LeishMANIAdb
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Putative U-box domain protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative U-box domain protein
Gene product:
U-box domain protein - putative
Species:
Leishmania infantum
UniProt:
A4I4D1_LEIIN
TriTrypDb:
LINF_290012900
Length:
601

Annotations

Annotations by Jardim et al.

Protein modification, U-box domain

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4D1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4D1

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 12
GO:0004842 ubiquitin-protein transferase activity 4 12
GO:0016740 transferase activity 2 12
GO:0019787 ubiquitin-like protein transferase activity 3 12
GO:0140096 catalytic activity, acting on a protein 2 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 278 282 PF00656 0.385
CLV_C14_Caspase3-7 32 36 PF00656 0.536
CLV_C14_Caspase3-7 514 518 PF00656 0.579
CLV_NRD_NRD_1 428 430 PF00675 0.501
CLV_NRD_NRD_1 50 52 PF00675 0.423
CLV_NRD_NRD_1 72 74 PF00675 0.419
CLV_PCSK_KEX2_1 428 430 PF00082 0.501
CLV_PCSK_KEX2_1 50 52 PF00082 0.375
CLV_PCSK_KEX2_1 72 74 PF00082 0.419
CLV_PCSK_SKI1_1 107 111 PF00082 0.499
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IMG8 Leptomonas seymouri 73% 100%
A0A0S4IVT7 Bodo saltans 48% 98%
A0A1X0NZM7 Trypanosomatidae 45% 96%
A0A3R7MLP4 Trypanosoma rangeli 45% 99%
A0A3S7X270 Leishmania donovani 100% 100%
A4HH85 Leishmania braziliensis 89% 100%
C9ZL32 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 96%
E9ADT0 Leishmania major 97% 100%
E9AM00 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5DLG6 Trypanosoma cruzi 45% 99%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS