LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I4F3_LEIIN
TriTrypDb:
LINF_290015300
Length:
574

Annotations

LeishMANIAdb annotations

Kinetoplastid-unique proteins with many disordered segments and a hydrophobic C-terminal region.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8
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Expansion

Sequence features

A4I4F3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4F3

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 128 130 PF00675 0.688
CLV_NRD_NRD_1 223 225 PF00675 0.637
CLV_NRD_NRD_1 420 422 PF00675 0.635
CLV_NRD_NRD_1 428 430 PF00675 0.666
CLV_NRD_NRD_1 461 463 PF00675 0.552
CLV_PCSK_KEX2_1 128 130 PF00082 0.748
CLV_PCSK_KEX2_1 223 225 PF00082 0.637
CLV_PCSK_KEX2_1 297 299 PF00082 0.549
CLV_PCSK_KEX2_1 420 422 PF00082 0.635
CLV_PCSK_KEX2_1 461 463 PF00082 0.552
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PF35 Leptomonas seymouri 68% 100%
A0A0S4JJG2 Bodo saltans 34% 100%
A0A1X0NZR0 Trypanosomatidae 43% 100%
A0A3Q8IF28 Leishmania donovani 99% 100%
A4HHA7 Leishmania braziliensis 81% 100%
C9ZLK3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9ADV3 Leishmania major 94% 100%
E9ALX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5BH52 Trypanosoma cruzi 38% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS