Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4G2_LEIIN

TriTrypDb:

LINF_290016200

Length:

197

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.506
CLV_NRD_NRD_1	115	117	PF00675	0.413
CLV_NRD_NRD_1	122	124	PF00675	0.356
CLV_NRD_NRD_1	42	44	PF00675	0.559
CLV_NRD_NRD_1	85	87	PF00675	0.587
CLV_PCSK_KEX2_1	109	111	PF00082	0.484
CLV_PCSK_KEX2_1	117	119	PF00082	0.394
CLV_PCSK_KEX2_1	122	124	PF00082	0.364
CLV_PCSK_KEX2_1	137	139	PF00082	0.473
CLV_PCSK_KEX2_1	158	160	PF00082	0.461
CLV_PCSK_KEX2_1	42	44	PF00082	0.521
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.457
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.496
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.461
CLV_PCSK_PC7_1	118	124	PF00082	0.416
CLV_PCSK_PC7_1	38	44	PF00082	0.501
CLV_PCSK_SKI1_1	142	146	PF00082	0.525
CLV_PCSK_SKI1_1	30	34	PF00082	0.504
CLV_PCSK_SKI1_1	42	46	PF00082	0.463
DOC_USP7_UBL2_3	137	141	PF12436	0.458
DOC_USP7_UBL2_3	55	59	PF12436	0.577
DOC_USP7_UBL2_3	94	98	PF12436	0.644
DOC_WW_Pin1_4	13	18	PF00397	0.550
LIG_14-3-3_CanoR_1	150	156	PF00244	0.460
LIG_14-3-3_CanoR_1	42	47	PF00244	0.516
LIG_FHA_1	173	179	PF00498	0.481
LIG_LIR_Apic_2	165	170	PF02991	0.419
LIG_LIR_Gen_1	4	14	PF02991	0.638
LIG_LIR_Nem_3	124	130	PF02991	0.444
LIG_LIR_Nem_3	161	167	PF02991	0.469
LIG_LIR_Nem_3	4	9	PF02991	0.611
LIG_Rb_pABgroove_1	64	72	PF01858	0.564
LIG_SH2_CRK	6	10	PF00017	0.620
LIG_SH2_PTP2	167	170	PF00017	0.535
LIG_SH2_SRC	167	170	PF00017	0.522
LIG_SH2_STAP1	127	131	PF00017	0.557
LIG_SH2_STAP1	70	74	PF00017	0.411
LIG_SH2_STAT3	28	31	PF00017	0.437
LIG_SH2_STAT3	70	73	PF00017	0.427
LIG_SH2_STAT5	167	170	PF00017	0.558
LIG_SH3_1	167	173	PF00018	0.495
LIG_SH3_3	167	173	PF00018	0.457
LIG_TRAF2_1	16	19	PF00917	0.459
MOD_CK2_1	13	19	PF00069	0.508
MOD_CK2_1	55	61	PF00069	0.514
MOD_CK2_1	77	83	PF00069	0.490
MOD_Cter_Amidation	139	142	PF01082	0.603
MOD_GSK3_1	172	179	PF00069	0.479
MOD_GSK3_1	42	49	PF00069	0.474
MOD_NEK2_1	190	195	PF00069	0.633
MOD_NEK2_1	46	51	PF00069	0.499
MOD_NEK2_1	77	82	PF00069	0.571
MOD_PIKK_1	116	122	PF00454	0.476
MOD_PKA_1	116	122	PF00069	0.411
MOD_PKA_1	42	48	PF00069	0.632
MOD_PKA_2	149	155	PF00069	0.459
MOD_PKA_2	188	194	PF00069	0.503
MOD_PKA_2	42	48	PF00069	0.611
MOD_ProDKin_1	13	19	PF00069	0.544
MOD_SUMO_rev_2	113	119	PF00179	0.561
MOD_SUMO_rev_2	80	89	PF00179	0.565
MOD_SUMO_rev_2	90	99	PF00179	0.367
TRG_DiLeu_BaEn_1	19	24	PF01217	0.448
TRG_DiLeu_BaEn_1	5	10	PF01217	0.479
TRG_DiLeu_BaEn_1	61	66	PF01217	0.478
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.417
TRG_ENDOCYTIC_2	29	32	PF00928	0.510
TRG_ENDOCYTIC_2	6	9	PF00928	0.621
TRG_ER_diArg_1	108	110	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS21	Leptomonas seymouri	28%	100%
A0A0N1PE73	Leptomonas seymouri	64%	99%
A0A0S4KEQ5	Bodo saltans	37%	100%
A0A1X0P0C6	Trypanosomatidae	58%	100%
A0A3Q8IR92	Leishmania donovani	99%	100%
A0A3R7K1K7	Trypanosoma rangeli	28%	100%
A0A422NF15	Trypanosoma rangeli	59%	100%
A0A422NMA5	Trypanosoma rangeli	28%	100%
A4HHB5	Leishmania braziliensis	80%	100%
C9ZLL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ADW1	Leishmania major	94%	100%
E9ALW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B1S3	Trypanosoma cruzi	56%	100%