ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Ankyrin repeats (many copies)/Ankyrin repeat - putative

Species:

Leishmania infantum

UniProt:

A4I4G8_LEIIN

TriTrypDb:

LINF_290016900

Length:

360

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I4G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4G8

PDB structure(s): 3ljn_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	44	50	PF00089	0.335
CLV_NRD_NRD_1	24	26	PF00675	0.293
CLV_NRD_NRD_1	325	327	PF00675	0.686
CLV_NRD_NRD_1	33	35	PF00675	0.290
CLV_PCSK_KEX2_1	325	327	PF00082	0.637
CLV_PCSK_KEX2_1	33	35	PF00082	0.299
CLV_PCSK_KEX2_1	335	337	PF00082	0.557
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.669
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.581
CLV_PCSK_SKI1_1	182	186	PF00082	0.507
CLV_PCSK_SKI1_1	335	339	PF00082	0.629
CLV_Separin_Metazoa	311	315	PF03568	0.453
DEG_APCC_DBOX_1	181	189	PF00400	0.501
DOC_MAPK_gen_1	180	187	PF00069	0.457
DOC_MAPK_JIP1_4	82	88	PF00069	0.292
DOC_MAPK_MEF2A_6	180	189	PF00069	0.465
DOC_MAPK_MEF2A_6	225	233	PF00069	0.500
DOC_MAPK_MEF2A_6	92	99	PF00069	0.427
DOC_MAPK_NFAT4_5	182	190	PF00069	0.430
DOC_PP1_RVXF_1	281	287	PF00149	0.370
DOC_USP7_MATH_1	193	197	PF00917	0.444
DOC_USP7_MATH_1	294	298	PF00917	0.446
DOC_USP7_MATH_1	353	357	PF00917	0.693
DOC_USP7_UBL2_3	325	329	PF12436	0.603
DOC_WW_Pin1_4	158	163	PF00397	0.292
DOC_WW_Pin1_4	168	173	PF00397	0.375
DOC_WW_Pin1_4	38	43	PF00397	0.404
LIG_14-3-3_CanoR_1	25	35	PF00244	0.292
LIG_14-3-3_CanoR_1	47	55	PF00244	0.335
LIG_14-3-3_CanoR_1	9	17	PF00244	0.544
LIG_FHA_1	239	245	PF00498	0.445
LIG_FHA_1	254	260	PF00498	0.265
LIG_FHA_1	27	33	PF00498	0.292
LIG_FHA_1	275	281	PF00498	0.401
LIG_FHA_1	91	97	PF00498	0.320
LIG_FHA_2	161	167	PF00498	0.404
LIG_LIR_Gen_1	147	156	PF02991	0.393
LIG_LIR_LC3C_4	93	97	PF02991	0.431
LIG_LIR_Nem_3	2	7	PF02991	0.535
LIG_MAD2	283	291	PF02301	0.396
LIG_PCNA_yPIPBox_3	306	314	PF02747	0.436
LIG_PTAP_UEV_1	340	345	PF05743	0.554
LIG_SH2_GRB2like	273	276	PF00017	0.424
LIG_SH2_STAT5	148	151	PF00017	0.311
LIG_SH2_STAT5	245	248	PF00017	0.388
LIG_SH2_STAT5	67	70	PF00017	0.370
LIG_SH3_1	338	344	PF00018	0.599
LIG_SH3_2	341	346	PF14604	0.560
LIG_SH3_3	338	344	PF00018	0.556
LIG_SUMO_SIM_anti_2	183	191	PF11976	0.428
LIG_SUMO_SIM_par_1	251	256	PF11976	0.438
LIG_SUMO_SIM_par_1	93	101	PF11976	0.431
LIG_TRAF2_1	297	300	PF00917	0.487
MOD_CDK_SPxxK_3	158	165	PF00069	0.292
MOD_CDK_SPxxK_3	168	175	PF00069	0.369
MOD_CK1_1	194	200	PF00069	0.465
MOD_CK1_1	315	321	PF00069	0.580
MOD_CK2_1	294	300	PF00069	0.470
MOD_CK2_1	67	73	PF00069	0.459
MOD_CK2_1	9	15	PF00069	0.560
MOD_GlcNHglycan	317	320	PF01048	0.409
MOD_GlcNHglycan	341	344	PF01048	0.557
MOD_GlcNHglycan	355	358	PF01048	0.724
MOD_GSK3_1	344	351	PF00069	0.626
MOD_GSK3_1	352	359	PF00069	0.715
MOD_LATS_1	131	137	PF00433	0.404
MOD_N-GLC_1	274	279	PF02516	0.349
MOD_N-GLC_1	90	95	PF02516	0.320
MOD_N-GLC_2	115	117	PF02516	0.311
MOD_NEK2_1	188	193	PF00069	0.436
MOD_NEK2_1	244	249	PF00069	0.383
MOD_NEK2_1	267	272	PF00069	0.456
MOD_NEK2_1	35	40	PF00069	0.374
MOD_NEK2_1	48	53	PF00069	0.206
MOD_PKA_2	353	359	PF00069	0.692
MOD_PKB_1	346	354	PF00069	0.684
MOD_Plk_1	238	244	PF00069	0.506
MOD_Plk_4	109	115	PF00069	0.404
MOD_Plk_4	275	281	PF00069	0.362
MOD_ProDKin_1	158	164	PF00069	0.292
MOD_ProDKin_1	168	174	PF00069	0.371
MOD_ProDKin_1	38	44	PF00069	0.404
TRG_DiLeu_BaEn_1	150	155	PF01217	0.361
TRG_DiLeu_BaEn_1	183	188	PF01217	0.424
TRG_DiLeu_BaEn_1	300	305	PF01217	0.509
TRG_DiLeu_BaEn_1	31	36	PF01217	0.335
TRG_DiLeu_LyEn_5	31	36	PF01217	0.404
TRG_ENDOCYTIC_2	148	151	PF00928	0.311
TRG_ENDOCYTIC_2	245	248	PF00928	0.428
TRG_ER_diArg_1	179	182	PF00400	0.492
TRG_ER_diArg_1	32	34	PF00400	0.365
TRG_ER_diArg_1	345	348	PF00400	0.597
TRG_NLS_Bipartite_1	325	339	PF00514	0.705
TRG_NLS_MonoCore_2	324	329	PF00514	0.644
TRG_NLS_MonoExtC_3	324	329	PF00514	0.648
TRG_NLS_MonoExtN_4	325	331	PF00514	0.587
TRG_NLS_MonoExtN_4	332	339	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S9	Leptomonas seymouri	71%	99%
A0A1X0NIN0	Trypanosomatidae	24%	91%
A0A1X0NZR2	Trypanosomatidae	56%	100%
A0A3Q8IDM3	Leishmania donovani	99%	100%
A0A3R7N419	Trypanosoma rangeli	25%	91%
A0A422MZY2	Trypanosoma rangeli	56%	100%
A4HHC0	Leishmania braziliensis	89%	100%
B6DTG8	Bodo saltans	53%	100%
C7B178	Petunia hybrida	25%	67%
C9ZLL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A6Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	92%
E9ADW8	Leishmania major	98%	100%
E9ALW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P14368	Fowlpox virus (strain NVSL)	25%	84%
Q495B1	Homo sapiens	23%	69%
Q91ZT7	Mus musculus	25%	77%