LeishMANIAdb
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Splicing factor YJU2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Splicing factor YJU2
Gene product:
Family of unknown function (DUF572) - putative
Species:
Leishmania infantum
UniProt:
A4I4H9_LEIIN
TriTrypDb:
LINF_290018100
Length:
477

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005681 spliceosomal complex 3 1
GO:0005684 U2-type spliceosomal complex 4 1
GO:0005737 cytoplasm 2 1
GO:0032991 protein-containing complex 1 1
GO:0071006 U2-type catalytic step 1 spliceosome 4 1
GO:0071012 catalytic step 1 spliceosome 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4I4H9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4H9

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 7
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 7
GO:0000398 mRNA splicing, via spliceosome 8 7
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006396 RNA processing 6 7
GO:0006397 mRNA processing 7 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0008380 RNA splicing 7 7
GO:0009987 cellular process 1 7
GO:0016070 RNA metabolic process 5 7
GO:0016071 mRNA metabolic process 6 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0043170 macromolecule metabolic process 3 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0046483 heterocycle metabolic process 3 7
GO:0071704 organic substance metabolic process 2 7
GO:0090304 nucleic acid metabolic process 4 7
GO:1901360 organic cyclic compound metabolic process 3 7
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 394 398 PF00656 0.672
CLV_NRD_NRD_1 20 22 PF00675 0.312
CLV_NRD_NRD_1 203 205 PF00675 0.291
CLV_NRD_NRD_1 286 288 PF00675 0.312
CLV_NRD_NRD_1 321 323 PF00675 0.388
CLV_NRD_NRD_1 331 333 PF00675 0.267
CLV_NRD_NRD_1 34 36 PF00675 0.312
CLV_NRD_NRD_1 455 457 PF00675 0.648
CLV_NRD_NRD_1 464 466 PF00675 0.590
CLV_NRD_NRD_1 66 68 PF00675 0.312
CLV_NRD_NRD_1 78 80 PF00675 0.312
CLV_PCSK_FUR_1 201 205 PF00082 0.291
CLV_PCSK_FUR_1 32 36 PF00082 0.312
CLV_PCSK_KEX2_1 127 129 PF00082 0.312
CLV_PCSK_KEX2_1 203 205 PF00082 0.291
CLV_PCSK_KEX2_1 286 288 PF00082 0.312
CLV_PCSK_KEX2_1 321 323 PF00082 0.436
CLV_PCSK_KEX2_1 331 333 PF00082 0.291
CLV_PCSK_KEX2_1 34 36 PF00082 0.312
CLV_PCSK_KEX2_1 464 466 PF00082 0.638
CLV_PCSK_KEX2_1 49 51 PF00082 0.312
CLV_PCSK_KEX2_1 66 68 PF00082 0.312
CLV_PCSK_KEX2_1 78 80 PF00082 0.312
CLV_PCSK_KEX2_1 83 85 PF00082 0.312
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.291
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.312
CLV_PCSK_PC1ET2_1 49 51 PF00082 0.312
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.388
CLV_PCSK_PC7_1 199 205 PF00082 0.291
