Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4D4_LEIIN

TriTrypDb:

LINF_290013200

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4D4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.782
CLV_C14_Caspase3-7	272	276	PF00656	0.720
CLV_NRD_NRD_1	15	17	PF00675	0.600
CLV_NRD_NRD_1	339	341	PF00675	0.777
CLV_NRD_NRD_1	422	424	PF00675	0.833
CLV_NRD_NRD_1	569	571	PF00675	0.666
CLV_PCSK_KEX2_1	137	139	PF00082	0.755
CLV_PCSK_KEX2_1	15	17	PF00082	0.600
CLV_PCSK_KEX2_1	422	424	PF00082	0.833
CLV_PCSK_KEX2_1	569	571	PF00082	0.666
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.695
CLV_PCSK_SKI1_1	102	106	PF00082	0.783
CLV_PCSK_SKI1_1	443	447	PF00082	0.666
DEG_APCC_DBOX_1	27	35	PF00400	0.607
DEG_Nend_Nbox_1	1	3	PF02207	0.690
DEG_SCF_FBW7_1	166	172	PF00400	0.686
DEG_SCF_FBW7_2	286	293	PF00400	0.595
DEG_SPOP_SBC_1	103	107	PF00917	0.633
DEG_SPOP_SBC_1	158	162	PF00917	0.759
DEG_SPOP_SBC_1	222	226	PF00917	0.607
DEG_SPOP_SBC_1	276	280	PF00917	0.649
DEG_SPOP_SBC_1	54	58	PF00917	0.722
DEG_SPOP_SBC_1	61	65	PF00917	0.705
DEG_SPOP_SBC_1	83	87	PF00917	0.724
DOC_CKS1_1	124	129	PF01111	0.603
DOC_CKS1_1	166	171	PF01111	0.687
DOC_MAPK_gen_1	251	261	PF00069	0.453
DOC_MAPK_gen_1	427	434	PF00069	0.670
DOC_MAPK_gen_1	469	478	PF00069	0.667
DOC_MAPK_gen_1	548	556	PF00069	0.612
DOC_USP7_MATH_1	128	132	PF00917	0.754
DOC_USP7_MATH_1	159	163	PF00917	0.763
DOC_USP7_MATH_1	201	205	PF00917	0.747
DOC_USP7_MATH_1	222	226	PF00917	0.674
DOC_USP7_MATH_1	231	235	PF00917	0.623
DOC_USP7_MATH_1	276	280	PF00917	0.742
DOC_USP7_MATH_1	296	300	PF00917	0.752
DOC_USP7_MATH_1	355	359	PF00917	0.657
DOC_USP7_MATH_1	412	416	PF00917	0.711
DOC_USP7_MATH_1	428	432	PF00917	0.504
DOC_USP7_MATH_1	435	439	PF00917	0.516
DOC_USP7_MATH_1	574	578	PF00917	0.565
DOC_USP7_MATH_1	83	87	PF00917	0.756
DOC_WW_Pin1_4	111	116	PF00397	0.710
DOC_WW_Pin1_4	123	128	PF00397	0.544
DOC_WW_Pin1_4	147	152	PF00397	0.706
DOC_WW_Pin1_4	165	170	PF00397	0.693
DOC_WW_Pin1_4	223	228	PF00397	0.713
DOC_WW_Pin1_4	286	291	PF00397	0.721
DOC_WW_Pin1_4	416	421	PF00397	0.748
DOC_WW_Pin1_4	84	89	PF00397	0.834
LIG_14-3-3_CanoR_1	246	250	PF00244	0.584
LIG_14-3-3_CanoR_1	28	32	PF00244	0.519
LIG_14-3-3_CanoR_1	400	410	PF00244	0.752
LIG_14-3-3_CanoR_1	411	421	PF00244	0.540
LIG_14-3-3_CanoR_1	472	478	PF00244	0.737
LIG_14-3-3_CanoR_1	540	546	PF00244	0.706
LIG_14-3-3_CanoR_1	583	587	PF00244	0.477
LIG_BRCT_BRCA1_1	429	433	PF00533	0.734
LIG_BRCT_BRCA1_1	51	55	PF00533	0.724
LIG_EH_1	394	398	PF12763	0.663
LIG_FHA_1	124	130	PF00498	0.667
LIG_FHA_1	161	167	PF00498	0.698
LIG_FHA_1	279	285	PF00498	0.783
LIG_FHA_1	434	440	PF00498	0.682
LIG_FHA_1	48	54	PF00498	0.595
LIG_FHA_1	542	548	PF00498	0.683
LIG_FHA_1	549	555	PF00498	0.542
LIG_FHA_1	8	14	PF00498	0.644
LIG_FHA_1	95	101	PF00498	0.627
LIG_FHA_2	1	7	PF00498	0.665
LIG_FHA_2	104	110	PF00498	0.752
LIG_FHA_2	224	230	PF00498	0.740
LIG_FHA_2	240	246	PF00498	0.484
LIG_FHA_2	287	293	PF00498	0.706
LIG_FHA_2	364	370	PF00498	0.704
LIG_LIR_Apic_2	48	54	PF02991	0.706
LIG_LIR_Gen_1	255	264	PF02991	0.719
LIG_LIR_Gen_1	288	298	PF02991	0.758
LIG_LIR_Gen_1	581	590	PF02991	0.587
LIG_LIR_Nem_3	255	259	PF02991	0.691
LIG_LIR_Nem_3	288	294	PF02991	0.765
LIG_LIR_Nem_3	581	587	PF02991	0.585
LIG_LIR_Nem_3	6	12	PF02991	0.643
LIG_Pex14_1	252	256	PF04695	0.608
LIG_Pex14_1	580	584	PF04695	0.645
LIG_PTAP_UEV_1	87	92	PF05743	0.784
LIG_SH2_CRK	256	260	PF00017	0.637
LIG_SH2_CRK	51	55	PF00017	0.724
LIG_SH2_CRK	584	588	PF00017	0.591
LIG_SH2_NCK_1	51	55	PF00017	0.724
LIG_SH2_STAP1	9	13	PF00017	0.643
LIG_SH2_STAT3	560	563	PF00017	0.639
LIG_SH2_STAT5	373	376	PF00017	0.765
LIG_SH2_STAT5	584	587	PF00017	0.546
LIG_SH2_STAT5	9	12	PF00017	0.640
LIG_SH3_3	124	130	PF00018	0.769
LIG_SH3_3	224	230	PF00018	0.703
LIG_SH3_3	280	286	PF00018	0.701
LIG_SH3_3	324	330	PF00018	0.596
LIG_SH3_3	414	420	PF00018	0.692
LIG_SH3_3	429	435	PF00018	0.508
LIG_SH3_3	69	75	PF00018	0.722
LIG_SH3_3	85	91	PF00018	0.618
LIG_TRAF2_1	4	7	PF00917	0.646
LIG_TRAF2_1	565	568	PF00917	0.547
MOD_CDC14_SPxK_1	419	422	PF00782	0.700
MOD_CDK_SPxK_1	165	171	PF00069	0.688
MOD_CDK_SPxK_1	416	422	PF00069	0.697
MOD_CDK_SPxxK_3	416	423	PF00069	0.698
MOD_CK1_1	107	113	PF00069	0.637
MOD_CK1_1	149	155	PF00069	0.668
MOD_CK1_1	160	166	PF00069	0.637
MOD_CK1_1	167	173	PF00069	0.601
MOD_CK1_1	196	202	PF00069	0.809
MOD_CK1_1	220	226	PF00069	0.782
MOD_CK1_1	278	284	PF00069	0.786
MOD_CK1_1	358	364	PF00069	0.728
MOD_CK1_1	49	55	PF00069	0.706
MOD_CK1_1	56	62	PF00069	0.676
MOD_CK1_1	63	69	PF00069	0.597
MOD_CK1_1	76	82	PF00069	0.506
MOD_CK1_1	86	92	PF00069	0.657
MOD_CK2_1	1	7	PF00069	0.665
MOD_CK2_1	103	109	PF00069	0.751
MOD_CK2_1	196	202	PF00069	0.774
MOD_CK2_1	223	229	PF00069	0.788
MOD_CK2_1	231	237	PF00069	0.675
MOD_CK2_1	239	245	PF00069	0.448
MOD_CK2_1	363	369	PF00069	0.708
MOD_Cter_Amidation	135	138	PF01082	0.617
MOD_GlcNHglycan	106	109	PF01048	0.718
MOD_GlcNHglycan	118	121	PF01048	0.626
MOD_GlcNHglycan	151	154	PF01048	0.634
MOD_GlcNHglycan	190	193	PF01048	0.814
MOD_GlcNHglycan	219	222	PF01048	0.757
MOD_GlcNHglycan	233	236	PF01048	0.656
MOD_GlcNHglycan	262	265	PF01048	0.662
MOD_GlcNHglycan	298	301	PF01048	0.788
MOD_GlcNHglycan	3	6	PF01048	0.556
MOD_GlcNHglycan	321	325	PF01048	0.723
MOD_GlcNHglycan	343	347	PF01048	0.612
MOD_GlcNHglycan	360	363	PF01048	0.630
MOD_GlcNHglycan	390	393	PF01048	0.719
MOD_GlcNHglycan	403	406	PF01048	0.706
MOD_GlcNHglycan	414	417	PF01048	0.554
MOD_GlcNHglycan	514	517	PF01048	0.771
MOD_GlcNHglycan	537	540	PF01048	0.747
MOD_GlcNHglycan	571	574	PF01048	0.694
MOD_GlcNHglycan	576	579	PF01048	0.644
MOD_GlcNHglycan	59	62	PF01048	0.709
MOD_GlcNHglycan	78	81	PF01048	0.523
MOD_GlcNHglycan	88	91	PF01048	0.688
MOD_GSK3_1	103	110	PF00069	0.813
MOD_GSK3_1	116	123	PF00069	0.617
MOD_GSK3_1	147	154	PF00069	0.700
MOD_GSK3_1	158	165	PF00069	0.572
MOD_GSK3_1	196	203	PF00069	0.776
MOD_GSK3_1	217	224	PF00069	0.754
MOD_GSK3_1	274	281	PF00069	0.723
MOD_GSK3_1	349	356	PF00069	0.748
MOD_GSK3_1	412	419	PF00069	0.729
MOD_GSK3_1	45	52	PF00069	0.669
MOD_GSK3_1	53	60	PF00069	0.640
MOD_GSK3_1	61	68	PF00069	0.555
MOD_GSK3_1	79	86	PF00069	0.571
MOD_N-GLC_1	358	363	PF02516	0.769
MOD_NEK2_1	146	151	PF00069	0.619
MOD_NEK2_1	259	264	PF00069	0.647
MOD_NEK2_1	45	50	PF00069	0.654
MOD_NEK2_1	55	60	PF00069	0.622
MOD_NEK2_1	94	99	PF00069	0.749
MOD_NEK2_2	428	433	PF00069	0.671
MOD_PIKK_1	120	126	PF00454	0.714
MOD_PIKK_1	208	214	PF00454	0.549
MOD_PKA_1	569	575	PF00069	0.667
MOD_PKA_1	73	79	PF00069	0.763
MOD_PKA_2	245	251	PF00069	0.584
MOD_PKA_2	267	273	PF00069	0.732
MOD_PKA_2	27	33	PF00069	0.524
MOD_PKA_2	471	477	PF00069	0.739
MOD_PKA_2	568	574	PF00069	0.670
MOD_PKA_2	582	588	PF00069	0.474
MOD_PKA_2	76	82	PF00069	0.776
MOD_Plk_1	201	207	PF00069	0.767
MOD_Plk_1	244	250	PF00069	0.588
MOD_Plk_1	37	43	PF00069	0.540
MOD_Plk_1	46	52	PF00069	0.558
MOD_Plk_4	128	134	PF00069	0.786
MOD_Plk_4	380	386	PF00069	0.579
MOD_Plk_4	428	434	PF00069	0.666
MOD_Plk_4	582	588	PF00069	0.474
MOD_ProDKin_1	111	117	PF00069	0.712
MOD_ProDKin_1	123	129	PF00069	0.546
MOD_ProDKin_1	147	153	PF00069	0.703
MOD_ProDKin_1	165	171	PF00069	0.694
MOD_ProDKin_1	223	229	PF00069	0.716
MOD_ProDKin_1	286	292	PF00069	0.719
MOD_ProDKin_1	416	422	PF00069	0.751
MOD_ProDKin_1	84	90	PF00069	0.834
MOD_SUMO_rev_2	131	139	PF00179	0.725
TRG_DiLeu_BaEn_1	255	260	PF01217	0.633
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.687
TRG_ENDOCYTIC_2	256	259	PF00928	0.644
TRG_ENDOCYTIC_2	584	587	PF00928	0.657
TRG_ER_diArg_1	15	17	PF00400	0.600
TRG_ER_diArg_1	421	423	PF00400	0.768
TRG_ER_diArg_1	553	556	PF00400	0.624
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIM2	Leishmania donovani	99%	100%
A4HH88	Leishmania braziliensis	69%	99%
E9ADT3	Leishmania major	90%	100%
E9ALZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%