LeishMANIAdb
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Putative U-box domain protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative U-box domain protein
Gene product:
U-box domain protein - putative
Species:
Leishmania infantum
UniProt:
A4I4D1_LEIIN
TriTrypDb:
LINF_290012900
Length:
601

Annotations

Annotations by Jardim et al.

Protein modification, U-box domain

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4D1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4D1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004842 ubiquitin-protein transferase activity 4 12
GO:0016740 transferase activity 2 12
GO:0019787 ubiquitin-like protein transferase activity 3 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 278 282 PF00656 0.385
CLV_C14_Caspase3-7 32 36 PF00656 0.536
CLV_C14_Caspase3-7 514 518 PF00656 0.579
CLV_NRD_NRD_1 428 430 PF00675 0.501
CLV_NRD_NRD_1 50 52 PF00675 0.423
CLV_NRD_NRD_1 72 74 PF00675 0.419
CLV_PCSK_KEX2_1 428 430 PF00082 0.501
CLV_PCSK_KEX2_1 50 52 PF00082 0.375
CLV_PCSK_KEX2_1 72 74 PF00082 0.419
CLV_PCSK_SKI1_1 107 111 PF00082 0.499
CLV_PCSK_SKI1_1 428 432 PF00082 0.490
CLV_PCSK_SKI1_1 562 566 PF00082 0.345
DOC_CDC14_PxL_1 477 485 PF14671 0.560
DOC_CYCLIN_yClb1_LxF_4 368 374 PF00134 0.423
DOC_MAPK_gen_1 107 117 PF00069 0.481
DOC_MAPK_gen_1 484 493 PF00069 0.519
DOC_MAPK_gen_1 50 57 PF00069 0.443
DOC_MAPK_gen_1 72 81 PF00069 0.305
DOC_MAPK_MEF2A_6 123 132 PF00069 0.298
DOC_MAPK_MEF2A_6 209 218 PF00069 0.305
DOC_PP1_RVXF_1 207 213 PF00149 0.355
DOC_PP1_RVXF_1 89 96 PF00149 0.433
DOC_PP4_FxxP_1 185 188 PF00568 0.306
DOC_USP7_MATH_1 116 120 PF00917 0.544
DOC_USP7_MATH_1 233 237 PF00917 0.485
DOC_USP7_MATH_1 357 361 PF00917 0.472
DOC_USP7_MATH_1 399 403 PF00917 0.362
DOC_USP7_MATH_1 43 47 PF00917 0.525
DOC_USP7_MATH_1 437 441 PF00917 0.493
DOC_USP7_MATH_1 89 93 PF00917 0.482
DOC_USP7_UBL2_3 205 209 PF12436 0.462
DOC_USP7_UBL2_3 260 264 PF12436 0.456
DOC_WW_Pin1_4 532 537 PF00397 0.291
LIG_14-3-3_CanoR_1 123 131 PF00244 0.295
LIG_14-3-3_CanoR_1 336 342 PF00244 0.364
LIG_14-3-3_CanoR_1 401 405 PF00244 0.474
LIG_14-3-3_CanoR_1 428 436 PF00244 0.424
LIG_14-3-3_CanoR_1 475 483 PF00244 0.650
LIG_14-3-3_CanoR_1 562 571 PF00244 0.390
LIG_14-3-3_CanoR_1 585 589 PF00244 0.515
LIG_Actin_WH2_2 125 143 PF00022 0.313
LIG_Actin_WH2_2 385 403 PF00022 0.406
LIG_AP2alpha_1 342 346 PF02296 0.430
LIG_BIR_II_1 1 5 PF00653 0.362
LIG_BIR_III_4 378 382 PF00653 0.350
LIG_BRCT_BRCA1_1 314 318 PF00533 0.348
LIG_BRCT_BRCA1_1 439 443 PF00533 0.422
LIG_BRCT_BRCA1_1 91 95 PF00533 0.477
LIG_CaM_IQ_9 577 593 PF13499 0.412
LIG_deltaCOP1_diTrp_1 421 427 PF00928 0.463
LIG_EH1_1 154 162 PF00400 0.312
LIG_EH1_1 385 393 PF00400 0.541
LIG_eIF4E_1 386 392 PF01652 0.512
LIG_EVH1_2 168 172 PF00568 0.426
LIG_FHA_1 205 211 PF00498 0.338
LIG_FHA_1 275 281 PF00498 0.300
LIG_FHA_1 523 529 PF00498 0.291
LIG_FHA_1 588 594 PF00498 0.554
LIG_FHA_2 13 19 PF00498 0.389
LIG_FHA_2 276 282 PF00498 0.297
LIG_GBD_Chelix_1 291 299 PF00786 0.453
LIG_GBD_Chelix_1 306 314 PF00786 0.216
LIG_LIR_Gen_1 23 31 PF02991 0.465
LIG_LIR_Gen_1 340 350 PF02991 0.431
LIG_LIR_Gen_1 440 451 PF02991 0.321
LIG_LIR_Gen_1 75 84 PF02991 0.382
LIG_LIR_Gen_1 92 101 PF02991 0.423
LIG_LIR_Nem_3 317 323 PF02991 0.365
LIG_LIR_Nem_3 340 345 PF02991 0.393
LIG_LIR_Nem_3 421 427 PF02991 0.508
LIG_LIR_Nem_3 440 446 PF02991 0.182
LIG_LIR_Nem_3 75 80 PF02991 0.358
LIG_LIR_Nem_3 85 90 PF02991 0.333
LIG_LIR_Nem_3 92 98 PF02991 0.260
LIG_MYND_1 481 485 PF01753 0.614
LIG_NRBOX 160 166 PF00104 0.301
LIG_PDZ_Class_2 596 601 PF00595 0.525
LIG_Pex14_1 423 427 PF04695 0.413
LIG_Pex14_2 338 342 PF04695 0.437
LIG_Pex14_2 419 423 PF04695 0.396
LIG_SH2_CRK 87 91 PF00017 0.385
LIG_SH2_GRB2like 367 370 PF00017 0.423
LIG_SH2_GRB2like 60 63 PF00017 0.313
LIG_SH2_PTP2 367 370 PF00017 0.402
LIG_SH2_STAP1 170 174 PF00017 0.370
LIG_SH2_STAP1 541 545 PF00017 0.411
LIG_SH2_STAT5 10 13 PF00017 0.493
LIG_SH2_STAT5 287 290 PF00017 0.307
LIG_SH2_STAT5 367 370 PF00017 0.317
LIG_SH2_STAT5 60 63 PF00017 0.329
LIG_SH3_2 482 487 PF14604 0.541
LIG_SH3_3 381 387 PF00018 0.514
LIG_SH3_3 461 467 PF00018 0.556
LIG_SH3_3 479 485 PF00018 0.636
LIG_SH3_3 530 536 PF00018 0.292
LIG_SUMO_SIM_anti_2 125 132 PF11976 0.294
LIG_SxIP_EBH_1 473 484 PF03271 0.568
LIG_TRAF2_1 331 334 PF00917 0.451
LIG_TYR_ITIM 365 370 PF00017 0.410
LIG_UBA3_1 132 141 PF00899 0.416
LIG_UBA3_1 159 166 PF00899 0.301
LIG_UBA3_1 255 260 PF00899 0.458
LIG_WRC_WIRS_1 338 343 PF05994 0.435
MOD_CK1_1 236 242 PF00069 0.506
MOD_CK1_1 263 269 PF00069 0.392
MOD_CK1_1 29 35 PF00069 0.411
MOD_CK1_1 290 296 PF00069 0.392
MOD_CK1_1 455 461 PF00069 0.491
MOD_CK2_1 100 106 PF00069 0.410
MOD_CK2_1 259 265 PF00069 0.530
MOD_CK2_1 399 405 PF00069 0.495
MOD_GlcNHglycan 12 15 PF01048 0.534
MOD_GlcNHglycan 179 182 PF01048 0.392
MOD_GlcNHglycan 245 248 PF01048 0.403
MOD_GlcNHglycan 359 362 PF01048 0.396
MOD_GlcNHglycan 396 399 PF01048 0.413
MOD_GlcNHglycan 506 509 PF01048 0.591
MOD_GSK3_1 259 266 PF00069 0.344
MOD_GSK3_1 310 317 PF00069 0.377
MOD_GSK3_1 570 577 PF00069 0.439
MOD_N-GLC_1 248 253 PF02516 0.487
MOD_N-GLC_1 552 557 PF02516 0.310
MOD_N-GLC_1 82 87 PF02516 0.449
MOD_NEK2_1 105 110 PF00069 0.358
MOD_NEK2_1 183 188 PF00069 0.304
MOD_NEK2_1 243 248 PF00069 0.395
MOD_NEK2_1 259 264 PF00069 0.326
MOD_NEK2_1 274 279 PF00069 0.233
MOD_NEK2_1 280 285 PF00069 0.307
MOD_NEK2_1 295 300 PF00069 0.339
MOD_NEK2_1 310 315 PF00069 0.308
MOD_NEK2_1 346 351 PF00069 0.344
MOD_NEK2_2 445 450 PF00069 0.374
MOD_PIKK_1 150 156 PF00454 0.376
MOD_PIKK_1 183 189 PF00454 0.314
MOD_PIKK_1 264 270 PF00454 0.344
MOD_PIKK_1 329 335 PF00454 0.459
MOD_PIKK_1 452 458 PF00454 0.529
MOD_PIKK_1 587 593 PF00454 0.462
MOD_PK_1 509 515 PF00069 0.608
MOD_PKA_1 428 434 PF00069 0.504
MOD_PKA_1 50 56 PF00069 0.430
MOD_PKA_1 72 78 PF00069 0.407
MOD_PKA_2 122 128 PF00069 0.304
MOD_PKA_2 357 363 PF00069 0.485
MOD_PKA_2 400 406 PF00069 0.413
MOD_PKA_2 428 434 PF00069 0.433
MOD_PKA_2 50 56 PF00069 0.375
MOD_PKA_2 584 590 PF00069 0.477
MOD_PKA_2 72 78 PF00069 0.407
MOD_Plk_1 248 254 PF00069 0.444
MOD_Plk_1 264 270 PF00069 0.377
MOD_Plk_1 438 444 PF00069 0.475
MOD_Plk_1 82 88 PF00069 0.440
MOD_Plk_1 99 105 PF00069 0.254
MOD_Plk_2-3 100 106 PF00069 0.504
MOD_Plk_4 100 106 PF00069 0.469
MOD_Plk_4 251 257 PF00069 0.392
MOD_Plk_4 275 281 PF00069 0.306
MOD_Plk_4 314 320 PF00069 0.428
MOD_Plk_4 337 343 PF00069 0.416
MOD_Plk_4 431 437 PF00069 0.379
MOD_ProDKin_1 532 538 PF00069 0.291
MOD_SUMO_for_1 109 112 PF00179 0.417
MOD_SUMO_for_1 408 411 PF00179 0.422
MOD_SUMO_rev_2 13 22 PF00179 0.504
TRG_DiLeu_BaEn_2 207 213 PF01217 0.379
TRG_DiLeu_BaLyEn_6 472 477 PF01217 0.613
TRG_ENDOCYTIC_2 367 370 PF00928 0.302
TRG_ENDOCYTIC_2 424 427 PF00928 0.469
TRG_ENDOCYTIC_2 87 90 PF00928 0.392
TRG_ER_diArg_1 427 429 PF00400 0.485
TRG_ER_diArg_1 49 51 PF00400 0.452
TRG_ER_diArg_1 71 73 PF00400 0.416
TRG_NLS_MonoExtN_4 70 77 PF00514 0.403
TRG_Pf-PMV_PEXEL_1 475 479 PF00026 0.517

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMG8 Leptomonas seymouri 73% 100%
A0A0S4IVT7 Bodo saltans 48% 98%
A0A1X0NZM7 Trypanosomatidae 45% 96%
A0A3R7MLP4 Trypanosoma rangeli 45% 99%
A0A3S7X270 Leishmania donovani 100% 100%
A4HH85 Leishmania braziliensis 89% 100%
C9ZL32 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 96%
E9ADT0 Leishmania major 97% 100%
E9AM00 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5DLG6 Trypanosoma cruzi 45% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS