LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
LETM1 and EF-hand domain-containing protein 1 - putative
Species:
Leishmania infantum
UniProt:
A4I4E9_LEIIN
TriTrypDb:
LINF_290014900
Length:
502

Annotations

Annotations by Jardim et al.

Membrane associated proteins, LETM1 and EF-hand domain-containing 1 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005743 mitochondrial inner membrane 5 12
GO:0016020 membrane 2 12
GO:0019866 organelle inner membrane 4 12
GO:0031090 organelle membrane 3 12
GO:0031966 mitochondrial membrane 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 2
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Expansion

Sequence features

A4I4E9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4E9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006811 monoatomic ion transport 4 2
GO:0006812 monoatomic cation transport 5 2
GO:0006816 calcium ion transport 7 2
GO:0006851 mitochondrial calcium ion transmembrane transport 4 2
GO:0006873 intracellular monoatomic ion homeostasis 4 1
GO:0006875 obsolete intracellular metal ion homeostasis 6 1
GO:0009987 cellular process 1 2
GO:0019725 cellular homeostasis 2 1
GO:0030001 metal ion transport 6 2
GO:0030003 intracellular monoatomic cation homeostasis 5 1
GO:0034220 monoatomic ion transmembrane transport 3 2
GO:0042592 homeostatic process 3 1
GO:0048878 chemical homeostasis 4 1
GO:0050801 monoatomic ion homeostasis 5 1
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055065 obsolete metal ion homeostasis 7 1
GO:0055080 monoatomic cation homeostasis 6 1
GO:0055082 intracellular chemical homeostasis 3 1
GO:0055085 transmembrane transport 2 2
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0070588 calcium ion transmembrane transport 6 2
GO:0098655 monoatomic cation transmembrane transport 4 2
GO:0098660 inorganic ion transmembrane transport 4 2
GO:0098662 inorganic cation transmembrane transport 5 2
GO:0098771 inorganic ion homeostasis 6 1
GO:1990542 mitochondrial transmembrane transport 3 2
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0043021 ribonucleoprotein complex binding 3 12
GO:0043022 ribosome binding 4 12
GO:0044877 protein-containing complex binding 2 12
GO:0005215 transporter activity 1 2
GO:0005432 calcium:sodium antiporter activity 7 2
GO:0005509 calcium ion binding 5 2
GO:0008324 monoatomic cation transmembrane transporter activity 4 2
GO:0015075 monoatomic ion transmembrane transporter activity 3 2
GO:0015081 sodium ion transmembrane transporter activity 6 2
GO:0015085 calcium ion transmembrane transporter activity 6 2
GO:0015291 secondary active transmembrane transporter activity 4 2
GO:0015297 antiporter activity 5 2
GO:0015298 obsolete solute:monoatomic cation antiporter activity 5 2
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 2
GO:0015368 calcium:monoatomic cation antiporter activity 7 2
GO:0022804 active transmembrane transporter activity 3 2
GO:0022853 active monoatomic ion transmembrane transporter activity 4 2
GO:0022857 transmembrane transporter activity 2 2
GO:0022890 inorganic cation transmembrane transporter activity 4 2
GO:0043167 ion binding 2 2
GO:0043169 cation binding 3 2
GO:0046872 metal ion binding 4 2
GO:0046873 metal ion transmembrane transporter activity 5 2
GO:0140828 metal cation:monoatomic cation antiporter activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 255 259 PF00656 0.381
CLV_C14_Caspase3-7 378 382 PF00656 0.561
CLV_NRD_NRD_1 172 174 PF00675 0.537
CLV_NRD_NRD_1 235 237 PF00675 0.487
CLV_NRD_NRD_1 240 242 PF00675 0.487
CLV_NRD_NRD_1 314 316 PF00675 0.654
CLV_NRD_NRD_1 326 328 PF00675 0.555
CLV_NRD_NRD_1 467 469 PF00675 0.671
CLV_NRD_NRD_1 8 10 PF00675 0.486
CLV_NRD_NRD_1 80 82 PF00675 0.287
CLV_PCSK_KEX2_1 172 174 PF00082 0.537
CLV_PCSK_KEX2_1 235 237 PF00082 0.482
CLV_PCSK_KEX2_1 240 242 PF00082 0.477
CLV_PCSK_KEX2_1 326 328 PF00082 0.619
CLV_PCSK_KEX2_1 403 405 PF00082 0.618
CLV_PCSK_KEX2_1 8 10 PF00082 0.486
CLV_PCSK_KEX2_1 80 82 PF00082 0.290
CLV_PCSK_PC1ET2_1 403 405 PF00082 0.618
CLV_PCSK_PC7_1 236 242 PF00082 0.562
CLV_PCSK_SKI1_1 28 32 PF00082 0.474
CLV_PCSK_SKI1_1 327 331 PF00082 0.625
CLV_PCSK_SKI1_1 403 407 PF00082 0.576
CLV_PCSK_SKI1_1 453 457 PF00082 0.595
CLV_PCSK_SKI1_1 458 462 PF00082 0.581
CLV_PCSK_SKI1_1 56 60 PF00082 0.359
CLV_PCSK_SKI1_1 70 74 PF00082 0.318
CLV_PCSK_SKI1_1 83 87 PF00082 0.267
CLV_PCSK_SKI1_1 91 95 PF00082 0.287
DEG_APCC_DBOX_1 325 333 PF00400 0.419
DEG_APCC_DBOX_1 339 347 PF00400 0.426
DEG_Nend_Nbox_1 1 3 PF02207 0.644
DEG_SPOP_SBC_1 484 488 PF00917 0.613
DOC_AGCK_PIF_2 443 448 PF00069 0.459
DOC_CYCLIN_RxL_1 80 90 PF00134 0.487
DOC_CYCLIN_yCln2_LP_2 110 116 PF00134 0.344
DOC_MAPK_gen_1 315 323 PF00069 0.446
DOC_MAPK_gen_1 326 332 PF00069 0.375
DOC_MAPK_gen_1 36 43 PF00069 0.663
DOC_MAPK_gen_1 70 78 PF00069 0.560
DOC_MAPK_gen_1 80 86 PF00069 0.487
DOC_MAPK_MEF2A_6 202 211 PF00069 0.337
DOC_PP1_RVXF_1 54 60 PF00149 0.552
DOC_PP1_RVXF_1 61 67 PF00149 0.521
DOC_PP2B_LxvP_1 110 113 PF13499 0.344
DOC_PP2B_LxvP_1 187 190 PF13499 0.308
DOC_PP4_FxxP_1 201 204 PF00568 0.381
DOC_USP7_MATH_1 19 23 PF00917 0.694
DOC_USP7_MATH_1 377 381 PF00917 0.505
