LeishMANIAdb
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Guanine deaminase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine deaminase
Gene product:
guanine deaminase - putative
Species:
Leishmania infantum
UniProt:
A4I4E1_LEIIN
TriTrypDb:
LINF_290014000
Length:
454

Annotations

Annotations by Jardim et al.

Purine metabolism, guanine deaminase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I4E1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4E1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006144 purine nucleobase metabolic process 5 11
GO:0006145 purine nucleobase catabolic process 6 11
GO:0006147 guanine catabolic process 7 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009056 catabolic process 2 11
GO:0009112 nucleobase metabolic process 4 11
GO:0009987 cellular process 1 11
GO:0019439 aromatic compound catabolic process 4 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044248 cellular catabolic process 3 11
GO:0044270 cellular nitrogen compound catabolic process 4 11
GO:0044281 small molecule metabolic process 2 11
GO:0046098 guanine metabolic process 6 11
GO:0046113 nucleobase catabolic process 5 11
GO:0046483 heterocycle metabolic process 3 11
GO:0046700 heterocycle catabolic process 4 11
GO:0055086 nucleobase-containing small molecule metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0072521 purine-containing compound metabolic process 4 11
GO:0072523 purine-containing compound catabolic process 5 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901361 organic cyclic compound catabolic process 4 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901565 organonitrogen compound catabolic process 4 11
GO:1901575 organic substance catabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0008270 zinc ion binding 6 11
GO:0008892 guanine deaminase activity 4 11
GO:0016787 hydrolase activity 2 11
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 11
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4 11
GO:0019239 deaminase activity 3 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0046914 transition metal ion binding 5 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 217 221 PF00656 0.454
CLV_NRD_NRD_1 271 273 PF00675 0.252
CLV_PCSK_KEX2_1 271 273 PF00082 0.252
CLV_PCSK_SKI1_1 196 200 PF00082 0.295
CLV_PCSK_SKI1_1 272 276 PF00082 0.252
CLV_PCSK_SKI1_1 314 318 PF00082 0.252
CLV_PCSK_SKI1_1 342 346 PF00082 0.320
DEG_APCC_DBOX_1 15 23 PF00400 0.353
DEG_ODPH_VHL_1 396 407 PF01847 0.534
DOC_CKS1_1 11 16 PF01111 0.391
DOC_CYCLIN_yCln2_LP_2 205 211 PF00134 0.448
DOC_MAPK_gen_1 254 263 PF00069 0.527
DOC_MAPK_gen_1 314 321 PF00069 0.485
DOC_MAPK_MEF2A_6 314 323 PF00069 0.536
DOC_PP1_RVXF_1 108 115 PF00149 0.452
DOC_PP2B_LxvP_1 205 208 PF13499 0.452
DOC_PP4_FxxP_1 11 14 PF00568 0.324
DOC_USP7_MATH_1 115 119 PF00917 0.501
DOC_USP7_MATH_1 181 185 PF00917 0.487
DOC_USP7_MATH_1 216 220 PF00917 0.447
DOC_USP7_MATH_1 333 337 PF00917 0.550
DOC_USP7_MATH_1 350 354 PF00917 0.469
DOC_USP7_MATH_1 370 374 PF00917 0.565
DOC_USP7_MATH_1 412 416 PF00917 0.495
DOC_WW_Pin1_4 10 15 PF00397 0.391
DOC_WW_Pin1_4 177 182 PF00397 0.495
LIG_14-3-3_CanoR_1 16 20 PF00244 0.474
LIG_14-3-3_CanoR_1 271 275 PF00244 0.465
LIG_14-3-3_CanoR_1 371 376 PF00244 0.487
LIG_BIR_III_2 178 182 PF00653 0.495
LIG_BRCT_BRCA1_1 187 191 PF00533 0.452
LIG_Clathr_ClatBox_1 416 420 PF01394 0.534
LIG_deltaCOP1_diTrp_1 95 103 PF00928 0.453
LIG_eIF4E_1 400 406 PF01652 0.452
LIG_eIF4E_1 445 451 PF01652 0.495
LIG_eIF4E_1 68 74 PF01652 0.452
LIG_FHA_1 129 135 PF00498 0.456
LIG_FHA_1 16 22 PF00498 0.525
LIG_FHA_1 200 206 PF00498 0.589
LIG_FHA_2 422 428 PF00498 0.485
LIG_FHA_2 7 13 PF00498 0.387
LIG_Integrin_isoDGR_2 447 449 PF01839 0.334
LIG_LIR_Apic_2 9 14 PF02991 0.327
LIG_LIR_Gen_1 116 127 PF02991 0.460
LIG_LIR_Gen_1 426 437 PF02991 0.440
LIG_LIR_Gen_1 46 54 PF02991 0.347
LIG_LIR_LC3C_4 24 28 PF02991 0.319
LIG_LIR_Nem_3 106 112 PF02991 0.449
LIG_LIR_Nem_3 116 122 PF02991 0.439
LIG_LIR_Nem_3 264 269 PF02991 0.470
LIG_LIR_Nem_3 426 432 PF02991 0.440
LIG_LIR_Nem_3 46 50 PF02991 0.347
LIG_Pex14_1 97 101 PF04695 0.495
LIG_PTB_Apo_2 300 307 PF02174 0.439
LIG_SH2_CRK 101 105 PF00017 0.486
LIG_SH2_CRK 119 123 PF00017 0.371
LIG_SH2_CRK 47 51 PF00017 0.384
LIG_SH2_GRB2like 445 448 PF00017 0.534
LIG_SH2_NCK_1 343 347 PF00017 0.520
LIG_SH2_NCK_1 434 438 PF00017 0.485
LIG_SH2_SRC 445 448 PF00017 0.534
LIG_SH2_SRC 68 71 PF00017 0.495
LIG_SH2_STAP1 119 123 PF00017 0.470
LIG_SH2_STAP1 343 347 PF00017 0.520
LIG_SH2_STAP1 47 51 PF00017 0.421
LIG_SH2_STAT5 136 139 PF00017 0.452
LIG_SH2_STAT5 280 283 PF00017 0.495
LIG_SH2_STAT5 305 308 PF00017 0.439
LIG_SH2_STAT5 445 448 PF00017 0.486
LIG_SH2_STAT5 68 71 PF00017 0.452
LIG_SH3_3 34 40 PF00018 0.414
LIG_SH3_3 75 81 PF00018 0.469
LIG_SUMO_SIM_anti_2 24 31 PF11976 0.315
LIG_SUMO_SIM_anti_2 403 410 PF11976 0.399
LIG_SUMO_SIM_par_1 24 31 PF11976 0.366
LIG_SUMO_SIM_par_1 403 410 PF11976 0.465
LIG_TYR_ITAM 106 122 PF00017 0.495
LIG_UBA3_1 147 155 PF00899 0.534
MOD_CDK_SPK_2 177 182 PF00069 0.399
MOD_CDK_SPxK_1 10 16 PF00069 0.390
MOD_CK1_1 118 124 PF00069 0.527
MOD_CK1_1 365 371 PF00069 0.454
MOD_CK1_1 93 99 PF00069 0.419
MOD_CK2_1 177 183 PF00069 0.519
MOD_CK2_1 241 247 PF00069 0.439
MOD_CK2_1 357 363 PF00069 0.536
MOD_CK2_1 370 376 PF00069 0.518
MOD_CK2_1 46 52 PF00069 0.494
MOD_CK2_1 6 12 PF00069 0.363
MOD_GlcNHglycan 123 126 PF01048 0.334
MOD_GlcNHglycan 306 309 PF01048 0.305
MOD_GlcNHglycan 328 332 PF01048 0.268
MOD_GlcNHglycan 333 336 PF01048 0.281
MOD_GlcNHglycan 352 355 PF01048 0.224
MOD_GlcNHglycan 359 362 PF01048 0.272
MOD_GlcNHglycan 367 370 PF01048 0.362
MOD_GlcNHglycan 54 57 PF01048 0.503
MOD_GSK3_1 117 124 PF00069 0.443
MOD_GSK3_1 177 184 PF00069 0.472
MOD_GSK3_1 327 334 PF00069 0.456
MOD_GSK3_1 39 46 PF00069 0.586
MOD_GSK3_1 407 414 PF00069 0.534
MOD_GSK3_1 6 13 PF00069 0.396
MOD_N-GLC_1 128 133 PF02516 0.252
MOD_N-GLC_1 412 417 PF02516 0.320
MOD_NEK2_1 142 147 PF00069 0.549
MOD_NEK2_1 229 234 PF00069 0.399
MOD_NEK2_1 304 309 PF00069 0.501
MOD_NEK2_1 379 384 PF00069 0.487
MOD_NEK2_1 6 11 PF00069 0.311
MOD_NEK2_2 136 141 PF00069 0.439
MOD_NEK2_2 333 338 PF00069 0.534
MOD_PIKK_1 362 368 PF00454 0.534
MOD_PK_1 371 377 PF00069 0.487
MOD_PKA_2 15 21 PF00069 0.418
MOD_PKA_2 270 276 PF00069 0.445
MOD_PKA_2 370 376 PF00069 0.510
MOD_Plk_1 115 121 PF00069 0.501
MOD_Plk_1 142 148 PF00069 0.445
MOD_Plk_1 407 413 PF00069 0.472
MOD_Plk_1 90 96 PF00069 0.453
MOD_Plk_4 118 124 PF00069 0.473
MOD_Plk_4 142 148 PF00069 0.495
MOD_Plk_4 333 339 PF00069 0.452
MOD_Plk_4 412 418 PF00069 0.514
MOD_Plk_4 46 52 PF00069 0.512
MOD_Plk_4 6 12 PF00069 0.398
MOD_Plk_4 93 99 PF00069 0.438
MOD_ProDKin_1 10 16 PF00069 0.390
MOD_ProDKin_1 177 183 PF00069 0.495
MOD_SUMO_rev_2 388 393 PF00179 0.474
TRG_DiLeu_BaEn_1 143 148 PF01217 0.534
TRG_DiLeu_BaEn_1 284 289 PF01217 0.452
TRG_ENDOCYTIC_2 109 112 PF00928 0.439
TRG_ENDOCYTIC_2 119 122 PF00928 0.439
TRG_ENDOCYTIC_2 47 50 PF00928 0.388
TRG_Pf-PMV_PEXEL_1 224 228 PF00026 0.262

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PG27 Leptomonas seymouri 80% 100%
A0A1X0NZN2 Trypanosomatidae 63% 100%
A0A3Q8IBE4 Leishmania donovani 100% 100%
A0A422NRP3 Trypanosoma rangeli 62% 100%
A0LMI3 Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) 27% 100%
A0RCM7 Bacillus thuringiensis (strain Al Hakam) 22% 100%
A1VD37 Desulfovibrio vulgaris subsp. vulgaris (strain DP4) 27% 100%
A3DEQ2 Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) 23% 100%
A4FW32 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 25% 100%
A4HH95 Leishmania braziliensis 89% 100%
A4J675 Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1) 25% 100%
A4XJI3 Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331) 24% 100%
A5D1G6 Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) 25% 100%
A5UMN6 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 26% 100%
A6UQD4 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 26% 100%
A6UUG9 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 28% 100%
A6VH76 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 26% 100%
A7GNR9 Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) 23% 100%
A7I6C5 Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) 27% 100%
A9A9H3 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 26% 100%
B0K2W0 Thermoanaerobacter sp. (strain X514) 25% 100%
B0K8R8 Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) 25% 100%
B5YDN9 Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) 23% 100%
B5YLB7 Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) 27% 100%
B6YUF8 Thermococcus onnurineus (strain NA1) 30% 100%
B7HIQ2 Bacillus cereus (strain B4264) 22% 100%
B7HMN9 Bacillus cereus (strain AH187) 23% 100%
B7IS56 Bacillus cereus (strain G9842) 23% 100%
B7JJI0 Bacillus cereus (strain AH820) 23% 100%
B8CX03 Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) 24% 100%
B8DKS6 Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F) 25% 100%
B8E183 Dictyoglomus turgidum (strain DSM 6724 / Z-1310) 25% 100%
B8FRL9 Desulfitobacterium hafniense (strain DSM 10664 / DCB-2) 26% 100%
B8J2Q8 Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB) 22% 100%
C1EPN0 Bacillus cereus (strain 03BB102) 22% 100%
C3L6N3 Bacillus anthracis (strain CDC 684 / NRRL 3495) 23% 100%
C3P768 Bacillus anthracis (strain A0248) 23% 100%
C5BSJ0 Teredinibacter turnerae (strain ATCC 39867 / T7901) 28% 100%
C6A048 Thermococcus sibiricus (strain DSM 12597 / MM 739) 29% 100%
C9ZPZ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 88%
E9ADU1 Leishmania major 96% 100%
E9ALY9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O14057 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 86%
O27549 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 28% 100%
O29265 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 30% 100%
O29701 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 26% 100%
O31352 Bacillus cereus (strain ATCC 10987 / NRS 248) 23% 100%
O59184 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 27% 100%
O66851 Aquifex aeolicus (strain VF5) 25% 100%
P0CI72 Unknown prokaryotic organism 23% 94%
P72156 Pseudomonas sp. (strain ADP) 25% 96%
P76641 Escherichia coli (strain K12) 28% 100%
Q07729 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 93%
Q0AYV2 Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) 26% 100%
Q12WS1 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 25% 100%
Q18EV7 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 23% 100%
Q1MR44 Lawsonia intracellularis (strain PHE/MN1-00) 23% 100%
Q21IS0 Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) 24% 100%
Q24UA2 Desulfitobacterium hafniense (strain Y51) 26% 100%
Q2FRU6 Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) 26% 100%
Q2LTB7 Syntrophus aciditrophicus (strain SB) 27% 100%
Q2LUH4 Syntrophus aciditrophicus (strain SB) 25% 100%
Q2NHL6 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 24% 100%
Q2RJW1 Moorella thermoacetica (strain ATCC 39073 / JCM 9320) 27% 100%
Q3AC64 Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) 25% 100%
Q3ITF7 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 26% 100%
Q466Q9 Methanosarcina barkeri (strain Fusaro / DSM 804) 25% 100%
Q58936 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 29% 100%
Q5JER0 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 27% 100%
Q5RAV9 Pongo abelii 34% 100%
Q5UYR3 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 27% 100%
Q5WGA8 Alkalihalobacillus clausii (strain KSM-K16) 24% 100%
Q63CU1 Bacillus cereus (strain ZK / E33L) 22% 100%
Q67NQ5 Symbiobacterium thermophilum (strain T / IAM 14863) 25% 100%
Q6HK87 Bacillus thuringiensis subsp. konkukian (strain 97-27) 22% 100%
Q6LX61 Methanococcus maripaludis (strain S2 / LL) 25% 100%
Q72B14 Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) 27% 100%
Q81F14 Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) 23% 100%
Q81S14 Bacillus anthracis 23% 100%
Q86AW9 Dictyostelium discoideum 33% 100%
Q891Y7 Clostridium tetani (strain Massachusetts / E88) 25% 100%
Q8PUQ3 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 27% 100%
Q8R9L4 Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) 27% 100%
Q8TRA4 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 26% 100%
Q8TYD4 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 29% 100%
Q8U0P7 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 29% 100%
Q92342 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 98%
Q9EYU0 Acidovorax citrulli 24% 96%
Q9HN51 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 29% 100%
Q9I6Z0 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 25% 100%
Q9KC82 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 24% 100%
Q9R111 Mus musculus 34% 100%
Q9RYX4 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 28% 100%
Q9V0Y5 Pyrococcus abyssi (strain GE5 / Orsay) 31% 100%
Q9VMY9 Drosophila melanogaster 35% 100%
Q9WTT6 Rattus norvegicus 34% 100%
Q9X034 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 23% 100%
Q9Y2T3 Homo sapiens 35% 100%
V5BLN7 Trypanosoma cruzi 62% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS