Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4F6_LEIIN

TriTrypDb:

LINF_290015600

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4F6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	363	367	PF00656	0.464
CLV_NRD_NRD_1	174	176	PF00675	0.765
CLV_NRD_NRD_1	19	21	PF00675	0.483
CLV_NRD_NRD_1	270	272	PF00675	0.755
CLV_NRD_NRD_1	323	325	PF00675	0.740
CLV_PCSK_FUR_1	166	170	PF00082	0.613
CLV_PCSK_FUR_1	17	21	PF00082	0.482
CLV_PCSK_FUR_1	268	272	PF00082	0.613
CLV_PCSK_KEX2_1	168	170	PF00082	0.643
CLV_PCSK_KEX2_1	174	176	PF00082	0.665
CLV_PCSK_KEX2_1	188	190	PF00082	0.553
CLV_PCSK_KEX2_1	19	21	PF00082	0.483
CLV_PCSK_KEX2_1	270	272	PF00082	0.755
CLV_PCSK_KEX2_1	323	325	PF00082	0.740
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.643
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.636
CLV_PCSK_SKI1_1	19	23	PF00082	0.483
DEG_APCC_DBOX_1	102	110	PF00400	0.525
DEG_APCC_DBOX_1	18	26	PF00400	0.489
DEG_Nend_UBRbox_1	1	4	PF02207	0.648
DEG_ODPH_VHL_1	36	47	PF01847	0.686
DEG_SCF_FBW7_1	202	209	PF00400	0.668
DEG_SCF_FBW7_1	311	316	PF00400	0.595
DEG_SCF_FBW7_2	537	543	PF00400	0.744
DEG_SPOP_SBC_1	59	63	PF00917	0.662
DEG_SPOP_SBC_1	72	76	PF00917	0.553
DOC_CKS1_1	182	187	PF01111	0.753
DOC_CKS1_1	203	208	PF01111	0.730
DOC_CKS1_1	458	463	PF01111	0.627
DOC_CKS1_1	46	51	PF01111	0.616
DOC_CKS1_1	537	542	PF01111	0.623
DOC_CKS1_1	83	88	PF01111	0.636
DOC_PP4_FxxP_1	458	461	PF00568	0.809
DOC_USP7_MATH_1	146	150	PF00917	0.739
DOC_USP7_MATH_1	206	210	PF00917	0.646
DOC_USP7_MATH_1	211	215	PF00917	0.622
DOC_USP7_MATH_1	226	230	PF00917	0.679
DOC_USP7_MATH_1	244	248	PF00917	0.710
DOC_USP7_MATH_1	317	321	PF00917	0.568
DOC_USP7_MATH_1	370	374	PF00917	0.564
DOC_USP7_MATH_1	41	45	PF00917	0.639
DOC_USP7_MATH_1	425	429	PF00917	0.774
DOC_USP7_MATH_1	502	506	PF00917	0.616
DOC_USP7_MATH_1	510	514	PF00917	0.621
DOC_USP7_MATH_1	529	533	PF00917	0.523
DOC_USP7_MATH_1	59	63	PF00917	0.674
DOC_USP7_MATH_2	302	308	PF00917	0.673
DOC_WW_Pin1_4	120	125	PF00397	0.518
DOC_WW_Pin1_4	178	183	PF00397	0.804
DOC_WW_Pin1_4	202	207	PF00397	0.627
DOC_WW_Pin1_4	221	226	PF00397	0.776
DOC_WW_Pin1_4	289	294	PF00397	0.639
DOC_WW_Pin1_4	309	314	PF00397	0.620
DOC_WW_Pin1_4	31	36	PF00397	0.593
DOC_WW_Pin1_4	322	327	PF00397	0.585
DOC_WW_Pin1_4	389	394	PF00397	0.697
DOC_WW_Pin1_4	405	410	PF00397	0.585
DOC_WW_Pin1_4	418	423	PF00397	0.753
DOC_WW_Pin1_4	428	433	PF00397	0.643
DOC_WW_Pin1_4	436	441	PF00397	0.604
DOC_WW_Pin1_4	45	50	PF00397	0.640
DOC_WW_Pin1_4	457	462	PF00397	0.622
DOC_WW_Pin1_4	479	484	PF00397	0.641
DOC_WW_Pin1_4	536	541	PF00397	0.619
DOC_WW_Pin1_4	60	65	PF00397	0.657
DOC_WW_Pin1_4	68	73	PF00397	0.665
DOC_WW_Pin1_4	82	87	PF00397	0.560
LIG_14-3-3_CanoR_1	175	185	PF00244	0.760
LIG_14-3-3_CanoR_1	2	11	PF00244	0.503
LIG_14-3-3_CanoR_1	270	278	PF00244	0.745
LIG_14-3-3_CanoR_1	280	286	PF00244	0.592
LIG_14-3-3_CanoR_1	328	335	PF00244	0.622
LIG_14-3-3_CanoR_1	40	46	PF00244	0.690
LIG_14-3-3_CanoR_1	497	502	PF00244	0.658
LIG_14-3-3_CanoR_1	517	522	PF00244	0.604
LIG_14-3-3_CanoR_1	530	538	PF00244	0.598
LIG_Actin_WH2_2	106	123	PF00022	0.545
LIG_deltaCOP1_diTrp_1	321	329	PF00928	0.705
LIG_FHA_1	182	188	PF00498	0.816
LIG_FHA_1	260	266	PF00498	0.647
LIG_FHA_1	310	316	PF00498	0.708
LIG_FHA_1	444	450	PF00498	0.734
LIG_FHA_1	451	457	PF00498	0.561
LIG_FHA_1	458	464	PF00498	0.518
LIG_FHA_1	5	11	PF00498	0.479
LIG_FHA_1	502	508	PF00498	0.751
LIG_FHA_2	154	160	PF00498	0.685
LIG_FHA_2	460	466	PF00498	0.709
LIG_FHA_2	480	486	PF00498	0.711
LIG_FHA_2	74	80	PF00498	0.761
LIG_LIR_Apic_2	195	201	PF02991	0.608
LIG_LIR_Apic_2	292	297	PF02991	0.663
LIG_LIR_Apic_2	457	461	PF02991	0.801
LIG_LIR_Gen_1	518	529	PF02991	0.539
LIG_LIR_Nem_3	518	524	PF02991	0.571
LIG_MYND_1	202	206	PF01753	0.721
LIG_MYND_1	405	409	PF01753	0.695
LIG_MYND_1	66	70	PF01753	0.718
LIG_NRBOX	115	121	PF00104	0.523
LIG_RPA_C_Fungi	525	537	PF08784	0.692
LIG_SH2_CRK	198	202	PF00017	0.608
LIG_SH2_NCK_1	198	202	PF00017	0.608
LIG_SH2_NCK_1	210	214	PF00017	0.653
LIG_SH2_SRC	198	201	PF00017	0.611
LIG_SH2_SRC	210	213	PF00017	0.652
LIG_SH2_STAT3	528	531	PF00017	0.679
LIG_SH2_STAT5	118	121	PF00017	0.646
LIG_SH3_1	197	203	PF00018	0.727
LIG_SH3_1	32	38	PF00018	0.626
LIG_SH3_2	35	40	PF14604	0.720
LIG_SH3_2	406	411	PF14604	0.700
LIG_SH3_2	433	438	PF14604	0.763
LIG_SH3_2	46	51	PF14604	0.630
LIG_SH3_3	179	185	PF00018	0.640
LIG_SH3_3	197	203	PF00018	0.508
LIG_SH3_3	32	38	PF00018	0.603
LIG_SH3_3	403	409	PF00018	0.747
LIG_SH3_3	421	427	PF00018	0.587
LIG_SH3_3	43	49	PF00018	0.637
LIG_SH3_3	430	436	PF00018	0.625
LIG_SH3_3	80	86	PF00018	0.725
LIG_SH3_3	95	101	PF00018	0.546
LIG_TRAF2_1	482	485	PF00917	0.717
LIG_TRAF2_1	541	544	PF00917	0.654
MOD_CDC14_SPxK_1	224	227	PF00782	0.754
MOD_CDC14_SPxK_1	292	295	PF00782	0.707
MOD_CDC14_SPxK_1	325	328	PF00782	0.615
MOD_CDC14_SPxK_1	408	411	PF00782	0.701
MOD_CDK_SPxK_1	221	227	PF00069	0.753
MOD_CDK_SPxK_1	289	295	PF00069	0.707
MOD_CDK_SPxK_1	322	328	PF00069	0.622
MOD_CDK_SPxK_1	405	411	PF00069	0.699
MOD_CDK_SPxK_1	45	51	PF00069	0.762
MOD_CDK_SPxxK_3	181	188	PF00069	0.753
MOD_CDK_SPxxK_3	438	445	PF00069	0.652
MOD_CDK_SPxxK_3	82	89	PF00069	0.575
MOD_CK1_1	102	108	PF00069	0.603
MOD_CK1_1	123	129	PF00069	0.661
MOD_CK1_1	141	147	PF00069	0.578
MOD_CK1_1	181	187	PF00069	0.754
MOD_CK1_1	282	288	PF00069	0.682
MOD_CK1_1	333	339	PF00069	0.571
MOD_CK1_1	388	394	PF00069	0.678
MOD_CK1_1	4	10	PF00069	0.567
MOD_CK1_1	400	406	PF00069	0.572
MOD_CK1_1	428	434	PF00069	0.774
MOD_CK1_1	496	502	PF00069	0.622
MOD_CK1_1	520	526	PF00069	0.577
MOD_CK1_1	71	77	PF00069	0.635
MOD_CK2_1	206	212	PF00069	0.695
MOD_CK2_1	260	266	PF00069	0.678
MOD_CK2_1	315	321	PF00069	0.678
MOD_CK2_1	459	465	PF00069	0.709
MOD_CK2_1	479	485	PF00069	0.712
MOD_CK2_1	538	544	PF00069	0.600
MOD_CK2_1	71	77	PF00069	0.794
MOD_DYRK1A_RPxSP_1	438	442	PF00069	0.686
MOD_GlcNHglycan	178	181	PF01048	0.804
MOD_GlcNHglycan	228	231	PF01048	0.783
MOD_GlcNHglycan	262	265	PF01048	0.676
MOD_GlcNHglycan	27	31	PF01048	0.536
MOD_GlcNHglycan	281	284	PF01048	0.746
MOD_GlcNHglycan	3	6	PF01048	0.595
MOD_GlcNHglycan	332	335	PF01048	0.717
MOD_GlcNHglycan	362	365	PF01048	0.536
MOD_GlcNHglycan	372	375	PF01048	0.564
MOD_GlcNHglycan	385	388	PF01048	0.610
MOD_GlcNHglycan	488	491	PF01048	0.719
MOD_GlcNHglycan	508	511	PF01048	0.605
MOD_GlcNHglycan	512	515	PF01048	0.585
MOD_GlcNHglycan	532	535	PF01048	0.489
MOD_GSK3_1	202	209	PF00069	0.668
MOD_GSK3_1	226	233	PF00069	0.716
MOD_GSK3_1	309	316	PF00069	0.661
MOD_GSK3_1	329	336	PF00069	0.662
MOD_GSK3_1	385	392	PF00069	0.702
MOD_GSK3_1	41	48	PF00069	0.644
MOD_GSK3_1	450	457	PF00069	0.762
MOD_GSK3_1	479	486	PF00069	0.788
MOD_GSK3_1	492	499	PF00069	0.633
MOD_GSK3_1	502	509	PF00069	0.618
MOD_GSK3_1	515	522	PF00069	0.640
MOD_GSK3_1	54	61	PF00069	0.698
MOD_GSK3_1	68	75	PF00069	0.657
MOD_N-GLC_1	138	143	PF02516	0.635
MOD_N-GLC_1	176	181	PF02516	0.758
MOD_N-GLC_1	272	277	PF02516	0.746
MOD_NEK2_1	1	6	PF00069	0.556
MOD_NEK2_1	125	130	PF00069	0.663
MOD_NEK2_1	260	265	PF00069	0.676
MOD_NEK2_1	330	335	PF00069	0.644
MOD_NEK2_1	360	365	PF00069	0.537
MOD_NEK2_1	443	448	PF00069	0.706
MOD_NEK2_1	449	454	PF00069	0.574
MOD_NEK2_1	472	477	PF00069	0.829
MOD_NEK2_1	516	521	PF00069	0.669
MOD_NEK2_2	272	277	PF00069	0.683
MOD_NEK2_2	483	488	PF00069	0.685
MOD_PIKK_1	125	131	PF00454	0.686
MOD_PIKK_1	146	152	PF00454	0.728
MOD_PIKK_1	251	257	PF00454	0.629
MOD_PIKK_1	4	10	PF00454	0.490
MOD_PKA_2	1	7	PF00069	0.614
MOD_PKA_2	102	108	PF00069	0.714
MOD_PKA_2	226	232	PF00069	0.658
MOD_PKA_2	279	285	PF00069	0.754
MOD_PKA_2	400	406	PF00069	0.750
MOD_PKA_2	496	502	PF00069	0.702
MOD_PKA_2	516	522	PF00069	0.682
MOD_PKA_2	529	535	PF00069	0.500
MOD_Plk_1	211	217	PF00069	0.708
MOD_Plk_1	272	278	PF00069	0.762
MOD_Plk_1	297	303	PF00069	0.765
MOD_Plk_1	355	361	PF00069	0.644
MOD_Plk_4	272	278	PF00069	0.746
MOD_Plk_4	355	361	PF00069	0.613
MOD_Plk_4	454	460	PF00069	0.653
MOD_ProDKin_1	120	126	PF00069	0.523
MOD_ProDKin_1	178	184	PF00069	0.805
MOD_ProDKin_1	202	208	PF00069	0.629
MOD_ProDKin_1	221	227	PF00069	0.778
MOD_ProDKin_1	289	295	PF00069	0.640
MOD_ProDKin_1	309	315	PF00069	0.620
MOD_ProDKin_1	31	37	PF00069	0.595
MOD_ProDKin_1	322	328	PF00069	0.584
MOD_ProDKin_1	389	395	PF00069	0.697
MOD_ProDKin_1	405	411	PF00069	0.588
MOD_ProDKin_1	418	424	PF00069	0.751
MOD_ProDKin_1	428	434	PF00069	0.645
MOD_ProDKin_1	436	442	PF00069	0.602
MOD_ProDKin_1	45	51	PF00069	0.644
MOD_ProDKin_1	457	463	PF00069	0.622
MOD_ProDKin_1	479	485	PF00069	0.643
MOD_ProDKin_1	536	542	PF00069	0.621
MOD_ProDKin_1	60	66	PF00069	0.656
MOD_ProDKin_1	68	74	PF00069	0.660
MOD_ProDKin_1	82	88	PF00069	0.560
TRG_DiLeu_BaEn_3	354	360	PF01217	0.618
TRG_DiLeu_BaEn_4	355	361	PF01217	0.644
TRG_ER_diArg_1	174	176	PF00400	0.761
TRG_ER_diArg_1	19	21	PF00400	0.483
TRG_ER_diArg_1	268	271	PF00400	0.751
TRG_ER_diArg_1	322	324	PF00400	0.750
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.484
TRG_PTS2	1	25	PF00400	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH2	Leptomonas seymouri	35%	100%
A0A3S7X2C5	Leishmania donovani	99%	100%
A4HHB0	Leishmania braziliensis	65%	100%
E9ADV6	Leishmania major	91%	100%
E9ALX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%