DOC_USP7_MATH_1 415 419 PF00917 0.419
DOC_USP7_UBL2_3 16 20 PF12436 0.699
DOC_USP7_UBL2_3 32 36 PF12436 0.670
DOC_USP7_UBL2_3 365 369 PF12436 0.484
DOC_USP7_UBL2_3 408 412 PF12436 0.446
DOC_WW_Pin1_4 228 233 PF00397 0.381
LIG_14-3-3_CanoR_1 275 283 PF00244 0.287
LIG_14-3-3_CanoR_1 3 7 PF00244 0.663
LIG_14-3-3_CanoR_1 315 319 PF00244 0.418
LIG_14-3-3_CanoR_1 340 344 PF00244 0.498
LIG_Actin_WH2_2 34 51 PF00022 0.672
LIG_Actin_WH2_2 57 75 PF00022 0.556
LIG_APCC_ABBA_1 104 109 PF00400 0.344
LIG_APCC_ABBAyCdc20_2 134 140 PF00400 0.362
LIG_BRCT_BRCA1_1 439 443 PF00533 0.353
LIG_Clathr_ClatBox_1 251 255 PF01394 0.301
LIG_eIF4E_1 52 58 PF01652 0.547
LIG_FHA_1 16 22 PF00498 0.730
LIG_FHA_1 225 231 PF00498 0.341
LIG_FHA_1 278 284 PF00498 0.284
LIG_FHA_1 88 94 PF00498 0.483
LIG_FHA_2 343 349 PF00498 0.428
LIG_FHA_2 439 445 PF00498 0.374
LIG_FHA_2 485 491 PF00498 0.580
LIG_FHA_2 77 83 PF00498 0.476
LIG_LIR_Apic_2 199 204 PF02991 0.337
LIG_LIR_Apic_2 303 309 PF02991 0.276
LIG_LIR_Gen_1 100 110 PF02991 0.328
LIG_LIR_Gen_1 195 204 PF02991 0.329
LIG_LIR_Gen_1 288 294 PF02991 0.287
LIG_LIR_Gen_1 298 309 PF02991 0.287
LIG_LIR_Gen_1 440 450 PF02991 0.377
LIG_LIR_Nem_3 100 105 PF02991 0.328
LIG_LIR_Nem_3 195 201 PF02991 0.287
LIG_LIR_Nem_3 288 293 PF02991 0.287
LIG_LIR_Nem_3 298 304 PF02991 0.287
LIG_LIR_Nem_3 383 389 PF02991 0.458
LIG_LIR_Nem_3 440 446 PF02991 0.365
LIG_MYND_1 120 124 PF01753 0.276
LIG_NRP_CendR_1 501 502 PF00754 0.813
LIG_PCNA_PIPBox_1 390 399 PF02747 0.385
LIG_PCNA_yPIPBox_3 390 404 PF02747 0.386
LIG_Pex14_2 55 59 PF04695 0.563
LIG_SH2_CRK 221 225 PF00017 0.338
LIG_SH2_CRK 40 44 PF00017 0.626
LIG_SH2_STAP1 68 72 PF00017 0.538
LIG_SH2_STAT3 68 71 PF00017 0.534
LIG_SH2_STAT5 154 157 PF00017 0.298
LIG_SH2_STAT5 191 194 PF00017 0.362
LIG_SH2_STAT5 396 399 PF00017 0.368
LIG_SH3_3 226 232 PF00018 0.362
LIG_SH3_3 468 474 PF00018 0.494
LIG_SH3_4 32 39 PF00018 0.638
LIG_Sin3_3 108 115 PF02671 0.363
LIG_TRAF2_1 479 482 PF00917 0.619
LIG_TRAF2_1 488 491 PF00917 0.592
LIG_TYR_ITIM 299 304 PF00017 0.276
LIG_TYR_ITIM 43 48 PF00017 0.646
LIG_UBA3_1 405 413 PF00899 0.374
LIG_WRC_WIRS_1 160 165 PF05994 0.283
MOD_CDK_SPxxK_3 228 235 PF00069 0.381
MOD_CK1_1 22 28 PF00069 0.691
MOD_CK1_1 342 348 PF00069 0.497
MOD_CK1_1 354 360 PF00069 0.444
MOD_CK1_1 486 492 PF00069 0.560
MOD_CK2_1 122 128 PF00069 0.276
MOD_CK2_1 342 348 PF00069 0.445
MOD_CK2_1 372 378 PF00069 0.475
MOD_CK2_1 484 490 PF00069 0.588
MOD_CK2_1 76 82 PF00069 0.487
MOD_Cter_Amidation 499 502 PF01082 0.804
MOD_DYRK1A_RPxSP_1 228 232 PF00069 0.381
MOD_GlcNHglycan 155 158 PF01048 0.544
MOD_GlcNHglycan 22 25 PF01048 0.528
MOD_GlcNHglycan 361 364 PF01048 0.708
MOD_GlcNHglycan 375 378 PF01048 0.612
MOD_GSK3_1 122 129 PF00069 0.267
MOD_GSK3_1 15 22 PF00069 0.713
MOD_GSK3_1 155 162 PF00069 0.312
MOD_GSK3_1 220 227 PF00069 0.381
MOD_GSK3_1 310 317 PF00069 0.367
MOD_GSK3_1 335 342 PF00069 0.471
MOD_GSK3_1 373 380 PF00069 0.473
MOD_GSK3_1 415 422 PF00069 0.389
MOD_GSK3_1 429 436 PF00069 0.379
MOD_GSK3_1 449 456 PF00069 0.252
MOD_GSK3_1 486 493 PF00069 0.560
MOD_N-GLC_1 268 273 PF02516 0.562
MOD_N-GLC_1 433 438 PF02516 0.645
MOD_NEK2_1 155 160 PF00069 0.296
MOD_NEK2_1 176 181 PF00069 0.332
MOD_NEK2_1 2 7 PF00069 0.617
MOD_NEK2_1 211 216 PF00069 0.283
MOD_NEK2_1 234 239 PF00069 0.387
MOD_NEK2_1 59 64 PF00069 0.545
MOD_NEK2_1 85 90 PF00069 0.486
MOD_NEK2_2 141 146 PF00069 0.301
MOD_NEK2_2 279 284 PF00069 0.362
MOD_PIKK_1 128 134 PF00454 0.287
MOD_PKA_2 2 8 PF00069 0.618
MOD_PKA_2 234 240 PF00069 0.391
MOD_PKA_2 274 280 PF00069 0.287
MOD_PKA_2 310 316 PF00069 0.376
MOD_PKA_2 339 345 PF00069 0.474
MOD_Plk_1 295 301 PF00069 0.325
MOD_Plk_1 415 421 PF00069 0.402
MOD_Plk_1 433 439 PF00069 0.332
MOD_Plk_1 490 496 PF00069 0.562
MOD_Plk_2-3 490 496 PF00069 0.615
MOD_Plk_4 2 8 PF00069 0.667
MOD_Plk_4 220 226 PF00069 0.325
MOD_Plk_4 300 306 PF00069 0.268
MOD_Plk_4 415 421 PF00069 0.465
MOD_Plk_4 438 444 PF00069 0.373
MOD_ProDKin_1 228 234 PF00069 0.381
MOD_SUMO_rev_2 486 494 PF00179 0.594
TRG_DiLeu_BaEn_1 247 252 PF01217 0.289
TRG_DiLeu_BaLyEn_6 80 85 PF01217 0.500
TRG_DiLeu_LyEn_5 247 252 PF01217 0.301
TRG_ENDOCYTIC_2 221 224 PF00928 0.277
TRG_ENDOCYTIC_2 301 304 PF00928 0.268
TRG_ENDOCYTIC_2 40 43 PF00928 0.584
TRG_ENDOCYTIC_2 45 48 PF00928 0.560
TRG_ENDOCYTIC_2 52 55 PF00928 0.509
TRG_ER_diArg_1 134 137 PF00400 0.315
TRG_ER_diArg_1 145 148 PF00400 0.235
TRG_ER_diArg_1 171 173 PF00400 0.337
TRG_ER_diArg_1 234 236 PF00400 0.287
TRG_ER_diArg_1 239 241 PF00400 0.287
TRG_ER_diArg_1 7 9 PF00400 0.688
TRG_NLS_MonoExtC_3 410 415 PF00514 0.509
TRG_NLS_MonoExtN_4 408 415 PF00514 0.435
TRG_Pf-PMV_PEXEL_1 412 416 PF00026 0.713
TRG_Pf-PMV_PEXEL_1 83 87 PF00026 0.286

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD73 Leptomonas seymouri 86% 99%
A0A0S4JFV9 Bodo saltans 52% 100%
A0A1X0NZY3 Trypanosomatidae 62% 100%
A0A3S5IR30 Trypanosoma rangeli 65% 100%
A0A3S7X2D5 Leishmania donovani 100% 100%
A4HHA3 Leishmania braziliensis 94% 100%
C9ZLK0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9ADU9 Leishmania major 99% 100%
E9ALY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
V5DI32 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS