Tryparedoxin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin-like protein

Species:

Leishmania infantum

UniProt:

A4I4H0_LEIIN

TriTrypDb:

LINF_290017200

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I4H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4H0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.634
CLV_NRD_NRD_1	147	149	PF00675	0.763
CLV_NRD_NRD_1	193	195	PF00675	0.560
CLV_NRD_NRD_1	288	290	PF00675	0.707
CLV_NRD_NRD_1	361	363	PF00675	0.468
CLV_NRD_NRD_1	94	96	PF00675	0.595
CLV_NRD_NRD_1	99	101	PF00675	0.590
CLV_PCSK_FUR_1	227	231	PF00082	0.567
CLV_PCSK_KEX2_1	107	109	PF00082	0.634
CLV_PCSK_KEX2_1	166	168	PF00082	0.702
CLV_PCSK_KEX2_1	19	21	PF00082	0.600
CLV_PCSK_KEX2_1	193	195	PF00082	0.593
CLV_PCSK_KEX2_1	229	231	PF00082	0.587
CLV_PCSK_KEX2_1	288	290	PF00082	0.707
CLV_PCSK_KEX2_1	360	362	PF00082	0.454
CLV_PCSK_KEX2_1	94	96	PF00082	0.595
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.695
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.600
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.587
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.438
CLV_PCSK_SKI1_1	216	220	PF00082	0.644
CLV_PCSK_SKI1_1	236	240	PF00082	0.488
CLV_PCSK_SKI1_1	362	366	PF00082	0.408
CLV_PCSK_SKI1_1	80	84	PF00082	0.504
CLV_Separin_Metazoa	11	15	PF03568	0.323
DEG_Nend_UBRbox_3	1	3	PF02207	0.322
DOC_CKS1_1	290	295	PF01111	0.434
DOC_CYCLIN_yCln2_LP_2	239	242	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.615
DOC_MAPK_FxFP_2	218	221	PF00069	0.350
DOC_MAPK_gen_1	166	173	PF00069	0.476
DOC_MAPK_gen_1	330	339	PF00069	0.292
DOC_MAPK_MEF2A_6	216	225	PF00069	0.335
DOC_MAPK_MEF2A_6	27	36	PF00069	0.284
DOC_PP2B_LxvP_1	239	242	PF13499	0.437
DOC_PP2B_LxvP_1	255	258	PF13499	0.418
DOC_PP2B_LxvP_1	365	368	PF13499	0.606
DOC_PP4_FxxP_1	218	221	PF00568	0.350
DOC_SPAK_OSR1_1	310	314	PF12202	0.334
DOC_USP7_MATH_1	181	185	PF00917	0.558
DOC_USP7_MATH_1	251	255	PF00917	0.579
DOC_USP7_MATH_1	264	268	PF00917	0.498
DOC_USP7_MATH_1	272	276	PF00917	0.537
DOC_WW_Pin1_4	154	159	PF00397	0.504
DOC_WW_Pin1_4	275	280	PF00397	0.516
DOC_WW_Pin1_4	289	294	PF00397	0.423
DOC_WW_Pin1_4	38	43	PF00397	0.376
LIG_14-3-3_CanoR_1	153	158	PF00244	0.516
LIG_14-3-3_CanoR_1	216	221	PF00244	0.351
LIG_14-3-3_CanoR_1	230	237	PF00244	0.408
LIG_14-3-3_CanoR_1	361	368	PF00244	0.639
LIG_CSL_BTD_1	261	264	PF09270	0.519
LIG_EVH1_1	240	244	PF00568	0.443
LIG_FHA_1	290	296	PF00498	0.424
LIG_FHA_1	344	350	PF00498	0.353
LIG_HP1_1	30	34	PF01393	0.276
LIG_IRF3_LxIS_1	350	357	PF10401	0.517
LIG_LIR_Apic_2	351	355	PF02991	0.421
LIG_LIR_Gen_1	28	38	PF02991	0.292
LIG_LIR_Gen_1	321	329	PF02991	0.422
LIG_LIR_Gen_1	45	55	PF02991	0.292
LIG_LIR_Nem_3	219	223	PF02991	0.329
LIG_LIR_Nem_3	28	34	PF02991	0.292
LIG_LIR_Nem_3	299	304	PF02991	0.356
LIG_LIR_Nem_3	45	50	PF02991	0.292
LIG_LYPXL_yS_3	220	223	PF13949	0.317
LIG_LYPXL_yS_3	301	304	PF13949	0.350
LIG_MYND_1	237	241	PF01753	0.436
LIG_Pex14_1	197	201	PF04695	0.319
LIG_Pex14_2	36	40	PF04695	0.292
LIG_SH2_NCK_1	201	205	PF00017	0.328
LIG_SH2_NCK_1	73	77	PF00017	0.292
LIG_SH2_PTP2	31	34	PF00017	0.292
LIG_SH2_SRC	201	204	PF00017	0.324
LIG_SH2_STAT3	3	6	PF00017	0.321
LIG_SH2_STAT5	3	6	PF00017	0.321
LIG_SH2_STAT5	31	34	PF00017	0.292
LIG_SH2_STAT5	68	71	PF00017	0.305
LIG_SH3_3	184	190	PF00018	0.533
LIG_SH3_3	204	210	PF00018	0.438
LIG_SH3_3	238	244	PF00018	0.471
LIG_SH3_3	292	298	PF00018	0.537
LIG_SUMO_SIM_anti_2	346	351	PF11976	0.453
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.415
LIG_SUMO_SIM_par_1	340	346	PF11976	0.340
LIG_SxIP_EBH_1	153	167	PF03271	0.511
LIG_TYR_ITIM	199	204	PF00017	0.323
LIG_TYR_ITIM	29	34	PF00017	0.292
LIG_WRC_WIRS_1	79	84	PF05994	0.308
LIG_WW_2	241	244	PF00397	0.457
MOD_CDK_SPxxK_3	275	282	PF00069	0.468
MOD_CK1_1	152	158	PF00069	0.518
MOD_CK1_1	275	281	PF00069	0.472
MOD_CK2_1	140	146	PF00069	0.555
MOD_CK2_1	5	11	PF00069	0.421
MOD_CK2_1	71	77	PF00069	0.292
MOD_Cter_Amidation	191	194	PF01082	0.636
MOD_GlcNHglycan	109	112	PF01048	0.686
MOD_GlcNHglycan	177	180	PF01048	0.762
MOD_GlcNHglycan	231	234	PF01048	0.697
MOD_GlcNHglycan	270	273	PF01048	0.711
MOD_GlcNHglycan	316	320	PF01048	0.621
MOD_GlcNHglycan	88	91	PF01048	0.652
MOD_GSK3_1	148	155	PF00069	0.525
MOD_GSK3_1	264	271	PF00069	0.530
MOD_GSK3_1	67	74	PF00069	0.298
MOD_GSK3_1	78	85	PF00069	0.305
MOD_LATS_1	147	153	PF00433	0.477
MOD_LATS_1	214	220	PF00433	0.354
MOD_N-GLC_1	153	158	PF02516	0.670
MOD_NEK2_1	345	350	PF00069	0.319
MOD_NEK2_1	36	41	PF00069	0.276
MOD_NEK2_1	78	83	PF00069	0.308
MOD_PIKK_1	266	272	PF00454	0.537
MOD_PIKK_1	354	360	PF00454	0.606
MOD_PKA_1	107	113	PF00069	0.467
MOD_PKA_1	119	125	PF00069	0.448
MOD_PKA_1	148	154	PF00069	0.555
MOD_PKA_1	229	235	PF00069	0.383
MOD_PKA_1	360	366	PF00069	0.641
MOD_PKA_2	107	113	PF00069	0.483
MOD_PKA_2	152	158	PF00069	0.599
MOD_PKA_2	229	235	PF00069	0.418
MOD_PKA_2	360	366	PF00069	0.641
MOD_PKA_2	86	92	PF00069	0.460
MOD_Plk_1	169	175	PF00069	0.518
MOD_Plk_1	251	257	PF00069	0.533
MOD_Plk_2-3	140	146	PF00069	0.464
MOD_Plk_4	140	146	PF00069	0.482
MOD_Plk_4	345	351	PF00069	0.436
MOD_Plk_4	78	84	PF00069	0.321
MOD_ProDKin_1	154	160	PF00069	0.502
MOD_ProDKin_1	275	281	PF00069	0.507
MOD_ProDKin_1	289	295	PF00069	0.411
MOD_ProDKin_1	38	44	PF00069	0.376
MOD_SUMO_rev_2	112	122	PF00179	0.570
MOD_SUMO_rev_2	56	64	PF00179	0.376
TRG_DiLeu_BaEn_2	42	48	PF01217	0.376
TRG_ENDOCYTIC_2	201	204	PF00928	0.324
TRG_ENDOCYTIC_2	220	223	PF00928	0.317
TRG_ENDOCYTIC_2	301	304	PF00928	0.350
TRG_ENDOCYTIC_2	31	34	PF00928	0.292
TRG_ER_diArg_1	107	109	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T6	Leptomonas seymouri	51%	100%
A0A3Q8IE94	Leishmania donovani	100%	100%
A4HHC4	Leishmania braziliensis	75%	100%
E9ADX1	Leishmania major	87%	99%
E9ALW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%