LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
Hsp70 protein/TPR repeat/Tetratricopeptide repeat - putative
Species:
Leishmania infantum
UniProt:
A4I4I1_LEIIN
TriTrypDb:
LINF_290018300
Length:
725

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 3
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0043226 organelle 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4I1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4I1

Function

Biological processes
Term Name Level Count
GO:0000413 protein peptidyl-prolyl isomerization 7 1
GO:0006457 protein folding 2 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018208 peptidyl-proline modification 6 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0061077 chaperone-mediated protein folding 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0044183 protein folding chaperone 1 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:0140657 ATP-dependent activity 1 10
GO:0140662 ATP-dependent protein folding chaperone 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3 1
GO:0003824 catalytic activity 1 1
GO:0016853 isomerase activity 2 1
GO:0016859 cis-trans isomerase activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 424 428 PF00656 0.391
CLV_C14_Caspase3-7 455 459 PF00656 0.403
CLV_NRD_NRD_1 258 260 PF00675 0.294
CLV_NRD_NRD_1 265 267 PF00675 0.259
CLV_NRD_NRD_1 387 389 PF00675 0.426
CLV_NRD_NRD_1 548 550 PF00675 0.416
CLV_NRD_NRD_1 581 583 PF00675 0.370
CLV_NRD_NRD_1 667 669 PF00675 0.254
CLV_PCSK_KEX2_1 387 389 PF00082 0.345
CLV_PCSK_KEX2_1 548 550 PF00082 0.414
CLV_PCSK_KEX2_1 580 582 PF00082 0.435
CLV_PCSK_KEX2_1 623 625 PF00082 0.413
CLV_PCSK_KEX2_1 667 669 PF00082 0.278
CLV_PCSK_PC1ET2_1 548 550 PF00082 0.411
CLV_PCSK_PC1ET2_1 580 582 PF00082 0.483
CLV_PCSK_PC1ET2_1 623 625 PF00082 0.374
CLV_PCSK_PC7_1 544 550 PF00082 0.450
CLV_PCSK_PC7_1 576 582 PF00082 0.456
CLV_PCSK_SKI1_1 112 116 PF00082 0.280
CLV_PCSK_SKI1_1 12 16 PF00082 0.318
CLV_PCSK_SKI1_1 259 263 PF00082 0.327
CLV_PCSK_SKI1_1 266 270 PF00082 0.318
CLV_PCSK_SKI1_1 312 316 PF00082 0.353
CLV_PCSK_SKI1_1 358 362 PF00082 0.292
CLV_PCSK_SKI1_1 387 391 PF00082 0.357
CLV_PCSK_SKI1_1 41 45 PF00082 0.324
CLV_PCSK_SKI1_1 442 446 PF00082 0.353
CLV_PCSK_SKI1_1 663 667 PF00082 0.329
CLV_PCSK_SKI1_1 706 710 PF00082 0.439
CLV_PCSK_SKI1_1 717 721 PF00082 0.402
DEG_APCC_DBOX_1 311 319 PF00400 0.331
DEG_Nend_UBRbox_2 1 3 PF02207 0.464
DOC_ANK_TNKS_1 339 346 PF00023 0.338
DOC_CYCLIN_yCln2_LP_2 100 106 PF00134 0.289
DOC_MAPK_gen_1 442 450 PF00069 0.295
DOC_MAPK_gen_1 548 557 PF00069 0.419
DOC_MAPK_gen_1 620 628 PF00069 0.378
DOC_MAPK_MEF2A_6 125 133 PF00069 0.289
DOC_MAPK_MEF2A_6 68 76 PF00069 0.369
DOC_PP2B_LxvP_1 131 134 PF13499 0.338
DOC_USP7_MATH_1 132 136 PF00917 0.311
DOC_USP7_MATH_1 377 381 PF00917 0.338
DOC_USP7_MATH_1 408 412 PF00917 0.449
DOC_USP7_MATH_1 486 490 PF00917 0.571
DOC_USP7_MATH_1 635 639 PF00917 0.391
DOC_USP7_UBL2_3 256 260 PF12436 0.278
DOC_USP7_UBL2_3 713 717 PF12436 0.399
DOC_USP7_UBL2_3 718 722 PF12436 0.425
DOC_WW_Pin1_4 124 129 PF00397 0.314
DOC_WW_Pin1_4 427 432 PF00397 0.394
DOC_WW_Pin1_4 75 80 PF00397 0.338
LIG_14-3-3_CanoR_1 312 322 PF00244 0.282
LIG_14-3-3_CanoR_1 365 371 PF00244 0.313
LIG_14-3-3_CanoR_1 434 441 PF00244 0.484
LIG_Actin_WH2_2 209 224 PF00022 0.338
LIG_Clathr_ClatBox_1 420 424 PF01394 0.402
LIG_deltaCOP1_diTrp_1 591 601 PF00928 0.371
LIG_EH1_1 108 116 PF00400 0.314
LIG_FHA_1 124 130 PF00498 0.357
LIG_FHA_1 18 24 PF00498 0.338
LIG_FHA_1 513 519 PF00498 0.360
LIG_FHA_1 597 603 PF00498 0.350
LIG_FHA_1 650 656 PF00498 0.412
LIG_FHA_1 82 88 PF00498 0.400
LIG_FHA_2 272 278 PF00498 0.304
LIG_FHA_2 401 407 PF00498 0.642
LIG_FHA_2 47 53 PF00498 0.280
LIG_FHA_2 59 65 PF00498 0.283
LIG_FHA_2 612 618 PF00498 0.422
LIG_Integrin_RGD_1 252 254 PF01839 0.338
LIG_LIR_Gen_1 141 150 PF02991 0.347
LIG_LIR_Gen_1 234 244 PF02991 0.314
LIG_LIR_Gen_1 446 454 PF02991 0.490
LIG_LIR_Gen_1 530 540 PF02991 0.470
LIG_LIR_Gen_1 629 639 PF02991 0.367
LIG_LIR_Nem_3 141 145 PF02991 0.347
LIG_LIR_Nem_3 234 240 PF02991 0.372
LIG_LIR_Nem_3 257 261 PF02991 0.278
LIG_LIR_Nem_3 446 450 PF02991 0.491
LIG_LIR_Nem_3 530 536 PF02991 0.395
LIG_LIR_Nem_3 537 543 PF02991 0.441
LIG_LIR_Nem_3 629 634 PF02991 0.372
LIG_Pex14_1 56 60 PF04695 0.338
LIG_Pex14_2 720 724 PF04695 0.433
LIG_Rb_pABgroove_1 606 614 PF01858 0.408
LIG_RPA_C_Fungi 465 477 PF08784 0.333
LIG_RPA_C_Fungi 663 675 PF08784 0.338
LIG_SH2_CRK 177 181 PF00017 0.338
LIG_SH2_CRK 672 676 PF00017 0.289
LIG_SH2_GRB2like 631 634 PF00017 0.370
LIG_SH2_SRC 631 634 PF00017 0.370
LIG_SH2_SRC 678 681 PF00017 0.255
LIG_SH2_STAP1 678 682 PF00017 0.255
LIG_SH2_STAT3 474 477 PF00017 0.353
LIG_SH2_STAT5 110 113 PF00017 0.348
LIG_SH2_STAT5 171 174 PF00017 0.338
LIG_SH2_STAT5 227 230 PF00017 0.336
LIG_SH2_STAT5 474 477 PF00017 0.353
LIG_SH2_STAT5 498 501 PF00017 0.440
LIG_SH2_STAT5 505 508 PF00017 0.459
LIG_SH2_STAT5 60 63 PF00017 0.338
LIG_SH2_STAT5 631 634 PF00017 0.370
LIG_SH3_3 429 435 PF00018 0.345
LIG_SH3_3 656 662 PF00018 0.377
LIG_SH3_3 73 79 PF00018 0.338
LIG_SUMO_SIM_anti_2 288 294 PF11976 0.338
LIG_SUMO_SIM_par_1 189 195 PF11976 0.287
LIG_SUMO_SIM_par_1 290 296 PF11976 0.362
LIG_TRAF2_1 615 618 PF00917 0.497
LIG_TYR_ITIM 175 180 PF00017 0.289
LIG_UBA3_1 114 121 PF00899 0.255
LIG_UBA3_1 314 321 PF00899 0.289
LIG_WRC_WIRS_1 23 28 PF05994 0.338
LIG_WRC_WIRS_1 255 260 PF05994 0.338
LIG_WW_3 337 341 PF00397 0.255
MOD_CDK_SPxxK_3 427 434 PF00069 0.362
MOD_CK1_1 201 207 PF00069 0.347
MOD_CK1_1 430 436 PF00069 0.370
MOD_CK1_1 542 548 PF00069 0.405
MOD_CK1_1 78 84 PF00069 0.289
MOD_CK2_1 271 277 PF00069 0.304
MOD_CK2_1 30 36 PF00069 0.367
MOD_CK2_1 372 378 PF00069 0.417
MOD_CK2_1 408 414 PF00069 0.493
MOD_CK2_1 511 517 PF00069 0.519
MOD_CK2_1 531 537 PF00069 0.459
MOD_CK2_1 58 64 PF00069 0.355
MOD_CK2_1 611 617 PF00069 0.510
MOD_Cter_Amidation 240 243 PF01082 0.255
MOD_GlcNHglycan 134 137 PF01048 0.308
MOD_GlcNHglycan 285 288 PF01048 0.401
MOD_GlcNHglycan 378 382 PF01048 0.314
MOD_GlcNHglycan 61 64 PF01048 0.289
MOD_GlcNHglycan 672 675 PF01048 0.323
MOD_GSK3_1 161 168 PF00069 0.367
MOD_GSK3_1 18 25 PF00069 0.347
MOD_GSK3_1 227 234 PF00069 0.309
MOD_GSK3_1 271 278 PF00069 0.259
MOD_GSK3_1 325 332 PF00069 0.251
MOD_GSK3_1 400 407 PF00069 0.694
MOD_GSK3_1 430 437 PF00069 0.363
MOD_GSK3_1 486 493 PF00069 0.447
MOD_GSK3_1 527 534 PF00069 0.335
MOD_GSK3_1 563 570 PF00069 0.570
MOD_N-GLC_1 372 377 PF02516 0.289
MOD_N-GLC_1 618 623 PF02516 0.451
MOD_N-GLC_1 649 654 PF02516 0.396
MOD_N-GLC_2 649 651 PF02516 0.404
MOD_NEK2_1 123 128 PF00069 0.335
MOD_NEK2_1 231 236 PF00069 0.338
MOD_NEK2_1 361 366 PF00069 0.346
MOD_NEK2_1 58 63 PF00069 0.338
MOD_NEK2_1 611 616 PF00069 0.419
MOD_NEK2_2 217 222 PF00069 0.195
MOD_NEK2_2 539 544 PF00069 0.403
MOD_NEK2_2 635 640 PF00069 0.373
MOD_OFUCOSY 630 637 PF10250 0.304
MOD_PIKK_1 206 212 PF00454 0.338
MOD_PIKK_1 275 281 PF00454 0.325
MOD_PIKK_1 329 335 PF00454 0.255
MOD_PIKK_1 689 695 PF00454 0.418
MOD_PIKK_1 93 99 PF00454 0.307
MOD_PKA_1 387 393 PF00069 0.359
MOD_PKA_2 387 393 PF00069 0.440
MOD_Plk_1 156 162 PF00069 0.289
MOD_Plk_1 165 171 PF00069 0.470
MOD_Plk_1 275 281 PF00069 0.351
MOD_Plk_1 372 378 PF00069 0.435
MOD_Plk_1 624 630 PF00069 0.406
MOD_Plk_2-3 30 36 PF00069 0.289
MOD_Plk_2-3 531 537 PF00069 0.330
MOD_Plk_2-3 613 619 PF00069 0.432
MOD_Plk_4 110 116 PF00069 0.306
MOD_Plk_4 156 162 PF00069 0.303
MOD_Plk_4 19 25 PF00069 0.370
MOD_Plk_4 201 207 PF00069 0.321
MOD_Plk_4 227 233 PF00069 0.251
MOD_Plk_4 46 52 PF00069 0.359
MOD_Plk_4 470 476 PF00069 0.348
MOD_Plk_4 6 12 PF00069 0.327
MOD_Plk_4 603 609 PF00069 0.363
MOD_ProDKin_1 124 130 PF00069 0.314
MOD_ProDKin_1 427 433 PF00069 0.392
MOD_ProDKin_1 75 81 PF00069 0.338
MOD_SUMO_for_1 182 185 PF00179 0.195
MOD_SUMO_for_1 589 592 PF00179 0.378
MOD_SUMO_rev_2 249 258 PF00179 0.384
MOD_SUMO_rev_2 320 328 PF00179 0.195
MOD_SUMO_rev_2 488 493 PF00179 0.398
MOD_SUMO_rev_2 563 570 PF00179 0.528
MOD_SUMO_rev_2 613 621 PF00179 0.468
TRG_DiLeu_BaEn_4 552 558 PF01217 0.454
TRG_ENDOCYTIC_2 177 180 PF00928 0.338
TRG_ENDOCYTIC_2 237 240 PF00928 0.338
TRG_ENDOCYTIC_2 540 543 PF00928 0.487
TRG_ENDOCYTIC_2 631 634 PF00928 0.370
TRG_ENDOCYTIC_2 672 675 PF00928 0.289
TRG_ER_diArg_1 386 388 PF00400 0.246
TRG_ER_diArg_1 574 577 PF00400 0.495
TRG_ER_diArg_1 666 668 PF00400 0.278
TRG_ER_FFAT_1 673 684 PF00635 0.338
TRG_Pf-PMV_PEXEL_1 260 264 PF00026 0.302
TRG_Pf-PMV_PEXEL_1 434 438 PF00026 0.378
TRG_Pf-PMV_PEXEL_1 92 97 PF00026 0.338

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6E2 Leptomonas seymouri 71% 94%
A0A0S4JRE7 Bodo saltans 41% 100%
A0A3S7X203 Leishmania donovani 23% 100%
A0A3S7X2D2 Leishmania donovani 100% 100%
A4HHD6 Leishmania braziliensis 86% 100%
E9ADY2 Leishmania major 94% 100%
E9ALU9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5BI61 Trypanosoma cruzi 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS