LeishMANIAdb
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Peptidase_M3 domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Peptidase_M3 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I4E3_LEIIN
TriTrypDb:
LINF_290014300
Length:
491

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase (SDH5)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4E3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4E3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 213 215 PF00675 0.452
CLV_NRD_NRD_1 30 32 PF00675 0.341
CLV_NRD_NRD_1 38 40 PF00675 0.432
CLV_PCSK_KEX2_1 213 215 PF00082 0.360
CLV_PCSK_KEX2_1 30 32 PF00082 0.328
CLV_PCSK_KEX2_1 398 400 PF00082 0.490
CLV_PCSK_KEX2_1 97 99 PF00082 0.284
CLV_PCSK_PC1ET2_1 398 400 PF00082 0.341
CLV_PCSK_PC1ET2_1 97 99 PF00082 0.278
CLV_PCSK_SKI1_1 16 20 PF00082 0.415
CLV_PCSK_SKI1_1 249 253 PF00082 0.449
CLV_PCSK_SKI1_1 409 413 PF00082 0.314
CLV_PCSK_SKI1_1 450 454 PF00082 0.260
CLV_PCSK_SKI1_1 470 474 PF00082 0.192
DEG_APCC_DBOX_1 66 74 PF00400 0.336
DEG_APCC_DBOX_1 8 16 PF00400 0.554
DEG_Nend_Nbox_1 1 3 PF02207 0.496
DEG_SCF_FBW7_1 363 369 PF00400 0.449
DEG_SPOP_SBC_1 366 370 PF00917 0.536
DOC_CKS1_1 282 287 PF01111 0.405
DOC_CKS1_1 363 368 PF01111 0.490
DOC_CYCLIN_RxL_1 405 415 PF00134 0.318
DOC_CYCLIN_RxL_1 447 456 PF00134 0.288
DOC_CYCLIN_RxL_1 457 466 PF00134 0.319
DOC_MAPK_gen_1 455 464 PF00069 0.375
DOC_MAPK_gen_1 97 105 PF00069 0.253
DOC_MAPK_MEF2A_6 97 105 PF00069 0.253
DOC_PP2B_LxvP_1 8 11 PF13499 0.499
DOC_SPAK_OSR1_1 98 102 PF12202 0.382
DOC_USP7_MATH_1 128 132 PF00917 0.386
DOC_USP7_MATH_1 295 299 PF00917 0.513
DOC_USP7_MATH_1 361 365 PF00917 0.507
DOC_USP7_MATH_1 366 370 PF00917 0.456
DOC_USP7_MATH_1 377 381 PF00917 0.263
DOC_USP7_MATH_1 384 388 PF00917 0.404
DOC_USP7_MATH_1 45 49 PF00917 0.324
DOC_USP7_UBL2_3 343 347 PF12436 0.507
DOC_USP7_UBL2_3 401 405 PF12436 0.428
DOC_WW_Pin1_4 145 150 PF00397 0.329
DOC_WW_Pin1_4 281 286 PF00397 0.408
DOC_WW_Pin1_4 305 310 PF00397 0.498
DOC_WW_Pin1_4 362 367 PF00397 0.566
DOC_WW_Pin1_4 434 439 PF00397 0.422
DOC_WW_Pin1_4 483 488 PF00397 0.565
LIG_14-3-3_CanoR_1 104 112 PF00244 0.415
LIG_14-3-3_CanoR_1 321 327 PF00244 0.498
LIG_14-3-3_CanoR_1 477 483 PF00244 0.448
LIG_Actin_WH2_2 1 18 PF00022 0.474
LIG_AP2alpha_1 277 281 PF02296 0.341
LIG_BRCT_BRCA1_1 327 331 PF00533 0.505
LIG_CaM_IQ_9 242 257 PF13499 0.349
LIG_CaM_NSCaTE_8 152 159 PF13499 0.384
LIG_eIF4E_1 447 453 PF01652 0.328
LIG_eIF4E_1 459 465 PF01652 0.422
LIG_FHA_1 23 29 PF00498 0.349
LIG_FHA_1 435 441 PF00498 0.416
LIG_FHA_1 59 65 PF00498 0.390
LIG_FHA_1 76 82 PF00498 0.418
LIG_FHA_2 124 130 PF00498 0.335
LIG_FHA_2 174 180 PF00498 0.303
LIG_FHA_2 255 261 PF00498 0.342
LIG_FHA_2 265 271 PF00498 0.277
LIG_FHA_2 281 287 PF00498 0.538
LIG_FHA_2 464 470 PF00498 0.439
LIG_FHA_2 484 490 PF00498 0.357
LIG_FHA_2 51 57 PF00498 0.468
LIG_GBD_Chelix_1 403 411 PF00786 0.410
LIG_LIR_Gen_1 169 178 PF02991 0.323
LIG_LIR_Gen_1 202 212 PF02991 0.370
LIG_LIR_Gen_1 444 453 PF02991 0.251
LIG_LIR_Nem_3 140 144 PF02991 0.295
LIG_LIR_Nem_3 160 164 PF02991 0.134
LIG_LIR_Nem_3 169 175 PF02991 0.290
LIG_LIR_Nem_3 202 208 PF02991 0.365
LIG_LIR_Nem_3 456 462 PF02991 0.345
LIG_LRP6_Inhibitor_1 24 30 PF00058 0.424
LIG_NRBOX 337 343 PF00104 0.435
LIG_PCNA_yPIPBox_3 26 40 PF02747 0.461
LIG_Pex14_2 277 281 PF04695 0.341
LIG_SH2_CRK 459 463 PF00017 0.438
LIG_SH2_STAT3 413 416 PF00017 0.337
LIG_SH2_STAT5 164 167 PF00017 0.402
LIG_SH2_STAT5 185 188 PF00017 0.356
LIG_SH2_STAT5 445 448 PF00017 0.273
LIG_SH2_STAT5 71 74 PF00017 0.326
LIG_SH3_3 279 285 PF00018 0.371
LIG_SH3_3 360 366 PF00018 0.490
LIG_TRAF2_1 167 170 PF00917 0.421
LIG_TRAF2_1 257 260 PF00917 0.347
LIG_TRAF2_1 267 270 PF00917 0.278
LIG_UBA3_1 111 115 PF00899 0.328
MOD_CDK_SPxxK_3 483 490 PF00069 0.579
MOD_CK1_1 162 168 PF00069 0.401
MOD_CK1_1 22 28 PF00069 0.284
MOD_CK1_1 325 331 PF00069 0.542
MOD_CK1_1 387 393 PF00069 0.373
MOD_CK2_1 104 110 PF00069 0.389
MOD_CK2_1 123 129 PF00069 0.240
MOD_CK2_1 173 179 PF00069 0.420
MOD_CK2_1 254 260 PF00069 0.331
MOD_CK2_1 264 270 PF00069 0.279
MOD_CK2_1 351 357 PF00069 0.502
MOD_CK2_1 45 51 PF00069 0.397
MOD_CK2_1 478 484 PF00069 0.533
MOD_GlcNHglycan 121 124 PF01048 0.487
MOD_GlcNHglycan 224 227 PF01048 0.459
MOD_GlcNHglycan 297 300 PF01048 0.489
MOD_GlcNHglycan 343 346 PF01048 0.465
MOD_GlcNHglycan 43 46 PF01048 0.409
MOD_GSK3_1 119 126 PF00069 0.463
MOD_GSK3_1 128 135 PF00069 0.368
MOD_GSK3_1 195 202 PF00069 0.409
MOD_GSK3_1 347 354 PF00069 0.444
MOD_GSK3_1 361 368 PF00069 0.418
MOD_GSK3_1 387 394 PF00069 0.485
MOD_GSK3_1 41 48 PF00069 0.417
MOD_GSK3_1 71 78 PF00069 0.417
MOD_N-GLC_1 41 46 PF02516 0.442
MOD_NEK2_1 119 124 PF00069 0.428
MOD_NEK2_1 144 149 PF00069 0.410
MOD_NEK2_1 19 24 PF00069 0.319
MOD_NEK2_1 264 269 PF00069 0.470
MOD_NEK2_1 341 346 PF00069 0.391
MOD_NEK2_1 412 417 PF00069 0.258
MOD_NEK2_1 453 458 PF00069 0.395
MOD_NEK2_1 478 483 PF00069 0.472
MOD_NEK2_1 58 63 PF00069 0.350
MOD_NEK2_2 11 16 PF00069 0.523
MOD_NEK2_2 159 164 PF00069 0.373
MOD_NEK2_2 377 382 PF00069 0.591
MOD_PIKK_1 22 28 PF00454 0.418
MOD_PIKK_1 412 418 PF00454 0.312
MOD_PK_1 347 353 PF00069 0.450
MOD_PKA_2 322 328 PF00069 0.496
MOD_PKA_2 355 361 PF00069 0.407
MOD_Plk_1 159 165 PF00069 0.400
MOD_Plk_1 203 209 PF00069 0.369
MOD_Plk_1 347 353 PF00069 0.450
MOD_Plk_1 41 47 PF00069 0.443
MOD_Plk_4 159 165 PF00069 0.403
MOD_Plk_4 347 353 PF00069 0.564
MOD_ProDKin_1 145 151 PF00069 0.322
MOD_ProDKin_1 281 287 PF00069 0.414
MOD_ProDKin_1 305 311 PF00069 0.501
MOD_ProDKin_1 362 368 PF00069 0.559
MOD_ProDKin_1 434 440 PF00069 0.418
MOD_ProDKin_1 483 489 PF00069 0.572
MOD_SUMO_for_1 219 222 PF00179 0.465
MOD_SUMO_for_1 314 317 PF00179 0.558
MOD_SUMO_rev_2 107 117 PF00179 0.339
MOD_SUMO_rev_2 135 144 PF00179 0.356
MOD_SUMO_rev_2 177 182 PF00179 0.365
MOD_SUMO_rev_2 333 338 PF00179 0.431
MOD_SUMO_rev_2 469 475 PF00179 0.376
TRG_DiLeu_BaEn_4 259 265 PF01217 0.439
TRG_ENDOCYTIC_2 141 144 PF00928 0.282
TRG_ENDOCYTIC_2 172 175 PF00928 0.280
TRG_ENDOCYTIC_2 445 448 PF00928 0.273
TRG_ENDOCYTIC_2 459 462 PF00928 0.330
TRG_ER_diArg_1 103 106 PF00400 0.265
TRG_ER_diArg_1 212 214 PF00400 0.463
TRG_ER_diArg_1 29 31 PF00400 0.328
TRG_Pf-PMV_PEXEL_1 470 474 PF00026 0.358

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9E1 Leptomonas seymouri 79% 100%
A0A0S4IX38 Bodo saltans 30% 95%
A0A1X0P156 Trypanosomatidae 45% 100%
A0A3S7X2A6 Leishmania donovani 100% 100%
A0A422NRS1 Trypanosoma rangeli 43% 100%
A4HH97 Leishmania braziliensis 87% 100%
C9ZL20 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9ADU3 Leishmania major 98% 100%
E9ALY7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BR79 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS