01652 0.356
LIG_FHA_1 126 132 PF00498 0.390
LIG_FHA_1 138 144 PF00498 0.305
LIG_FHA_1 170 176 PF00498 0.372
LIG_FHA_1 227 233 PF00498 0.313
LIG_FHA_1 347 353 PF00498 0.352
LIG_FHA_1 431 437 PF00498 0.400
LIG_FHA_1 444 450 PF00498 0.236
LIG_FHA_1 484 490 PF00498 0.422
LIG_FHA_1 589 595 PF00498 0.434
LIG_FHA_2 176 182 PF00498 0.304
LIG_FHA_2 319 325 PF00498 0.407
LIG_FHA_2 386 392 PF00498 0.329
LIG_FHA_2 450 456 PF00498 0.383
LIG_FHA_2 605 611 PF00498 0.460
LIG_FHA_2 70 76 PF00498 0.418
LIG_FHA_2 80 86 PF00498 0.399
LIG_LIR_Apic_2 547 553 PF02991 0.337
LIG_LIR_Gen_1 412 422 PF02991 0.278
LIG_LIR_LC3C_4 265 270 PF02991 0.407
LIG_LIR_Nem_3 551 557 PF02991 0.327
LIG_PCNA_yPIPBox_3 252 263 PF02747 0.407
LIG_Pex14_1 243 247 PF04695 0.303
LIG_Pex14_1 554 558 PF04695 0.322
LIG_Pex14_2 550 554 PF04695 0.416
LIG_PTB_Apo_2 295 302 PF02174 0.372
LIG_PTB_Apo_2 425 432 PF02174 0.356
LIG_PTB_Phospho_1 295 301 PF10480 0.407
LIG_PTB_Phospho_1 425 431 PF10480 0.356
LIG_RPA_C_Fungi 375 387 PF08784 0.303
LIG_SH2_SRC 83 86 PF00017 0.322
LIG_SH2_STAP1 509 513 PF00017 0.434
LIG_SH2_STAT5 558 561 PF00017 0.407
LIG_SH2_STAT5 572 575 PF00017 0.287
LIG_SH2_STAT5 83 86 PF00017 0.287
LIG_SH3_3 14 20 PF00018 0.374
LIG_SH3_3 143 149 PF00018 0.395
LIG_SH3_3 40 46 PF00018 0.341
LIG_SUMO_SIM_anti_2 184 191 PF11976 0.356
LIG_SUMO_SIM_anti_2 229 236 PF11976 0.322
LIG_SUMO_SIM_anti_2 265 271 PF11976 0.344
LIG_SUMO_SIM_anti_2 334 341 PF11976 0.430
LIG_SUMO_SIM_anti_2 382 391 PF11976 0.374
LIG_SUMO_SIM_par_1 184 191 PF11976 0.305
LIG_SUMO_SIM_par_1 217 223 PF11976 0.297
LIG_SUMO_SIM_par_1 229 236 PF11976 0.269
LIG_TRAF2_1 246 249 PF00917 0.407
LIG_TRAF2_1 292 295 PF00917 0.434
LIG_TRAF2_1 379 382 PF00917 0.407
LIG_TRAF2_1 453 456 PF00917 0.344
LIG_TRAF2_1 97 100 PF00917 0.356
LIG_UBA3_1 457 462 PF00899 0.407
LIG_WRC_WIRS_1 557 562 PF05994 0.407
MOD_CDK_SPxxK_3 175 182 PF00069 0.322
MOD_CK1_1 125 131 PF00069 0.375
MOD_CK1_1 169 175 PF00069 0.434
MOD_CK1_1 230 236 PF00069 0.322
MOD_CK1_1 320 326 PF00069 0.391
MOD_CK1_1 345 351 PF00069 0.292
MOD_CK1_1 371 377 PF00069 0.337
MOD_CK1_1 543 549 PF00069 0.308
MOD_CK1_1 584 590 PF00069 0.303
MOD_CK1_1 604 610 PF00069 0.133
MOD_CK2_1 175 181 PF00069 0.311
MOD_CK2_1 2 8 PF00069 0.539
MOD_CK2_1 279 285 PF00069 0.365
MOD_CK2_1 289 295 PF00069 0.332
MOD_CK2_1 385 391 PF00069 0.312
MOD_CK2_1 429 435 PF00069 0.395
MOD_CK2_1 449 455 PF00069 0.284
MOD_CK2_1 501 507 PF00069 0.364
MOD_CK2_1 543 549 PF00069 0.395
MOD_CK2_1 604 610 PF00069 0.470
MOD_CK2_1 69 75 PF00069 0.318
MOD_CK2_1 79 85 PF00069 0.270
MOD_CK2_1 94 100 PF00069 0.287
MOD_CMANNOS 328 331 PF00535 0.287
MOD_GlcNHglycan 124 127 PF01048 0.407
MOD_GlcNHglycan 285 289 PF01048 0.434
MOD_GlcNHglycan 344 347 PF01048 0.346
MOD_GlcNHglycan 4 7 PF01048 0.505
MOD_GlcNHglycan 404 407 PF01048 0.385
MOD_GlcNHglycan 57 60 PF01048 0.319
MOD_GlcNHglycan 583 586 PF01048 0.278
MOD_GlcNHglycan 75 78 PF01048 0.303
MOD_GlcNHglycan 90 93 PF01048 0.360
MOD_GSK3_1 137 144 PF00069 0.397
MOD_GSK3_1 153 160 PF00069 0.259
MOD_GSK3_1 162 169 PF00069 0.366
MOD_GSK3_1 20 27 PF00069 0.317
MOD_GSK3_1 226 233 PF00069 0.312
MOD_GSK3_1 342 349 PF00069 0.335
MOD_GSK3_1 364 371 PF00069 0.318
MOD_GSK3_1 37 44 PF00069 0.303
MOD_GSK3_1 387 394 PF00069 0.359
MOD_GSK3_1 431 438 PF00069 0.387
MOD_GSK3_1 497 504 PF00069 0.424
MOD_GSK3_1 540 547 PF00069 0.302
MOD_GSK3_1 584 591 PF00069 0.309
MOD_GSK3_1 69 76 PF00069 0.313
MOD_GSK3_1 88 95 PF00069 0.405
MOD_N-GLC_1 103 108 PF02516 0.358
MOD_N-GLC_1 227 232 PF02516 0.322
MOD_N-GLC_1 55 60 PF02516 0.434
MOD_NEK2_1 103 108 PF00069 0.233
MOD_NEK2_1 162 167 PF00069 0.287
MOD_NEK2_1 174 179 PF00069 0.287
MOD_NEK2_1 218 223 PF00069 0.352
MOD_NEK2_1 263 268 PF00069 0.407
MOD_NEK2_1 318 323 PF00069 0.344
MOD_NEK2_1 364 369 PF00069 0.287
MOD_NEK2_1 449 454 PF00069 0.385
MOD_NEK2_1 537 542 PF00069 0.311
MOD_NEK2_1 54 59 PF00069 0.288
MOD_NEK2_1 601 606 PF00069 0.407
MOD_NEK2_1 88 93 PF00069 0.333
MOD_NEK2_2 271 276 PF00069 0.356
MOD_NEK2_2 31 36 PF00069 0.369
MOD_PIKK_1 116 122 PF00454 0.289
MOD_PIKK_1 548 554 PF00454 0.428
MOD_PK_1 362 368 PF00069 0.407
MOD_PKA_1 2 8 PF00069 0.539
MOD_PKA_2 2 8 PF00069 0.529
MOD_PKA_2 31 37 PF00069 0.303
MOD_PKA_2 489 495 PF00069 0.342
MOD_PKA_2 579 585 PF00069 0.372
MOD_Plk_1 103 109 PF00069 0.384
MOD_Plk_1 279 285 PF00069 0.407
MOD_Plk_4 103 109 PF00069 0.346
MOD_Plk_4 230 236 PF00069 0.302
MOD_Plk_4 263 269 PF00069 0.424
MOD_Plk_4 334 340 PF00069 0.424
MOD_Plk_4 368 374 PF00069 0.357
MOD_ProDKin_1 153 159 PF00069 0.303
MOD_ProDKin_1 175 181 PF00069 0.292
MOD_ProDKin_1 220 226 PF00069 0.303
MOD_ProDKin_1 227 233 PF00069 0.303
MOD_ProDKin_1 250 256 PF00069 0.322
MOD_ProDKin_1 37 43 PF00069 0.434
MOD_ProDKin_1 586 592 PF00069 0.287
MOD_ProDKin_1 94 100 PF00069 0.400
MOD_SUMO_for_1 407 410 PF00179 0.392
TRG_DiLeu_BaEn_2 409 415 PF01217 0.392
TRG_DiLeu_BaEn_2 532 538 PF01217 0.434
TRG_DiLeu_BaEn_4 455 461 PF01217 0.434
TRG_DiLeu_BaLyEn_6 154 159 PF01217 0.344
TRG_DiLeu_BaLyEn_6 207 212 PF01217 0.395
TRG_ENDOCYTIC_2 247 250 PF00928 0.303
TRG_ENDOCYTIC_2 557 560 PF00928 0.333
TRG_ER_diArg_1 209 211 PF00400 0.395
TRG_Pf-PMV_PEXEL_1 209 213 PF00026 0.407
TRG_Pf-PMV_PEXEL_1 64 68 PF00026 0.407

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6E3 Leptomonas seymouri 75% 100%
A0A0N1I7U1 Leptomonas seymouri 23% 72%
A0A0S4JAG1 Bodo saltans 27% 86%
A0A0S4JRH6 Bodo saltans 27% 92%
A0A0S4JRL8 Bodo saltans 24% 78%
A0A0S4JY55 Bodo saltans 36% 100%
A0A0S4KE24 Bodo saltans 24% 76%
A0A1X0NT49 Trypanosomatidae 25% 85%
A0A1X0NT60 Trypanosomatidae 25% 92%
A0A1X0NZS6 Trypanosomatidae 51% 100%
A0A1X0P523 Trypanosomatidae 24% 83%
A0A1X0P5Y2 Trypanosomatidae 24% 79%
A0A3Q8IRB8 Leishmania donovani 100% 100%
A0A3R7K5Z4 Trypanosoma rangeli 23% 92%
A0A3R7L2D0 Trypanosoma rangeli 49% 100%
A0A3S5IQT1 Trypanosoma rangeli 25% 84%
A0A422NAV0 Trypanosoma rangeli 23% 85%
A0A422NSK2 Trypanosoma rangeli 25% 93%
A4HC81 Leishmania braziliensis 22% 100%
A4HHE2 Leishmania braziliensis 91% 100%
B2ZGJ1 Danio rerio 24% 98%
C9ZL75 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
C9ZRI9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 94%
D0A627 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 81%
E9ADY9 Leishmania major 98% 100%
E9ALU2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
F1LN46 Rattus norvegicus 24% 78%
O19094 Bos taurus 26% 100%
P07668 Drosophila melanogaster 23% 87%
P11466 Rattus norvegicus 24% 100%
P13222 Sus scrofa 23% 98%
P18886 Rattus norvegicus 25% 95%
P23786 Homo sapiens 25% 95%
P28329 Homo sapiens 25% 84%
P32198 Rattus norvegicus 26% 81%
P32738 Rattus norvegicus 24% 98%
P32756 Caenorhabditis elegans 22% 100%
P32796 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 94%
P43155 Homo sapiens 26% 100%
P47934 Mus musculus 25% 100%
P50416 Homo sapiens 26% 81%
P52825 Mus musculus 25% 95%
P52826 Columba livia 25% 100%
P75448 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) 22% 100%
P80235 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 91%
P97742 Mus musculus 25% 81%
Q00614 Candida tropicalis 23% 100%
Q03059 Mus musculus 24% 98%
Q2KJB7 Bos taurus 26% 95%
Q58DK1 Bos taurus 28% 81%
Q5U3U3 Danio rerio 26% 94%
Q60HG9 Macaca fascicularis 25% 95%
Q63704 Rattus norvegicus 28% 81%
Q68Y62 Equus caballus 26% 81%
Q6P4X5 Xenopus tropicalis 26% 95%
Q704S8 Rattus norvegicus 25% 100%
Q7ZXE1 Xenopus laevis 26% 95%
Q8BGD5 Mus musculus 25% 79%
Q8HY46 Sus scrofa 26% 81%
Q8TCG5 Homo sapiens 25% 78%
Q90YJ9 Gallus gallus 23% 98%
Q924X2 Mus musculus 28% 81%
Q92523 Homo sapiens 27% 81%
Q9DC50 Mus musculus 23% 100%
Q9UKG9 Homo sapiens 25% 100%
V5BH74 Trypanosoma cruzi 49% 100%
V5BP17 Trypanosoma cruzi 22% 92%
V5BQH8 Trypanosoma cruzi 27% 79%
V5D4R1 Trypanosoma cruzi 25% 79%
V5DBT5 Trypanosoma cruzi 24% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS