Solute carrier family 35 member F6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF914)/EamA-like transporter family - putative

Species:

Leishmania infantum

UniProt:

A4I4E6_LEIIN

TriTrypDb:

LINF_290014600

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4I4E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4E6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.527
CLV_PCSK_KEX2_1	17	19	PF00082	0.289
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.339
CLV_PCSK_PC7_1	13	19	PF00082	0.227
CLV_PCSK_SKI1_1	13	17	PF00082	0.227
CLV_PCSK_SKI1_1	18	22	PF00082	0.265
CLV_PCSK_SKI1_1	203	207	PF00082	0.669
CLV_PCSK_SKI1_1	285	289	PF00082	0.312
CLV_PCSK_SKI1_1	353	357	PF00082	0.408
DEG_APCC_DBOX_1	12	20	PF00400	0.470
DEG_APCC_KENBOX_2	391	395	PF00400	0.460
DOC_CYCLIN_yClb1_LxF_4	351	356	PF00134	0.512
DOC_MAPK_gen_1	86	95	PF00069	0.433
DOC_MAPK_MEF2A_6	253	260	PF00069	0.374
DOC_PP1_RVXF_1	351	357	PF00149	0.512
DOC_PP2B_PxIxI_1	316	322	PF00149	0.298
DOC_PP4_FxxP_1	122	125	PF00568	0.261
DOC_PP4_FxxP_1	198	201	PF00568	0.234
DOC_PP4_FxxP_1	61	64	PF00568	0.317
DOC_USP7_MATH_1	226	230	PF00917	0.516
DOC_USP7_MATH_1	265	269	PF00917	0.404
DOC_USP7_MATH_1	289	293	PF00917	0.487
DOC_USP7_MATH_1	3	7	PF00917	0.502
DOC_WW_Pin1_4	224	229	PF00397	0.478
DOC_WW_Pin1_4	417	422	PF00397	0.429
LIG_14-3-3_CanoR_1	291	295	PF00244	0.512
LIG_AP2alpha_2	389	391	PF02296	0.481
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BIR_III_4	161	165	PF00653	0.209
LIG_BRCT_BRCA1_1	235	239	PF00533	0.365
LIG_BRCT_BRCA1_1	323	327	PF00533	0.212
LIG_BRCT_BRCA1_1	5	9	PF00533	0.577
LIG_Clathr_ClatBox_1	157	161	PF01394	0.245
LIG_deltaCOP1_diTrp_1	283	287	PF00928	0.420
LIG_deltaCOP1_diTrp_1	298	305	PF00928	0.437
LIG_EH1_1	304	312	PF00400	0.317
LIG_eIF4E_1	62	68	PF01652	0.276
LIG_FHA_1	109	115	PF00498	0.217
LIG_FHA_1	140	146	PF00498	0.294
LIG_FHA_1	188	194	PF00498	0.268
LIG_FHA_1	306	312	PF00498	0.323
LIG_FHA_1	332	338	PF00498	0.339
LIG_FHA_1	34	40	PF00498	0.245
LIG_FHA_1	370	376	PF00498	0.499
LIG_FHA_1	436	442	PF00498	0.523
LIG_FHA_2	293	299	PF00498	0.435
LIG_FHA_2	396	402	PF00498	0.567
LIG_FHA_2	9	15	PF00498	0.489
LIG_LIR_Apic_2	195	201	PF02991	0.235
LIG_LIR_Gen_1	268	277	PF02991	0.349
LIG_LIR_Gen_1	298	309	PF02991	0.422
LIG_LIR_Gen_1	324	335	PF02991	0.220
LIG_LIR_Gen_1	358	367	PF02991	0.284
LIG_LIR_Gen_1	53	63	PF02991	0.251
LIG_LIR_Gen_1	99	110	PF02991	0.304
LIG_LIR_Nem_3	131	135	PF02991	0.268
LIG_LIR_Nem_3	268	273	PF02991	0.312
LIG_LIR_Nem_3	276	282	PF02991	0.250
LIG_LIR_Nem_3	283	287	PF02991	0.365
LIG_LIR_Nem_3	298	304	PF02991	0.454
LIG_LIR_Nem_3	324	330	PF02991	0.209
LIG_LIR_Nem_3	345	350	PF02991	0.313
LIG_LIR_Nem_3	358	362	PF02991	0.252
LIG_LIR_Nem_3	45	49	PF02991	0.215
LIG_LIR_Nem_3	53	58	PF02991	0.248
LIG_LIR_Nem_3	6	12	PF02991	0.561
LIG_LIR_Nem_3	79	84	PF02991	0.431
LIG_LIR_Nem_3	99	105	PF02991	0.193
LIG_LYPXL_yS_3	46	49	PF13949	0.234
LIG_Pex14_2	270	274	PF04695	0.284
LIG_Pex14_2	280	284	PF04695	0.210
LIG_Pex14_2	301	305	PF04695	0.339
LIG_Pex14_2	379	383	PF04695	0.433
LIG_Pex14_2	57	61	PF04695	0.338
LIG_Pex14_2	83	87	PF04695	0.436
LIG_PTB_Apo_2	77	84	PF02174	0.452
LIG_REV1ctd_RIR_1	130	140	PF16727	0.305
LIG_SH2_CRK	55	59	PF00017	0.269
LIG_SH2_CRK	90	94	PF00017	0.280
LIG_SH2_GRB2like	110	113	PF00017	0.312
LIG_SH2_PTP2	102	105	PF00017	0.339
LIG_SH2_PTP2	359	362	PF00017	0.226
LIG_SH2_SRC	338	341	PF00017	0.259
LIG_SH2_SRC	359	362	PF00017	0.273
LIG_SH2_SRC	62	65	PF00017	0.372
LIG_SH2_STAP1	110	114	PF00017	0.119
LIG_SH2_STAP1	338	342	PF00017	0.257
LIG_SH2_STAP1	55	59	PF00017	0.280
LIG_SH2_STAP1	90	94	PF00017	0.339
LIG_SH2_STAT5	102	105	PF00017	0.276
LIG_SH2_STAT5	110	113	PF00017	0.201
LIG_SH2_STAT5	313	316	PF00017	0.245
LIG_SH2_STAT5	359	362	PF00017	0.276
LIG_SH2_STAT5	62	65	PF00017	0.282
LIG_SH3_3	198	204	PF00018	0.329
LIG_SH3_3	253	259	PF00018	0.327
LIG_SH3_3	372	378	PF00018	0.373
LIG_SUMO_SIM_par_1	156	161	PF11976	0.249
LIG_SUMO_SIM_par_1	308	314	PF11976	0.357
LIG_SUMO_SIM_par_1	91	97	PF11976	0.339
LIG_TYR_ITIM	357	362	PF00017	0.305
LIG_TYR_ITSM	51	58	PF00017	0.245
LIG_UBA3_1	346	353	PF00899	0.362
LIG_UBA3_1	67	72	PF00899	0.389
LIG_WRC_WIRS_1	129	134	PF05994	0.280
LIG_WRC_WIRS_1	267	272	PF05994	0.399
MOD_CDC14_SPxK_1	420	423	PF00782	0.373
MOD_CDK_SPxK_1	417	423	PF00069	0.372
MOD_CK1_1	227	233	PF00069	0.454
MOD_CK1_1	292	298	PF00069	0.512
MOD_CK1_1	331	337	PF00069	0.265
MOD_CK1_1	42	48	PF00069	0.227
MOD_CK1_1	422	428	PF00069	0.551
MOD_CK2_1	163	169	PF00069	0.306
MOD_CK2_1	397	403	PF00069	0.538
MOD_CK2_1	8	14	PF00069	0.574
MOD_GlcNHglycan	215	218	PF01048	0.660
MOD_GlcNHglycan	323	326	PF01048	0.409
MOD_GlcNHglycan	424	427	PF01048	0.780
MOD_GSK3_1	108	115	PF00069	0.209
MOD_GSK3_1	165	172	PF00069	0.269
MOD_GSK3_1	183	190	PF00069	0.197
MOD_GSK3_1	29	36	PF00069	0.250
MOD_GSK3_1	431	438	PF00069	0.435
MOD_N-GLC_1	213	218	PF02516	0.603
MOD_N-GLC_1	289	294	PF02516	0.295
MOD_N-GLC_1	328	333	PF02516	0.245
MOD_N-GLC_1	342	347	PF02516	0.245
MOD_N-GLC_1	369	374	PF02516	0.514
MOD_N-GLC_1	395	400	PF02516	0.596
MOD_N-GLC_1	42	47	PF02516	0.420
MOD_N-GLC_2	209	211	PF02516	0.590
MOD_NEK2_1	128	133	PF00069	0.269
MOD_NEK2_1	139	144	PF00069	0.457
MOD_NEK2_1	182	187	PF00069	0.249
MOD_NEK2_1	266	271	PF00069	0.360
MOD_NEK2_1	27	32	PF00069	0.273
MOD_NEK2_1	272	277	PF00069	0.352
MOD_NEK2_1	305	310	PF00069	0.245
MOD_NEK2_1	311	316	PF00069	0.245
MOD_NEK2_1	320	325	PF00069	0.248
MOD_NEK2_1	355	360	PF00069	0.299
MOD_NEK2_1	39	44	PF00069	0.209
MOD_NEK2_2	342	347	PF00069	0.261
MOD_NEK2_2	8	13	PF00069	0.494
MOD_PIKK_1	169	175	PF00454	0.310
MOD_PIKK_1	221	227	PF00454	0.467
MOD_PIKK_1	440	446	PF00454	0.499
MOD_PKA_2	169	175	PF00069	0.315
MOD_PKA_2	290	296	PF00069	0.476
MOD_PKA_2	76	82	PF00069	0.427
MOD_Plk_1	289	295	PF00069	0.467
MOD_Plk_1	328	334	PF00069	0.245
MOD_Plk_1	342	348	PF00069	0.245
MOD_Plk_1	42	48	PF00069	0.209
MOD_Plk_2-3	397	403	PF00069	0.424
MOD_Plk_4	128	134	PF00069	0.263
MOD_Plk_4	183	189	PF00069	0.294
MOD_Plk_4	234	240	PF00069	0.405
MOD_Plk_4	305	311	PF00069	0.253
MOD_Plk_4	342	348	PF00069	0.320
MOD_Plk_4	355	361	PF00069	0.366
MOD_ProDKin_1	224	230	PF00069	0.477
MOD_ProDKin_1	417	423	PF00069	0.430
MOD_SUMO_for_1	219	222	PF00179	0.420
TRG_ENDOCYTIC_2	102	105	PF00928	0.245
TRG_ENDOCYTIC_2	110	113	PF00928	0.119
TRG_ENDOCYTIC_2	313	316	PF00928	0.289
TRG_ENDOCYTIC_2	338	341	PF00928	0.286
TRG_ENDOCYTIC_2	359	362	PF00928	0.280
TRG_ENDOCYTIC_2	46	49	PF00928	0.214
TRG_ENDOCYTIC_2	55	58	PF00928	0.235
TRG_ENDOCYTIC_2	90	93	PF00928	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D2	Leptomonas seymouri	64%	100%
A0A0S4ISV7	Bodo saltans	41%	100%
A0A1X0PAA4	Trypanosomatidae	53%	100%
A0A3S7X2D4	Leishmania donovani	100%	100%
A0A422NJ67	Trypanosoma rangeli	50%	100%
A4HHA0	Leishmania braziliensis	79%	100%
C9ZLM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ADU6	Leishmania major	92%	100%
E9ALY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O59785	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	90%
V5BCU4	Trypanosoma cruzi	48%	100%