EXS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Etoposide-induced protein 2.4 (EI24) - putative

Species:

Leishmania infantum

UniProt:

A4I4H6_LEIIN

TriTrypDb:

LINF_290017800

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4I4H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4H6

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016236	macroautophagy	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0061919	process utilizing autophagic mechanism	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.632
CLV_NRD_NRD_1	126	128	PF00675	0.375
CLV_NRD_NRD_1	239	241	PF00675	0.422
CLV_NRD_NRD_1	38	40	PF00675	0.509
CLV_PCSK_KEX2_1	37	39	PF00082	0.436
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.436
CLV_PCSK_SKI1_1	106	110	PF00082	0.436
CLV_PCSK_SKI1_1	128	132	PF00082	0.385
CLV_PCSK_SKI1_1	187	191	PF00082	0.275
CLV_PCSK_SKI1_1	353	357	PF00082	0.483
DEG_APCC_DBOX_1	202	210	PF00400	0.444
DEG_SPOP_SBC_1	57	61	PF00917	0.694
DOC_AGCK_PIF_2	465	470	PF00069	0.386
DOC_CKS1_1	450	455	PF01111	0.312
DOC_CYCLIN_yClb5_NLxxxL_5	125	134	PF00134	0.529
DOC_MAPK_gen_1	118	126	PF00069	0.615
DOC_MAPK_gen_1	37	46	PF00069	0.576
DOC_MAPK_MEF2A_6	574	582	PF00069	0.388
DOC_MAPK_RevD_3	25	39	PF00069	0.678
DOC_PP2B_LxvP_1	582	585	PF13499	0.312
DOC_PP4_FxxP_1	108	111	PF00568	0.661
DOC_PP4_FxxP_1	53	56	PF00568	0.640
DOC_PP4_FxxP_1	542	545	PF00568	0.565
DOC_USP7_MATH_1	177	181	PF00917	0.729
DOC_USP7_MATH_1	185	189	PF00917	0.661
DOC_USP7_MATH_1	255	259	PF00917	0.730
DOC_USP7_MATH_1	308	312	PF00917	0.775
DOC_USP7_MATH_1	380	384	PF00917	0.676
DOC_USP7_MATH_1	393	397	PF00917	0.625
DOC_USP7_MATH_1	401	405	PF00917	0.685
DOC_USP7_MATH_1	433	437	PF00917	0.343
DOC_USP7_MATH_1	545	549	PF00917	0.570
DOC_USP7_MATH_1	57	61	PF00917	0.700
DOC_WW_Pin1_4	151	156	PF00397	0.433
DOC_WW_Pin1_4	282	287	PF00397	0.770
DOC_WW_Pin1_4	397	402	PF00397	0.735
DOC_WW_Pin1_4	407	412	PF00397	0.640
DOC_WW_Pin1_4	449	454	PF00397	0.312
DOC_WW_Pin1_4	51	56	PF00397	0.717
DOC_WW_Pin1_4	58	63	PF00397	0.714
DOC_WW_Pin1_4	76	81	PF00397	0.711
LIG_14-3-3_CanoR_1	103	109	PF00244	0.781
LIG_14-3-3_CanoR_1	187	197	PF00244	0.529
LIG_14-3-3_CanoR_1	323	332	PF00244	0.651
LIG_14-3-3_CanoR_1	345	352	PF00244	0.664
LIG_14-3-3_CanoR_1	353	360	PF00244	0.647
LIG_Actin_WH2_2	195	212	PF00022	0.388
LIG_Actin_WH2_2	322	340	PF00022	0.664
LIG_AP2alpha_2	412	414	PF02296	0.703
LIG_BRCT_BRCA1_1	191	195	PF00533	0.340
LIG_BRCT_BRCA1_1	555	559	PF00533	0.558
LIG_CtBP_PxDLS_1	2	6	PF00389	0.705
LIG_deltaCOP1_diTrp_1	235	243	PF00928	0.587
LIG_eIF4E_1	233	239	PF01652	0.561
LIG_FHA_1	168	174	PF00498	0.340
LIG_FHA_1	184	190	PF00498	0.746
LIG_FHA_1	234	240	PF00498	0.572
LIG_FHA_1	332	338	PF00498	0.618
LIG_FHA_1	345	351	PF00498	0.581
LIG_FHA_1	359	365	PF00498	0.630
LIG_FHA_1	414	420	PF00498	0.639
LIG_FHA_1	487	493	PF00498	0.567
LIG_FHA_1	5	11	PF00498	0.679
LIG_FHA_1	515	521	PF00498	0.426
LIG_FHA_1	89	95	PF00498	0.779
LIG_FHA_2	316	322	PF00498	0.703
LIG_FHA_2	407	413	PF00498	0.662
LIG_GBD_Chelix_1	576	584	PF00786	0.340
LIG_LIR_Apic_2	107	111	PF02991	0.668
LIG_LIR_Apic_2	540	545	PF02991	0.555
LIG_LIR_Gen_1	112	120	PF02991	0.660
LIG_LIR_Gen_1	192	202	PF02991	0.388
LIG_LIR_Gen_1	412	421	PF02991	0.628
LIG_LIR_Gen_1	434	444	PF02991	0.312
LIG_LIR_Gen_1	534	543	PF02991	0.394
LIG_LIR_Nem_3	112	116	PF02991	0.653
LIG_LIR_Nem_3	140	146	PF02991	0.312
LIG_LIR_Nem_3	192	198	PF02991	0.388
LIG_LIR_Nem_3	23	28	PF02991	0.655
LIG_LIR_Nem_3	412	417	PF02991	0.635
LIG_LIR_Nem_3	426	432	PF02991	0.493
LIG_LIR_Nem_3	434	440	PF02991	0.183
LIG_LIR_Nem_3	499	505	PF02991	0.529
LIG_LIR_Nem_3	534	538	PF02991	0.324
LIG_LIR_Nem_3	556	562	PF02991	0.569
LIG_NRBOX	121	127	PF00104	0.602
LIG_NRBOX	192	198	PF00104	0.388
LIG_PALB2_WD40_1	224	232	PF16756	0.388
LIG_PDZ_Class_1	592	597	PF00595	0.578
LIG_Pex14_1	207	211	PF04695	0.398
LIG_Pex14_2	555	559	PF04695	0.558
LIG_SH2_CRK	143	147	PF00017	0.312
LIG_SH2_CRK	218	222	PF00017	0.312
LIG_SH2_STAP1	533	537	PF00017	0.312
LIG_SH2_STAP1	560	564	PF00017	0.564
LIG_SH2_STAP1	569	573	PF00017	0.604
LIG_SH2_STAT3	211	214	PF00017	0.397
LIG_SH2_STAT3	472	475	PF00017	0.572
LIG_SH2_STAT3	533	536	PF00017	0.312
LIG_SH2_STAT5	211	214	PF00017	0.397
LIG_SH2_STAT5	218	221	PF00017	0.312
LIG_SH2_STAT5	343	346	PF00017	0.700
LIG_SH2_STAT5	463	466	PF00017	0.326
LIG_SH2_STAT5	583	586	PF00017	0.312
LIG_SH3_3	280	286	PF00018	0.715
LIG_SH3_3	541	547	PF00018	0.578
LIG_SUMO_SIM_anti_2	326	334	PF11976	0.678
LIG_SUMO_SIM_par_1	1	8	PF11976	0.667
LIG_SUMO_SIM_par_1	195	201	PF11976	0.340
LIG_SUMO_SIM_par_1	26	32	PF11976	0.686
LIG_TYR_ITIM	141	146	PF00017	0.312
LIG_TYR_ITIM	581	586	PF00017	0.304
LIG_WRC_WIRS_1	22	27	PF05994	0.595
MOD_CK1_1	156	162	PF00069	0.487
MOD_CK1_1	167	173	PF00069	0.308
MOD_CK1_1	180	186	PF00069	0.621
MOD_CK1_1	188	194	PF00069	0.315
MOD_CK1_1	383	389	PF00069	0.681
MOD_CK1_1	4	10	PF00069	0.667
MOD_CK1_1	486	492	PF00069	0.591
MOD_CK2_1	111	117	PF00069	0.576
MOD_CK2_1	303	309	PF00069	0.753
MOD_CK2_1	315	321	PF00069	0.676
MOD_CK2_1	439	445	PF00069	0.312
MOD_GlcNHglycan	166	169	PF01048	0.375
MOD_GlcNHglycan	173	176	PF01048	0.468
MOD_GlcNHglycan	257	260	PF01048	0.515
MOD_GlcNHglycan	305	308	PF01048	0.490
MOD_GlcNHglycan	309	313	PF01048	0.482
MOD_GlcNHglycan	382	385	PF01048	0.501
MOD_GlcNHglycan	386	389	PF01048	0.535
MOD_GlcNHglycan	395	398	PF01048	0.478
MOD_GlcNHglycan	441	444	PF01048	0.502
MOD_GlcNHglycan	485	488	PF01048	0.392
MOD_GlcNHglycan	508	511	PF01048	0.332
MOD_GlcNHglycan	539	542	PF01048	0.340
MOD_GlcNHglycan	83	86	PF01048	0.501
MOD_GlcNHglycan	94	97	PF01048	0.519
MOD_GlcNHglycan	98	101	PF01048	0.460
MOD_GSK3_1	1	8	PF00069	0.740
MOD_GSK3_1	149	156	PF00069	0.443
MOD_GSK3_1	167	174	PF00069	0.408
MOD_GSK3_1	176	183	PF00069	0.725
MOD_GSK3_1	185	192	PF00069	0.429
MOD_GSK3_1	282	289	PF00069	0.780
MOD_GSK3_1	303	310	PF00069	0.726
MOD_GSK3_1	380	387	PF00069	0.696
MOD_GSK3_1	393	400	PF00069	0.704
MOD_GSK3_1	401	408	PF00069	0.737
MOD_GSK3_1	506	513	PF00069	0.342
MOD_GSK3_1	527	534	PF00069	0.319
MOD_GSK3_1	88	95	PF00069	0.773
MOD_N-GLC_1	180	185	PF02516	0.479
MOD_NEK2_1	104	109	PF00069	0.561
MOD_NEK2_1	144	149	PF00069	0.313
MOD_NEK2_1	189	194	PF00069	0.407
MOD_NEK2_1	198	203	PF00069	0.304
MOD_NEK2_1	29	34	PF00069	0.732
MOD_NEK2_1	325	330	PF00069	0.657
MOD_NEK2_1	331	336	PF00069	0.674
MOD_NEK2_1	439	444	PF00069	0.285
MOD_NEK2_1	5	10	PF00069	0.712
MOD_NEK2_1	514	519	PF00069	0.344
MOD_NEK2_1	592	597	PF00069	0.608
MOD_NEK2_1	94	99	PF00069	0.799
MOD_PIKK_1	227	233	PF00454	0.291
MOD_PIKK_1	401	407	PF00454	0.737
MOD_PIKK_1	5	11	PF00454	0.734
MOD_PKA_2	177	183	PF00069	0.674
MOD_PKA_2	233	239	PF00069	0.561
MOD_PKA_2	245	251	PF00069	0.643
MOD_PKA_2	344	350	PF00069	0.643
MOD_PKA_2	483	489	PF00069	0.603
MOD_Plk_2-3	316	322	PF00069	0.642
MOD_Plk_4	1	7	PF00069	0.768
MOD_Plk_4	137	143	PF00069	0.388
MOD_Plk_4	153	159	PF00069	0.388
MOD_Plk_4	189	195	PF00069	0.388
MOD_Plk_4	216	222	PF00069	0.298
MOD_Plk_4	233	239	PF00069	0.561
MOD_Plk_4	297	303	PF00069	0.643
MOD_Plk_4	325	331	PF00069	0.640
MOD_Plk_4	413	419	PF00069	0.657
MOD_Plk_4	496	502	PF00069	0.604
MOD_Plk_4	510	516	PF00069	0.235
MOD_Plk_4	519	525	PF00069	0.312
MOD_Plk_4	527	533	PF00069	0.312
MOD_ProDKin_1	151	157	PF00069	0.436
MOD_ProDKin_1	282	288	PF00069	0.770
MOD_ProDKin_1	397	403	PF00069	0.736
MOD_ProDKin_1	407	413	PF00069	0.636
MOD_ProDKin_1	449	455	PF00069	0.312
MOD_ProDKin_1	51	57	PF00069	0.715
MOD_ProDKin_1	58	64	PF00069	0.711
MOD_ProDKin_1	76	82	PF00069	0.710
MOD_SUMO_rev_2	114	122	PF00179	0.574
TRG_DiLeu_LyEn_5	445	450	PF01217	0.329
TRG_ENDOCYTIC_2	143	146	PF00928	0.312
TRG_ENDOCYTIC_2	218	221	PF00928	0.312
TRG_ENDOCYTIC_2	569	572	PF00928	0.610
TRG_ENDOCYTIC_2	583	586	PF00928	0.312
TRG_ER_diArg_1	38	41	PF00400	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR7	Leptomonas seymouri	50%	100%
A0A3S7X2B9	Leishmania donovani	99%	100%
A4HHD1	Leishmania braziliensis	84%	100%
E9ADX7	Leishmania major	94%	100%
E9ALV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%