CLV_PCSK_PC7_1 79 85 PF00082 0.388
CLV_PCSK_SKI1_1 253 257 PF00082 0.327
CLV_PCSK_SKI1_1 321 325 PF00082 0.410
CLV_PCSK_SKI1_1 331 335 PF00082 0.331
CLV_PCSK_SKI1_1 413 417 PF00082 0.552
CLV_PCSK_SKI1_1 441 445 PF00082 0.552
CLV_PCSK_SKI1_1 78 82 PF00082 0.279
DEG_SCF_FBW7_1 111 117 PF00400 0.312
DEG_SCF_FBW7_1 360 365 PF00400 0.330
DEG_SCF_TRCP1_1 222 228 PF00400 0.255
DEG_SPOP_SBC_1 229 233 PF00917 0.388
DEG_SPOP_SBC_1 241 245 PF00917 0.255
DEG_SPOP_SBC_1 337 341 PF00917 0.315
DEG_SPOP_SBC_1 362 366 PF00917 0.340
DOC_CKS1_1 111 116 PF01111 0.312
DOC_CKS1_1 442 447 PF01111 0.554
DOC_CYCLIN_yClb3_PxF_3 410 416 PF00134 0.541
DOC_CYCLIN_yCln2_LP_2 351 357 PF00134 0.315
DOC_MAPK_gen_1 49 57 PF00069 0.312
DOC_MAPK_gen_1 83 91 PF00069 0.388
DOC_PP2B_LxvP_1 351 354 PF13499 0.315
DOC_PP4_FxxP_1 249 252 PF00568 0.388
DOC_PP4_FxxP_1 442 445 PF00568 0.682
DOC_PP4_FxxP_1 53 56 PF00568 0.312
DOC_USP7_MATH_1 220 224 PF00917 0.474
DOC_USP7_MATH_1 242 246 PF00917 0.343
DOC_USP7_MATH_1 355 359 PF00917 0.312
DOC_USP7_MATH_1 372 376 PF00917 0.688
DOC_USP7_MATH_1 398 402 PF00917 0.672
DOC_USP7_MATH_1 415 419 PF00917 0.534
DOC_USP7_MATH_1 446 450 PF00917 0.598
DOC_USP7_MATH_1 69 73 PF00917 0.312
DOC_USP7_UBL2_3 374 378 PF12436 0.584
DOC_WW_Pin1_4 110 115 PF00397 0.312
DOC_WW_Pin1_4 237 242 PF00397 0.410
DOC_WW_Pin1_4 358 363 PF00397 0.366
DOC_WW_Pin1_4 430 435 PF00397 0.573
DOC_WW_Pin1_4 441 446 PF00397 0.538
LIG_14-3-3_CanoR_1 286 292 PF00244 0.364
LIG_14-3-3_CanoR_1 331 338 PF00244 0.442
LIG_14-3-3_CanoR_1 421 428 PF00244 0.595
LIG_14-3-3_CanoR_1 50 54 PF00244 0.312
LIG_14-3-3_CanoR_1 78 86 PF00244 0.279
LIG_BIR_II_1 1 5 PF00653 0.521
LIG_BRCT_BRCA1_1 245 249 PF00533 0.388
LIG_FHA_1 337 343 PF00498 0.383
LIG_FHA_1 421 427 PF00498 0.616
LIG_FHA_1 50 56 PF00498 0.312
LIG_FHA_2 107 113 PF00498 0.312
LIG_FHA_2 231 237 PF00498 0.470
LIG_LIR_Apic_2 10 16 PF02991 0.312
LIG_LIR_Apic_2 246 252 PF02991 0.388
LIG_LIR_Apic_2 440 445 PF02991 0.680
LIG_LIR_Apic_2 52 56 PF02991 0.312
LIG_LIR_Nem_3 130 136 PF02991 0.413
LIG_LIR_Nem_3 17 23 PF02991 0.312
LIG_LIR_Nem_3 274 280 PF02991 0.312
LIG_LIR_Nem_3 285 291 PF02991 0.312
LIG_Pex14_2 53 57 PF04695 0.312
LIG_SH2_GRB2like 75 78 PF00017 0.312
LIG_SH2_PTP2 13 16 PF00017 0.312
LIG_SH2_SRC 85 88 PF00017 0.279
LIG_SH2_STAT5 106 109 PF00017 0.316
LIG_SH2_STAT5 120 123 PF00017 0.327
LIG_SH2_STAT5 13 16 PF00017 0.312
LIG_SH2_STAT5 85 88 PF00017 0.312
LIG_SH3_1 108 114 PF00018 0.312
LIG_SH3_2 451 456 PF14604 0.580
LIG_SH3_3 108 114 PF00018 0.312
LIG_SH3_3 406 412 PF00018 0.719
LIG_SH3_3 448 454 PF00018 0.697
LIG_SH3_CIN85_PxpxPR_1 451 456 PF14604 0.628
LIG_SUMO_SIM_anti_2 93 98 PF11976 0.312
LIG_TRAF2_1 143 146 PF00917 0.307
LIG_TRAF2_1 182 185 PF00917 0.400
LIG_WW_3 453 457 PF00397 0.585
MOD_CDK_SPK_2 110 115 PF00069 0.312
MOD_CK1_1 231 237 PF00069 0.451
MOD_CK1_1 240 246 PF00069 0.332
MOD_CK1_1 358 364 PF00069 0.422
MOD_CK1_1 424 430 PF00069 0.616
MOD_CK2_1 106 112 PF00069 0.312
MOD_CK2_1 230 236 PF00069 0.470
MOD_CK2_1 261 267 PF00069 0.341
MOD_Cter_Amidation 32 35 PF01082 0.312
MOD_GlcNHglycan 221 225 PF01048 0.373
MOD_GlcNHglycan 233 236 PF01048 0.298
MOD_GlcNHglycan 262 266 PF01048 0.376
MOD_GlcNHglycan 355 358 PF01048 0.361
MOD_GlcNHglycan 365 368 PF01048 0.332
MOD_GlcNHglycan 417 420 PF01048 0.636
MOD_GlcNHglycan 423 426 PF01048 0.693
MOD_GlcNHglycan 9 12 PF01048 0.465
MOD_GSK3_1 106 113 PF00069 0.312
MOD_GSK3_1 193 200 PF00069 0.319
MOD_GSK3_1 225 232 PF00069 0.400
MOD_GSK3_1 236 243 PF00069 0.422
MOD_GSK3_1 358 365 PF00069 0.371
MOD_GSK3_1 420 427 PF00069 0.715
MOD_GSK3_1 437 444 PF00069 0.493
MOD_N-GLC_1 4 9 PF02516 0.480
MOD_NEK2_1 197 202 PF00069 0.312
MOD_NEK2_1 363 368 PF00069 0.464
MOD_NEK2_2 85 90 PF00069 0.302
MOD_PIKK_1 446 452 PF00454 0.679
MOD_PK_1 373 379 PF00069 0.587
MOD_PKA_1 331 337 PF00069 0.279
MOD_PKA_1 373 379 PF00069 0.599
MOD_PKA_1 49 55 PF00069 0.312
MOD_PKA_1 78 84 PF00069 0.302
MOD_PKA_2 202 208 PF00069 0.340
MOD_PKA_2 331 337 PF00069 0.279
MOD_PKA_2 420 426 PF00069 0.572
MOD_PKA_2 49 55 PF00069 0.312
MOD_PKA_2 69 75 PF00069 0.183
MOD_PKA_2 78 84 PF00069 0.312
MOD_Plk_1 309 315 PF00069 0.313
MOD_Plk_1 398 404 PF00069 0.636
MOD_Plk_1 4 10 PF00069 0.482
MOD_Plk_4 193 199 PF00069 0.312
MOD_Plk_4 303 309 PF00069 0.255
MOD_Plk_4 338 344 PF00069 0.315
MOD_Plk_4 398 404 PF00069 0.747
MOD_Plk_4 458 464 PF00069 0.678
MOD_ProDKin_1 110 116 PF00069 0.312
MOD_ProDKin_1 237 243 PF00069 0.410
MOD_ProDKin_1 358 364 PF00069 0.366
MOD_ProDKin_1 430 436 PF00069 0.573
MOD_ProDKin_1 441 447 PF00069 0.537
MOD_SUMO_for_1 150 153 PF00179 0.312
TRG_ER_diArg_1 198 201 PF00400 0.312
TRG_ER_diArg_1 202 204 PF00400 0.312
TRG_ER_diArg_1 286 288 PF00400 0.312
TRG_ER_diArg_1 320 322 PF00400 0.333
TRG_ER_diArg_1 463 465 PF00400 0.638
TRG_ER_diArg_1 66 68 PF00400 0.312
TRG_NLS_Bipartite_1 21 38 PF00514 0.312
TRG_NLS_MonoExtN_4 32 38 PF00514 0.312
TRG_Pf-PMV_PEXEL_1 170 174 PF00026 0.312
TRG_Pf-PMV_PEXEL_1 177 181 PF00026 0.312
TRG_Pf-PMV_PEXEL_1 21 25 PF00026 0.312
TRG_Pf-PMV_PEXEL_1 289 294 PF00026 0.312
TRG_Pf-PMV_PEXEL_1 464 468 PF00026 0.594

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY11 Leptomonas seymouri 55% 100%
A0A3Q8IF48 Leishmania donovani 100% 100%
A4HHD4 Leishmania braziliensis 77% 99%
E9ADY0 Leishmania major 90% 100%
E9ALV1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS